GREMLIN Database
PTFC1 - Fructose-like permease IIC component 1
UniProt: P77579 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14154
Length: 415 (343)
Sequences: 1845 (975)
Seq/√Len: 52.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
290_G393_T5.3561.00
134_G170_I4.0851.00
294_A307_F4.0581.00
38_H121_S3.9331.00
115_A170_I3.7701.00
296_I319_M3.6581.00
123_G127_A3.5761.00
362_V377_T3.5211.00
252_I258_I3.5201.00
295_T315_G3.4481.00
111_I167_A3.4311.00
177_L207_F3.4171.00
347_V396_M3.3761.00
248_A346_M3.2231.00
282_I386_I3.1701.00
49_T132_F2.9511.00
252_I346_M2.9111.00
337_S340_T2.6511.00
298_D398_V2.5771.00
381_V384_A2.4791.00
355_A359_L2.4721.00
251_A349_A2.4301.00
109_F136_L2.4251.00
106_L133_I2.3671.00
307_F398_V2.3501.00
351_V392_I2.2141.00
203_L207_F2.1761.00
289_I390_A2.1331.00
344_S396_M2.1221.00
45_R128_F2.1041.00
97_W101_S2.0701.00
291_L397_V2.0541.00
41_S120_N2.0301.00
178_V204_S2.0041.00
264_F267_F1.9471.00
266_A280_R1.9441.00
384_A388_L1.9401.00
223_I226_G1.9040.99
60_S100_Q1.8680.99
313_P316_K1.8540.99
282_I352_G1.8180.99
388_L392_I1.8130.99
246_I280_R1.7970.99
292_G319_M1.7600.99
305_R403_M1.7580.99
180_W184_K1.7480.99
98_L214_Y1.7460.99
292_G296_I1.7120.99
359_L381_V1.7090.99
100_Q104_G1.6690.99
225_G229_T1.6650.99
394_A398_V1.6630.99
129_P205_A1.6620.98
45_R117_F1.6120.98
361_A381_V1.6100.98
284_I325_G1.6080.98
134_G208_V1.5970.98
181_M185_I1.5810.98
65_Y68_L1.5730.98
52_M205_A1.5710.98
108_G136_L1.5660.98
306_L403_M1.5570.98
117_F120_N1.5480.98
57_L107_F1.5430.98
344_S400_L1.5310.97
337_S401_R1.5310.97
185_I203_L1.5240.97
355_A388_L1.5220.97
354_T358_W1.5140.97
347_V388_L1.5010.97
221_G225_G1.4750.97
293_L390_A1.4720.97
113_M132_F1.4640.97
169_I173_V1.4610.97
131_G174_A1.4490.96
119_A174_A1.4490.96
324_M371_W1.4400.96
116_A132_F1.4390.96
309_A312_Y1.4310.96
178_V200_L1.4290.96
117_F128_F1.4240.96
251_A327_S1.4200.96
222_W226_G1.4160.96
180_W185_I1.4090.96
294_A398_V1.3930.95
102_F209_M1.3820.95
179_K183_Q1.3770.95
185_I199_L1.3630.95
165_I169_I1.3630.95
355_A385_G1.3380.94
341_A397_V1.3290.94
342_I346_M1.3220.94
254_L327_S1.3200.94
373_W379_L1.3080.94
395_L399_F1.3060.94
55_V202_I1.3000.93
240_L358_W1.2870.93
244_M354_T1.2830.93
304_K312_Y1.2760.93
119_A131_G1.2750.93
396_M400_L1.2720.93
226_G230_V1.2720.93
122_I172_I1.2550.92
378_N381_V1.2520.92
380_G384_A1.2410.92
355_A381_V1.2260.91
41_S45_R1.2240.91
248_A252_I1.2120.91
361_A377_T1.2110.91
343_P346_M1.2070.91
192_L195_K1.2050.91
244_M350_I1.2030.90
68_L96_A1.2000.90
286_I349_A1.1960.90
211_A215_V1.1950.90
250_T284_I1.1810.90
115_A167_A1.1790.90
173_V177_L1.1780.90
309_A313_P1.1710.89
64_A96_A1.1700.89
306_L402_L1.1690.89
36_P40_M1.1680.89
281_S284_I1.1520.88
308_N311_L1.1510.88
251_A287_P1.1490.88
195_K199_L1.1350.88
306_L398_V1.1320.88
187_L195_K1.1310.88
293_L391_V1.1290.87
390_A394_A1.1280.87
244_M248_A1.1250.87
385_G388_L1.1250.87
182_N327_S1.1220.87
248_A283_A1.1110.87
220_G261_A1.1100.87
177_L208_V1.1020.86
281_S325_G1.1000.86
351_V388_L1.1000.86
137_M213_Y1.0970.86
279_A357_V1.0930.86
248_A350_I1.0880.85
38_H122_I1.0760.85
298_D306_L1.0720.85
263_G277_V1.0710.84
285_V325_G1.0630.84
95_F206_I1.0580.84
130_A205_A1.0550.84
254_L345_Y1.0480.83
200_L204_S1.0450.83
293_L394_A1.0440.83
391_V394_A1.0440.83
391_V395_L1.0400.83
31_F35_L1.0380.83
115_A135_G1.0360.82
228_R232_T1.0330.82
348_G393_T1.0230.82
132_F136_L1.0180.81
231_L265_V1.0180.81
224_N261_A1.0170.81
124_G182_N1.0110.81
355_A358_W1.0110.81
206_I210_L1.0110.81
356_A361_A1.0090.81
251_A345_Y1.0070.81
234_A245_G1.0050.80
238_G241_M1.0040.80
234_A238_G1.0020.80
239_A360_G1.0010.80
29_T33_G0.9990.80
31_F34_E0.9980.80
170_I212_M0.9950.80
250_T325_G0.9900.79
286_I352_G0.9880.79
250_T281_S0.9860.79
98_L210_L0.9840.79
178_V181_M0.9830.79
51_I197_T0.9800.79
161_P221_G0.9720.78
237_K240_L0.9670.78
230_V233_A0.9670.78
297_I390_A0.9630.78
361_A378_N0.9610.77
119_A127_A0.9570.77
122_I176_Y0.9560.77
246_I276_P0.9530.77
339_I343_P0.9490.77
216_I220_G0.9470.76
267_F277_V0.9440.76
115_A119_A0.9440.76
277_V280_R0.9420.76
306_L404_M0.9410.76
181_M204_S0.9390.76
343_P400_L0.9380.76
308_N336_E0.9290.75
204_S208_V0.9250.75
240_L354_T0.9250.75
359_L388_L0.9210.74
334_A341_A0.9190.74
115_A134_G0.9140.74
281_S285_V0.9110.74
34_E38_H0.9100.73
131_G135_G0.9080.73
267_F271_T0.9080.73
291_L318_A0.9060.73
41_S128_F0.8990.73
263_G270_T0.8970.72
39_V172_I0.8950.72
60_S65_Y0.8950.72
350_I354_T0.8910.72
263_G267_F0.8910.72
21_V25_Q0.8870.72
226_G229_T0.8850.71
130_A204_S0.8830.71
285_V371_W0.8760.71
31_F176_Y0.8740.70
282_I356_A0.8740.70
278_T281_S0.8720.70
259_N262_A0.8680.70
295_T298_D0.8680.70
210_L214_Y0.8650.70
21_V28_K0.8640.70
293_L297_I0.8630.69
327_S349_A0.8630.69
340_T401_R0.8590.69
237_K241_M0.8580.69
243_A247_A0.8570.69
64_A90_L0.8570.69
110_A167_A0.8530.69
39_V168_L0.8500.68
162_S166_G0.8500.68
243_A353_S0.8470.68
30_S33_G0.8470.68
169_I203_L0.8420.68
383_M387_A0.8410.67
227_I230_V0.8400.67
25_Q28_K0.8360.67
230_V245_G0.8320.67
291_L327_S0.8300.66
252_I345_Y0.8290.66
242_Y265_V0.8270.66
63_I95_F0.8200.65
21_V27_S0.8190.65
323_F370_I0.8180.65
136_L140_Q0.8150.65
221_G229_T0.8120.65
191_L324_M0.8090.64
20_A23_N0.8040.64
22_K26_A0.8040.64
241_M245_G0.8020.64
220_G223_I0.7990.63
331_I334_A0.7960.63
168_L268_S0.7950.63
179_K184_K0.7930.63
341_A345_Y0.7910.63
345_Y393_T0.7890.62
250_T279_A0.7840.62
269_F274_V0.7790.61
101_S104_G0.7790.61
32_W35_L0.7730.61
137_M217_T0.7660.60
128_F346_M0.7630.60
126_L182_N0.7610.60
259_N283_A0.7590.59
105_V136_L0.7550.59
117_F132_F0.7540.59
27_S30_S0.7510.59
60_S67_W0.7490.58
194_F199_L0.7480.58
127_A178_V0.7460.58
176_Y179_K0.7450.58
29_T34_E0.7430.58
123_G132_F0.7400.58
20_A25_Q0.7390.57
394_A397_V0.7370.57
344_S393_T0.7350.57
247_A283_A0.7330.57
181_M200_L0.7310.57
45_R120_N0.7280.56
367_E372_A0.7270.56
361_A385_G0.7270.56
51_I125_K0.7260.56
47_V195_K0.7240.56
233_A236_E0.7230.56
21_V169_I0.7220.56
187_L194_F0.7200.55
47_V51_I0.7180.55
53_G106_L0.7120.55
382_Y386_I0.7110.54
129_P204_S0.7110.54
227_I245_G0.7100.54
297_I398_V0.7100.54
250_T283_A0.7100.54
57_L100_Q0.7080.54
270_T277_V0.7070.54
95_F99_S0.7060.54
281_S367_E0.7060.54
173_V211_A0.7050.54
19_A24_P0.7050.54
105_V108_G0.7050.54
93_L97_W0.7020.54
160_V217_T0.7020.54
37_Q121_S0.7010.53
182_N200_L0.7010.53
244_M247_A0.7000.53
185_I207_F0.6990.53
128_F132_F0.6990.53
297_I304_K0.6960.53
284_I324_M0.6960.53
120_N128_F0.6940.53
289_I323_F0.6900.52
387_A390_A0.6880.52
311_L401_R0.6870.52
285_V370_I0.6860.52
22_K25_Q0.6860.52
109_F132_F0.6840.52
310_Q313_P0.6820.51
376_V382_Y0.6810.51
296_I316_K0.6730.51
361_A375_L0.6730.51
224_N318_A0.6720.50
250_T370_I0.6690.50
66_S109_F0.6690.50
278_T285_V0.6660.50
250_T285_V0.6650.50
49_T113_M0.6640.50
184_K200_L0.6640.50
268_S271_T0.6630.49
281_S371_W0.6630.49
43_I50_L0.6620.49
61_Q367_E0.6600.49
24_P29_T0.6550.49
179_K182_N0.6550.49
288_P318_A0.6540.49
63_I67_W0.6540.49
168_L202_I0.6530.48
340_T344_S0.6530.48
23_N28_K0.6520.48
203_L206_I0.6520.48
45_R125_K0.6510.48
105_V137_M0.6480.48
291_L345_Y0.6470.48
123_G126_L0.6460.48
19_A25_Q0.6440.47
249_A262_A0.6440.47
64_A92_L0.6440.47
112_P331_I0.6430.47
285_V353_S0.6430.47
265_V269_F0.6430.47
219_F276_P0.6400.47
129_P401_R0.6400.47
305_R404_M0.6400.47
286_I345_Y0.6390.47
351_V394_A0.6360.47
162_S217_T0.6360.47
395_L398_V0.6360.47
293_L296_I0.6360.47
352_G356_A0.6350.47
291_L307_F0.6350.47
284_I367_E0.6320.46
365_F372_A0.6320.46
320_F346_M0.6310.46
59_F63_I0.6250.45
254_L288_P0.6240.45
63_I92_L0.6230.45
345_Y349_A0.6230.45
178_V185_I0.6220.45
311_L336_E0.6220.45
249_A259_N0.6210.45
218_P221_G0.6180.45
269_F275_L0.6170.45
168_L172_I0.6170.45
211_A258_I0.6160.45
114_F254_L0.6150.44
363_Q382_Y0.6140.44
298_D402_L0.6130.44
62_L65_Y0.6100.44
97_W100_Q0.6100.44
373_W376_V0.6090.44
368_S372_A0.6090.44
23_N26_A0.6070.44
275_L356_A0.6070.44
35_L172_I0.6060.44
59_F62_L0.6060.44
325_G371_W0.6060.44
65_Y92_L0.6050.43
194_F276_P0.6050.43
193_A318_A0.6040.43
355_A384_A0.6020.43
364_W377_T0.6000.43
22_K27_S0.6000.43
247_A382_Y0.6000.43
137_M304_K0.5990.43
61_Q284_I0.5980.43
373_W383_M0.5970.43
132_F204_S0.5960.42
281_S363_Q0.5950.42
223_I258_I0.5920.42
193_A327_S0.5920.42
298_D307_F0.5920.42
258_I346_M0.5900.42
122_I179_K0.5890.42
311_L397_V0.5890.42
165_I349_A0.5890.42
125_K195_K0.5880.42
251_A254_L0.5870.42
284_I370_I0.5860.41
374_P383_M0.5860.41
286_I393_T0.5860.41
21_V26_A0.5860.41
223_I230_V0.5850.41
277_V368_S0.5850.41
202_I206_I0.5840.41
347_V392_I0.5840.41
43_I267_F0.5820.41
129_P269_F0.5780.41
19_A22_K0.5770.41
125_K322_A0.5770.41
18_A22_K0.5760.40
22_K399_F0.5760.40
254_L286_I0.5750.40
129_P276_P0.5710.40
19_A23_N0.5710.40
18_A21_V0.5700.40
134_G174_A0.5700.40
114_F118_V0.5700.40
210_L213_Y0.5690.40
364_W375_L0.5680.40
284_I371_W0.5680.40
225_G228_R0.5660.39
20_A29_T0.5640.39
133_I205_A0.5640.39
63_I98_L0.5630.39
387_A391_V0.5620.39
229_T232_T0.5610.39
168_L335_L0.5600.39
269_F276_P0.5600.39
255_G259_N0.5600.39
110_A115_A0.5570.39
55_V336_E0.5540.38
243_A354_T0.5540.38
20_A27_S0.5540.38
132_F230_V0.5530.38
61_Q325_G0.5520.38
347_V351_V0.5510.38
281_S370_I0.5500.38
63_I66_S0.5500.38
379_L383_M0.5490.38
325_G367_E0.5490.38
385_G392_I0.5470.38
45_R200_L0.5470.38
123_G179_K0.5450.37
277_V367_E0.5450.37
131_G138_S0.5440.37
282_I382_Y0.5440.37
287_P349_A0.5430.37
187_L199_L0.5430.37
19_A28_K0.5420.37
267_F270_T0.5420.37
297_I319_M0.5410.37
381_V388_L0.5400.37
66_S91_S0.5380.37
38_H172_I0.5380.37
242_Y320_F0.5360.36
110_A128_F0.5360.36
297_I395_L0.5360.36
279_A284_I0.5360.36
30_S34_E0.5350.36
278_T371_W0.5340.36
62_L365_F0.5330.36
129_P202_I0.5330.36
38_H176_Y0.5320.36
325_G353_S0.5310.36
181_M203_L0.5310.36
63_I68_L0.5310.36
68_L100_Q0.5310.36
266_A277_V0.5300.36
62_L66_S0.5300.36
21_V24_P0.5290.36
168_L354_T0.5270.36
219_F333_F0.5270.36
113_M381_V0.5260.35
286_I290_G0.5230.35
44_S117_F0.5220.35
105_V167_A0.5220.35
219_F327_S0.5210.35
36_P172_I0.5200.35
235_G238_G0.5190.35
51_I314_Q0.5190.35
297_I394_A0.5180.35
106_L122_I0.5150.34
219_F268_S0.5140.34
173_V207_F0.5130.34
263_G325_G0.5120.34
26_A216_I0.5120.34
294_A393_T0.5100.34
61_Q365_F0.5100.34
356_A363_Q0.5100.34
399_F403_M0.5100.34
135_G167_A0.5100.34
173_V216_I0.5080.34
64_A167_A0.5080.34
284_I321_L0.5070.34
199_L221_G0.5070.34
91_S94_K0.5060.34
49_T292_G0.5060.34
130_A317_T0.5060.34
263_G280_R0.5040.33
29_T32_W0.5040.33
282_I289_I0.5040.33
25_Q29_T0.5040.33
219_F222_W0.5030.33
24_P28_K0.5010.33
291_L341_A0.5010.33
314_Q344_S0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.8988 100 0.734 Contact Map
3orgA 2 0.5229 51.8 0.973 Contact Map
2kncA 1 0.1157 47.2 0.973 Contact Map
2kluA 1 0.0988 44.6 0.974 Contact Map
4tkrA 2 0.4361 40.4 0.974 Contact Map
3d31C 2 0.5807 24 0.977 Contact Map
4j05A 3 0.812 20.2 0.978 Contact Map
2nq2A 2 0.2771 14.2 0.979 Contact Map
2l8sA 1 0.0964 13.5 0.98 Contact Map
2m20A 2 0.0916 10 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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