GREMLIN Database
MHPR - Mhp operon transcriptional activator
UniProt: P77569 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20276
Length: 277 (245)
Sequences: 12655 (9313)
Seq/√Len: 595.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_L18_G3.3601.00
103_E248_A3.1661.00
111_S148_S2.8911.00
96_L252_V2.8361.00
16_T58_E2.8241.00
191_R195_E2.6251.00
23_N75_K2.5571.00
150_L188_I2.4291.00
94_A122_E2.4101.00
162_K186_E2.3911.00
19_L60_Y2.3611.00
150_L203_G2.3531.00
117_A140_R2.2051.00
106_W235_A2.1631.00
96_L255_Q2.1051.00
25_L61_V2.0741.00
20_M58_E2.0661.00
64_S67_D2.0571.00
98_G124_T2.0401.00
200_N212_S1.9691.00
156_C160_D1.9641.00
201_Y211_A1.9331.00
113_L143_L1.9331.00
155_F218_R1.9301.00
215_V249_L1.9061.00
215_V253_A1.8541.00
96_L259_G1.8251.00
211_A233_A1.8181.00
99_D255_Q1.7681.00
23_N58_E1.7561.00
62_R71_R1.7311.00
181_E184_K1.7211.00
93_A256_I1.7121.00
246_L250_Q1.7051.00
21_L37_L1.6921.00
101_L108_T1.6871.00
24_M41_S1.6821.00
99_D103_E1.6791.00
231_Y236_M1.6701.00
52_L61_V1.6671.00
24_M32_A1.6661.00
182_P186_E1.6531.00
24_M37_L1.6531.00
229_L245_H1.5831.00
215_V250_Q1.5771.00
24_M40_L1.5721.00
202_R233_A1.5701.00
188_I191_R1.5481.00
52_L70_F1.5441.00
157_P160_D1.5371.00
32_A40_L1.5371.00
96_L99_D1.5211.00
240_Q244_K1.5151.00
33_S36_L1.5081.00
197_Y246_L1.5041.00
37_L48_V1.5001.00
161_R186_E1.4831.00
248_A251_R1.4761.00
202_R209_K1.4761.00
104_V248_A1.4531.00
31_G71_R1.4521.00
31_G69_S1.4391.00
43_L48_V1.4381.00
162_K182_P1.4301.00
125_H131_S1.4291.00
192_A198_G1.4271.00
118_M143_L1.4171.00
118_M152_W1.4021.00
75_K78_Q1.4021.00
218_R257_E1.3971.00
90_S122_E1.3811.00
101_L124_T1.3641.00
100_L248_A1.3621.00
23_N60_Y1.3551.00
25_L32_A1.3551.00
56_Q61_V1.3521.00
25_L31_G1.3181.00
97_L110_V1.3161.00
253_A257_E1.3121.00
19_L58_E1.3061.00
56_Q63_R1.3001.00
93_A110_V1.2911.00
64_S71_R1.2841.00
44_H47_T1.2841.00
28_L40_L1.2701.00
49_R53_E1.2501.00
28_L32_A1.2381.00
251_R255_Q1.2381.00
100_L252_V1.2381.00
158_E186_E1.2351.00
116_D167_M1.2301.00
174_D178_L1.2271.00
145_K178_L1.2261.00
38_A48_V1.2221.00
155_F216_P1.2091.00
158_E162_K1.2001.00
94_A98_G1.2001.00
166_E182_P1.2001.00
179_A188_I1.1981.00
37_L52_L1.1961.00
104_V245_H1.1821.00
218_R223_V1.1821.00
145_K173_G1.1741.00
111_S118_M1.1671.00
34_V49_R1.1641.00
215_V246_L1.1531.00
189_L192_A1.1521.00
154_A192_A1.1411.00
144_L178_L1.1291.00
250_Q254_K1.1221.00
112_T225_G1.1221.00
155_F223_V1.1181.00
16_T57_E1.1091.00
98_G102_R1.0931.00
176_Y202_R1.0871.00
113_L116_D1.0861.00
243_E247_P1.0751.00
33_S69_S1.0741.00
35_G39_E1.0711.00
165_I182_P1.0661.00
12_V54_T1.0651.00
76_V83_F1.0651.00
114_D140_R1.0651.00
158_E161_R1.0641.00
161_R193_R1.0631.00
104_V229_L1.0571.00
26_N29_D1.0561.00
158_E190_A1.0561.00
16_T54_T1.0541.00
146_T149_G1.0521.00
110_V217_L1.0521.00
110_V225_G1.0521.00
255_Q259_G1.0491.00
148_S226_C1.0381.00
227_L256_I1.0381.00
97_L108_T1.0301.00
247_P251_R1.0291.00
34_V38_A1.0281.00
113_L156_C1.0131.00
219_S222_R1.0131.00
175_D208_E1.0031.00
173_G178_L0.9941.00
162_K166_E0.9931.00
36_L39_E0.9901.00
237_T240_Q0.9831.00
60_Y79_L0.9791.00
89_I225_G0.9721.00
254_K258_E0.9651.00
94_A124_T0.9591.00
13_R17_R0.9571.00
111_S120_V0.9521.00
103_E251_R0.9491.00
35_G45_R0.9431.00
147_A212_S0.9381.00
160_D163_E0.9361.00
190_A194_K0.9191.00
22_L76_V0.9171.00
192_A195_E0.9141.00
187_A191_R0.9061.00
27_K40_L0.9041.00
153_L185_L0.9021.00
216_P223_V0.9011.00
184_K188_I0.9001.00
119_V140_R0.8991.00
151_T155_F0.8981.00
97_L122_E0.8971.00
213_I246_L0.8921.00
187_A190_A0.8831.00
21_L41_S0.8781.00
31_G64_S0.8761.00
108_T229_L0.8751.00
11_T57_E0.8711.00
172_P180_R0.8641.00
92_L259_G0.8621.00
201_Y233_A0.8591.00
17_R47_T0.8581.00
36_L40_L0.8571.00
163_E167_M0.8561.00
214_A228_N0.8531.00
99_D252_V0.8521.00
90_S94_A0.8471.00
109_D230_V0.8461.00
184_K187_A0.8441.00
173_G206_Q0.8431.00
97_L227_L0.8411.00
202_R208_E0.8411.00
46_T49_R0.8341.00
151_T192_A0.8331.00
195_E246_L0.8311.00
219_S224_I0.8281.00
148_S228_N0.8271.00
151_T223_V0.8221.00
160_D164_L0.8201.00
249_L253_A0.8191.00
188_I192_A0.8181.00
186_E190_A0.8161.00
96_L256_I0.8121.00
161_R189_L0.8121.00
41_S48_V0.8101.00
25_L28_L0.8081.00
34_V52_L0.8031.00
188_I195_E0.8021.00
56_Q70_F0.8001.00
191_R194_K0.7941.00
21_L51_L0.7911.00
106_W128_S0.7891.00
232_M235_A0.7751.00
179_A185_L0.7721.00
212_S230_V0.7721.00
244_K248_A0.7681.00
22_L60_Y0.7611.00
72_L76_V0.7561.00
114_D119_V0.7531.00
113_L160_D0.7521.00
11_T16_T0.7501.00
14_G18_G0.7421.00
147_A214_A0.7391.00
161_R164_L0.7391.00
212_S228_N0.7391.00
179_A184_K0.7381.00
152_W226_C0.7371.00
76_V79_L0.7361.00
89_I93_A0.7201.00
154_A189_L0.7191.00
109_D123_T0.7181.00
252_V255_Q0.7161.00
25_L30_G0.7121.00
43_L47_T0.7101.00
97_L124_T0.7081.00
76_V80_S0.7061.00
145_K206_Q0.7041.00
63_R68_D0.7031.00
88_W91_A0.7011.00
109_D135_A0.7011.00
62_R73_T0.6941.00
128_S235_A0.6861.00
34_V48_V0.6841.00
21_L48_V0.6841.00
53_E56_Q0.6831.00
113_L152_W0.6771.00
63_R67_D0.6771.00
32_A37_L0.6761.00
190_A193_R0.6751.00
116_D164_L0.6741.00
164_L168_L0.6731.00
34_V70_F0.6701.00
53_E57_E0.6701.00
247_P250_Q0.6691.00
34_V45_R0.6581.00
180_R184_K0.6581.00
161_R165_I0.6581.00
38_A41_S0.6551.00
170_S174_D0.6551.00
15_L51_L0.6501.00
26_N79_L0.6491.00
156_C161_R0.6471.00
227_L253_A0.6471.00
158_E193_R0.6451.00
254_K257_E0.6451.00
15_L19_L0.6441.00
255_Q258_E0.6411.00
80_S83_F0.6411.00
101_L126_R0.6411.00
25_L29_D0.6381.00
250_Q253_A0.6361.00
161_R190_A0.6351.00
150_L192_A0.6351.00
99_D102_R0.6341.00
251_R254_K0.6301.00
100_L229_L0.6291.00
201_Y238_I0.6291.00
152_W156_C0.6281.00
146_T212_S0.6261.00
109_D212_S0.6261.00
17_R43_L0.6251.00
176_Y208_E0.6251.00
244_K247_P0.6231.00
62_R74_I0.6231.00
153_L189_L0.6221.00
106_W231_Y0.6181.00
14_G51_L0.6181.00
153_L161_R0.6161.00
112_T121_R0.6161.00
252_V256_I0.6141.00
218_R224_I0.6141.00
142_P145_K0.6041.00
227_L252_V0.6031.00
100_L104_V0.6021.00
98_G122_E0.5991.00
215_V257_E0.5971.00
92_L95_P0.5951.00
23_N78_Q0.5881.00
183_L186_E0.5881.00
111_S146_T0.5861.00
60_Y75_K0.5851.00
150_L200_N0.5821.00
95_P259_G0.5791.00
63_R70_F0.5761.00
36_L69_S0.5751.00
240_Q245_H0.5751.00
100_L108_T0.5751.00
29_D40_L0.5741.00
202_R211_A0.5741.00
151_T216_P0.5721.00
38_A45_R0.5691.00
172_P175_D0.5681.00
26_N72_L0.5661.00
152_W225_G0.5611.00
123_T137_V0.5580.99
23_N79_L0.5580.99
130_L234_S0.5560.99
118_M146_T0.5560.99
151_T214_A0.5550.99
136_M139_R0.5540.99
118_M148_S0.5520.99
248_A252_V0.5520.99
120_V135_A0.5510.99
144_L170_S0.5510.99
196_G218_R0.5500.99
174_D179_A0.5500.99
106_W229_L0.5490.99
123_T135_A0.5490.99
33_S45_R0.5490.99
59_G75_K0.5480.99
172_P178_L0.5460.99
245_H248_A0.5450.99
151_T198_G0.5440.99
108_T124_T0.5440.99
118_M141_L0.5430.99
105_V127_F0.5430.99
120_V148_S0.5430.99
20_M23_N0.5410.99
102_R127_F0.5410.99
17_R51_L0.5410.99
227_L249_L0.5380.99
107_P123_T0.5380.99
15_L54_T0.5370.99
165_I169_A0.5370.99
213_I241_A0.5360.99
64_S69_S0.5320.99
170_S178_L0.5320.99
125_H136_M0.5310.99
18_G51_L0.5290.99
20_M24_M0.5270.99
185_L189_L0.5270.99
217_L225_G0.5270.99
53_E63_R0.5260.99
12_V51_L0.5250.99
197_Y250_Q0.5240.99
148_S212_S0.5230.99
215_V227_L0.5220.99
28_L31_G0.5220.99
77_R84_R0.5190.99
122_E137_V0.5190.99
220_E257_E0.5190.99
13_R54_T0.5150.99
214_A226_C0.5150.99
93_A97_L0.5130.99
183_L187_A0.5120.99
217_L256_I0.5100.99
65_P68_D0.5040.99
109_D228_N0.5030.99
24_M28_L0.5030.99
120_V146_T0.5020.99
135_A139_R0.5020.99
22_L79_L0.5010.99
218_R225_G0.5010.99
81_E84_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mq0A 2 0.9025 100 0.149 Contact Map
2ia2A 4 0.8989 100 0.149 Contact Map
2g7uA 6 0.9061 100 0.154 Contact Map
3r4kA 2 0.917 100 0.161 Contact Map
1mkmA 4 0.8881 100 0.166 Contact Map
2xrnA 3 0.87 100 0.185 Contact Map
2o0yA 4 0.9097 100 0.207 Contact Map
1ysqA 1 0.639 100 0.447 Contact Map
1tf1A 1 0.6606 100 0.448 Contact Map
1yspA 1 0.5884 100 0.457 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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