GREMLIN Database
ACDH - Acetaldehyde dehydrogenase
UniProt: P77580 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13625
Length: 316 (286)
Sequences: 723 (292)
Seq/√Len: 17.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_M272_V6.8271.00
210_V274_L4.9841.00
145_R225_S4.9751.00
59_V86_N4.8011.00
143_V212_V4.0361.00
5_K30_E3.7761.00
145_R232_A3.6141.00
6_V29_L3.5681.00
87_D91_R3.5411.00
139_M230_A3.4821.00
218_S221_D3.4371.00
63_M89_A2.9750.99
214_S270_T2.8350.98
137_I181_A2.6520.97
76_D90_L2.6350.97
212_V270_T2.5770.96
280_A285_A2.5750.96
42_D282_Y2.4790.96
57_E64_N2.4450.95
19_M31_M2.3620.94
90_L99_L2.3270.94
180_R184_V2.2240.92
224_A228_E2.1900.91
231_E234_Q2.1740.91
126_V300_T2.1180.90
137_I182_I2.1090.90
22_I31_M2.0940.89
85_K89_A2.0230.88
175_T195_I2.0180.88
140_V152_A1.9680.86
112_V129_V1.9650.86
11_S37_I1.9650.86
223_E245_R1.9500.86
40_Q45_A1.9330.85
303_K306_Q1.9020.84
183_E191_G1.8630.83
6_V22_I1.8550.83
74_V97_I1.8300.82
156_A208_D1.8060.81
277_E285_A1.7450.78
163_A197_L1.7440.78
48_R54_T1.7360.78
63_M93_A1.7340.78
150_H189_A1.7140.77
220_D223_E1.7080.77
35_V62_L1.7000.77
241_R277_E1.6950.76
60_I89_A1.6530.75
31_M52_V1.6470.74
183_E190_K1.6030.72
99_L125_N1.5980.72
111_C300_T1.5940.72
225_S229_M1.5750.71
98_R308_L1.5750.71
129_V181_A1.5420.69
81_G84_V1.5240.68
241_R275_E1.5230.68
98_R304_M1.5200.68
4_R72_D1.5190.68
68_F93_A1.5160.68
139_M143_V1.5090.67
100_I301_A1.4850.66
143_V272_V1.4830.66
227_N245_R1.4790.66
9_I90_L1.4760.66
22_I298_L1.4730.65
157_S247_Q1.4600.65
87_D99_L1.4450.64
23_L52_V1.4350.63
147_A215_D1.4200.63
9_I76_D1.4190.62
26_G29_L1.4060.62
158_I176_E1.4020.62
39_P44_L1.3880.61
6_V111_C1.3800.60
148_R215_D1.3550.59
4_R73_I1.3500.58
132_G171_I1.3420.58
118_E303_K1.3320.57
33_V61_G1.3290.57
11_S38_D1.3260.57
55_T61_G1.3200.57
115_V185_V1.3130.56
84_V88_A1.3020.56
166_G175_T1.2770.54
5_K97_I1.2590.53
230_A242_L1.2390.52
85_K88_A1.2340.52
35_V71_I1.2110.50
140_V186_G1.2100.50
20_I42_D1.1970.49
88_A92_E1.1960.49
92_E234_Q1.1920.49
100_I126_V1.1820.48
224_A231_E1.1780.48
130_T195_I1.1770.48
34_M48_R1.1660.48
42_D158_I1.1600.47
175_T193_A1.1290.45
22_I32_A1.1200.45
79_S82_A1.1070.44
31_M34_M1.1040.44
91_R99_L1.0870.43
154_I175_T1.0630.41
273_W293_M1.0550.41
53_A67_E1.0550.41
281_H295_S1.0520.41
130_T171_I1.0520.41
19_M23_L1.0320.40
181_A185_V1.0300.39
217_A222_I1.0300.39
9_I181_A1.0290.39
148_R214_S1.0280.39
65_M68_F1.0260.39
4_R305_A1.0220.39
141_A145_R1.0220.39
158_I163_A1.0210.39
234_Q267_G1.0210.39
114_V229_M1.0190.39
132_G195_I1.0120.38
87_D111_C1.0100.38
232_A235_A1.0090.38
287_A295_S1.0030.38
235_A299_A1.0010.38
27_Q100_I1.0000.38
35_V55_T0.9990.38
182_I191_G0.9970.38
59_V99_L0.9950.37
93_A97_I0.9950.37
33_V244_Q0.9910.37
59_V89_A0.9870.37
92_E99_L0.9850.37
90_L97_I0.9820.37
6_V9_I0.9700.36
29_L301_A0.9680.36
128_M181_A0.9680.36
66_P69_A0.9590.35
53_A65_M0.9550.35
7_A33_V0.9550.35
10_G17_D0.9410.34
11_S44_L0.9400.34
33_V65_M0.9380.34
278_G291_D0.9210.33
132_G197_L0.9190.33
192_K199_P0.9160.33
269_K277_E0.9100.33
61_G90_L0.9080.33
301_A304_M0.9030.32
87_D92_E0.8980.32
76_D99_L0.8900.32
224_A306_Q0.8880.32
4_R97_I0.8840.31
55_T65_M0.8810.31
136_T186_G0.8800.31
299_A303_K0.8800.31
12_G17_D0.8770.31
214_S268_L0.8770.31
246_V268_L0.8710.31
137_I274_L0.8660.31
81_G176_E0.8660.31
227_N231_E0.8620.30
76_D213_L0.8610.30
87_D107_I0.8590.30
33_V62_L0.8580.30
69_A211_Y0.8560.30
122_D307_S0.8550.30
61_G76_D0.8480.30
26_G302_E0.8480.30
126_V304_M0.8470.30
45_A150_H0.8470.30
62_L247_Q0.8450.29
44_L56_H0.8450.29
48_R56_H0.8440.29
76_D97_I0.8430.29
34_M46_R0.8390.29
29_L298_L0.8360.29
206_M278_G0.8350.29
169_A247_Q0.8330.29
33_V82_A0.8330.29
65_M226_I0.8320.29
52_V70_D0.8280.29
150_H215_D0.8270.29
233_V274_L0.8250.28
157_S169_A0.8210.28
189_A215_D0.8210.28
84_V107_I0.8180.28
182_I208_D0.8110.28
136_T174_F0.8100.28
23_L295_S0.8100.28
137_I208_D0.8100.28
152_A186_G0.8070.28
128_M185_V0.8020.27
22_I295_S0.8000.27
35_V86_N0.7980.27
31_M82_A0.7970.27
166_G193_A0.7950.27
60_I84_V0.7920.27
215_D235_A0.7900.27
130_T163_A0.7900.27
49_R281_H0.7810.26
293_M298_L0.7800.26
10_G15_G0.7800.26
62_L157_S0.7790.26
76_D86_N0.7780.26
37_I136_T0.7770.26
155_I197_L0.7740.26
171_I195_I0.7710.26
48_R161_K0.7680.26
224_A227_N0.7650.26
220_D224_A0.7650.26
65_M69_A0.7630.26
73_I305_A0.7620.25
295_S298_L0.7580.25
5_K76_D0.7580.25
8_I31_M0.7560.25
48_R123_Q0.7560.25
33_V55_T0.7560.25
148_R189_A0.7540.25
89_A93_A0.7490.25
9_I74_V0.7470.25
96_D190_K0.7470.25
136_T208_D0.7460.25
105_A198_N0.7440.25
144_S271_A0.7420.25
46_R50_M0.7420.25
59_V85_K0.7390.24
223_E227_N0.7380.24
112_V117_L0.7380.24
70_D155_I0.7380.24
265_F268_L0.7380.24
71_I100_I0.7370.24
61_G65_M0.7360.24
154_I208_D0.7360.24
11_S19_M0.7360.24
13_N16_T0.7350.24
71_I90_L0.7290.24
65_M246_V0.7220.24
157_S204_L0.7210.24
86_N111_C0.7210.24
112_V200_A0.7200.24
12_G15_G0.7100.23
81_G295_S0.7050.23
106_A186_G0.7030.23
21_K291_D0.7030.23
109_P174_F0.7030.23
73_I234_Q0.6970.23
59_V118_E0.6940.23
155_I163_A0.6930.22
216_E245_R0.6910.22
208_D273_W0.6890.22
28_H306_Q0.6880.22
35_V107_I0.6850.22
10_G18_L0.6830.22
68_F246_V0.6800.22
196_V234_Q0.6790.22
6_V298_L0.6790.22
5_K72_D0.6780.22
204_L247_Q0.6770.22
136_T294_T0.6760.22
89_A92_E0.6750.22
60_I227_N0.6720.22
14_I21_K0.6720.22
136_T166_G0.6700.22
20_I52_V0.6680.21
33_V52_V0.6670.21
76_D88_A0.6660.21
166_G195_I0.6660.21
91_R124_L0.6650.21
119_A300_T0.6640.21
237_V278_G0.6630.21
207_R275_E0.6620.21
114_V232_A0.6620.21
226_I280_A0.6590.21
42_D120_N0.6560.21
40_Q48_R0.6520.21
33_V212_V0.6500.21
303_K307_S0.6500.21
125_N139_M0.6500.21
221_D270_T0.6490.21
122_D228_E0.6490.21
87_D93_A0.6480.21
154_I193_A0.6480.21
224_A232_A0.6470.21
159_A227_N0.6470.21
41_S105_A0.6450.21
32_A66_P0.6440.20
3_K30_E0.6420.20
172_D197_L0.6410.20
105_A177_T0.6400.20
74_V90_L0.6380.20
74_V297_A0.6370.20
46_R49_R0.6370.20
6_V31_M0.6350.20
27_Q220_D0.6340.20
4_R308_L0.6320.20
206_M237_V0.6310.20
37_I174_F0.6310.20
60_I235_A0.6290.20
98_R124_L0.6290.20
246_V281_H0.6250.20
63_M97_I0.6230.20
5_K32_A0.6230.20
139_M210_V0.6210.20
8_I125_N0.6210.20
280_A302_E0.6190.20
179_S195_I0.6180.19
12_G18_L0.6150.19
3_K40_Q0.6150.19
132_G177_T0.6130.19
179_S185_V0.6130.19
54_T222_I0.6120.19
130_T133_G0.6090.19
59_V204_L0.6090.19
46_R287_A0.6090.19
212_V216_E0.6090.19
102_L294_T0.6060.19
38_D44_L0.6050.19
40_Q215_D0.6050.19
169_A190_K0.6040.19
44_L282_Y0.6030.19
62_L65_M0.6000.19
16_T293_M0.5980.19
97_I126_V0.5980.19
79_S292_I0.5960.19
181_A307_S0.5950.19
215_D220_D0.5930.19
92_E129_V0.5930.19
153_E202_P0.5920.19
179_S194_I0.5910.18
48_R217_A0.5870.18
40_Q56_H0.5860.18
219_Q268_L0.5850.18
211_Y271_A0.5840.18
266_S270_T0.5830.18
37_I186_G0.5820.18
52_V303_K0.5820.18
121_V124_L0.5810.18
176_E308_L0.5800.18
19_M50_M0.5800.18
60_I63_M0.5800.18
154_I195_I0.5790.18
69_A97_I0.5790.18
181_A277_E0.5790.18
145_R270_T0.5770.18
55_T62_L0.5760.18
213_L265_F0.5760.18
174_F186_G0.5760.18
86_N234_Q0.5750.18
198_N237_V0.5740.18
34_M117_L0.5710.18
68_F281_H0.5710.18
205_M221_D0.5700.18
9_I61_G0.5690.18
198_N206_M0.5670.18
71_I299_A0.5670.18
220_D227_N0.5660.18
146_V203_P0.5650.18
243_K271_A0.5650.18
180_R183_E0.5630.17
159_A280_A0.5620.17
56_H63_M0.5600.17
112_V185_V0.5590.17
110_Y303_K0.5590.17
214_S301_A0.5580.17
48_R126_V0.5570.17
304_M308_L0.5560.17
13_N198_N0.5550.17
140_V182_I0.5530.17
213_L268_L0.5510.17
52_V82_A0.5510.17
69_A267_G0.5490.17
91_R230_A0.5470.17
85_K91_R0.5450.17
229_M232_A0.5450.17
110_Y129_V0.5440.17
203_P275_E0.5420.17
27_Q89_A0.5410.17
31_M157_S0.5400.17
233_V272_V0.5400.17
266_S280_A0.5390.17
14_I291_D0.5390.17
136_T175_T0.5380.17
109_P186_G0.5370.17
201_E204_L0.5370.17
148_R216_E0.5350.17
119_A226_I0.5350.17
8_I32_A0.5340.16
22_I52_V0.5330.16
281_H298_L0.5320.16
69_A281_H0.5320.16
214_S223_E0.5310.16
152_A294_T0.5310.16
83_H292_I0.5300.16
46_R210_V0.5280.16
117_L196_V0.5280.16
93_A159_A0.5270.16
35_V301_A0.5270.16
49_R176_E0.5260.16
36_G41_S0.5260.16
141_A148_R0.5250.16
9_I67_E0.5240.16
72_D190_K0.5230.16
149_V207_R0.5230.16
91_R107_I0.5230.16
186_G191_G0.5200.16
270_T299_A0.5200.16
180_R271_A0.5200.16
29_L45_A0.5170.16
31_M152_A0.5160.16
4_R27_Q0.5160.16
182_I223_E0.5150.16
87_D124_L0.5130.16
109_P188_A0.5120.16
20_I49_R0.5120.16
168_R202_P0.5120.16
15_G18_L0.5120.16
222_I228_E0.5110.16
45_A189_A0.5080.16
105_A237_V0.5080.16
8_I19_M0.5060.16
32_A53_A0.5060.16
199_P202_P0.5060.16
136_T275_E0.5050.16
5_K220_D0.5040.16
247_Q279_A0.5040.16
191_G196_V0.5040.16
106_A195_I0.5020.15
31_M84_V0.5000.15
40_Q189_A0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lrtB 1 0.9272 100 0.542 Contact Map
1nvmB 2 0.9842 100 0.567 Contact Map
3dr3A 4 0.8671 99.8 0.87 Contact Map
2r00A 2 0.8671 99.7 0.878 Contact Map
2hjsA 2 0.8766 99.7 0.881 Contact Map
3uw3A 2 0.8671 99.7 0.883 Contact Map
3tz6A 2 0.8608 99.6 0.885 Contact Map
3hskA 4 0.9177 99.6 0.885 Contact Map
1t4bA 2 0.8639 99.6 0.887 Contact Map
2ep5A 4 0.9272 99.6 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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