GREMLIN Database
NHOA - N-hydroxyarylamine O-acetyltransferase
UniProt: P77567 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13780
Length: 281 (250)
Sequences: 1728 (1289)
Seq/√Len: 81.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_Q55_S4.2831.00
28_L76_F3.8671.00
152_L161_Q3.7661.00
8_Y32_H3.4001.00
234_R241_S3.2211.00
236_L245_V3.1231.00
59_K71_E2.9731.00
42_D47_R2.9331.00
150_R161_Q2.9261.00
86_N113_E2.9191.00
90_L111_L2.8681.00
161_Q170_S2.7461.00
52_D55_S2.7341.00
36_I60_L2.6541.00
94_V125_F2.5251.00
68_Y188_N2.4571.00
205_M246_M2.4471.00
117_E135_R2.4451.00
58_E63_A2.4011.00
58_E62_I2.3301.00
51_L56_P2.2781.00
244_A248_E2.2031.00
113_E118_K2.1231.00
76_F123_V2.1211.00
26_R133_P2.1081.00
87_V110_L2.0881.00
150_R168_W2.0791.00
29_H130_L2.0611.00
247_Q253_G2.0161.00
29_H121_A1.9581.00
135_R142_Q1.9411.00
141_V148_E1.9321.00
21_N24_T1.9191.00
76_F121_A1.9131.00
57_E61_V1.9031.00
220_F235_N1.9001.00
77_E87_V1.8671.00
72_Q79_V1.8421.00
29_H133_P1.8411.00
109_L120_I1.8151.00
215_L249_Q1.8021.00
5_L79_V1.7811.00
90_L109_L1.7801.00
53_N78_R1.7471.00
14_W24_T1.7011.00
189_F193_H1.6971.00
88_R178_E1.6541.00
222_F245_V1.6471.00
111_L118_K1.6291.00
42_D65_R1.5921.00
89_S184_Y1.5841.00
12_I79_V1.5771.00
7_H62_I1.5761.00
27_A31_K1.5591.00
22_I26_R1.5571.00
236_L242_L1.5481.00
49_I192_A1.5390.99
39_E66_G1.4790.99
39_E65_R1.4770.99
148_E163_N1.4460.99
5_L82_E1.3990.99
159_V173_R1.3980.99
245_V249_Q1.3880.99
108_R184_Y1.3500.99
209_L212_G1.3490.99
16_G24_T1.3480.99
77_E89_S1.3290.99
56_P60_L1.3250.98
154_E159_V1.3210.98
221_H233_Q1.3110.98
190_W194_W1.3040.98
237_P241_S1.3020.98
43_V49_I1.2950.98
30_L34_C1.2870.98
30_L132_A1.2860.98
9_F79_V1.2820.98
26_R29_H1.2620.98
32_H72_Q1.2570.98
28_L79_V1.2570.98
125_F172_Y1.2530.98
41_L203_L1.2530.98
32_H123_V1.2500.98
77_E110_L1.2460.98
4_I7_H1.2320.98
137_V140_L1.2120.97
188_N192_A1.2030.97
143_T148_E1.1940.97
57_E75_V1.1840.97
64_R253_G1.1820.97
77_E81_R1.1760.97
161_Q168_W1.1760.97
151_L160_L1.1710.97
22_I119_W1.1660.97
56_P74_G1.1610.96
14_W18_A1.1490.96
14_W27_A1.1450.96
25_L112_V1.1420.96
202_H218_T1.1370.96
28_L123_V1.1340.96
151_L158_W1.1230.96
88_R111_L1.1140.96
117_E137_V1.1120.95
79_V83_L1.1090.95
106_T191_S1.1030.95
180_Q183_D1.0970.95
68_Y191_S1.0970.95
22_I114_L1.0960.95
24_T85_F1.0730.95
223_T233_Q1.0690.94
105_R179_Q1.0670.94
38_F199_F1.0640.94
57_E62_I1.0640.94
138_S153_Q1.0420.94
88_R118_K1.0420.94
224_H249_Q1.0410.94
36_I39_E1.0400.94
226_E229_H1.0390.94
12_I35_T1.0290.93
20_V85_F1.0200.93
217_L236_L1.0200.93
224_H234_R1.0170.93
59_K65_R1.0150.93
202_H219_N1.0130.93
49_I59_K1.0120.93
215_L224_H1.0110.93
88_R113_E1.0030.92
18_A83_L0.9960.92
114_L117_E0.9850.92
4_I57_E0.9820.91
222_F249_Q0.9810.91
91_L179_Q0.9730.91
26_R132_A0.9600.90
65_R71_E0.9580.90
76_F79_V0.9570.90
212_G215_L0.9520.90
131_T146_H0.9500.90
29_H144_T0.9350.89
44_L203_L0.9220.89
78_R82_E0.9140.88
4_I82_E0.9130.88
56_P75_V0.9100.88
194_W200_R0.9050.88
141_V150_R0.9000.87
240_A244_A0.9000.87
68_Y192_A0.8970.87
241_S245_V0.8970.87
224_H232_E0.8970.87
137_V158_W0.8940.87
6_N10_A0.8930.87
81_R89_S0.8910.87
153_Q158_W0.8900.87
136_L174_F0.8890.87
79_V82_E0.8880.87
105_R175_D0.8880.87
13_N35_T0.8860.87
118_K176_L0.8800.86
29_H76_F0.8790.86
216_T223_T0.8790.86
76_F110_L0.8690.86
29_H123_V0.8670.85
20_V24_T0.8620.85
32_H79_V0.8600.85
187_G191_S0.8520.84
15_S58_E0.8480.84
43_V46_P0.8410.84
60_L72_Q0.8380.83
109_L174_F0.8370.83
85_F112_V0.8290.83
211_D226_E0.8270.83
234_R245_V0.8270.83
179_Q183_D0.8180.82
93_R189_F0.8140.82
134_I164_H0.8110.81
45_L254_V0.8000.80
85_F88_R0.8000.80
9_F32_H0.7970.80
144_T147_G0.7860.79
25_L85_F0.7810.79
53_N57_E0.7700.78
14_W31_K0.7700.78
6_N16_G0.7690.78
132_A145_P0.7680.78
34_C210_P0.7520.76
179_Q184_Y0.7510.76
149_Y171_M0.7500.76
159_V170_S0.7490.76
204_L218_T0.7490.76
49_I188_N0.7490.76
90_L176_L0.7450.76
93_R183_D0.7450.76
212_G224_H0.7450.76
69_C107_H0.7440.75
17_A27_A0.7430.75
91_L184_Y0.7420.75
188_N191_S0.7420.75
135_R139_D0.7400.75
206_C216_T0.7400.75
105_R187_G0.7380.75
9_F31_K0.7330.74
8_Y79_V0.7320.74
104_P186_M0.7310.74
234_R249_Q0.7290.74
221_H235_N0.7280.74
68_Y106_T0.7250.74
11_R39_E0.7210.73
91_L187_G0.7200.73
155_G161_Q0.7150.73
244_A252_L0.7120.72
217_L222_F0.7110.72
163_N168_W0.7100.72
91_L105_R0.7070.72
164_H167_H0.7040.71
194_W197_S0.7030.71
41_L59_K0.6990.71
70_F91_L0.6980.71
106_T125_F0.6980.71
29_H33_N0.6970.71
142_Q146_H0.6890.70
120_I172_Y0.6820.69
25_L37_P0.6780.68
93_R188_N0.6750.68
75_V79_V0.6710.68
215_L222_F0.6690.67
128_Q162_F0.6690.67
4_I62_I0.6650.67
51_L184_Y0.6630.67
49_I71_E0.6630.67
12_I31_K0.6630.67
127_G204_L0.6620.67
39_E59_K0.6600.66
51_L68_Y0.6570.66
147_G206_C0.6560.66
160_L172_Y0.6530.66
134_I151_L0.6520.65
158_W176_L0.6510.65
30_L145_P0.6500.65
56_P71_E0.6490.65
138_S158_W0.6460.65
92_G95_V0.6440.65
102_L180_Q0.6440.65
192_A200_R0.6440.65
244_A247_Q0.6430.64
70_F191_S0.6420.64
43_V68_Y0.6410.64
121_A128_Q0.6400.64
60_L75_V0.6350.63
29_H119_W0.6330.63
142_Q149_Y0.6330.63
96_L100_P0.6310.63
222_F236_L0.6300.63
11_R36_I0.6250.62
198_H218_T0.6250.62
68_Y83_L0.6240.62
54_Q57_E0.6230.62
11_R59_K0.6220.62
135_R140_L0.6210.62
158_W174_F0.6210.62
97_S100_P0.6200.62
41_L65_R0.6200.62
36_I72_Q0.6180.61
131_T144_T0.6170.61
198_H201_H0.6160.61
36_I220_F0.6160.61
67_G71_E0.6160.61
130_L149_Y0.6130.61
42_D59_K0.6120.61
19_A156_D0.6110.60
64_R232_E0.6110.60
10_A15_S0.6100.60
209_L215_L0.6090.60
157_D173_R0.6090.60
16_G36_I0.6060.60
39_E205_M0.6040.60
40_N200_R0.6030.59
130_L151_L0.6020.59
196_Q254_V0.6000.59
94_V199_F0.5990.59
17_A64_R0.5980.59
60_L79_V0.5970.59
162_F171_M0.5960.59
59_K188_N0.5940.58
51_L63_A0.5940.58
91_L188_N0.5930.58
216_T225_Y0.5910.58
189_F192_A0.5900.58
98_N103_P0.5870.57
46_P116_E0.5860.57
205_M242_L0.5860.57
220_F224_H0.5850.57
119_W135_R0.5840.57
120_I160_L0.5830.57
57_E78_R0.5820.57
126_G199_F0.5820.57
36_I90_L0.5820.57
17_A178_E0.5810.57
203_L207_R0.5800.57
73_N123_V0.5790.56
118_K251_G0.5790.56
16_G27_A0.5780.56
23_D165_H0.5770.56
182_S192_A0.5760.56
219_N222_F0.5730.56
105_R177_C0.5710.55
9_F19_A0.5710.55
61_V75_V0.5700.55
89_S108_R0.5700.55
64_R154_E0.5690.55
158_W162_F0.5690.55
117_E217_L0.5690.55
36_I112_V0.5680.55
34_C208_H0.5680.55
43_V96_L0.5680.55
139_D143_T0.5670.55
36_I61_V0.5620.54
214_K225_Y0.5610.54
95_V173_R0.5550.53
93_R104_P0.5540.53
42_D49_I0.5540.53
86_N221_H0.5520.53
72_Q212_G0.5520.53
139_D142_Q0.5520.53
6_N18_A0.5490.53
203_L242_L0.5460.52
95_V159_V0.5460.52
43_V200_R0.5460.52
17_A24_T0.5450.52
131_T145_P0.5420.52
70_F199_F0.5400.51
113_E116_E0.5400.51
88_R175_D0.5400.51
70_F187_G0.5400.51
97_S171_M0.5390.51
106_T126_G0.5390.51
23_D54_Q0.5380.51
119_W145_P0.5380.51
97_S194_W0.5370.51
108_R191_S0.5360.51
64_R153_Q0.5360.51
45_L239_V0.5350.51
12_I180_Q0.5350.51
185_V196_Q0.5330.50
241_S244_A0.5330.50
208_H214_K0.5310.50
74_G108_R0.5280.50
68_Y93_R0.5270.50
43_V191_S0.5260.49
51_L188_N0.5250.49
15_S240_A0.5250.49
41_L71_E0.5230.49
9_F18_A0.5230.49
11_R35_T0.5210.49
217_L250_F0.5200.49
94_V126_G0.5200.49
119_W157_D0.5190.49
58_E252_L0.5180.48
38_F172_Y0.5180.48
44_L205_M0.5170.48
92_G172_Y0.5160.48
10_A64_R0.5150.48
49_I185_V0.5150.48
41_L205_M0.5110.48
70_F201_H0.5100.47
126_G188_N0.5090.47
128_Q208_H0.5070.47
161_Q167_H0.5070.47
186_M190_W0.5050.47
91_L191_S0.5050.47
43_V165_H0.5050.47
97_S103_P0.5040.47
32_H188_N0.5030.46
132_A144_T0.5020.46
217_L243_Y0.5020.46
59_K197_S0.5010.46
92_G129_T0.5000.46
10_A62_I0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e2tA 5 0.9573 100 0.088 Contact Map
1w5rA 2 0.9537 100 0.093 Contact Map
4nv8A 2 0.9502 100 0.095 Contact Map
4guzA 2 0.9431 100 0.095 Contact Map
4c5pA 1 0.9466 100 0.1 Contact Map
1w4tA 1 0.9537 100 0.101 Contact Map
3d9wA 2 0.9466 100 0.11 Contact Map
2ijaA 1 0.9502 100 0.138 Contact Map
4dmoA 1 0.8861 100 0.139 Contact Map
3lnbA 1 0.879 100 0.147 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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