GREMLIN Database
ANMK - Anhydro-N-acetylmuramic acid kinase
UniProt: P77570 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13942
Length: 369 (359)
Sequences: 2225 (1632)
Seq/√Len: 86.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_I191_G5.4071.00
272_E306_R4.8061.00
293_V304_M4.0251.00
230_D245_Y3.9461.00
95_G338_A3.7691.00
233_F273_L3.2031.00
215_R305_A3.1991.00
24_T31_A3.0391.00
201_R252_E3.0361.00
299_R327_D2.9891.00
341_T364_I2.9211.00
292_M319_T2.7911.00
220_I261_V2.6621.00
292_M322_V2.6461.00
123_A136_R2.6001.00
47_A68_Q2.5401.00
215_R302_L2.4761.00
195_M271_A2.4531.00
118_N131_G2.4481.00
161_E290_R2.4431.00
71_Q124_R2.4161.00
148_V333_A2.3901.00
101_V115_I2.3641.00
94_I125_T2.3561.00
166_L278_I2.3311.00
131_G365_F2.3101.00
6_F93_A2.2811.00
320_D326_G2.2811.00
35_S328_D2.1751.00
140_L359_T2.1641.00
93_A342_L2.1581.00
9_V77_V2.1461.00
211_A302_L2.0701.00
186_Y281_Q2.0171.00
195_M267_Q1.9601.00
20_V80_L1.9461.00
36_L83_E1.9321.00
276_V310_L1.9241.00
23_A332_L1.8851.00
73_F96_C1.8591.00
47_A61_Q1.8581.00
128_T364_I1.8291.00
168_I278_I1.8291.00
216_A264_R1.8231.00
166_L293_V1.8141.00
17_G37_S1.7811.00
219_V268_A1.7741.00
163_R290_R1.7731.00
198_W266_V1.7661.00
112_T138_I1.7511.00
188_T277_T1.7471.00
51_I65_L1.7411.00
340_R345_L1.7361.00
32_Q332_L1.7071.00
318_T326_G1.7071.00
164_M282_V1.6951.00
202_Q263_P1.6931.00
210_D301_P1.6911.00
171_I193_M1.6851.00
199_I203_A1.6821.00
5_R22_L1.6731.00
302_L306_R1.6561.00
18_V72_L1.6461.00
132_D363_A1.6461.00
123_A140_L1.6381.00
25_I339_W1.6341.00
172_A188_T1.6321.00
197_A248_Y1.6151.00
63_G111_H1.6131.00
217_G265_D1.6011.00
226_N257_H1.5841.00
306_R310_L1.5821.00
5_R24_T1.5741.00
71_Q120_Q1.5461.00
9_V20_V1.5401.00
275_A306_R1.5401.00
209_K212_E1.5301.00
78_N124_R1.4950.99
306_R309_A1.4780.99
123_A359_T1.4760.99
199_I213_W1.4690.99
15_L48_V1.4640.99
70_G121_I1.4610.99
271_A302_L1.4410.99
86_L91_I1.4270.99
317_T321_A1.4250.99
69_L73_F1.4230.99
205_K209_K1.4170.99
272_E276_V1.4140.99
272_E310_L1.4010.99
211_A301_P1.3910.99
320_D325_S1.3740.99
275_A310_L1.3720.99
119_N135_R1.3590.99
291_L314_T1.3590.99
87_Q90_D1.3460.99
166_L291_L1.3390.99
198_W267_Q1.3350.99
18_V76_A1.3310.99
164_M288_C1.3300.99
213_W267_Q1.3260.99
282_V291_L1.3230.99
164_M176_L1.3220.99
86_L90_D1.3170.99
41_P44_L1.2950.99
275_A307_L1.2900.98
268_A302_L1.2750.98
152_H329_M1.2740.98
290_R317_T1.2670.98
228_L276_V1.2670.98
67_T117_D1.2560.98
183_V349_L1.2540.98
67_T120_Q1.2460.98
49_L193_M1.2310.98
193_M243_R1.2300.98
9_V96_C1.2250.98
74_A124_R1.2170.98
81_L127_I1.2140.98
130_V342_L1.2110.98
34_A84_Q1.2090.98
40_I69_L1.2070.98
290_R315_E1.2010.98
21_V331_A1.1980.98
73_F121_I1.1880.97
147_L334_F1.1880.97
48_V65_L1.1880.97
198_W202_Q1.1820.97
271_A275_A1.1810.97
81_L88_A1.1800.97
348_N361_L1.1740.97
285_S288_C1.1730.97
151_F336_W1.1660.97
41_P72_L1.1600.97
221_L225_Q1.1590.97
17_G40_I1.1570.97
44_L72_L1.1550.97
121_I129_V1.1510.97
80_L84_Q1.1430.97
18_V73_F1.1380.97
302_L305_A1.1350.97
20_V76_A1.1300.96
224_L227_M1.1300.96
324_I332_L1.1270.96
58_T61_Q1.1230.96
191_G278_I1.1220.96
199_I267_Q1.1200.96
347_G361_L1.1170.96
352_V355_A1.1160.96
198_W270_L1.1080.96
130_V364_I1.1010.96
66_D116_G1.0970.96
194_L270_L1.0950.96
25_I30_V1.0930.96
211_A215_R1.0860.96
213_W216_A1.0840.96
228_L273_L1.0820.95
298_S318_T1.0790.95
120_Q124_R1.0750.95
228_L280_E1.0750.95
339_W343_A1.0720.95
307_L311_L1.0680.95
73_F77_V1.0650.95
67_T71_Q1.0630.95
96_C116_G1.0520.95
136_R140_L1.0470.95
75_D79_A1.0410.94
305_A309_A1.0400.94
200_W206_P1.0350.94
140_L357_Q1.0350.94
94_I127_I1.0330.94
66_D70_G1.0310.94
78_N125_T1.0250.94
6_F339_W1.0220.94
298_S326_G1.0220.94
117_D135_R1.0200.94
117_D120_Q1.0190.94
88_A127_I1.0160.94
341_T344_G1.0100.93
136_R359_T1.0050.93
55_Q58_T1.0020.93
128_T342_L1.0010.93
15_L49_L0.9980.93
271_A303_L0.9980.93
66_D135_R0.9970.93
279_S307_L0.9910.93
166_L172_A0.9860.93
227_M273_L0.9840.93
162_R289_E0.9810.92
220_I265_D0.9800.92
284_L288_C0.9780.92
21_V32_Q0.9730.92
60_S104_E0.9600.92
95_G133_F0.9540.91
219_V224_L0.9520.91
23_A335_A0.9510.91
91_I127_I0.9510.91
195_M303_L0.9480.91
20_V77_V0.9470.91
267_Q271_A0.9470.91
224_L273_L0.9460.91
341_T360_V0.9300.90
193_M247_N0.9270.90
24_T33_L0.9220.90
128_T341_T0.9220.90
15_L52_C0.9180.90
291_L311_L0.9170.90
22_L86_L0.9150.90
149_P240_S0.9140.90
52_C244_E0.9120.89
213_W264_R0.9100.89
279_S311_L0.9090.89
133_F334_F0.9080.89
279_S310_L0.9080.89
96_C121_I0.9070.89
230_D246_F0.9050.89
65_L70_G0.9020.89
203_A213_W0.8990.89
226_N254_H0.8990.89
70_G117_D0.8930.88
48_V69_L0.8910.88
193_M197_A0.8910.88
176_L285_S0.8860.88
54_G57_L0.8830.88
152_H294_C0.8750.87
162_R179_P0.8720.87
20_V36_L0.8690.87
5_R33_L0.8680.87
20_V84_Q0.8660.87
151_F155_L0.8640.87
118_N365_F0.8620.87
233_F277_T0.8590.86
233_F246_F0.8570.86
57_L102_W0.8430.85
78_N88_A0.8410.85
143_Q235_Q0.8360.85
303_L307_L0.8360.85
70_G73_F0.8350.85
123_A357_Q0.8340.85
72_L75_D0.8320.85
60_S102_W0.8260.84
6_F92_V0.8250.84
312_P315_E0.8240.84
275_A303_L0.8230.84
218_K265_D0.8210.84
293_V307_L0.8200.84
341_T347_G0.8190.84
66_D117_D0.8190.84
59_L113_L0.8190.84
282_V311_L0.8180.84
47_A65_L0.8150.83
294_C329_M0.8110.83
232_Y239_K0.8110.83
7_I77_V0.8100.83
151_F333_A0.8070.83
58_T62_F0.8060.83
21_V328_D0.8050.83
191_G274_T0.8040.83
347_G360_V0.8040.83
62_F101_V0.8040.83
15_L65_L0.7980.82
162_R176_L0.7970.82
292_M317_T0.7970.82
294_C319_T0.7960.82
59_L62_F0.7950.82
174_L282_V0.7940.82
60_S111_H0.7940.82
132_D135_R0.7940.82
268_A306_R0.7930.82
65_L68_Q0.7880.81
224_L269_T0.7880.81
137_D353_T0.7870.81
150_A349_L0.7860.81
155_L324_I0.7850.81
30_V332_L0.7850.81
226_N258_F0.7840.81
27_E339_W0.7840.81
55_Q61_Q0.7810.81
45_K200_W0.7810.81
177_L183_V0.7810.81
45_K49_L0.7800.81
195_M214_A0.7770.80
163_R177_L0.7770.80
150_A347_G0.7750.80
158_H179_P0.7710.80
79_A83_E0.7710.80
58_T102_W0.7690.80
175_S178_I0.7670.80
136_R341_T0.7660.79
188_T232_Y0.7640.79
165_V322_V0.7640.79
166_L282_V0.7630.79
101_V113_L0.7620.79
182_P351_S0.7620.79
45_K206_P0.7610.79
212_E216_A0.7610.79
106_T143_Q0.7550.78
49_L243_R0.7540.78
121_I131_G0.7530.78
293_V298_S0.7500.78
213_W263_P0.7490.78
46_Q50_D0.7490.78
81_L91_I0.7480.78
62_F66_D0.7470.78
241_T245_Y0.7470.78
38_W79_A0.7460.78
107_G110_P0.7430.77
70_G74_A0.7410.77
348_N355_A0.7380.77
36_L80_L0.7350.77
62_F113_L0.7330.76
291_L312_P0.7330.76
164_M174_L0.7310.76
308_A312_P0.7280.76
22_L80_L0.7280.76
10_M15_L0.7250.76
150_A340_R0.7240.76
152_H336_W0.7230.75
327_D331_A0.7210.75
350_P358_E0.7210.75
153_H183_V0.7210.75
249_G252_E0.7200.75
228_L277_T0.7200.75
304_M318_T0.7150.75
348_N358_E0.7150.75
9_V73_F0.7140.75
151_F332_L0.7140.75
212_E215_R0.7090.74
118_N363_A0.7080.74
158_H163_R0.7070.74
174_L291_L0.7060.74
10_M151_F0.7060.74
66_D96_C0.7060.74
36_L79_A0.7040.73
222_P225_Q0.7030.73
329_M332_L0.7020.73
342_L364_I0.7000.73
44_L68_Q0.6990.73
189_G246_F0.6970.73
48_V99_Q0.6950.73
220_I262_D0.6950.73
202_Q266_V0.6930.72
59_L101_V0.6930.72
299_R326_G0.6930.72
176_L284_L0.6920.72
22_L91_I0.6920.72
50_D61_Q0.6920.72
203_A267_Q0.6900.72
69_L96_C0.6880.72
234_S280_E0.6830.71
261_V266_V0.6800.71
11_S14_S0.6800.71
276_V280_E0.6790.71
63_G244_E0.6790.71
230_D273_L0.6780.71
77_V91_I0.6750.70
119_N123_A0.6730.70
272_E309_A0.6700.70
37_S40_I0.6690.70
5_R90_D0.6670.69
37_S327_D0.6660.69
21_V35_S0.6650.69
77_V81_L0.6640.69
7_I20_V0.6640.69
209_K301_P0.6620.69
129_V365_F0.6610.69
49_L200_W0.6600.69
51_I54_G0.6600.69
149_P185_G0.6600.69
271_A306_R0.6590.68
307_L313_G0.6590.68
153_H157_A0.6580.68
317_T322_V0.6570.68
221_L261_V0.6560.68
348_N352_V0.6530.68
319_T329_M0.6490.67
57_L62_F0.6480.67
268_A272_E0.6470.67
165_V177_L0.6440.67
163_R178_I0.6440.67
84_Q91_I0.6440.67
52_C193_M0.6430.67
68_Q72_L0.6420.66
117_D132_D0.6400.66
275_A311_L0.6360.66
179_P182_P0.6360.66
10_M333_A0.6320.65
293_V316_V0.6280.65
44_L65_L0.6260.65
30_V34_A0.6260.65
143_Q354_G0.6250.64
188_T281_Q0.6240.64
165_V294_C0.6230.64
95_G130_V0.6220.64
136_R357_Q0.6210.64
37_S121_I0.6200.64
199_I206_P0.6180.64
159_P163_R0.6170.63
261_V265_D0.6150.63
66_D121_I0.6130.63
59_L102_W0.6110.63
226_N259_P0.6070.62
70_G116_G0.6070.62
29_R33_L0.6060.62
34_A83_E0.6050.62
66_D73_F0.6040.62
290_R322_V0.6040.62
57_L61_Q0.6020.62
132_D365_F0.5980.61
21_V148_V0.5980.61
70_G120_Q0.5960.61
96_C131_G0.5960.61
194_L198_W0.5940.61
172_A189_G0.5930.60
15_L196_D0.5910.60
325_S328_D0.5910.60
203_A206_P0.5890.60
51_I59_L0.5860.59
18_V44_L0.5860.59
128_T344_G0.5830.59
103_H114_Q0.5810.59
298_S325_S0.5800.59
189_G241_T0.5790.59
277_T280_E0.5790.59
75_D124_R0.5790.59
194_L274_T0.5780.58
112_T135_R0.5760.58
117_D121_I0.5730.58
70_G124_R0.5730.58
165_V175_S0.5730.58
130_V341_T0.5720.58
153_H177_L0.5720.58
219_V272_E0.5700.57
200_W315_E0.5690.57
119_N363_A0.5690.57
191_G246_F0.5680.57
104_E245_Y0.5680.57
5_R92_V0.5680.57
195_M199_I0.5670.57
106_T110_P0.5670.57
293_V318_T0.5670.57
32_Q35_S0.5660.57
97_H334_F0.5650.57
339_W345_L0.5650.57
176_L184_G0.5650.57
158_H161_E0.5640.57
11_S73_F0.5620.56
214_A271_A0.5610.56
61_Q65_L0.5600.56
21_V327_D0.5590.56
7_I80_L0.5590.56
219_V306_R0.5580.56
60_S64_Q0.5580.56
233_F250_W0.5570.56
45_K196_D0.5570.56
199_I205_K0.5560.56
7_I101_V0.5550.55
228_L233_F0.5540.55
183_V352_V0.5530.55
93_A338_A0.5530.55
185_G352_V0.5500.55
148_V348_N0.5480.54
230_D233_F0.5470.54
49_L52_C0.5460.54
148_V347_G0.5460.54
131_G363_A0.5460.54
347_G352_V0.5450.54
137_D354_G0.5430.54
20_V38_W0.5420.54
103_H112_T0.5420.54
38_W75_D0.5410.54
23_A32_Q0.5410.54
54_G58_T0.5400.53
252_E256_R0.5400.53
227_M248_Y0.5400.53
21_V332_L0.5400.53
221_L276_V0.5390.53
11_S40_I0.5390.53
299_R320_D0.5360.53
63_G119_N0.5360.53
152_H156_L0.5350.53
36_L328_D0.5350.53
95_G152_H0.5340.53
156_L329_M0.5340.53
349_L352_V0.5330.52
149_P353_T0.5330.52
327_D364_I0.5330.52
135_R363_A0.5330.52
106_T232_Y0.5330.52
193_M244_E0.5330.52
118_N123_A0.5320.52
347_G355_A0.5320.52
340_R349_L0.5310.52
70_G96_C0.5310.52
78_N82_K0.5290.52
347_G350_P0.5290.52
173_N330_E0.5280.52
319_T322_V0.5280.52
16_D19_D0.5270.52
32_Q328_D0.5260.52
49_L197_A0.5250.51
246_F270_L0.5250.51
111_H365_F0.5240.51
212_E301_P0.5240.51
95_G118_N0.5220.51
304_M316_V0.5220.51
299_R312_P0.5210.51
329_M336_W0.5210.51
88_A206_P0.5210.51
137_D186_Y0.5210.51
227_M233_F0.5210.51
241_T244_E0.5200.51
5_R86_L0.5200.51
274_T303_L0.5190.51
154_A185_G0.5190.51
94_I338_A0.5180.50
229_S254_H0.5170.50
166_L214_A0.5150.50
140_L356_S0.5140.50
218_K268_A0.5130.50
154_A336_W0.5120.50
273_L277_T0.5110.49
347_G359_T0.5110.49
202_Q267_Q0.5110.49
121_I125_T0.5090.49
66_D115_I0.5080.49
164_M291_L0.5070.49
122_V128_T0.5070.49
186_Y237_A0.5070.49
40_I171_I0.5070.49
77_V80_L0.5050.49
157_A178_I0.5030.48
77_V94_I0.5030.48
62_F102_W0.5020.48
16_D173_N0.5020.48
44_L99_Q0.5020.48
36_L39_P0.5020.48
325_S329_M0.5000.48
51_I102_W0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cqyA 3 0.9973 100 0.072 Contact Map
4mo4A 2 0.9566 100 0.082 Contact Map
4bgbA 1 0.7967 100 0.369 Contact Map
1huxA 2 0.6829 99.7 0.869 Contact Map
4ehuA 2 0.71 99.6 0.884 Contact Map
3enoA 1 0.8049 98.5 0.927 Contact Map
2ivnA 1 0.8157 98.1 0.935 Contact Map
3en9A 1 0.8184 98 0.937 Contact Map
3zeuB 1 0.832 97.9 0.939 Contact Map
3wt0A 1 0.8564 97.8 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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