GREMLIN Database
YAIW - Uncharacterized protein YaiW
UniProt: P77562 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13608
Length: 364 (348)
Sequences: 246 (140)
Seq/√Len: 7.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
250_V279_T6.1931.00
223_S306_E5.1670.99
210_L214_T4.6260.99
225_S329_E3.7120.95
196_D201_Q3.5680.94
311_Y362_M3.5490.93
80_L89_Y3.1620.89
319_E326_L3.0530.87
80_L251_S2.8060.81
94_A143_T2.7230.79
78_S358_R2.6230.77
62_T256_V2.5960.76
60_L214_T2.5410.74
154_L157_M2.3510.68
67_Q219_N2.3270.67
103_W139_D2.2460.64
272_P352_K2.2310.64
294_R298_E2.2090.63
227_P362_M2.1520.61
125_K133_S2.1460.61
315_Y319_E2.1450.61
84_Q360_R2.1440.60
299_K308_T2.1270.60
70_A288_M2.1220.60
34_K37_D2.1120.59
53_R306_E2.0880.58
63_T193_W2.0860.58
45_K89_Y2.0750.58
266_R272_P2.0240.56
288_M310_L2.0130.55
211_W214_T1.9920.55
90_Q141_V1.9750.54
91_A141_V1.9270.52
152_D201_Q1.9020.51
66_S211_W1.8500.49
74_E358_R1.8230.48
287_G313_K1.8050.47
141_V168_L1.7960.47
283_A290_D1.7910.47
205_S234_F1.7900.47
42_V136_E1.7880.47
303_F306_E1.7820.46
253_A326_L1.7760.46
172_R222_A1.7550.45
93_P311_Y1.7480.45
105_E109_R1.7470.45
138_L238_W1.7450.45
99_S329_E1.7410.45
102_A276_E1.7360.44
356_E360_R1.7260.44
80_L84_Q1.7210.44
89_Y253_A1.7010.43
83_A210_L1.6980.43
181_I210_L1.6970.43
141_V147_L1.6900.43
151_F289_S1.6850.42
223_S303_F1.6820.42
267_Y358_R1.6720.42
335_Q344_N1.6650.42
133_S136_E1.6270.40
122_T133_S1.6060.39
84_Q344_N1.6000.39
92_D145_K1.5610.38
288_M308_T1.5550.38
105_E159_P1.5550.38
154_L199_V1.5450.37
103_W122_T1.5430.37
256_V281_K1.5220.36
88_N210_L1.5110.36
146_Q149_A1.5090.36
267_Y301_D1.5040.36
331_L352_K1.4990.35
161_G164_L1.4840.35
135_S205_S1.4680.34
268_D298_E1.4620.34
42_V76_V1.4610.34
159_P164_L1.4590.34
14_A17_V1.4580.34
134_Y353_R1.4520.34
66_S215_Y1.4520.34
100_K104_Q1.4480.34
80_L138_L1.4390.33
106_I120_V1.4330.33
211_W215_Y1.4150.32
272_P307_E1.4020.32
65_E257_K1.4010.32
134_Y343_R1.3900.32
253_A319_E1.3840.31
141_V222_A1.3820.31
48_A303_F1.3720.31
90_Q93_P1.3630.31
268_D294_R1.3620.31
331_L348_A1.3600.31
195_M199_V1.3560.30
140_S257_K1.3480.30
23_S253_A1.3340.30
249_A315_Y1.3300.30
140_S329_E1.3290.30
160_M267_Y1.3190.29
250_V253_A1.3150.29
265_I294_R1.3070.29
92_D350_F1.2920.28
41_V45_K1.2910.28
114_H154_L1.2910.28
287_G296_Q1.2830.28
52_D55_A1.2690.28
52_D327_P1.2660.27
22_S25_A1.2650.27
203_V342_T1.2470.27
90_Q186_Q1.2390.27
102_A148_S1.2340.26
79_V214_T1.2320.26
107_D120_V1.2290.26
132_K320_T1.2220.26
14_A205_S1.2220.26
240_A342_T1.2210.26
142_R219_N1.2160.26
308_T358_R1.2110.26
13_L76_V1.2100.26
238_W348_A1.2010.25
158_V164_L1.1980.25
292_E312_K1.1980.25
23_S26_P1.1820.25
289_S296_Q1.1820.25
144_E173_T1.1820.25
88_N99_S1.1740.25
61_A181_I1.1720.25
234_F312_K1.1720.25
267_Y273_G1.1690.25
254_S316_Q1.1690.25
58_K274_K1.1620.24
251_S352_K1.1620.24
42_V61_A1.1530.24
24_Q27_Q1.1500.24
42_V359_A1.1430.24
14_A234_F1.1370.24
104_Q312_K1.1290.23
205_S363_K1.1260.23
96_P99_S1.1250.23
98_L146_Q1.1230.23
154_L158_V1.1160.23
79_V150_I1.1140.23
273_G301_D1.1130.23
39_A193_W1.1060.23
238_W333_G1.1050.23
205_S248_N1.1020.23
248_N330_M1.1000.23
204_F212_F1.0960.22
117_A121_H1.0930.22
91_A146_Q1.0870.22
64_F214_T1.0770.22
15_V45_K1.0740.22
104_Q304_S1.0690.22
147_L276_E1.0690.22
94_A281_K1.0680.22
166_G269_S1.0630.22
223_S271_E1.0580.21
42_V254_S1.0550.21
146_Q174_G1.0550.21
196_D288_M1.0540.21
273_G290_D1.0500.21
136_E270_K1.0490.21
39_A84_Q1.0460.21
210_L248_N1.0430.21
97_G134_Y1.0430.21
13_L17_V1.0370.21
229_Y311_Y1.0360.21
99_S201_Q1.0320.21
151_F331_L1.0320.21
98_L141_V1.0280.21
273_G314_V1.0270.21
143_T146_Q1.0260.21
55_A84_Q1.0250.21
162_Q167_S1.0250.21
163_T296_Q1.0210.20
276_E294_R1.0170.20
176_P204_F1.0170.20
27_Q362_M1.0150.20
163_T290_D1.0130.20
79_V83_A1.0080.20
121_H352_K1.0070.20
99_S267_Y1.0060.20
68_G312_K0.9990.20
65_E248_N0.9990.20
43_R73_L0.9980.20
252_K319_E0.9960.20
67_Q190_G0.9930.20
69_L295_R0.9930.20
149_A162_Q0.9890.20
315_Y330_M0.9890.20
67_Q238_W0.9860.20
319_E322_T0.9850.20
40_S142_R0.9850.20
145_K329_E0.9740.19
254_S302_S0.9710.19
113_M138_L0.9710.19
97_G292_E0.9690.19
141_V150_I0.9660.19
90_Q205_S0.9630.19
338_S345_L0.9630.19
109_R134_Y0.9610.19
83_A308_T0.9600.19
129_P157_M0.9580.19
84_Q215_Y0.9570.19
64_F79_V0.9550.19
260_L330_M0.9530.19
176_P203_V0.9520.19
113_M141_V0.9520.19
203_V212_F0.9480.19
204_F318_A0.9390.18
60_L64_F0.9330.18
148_S216_H0.9310.18
112_R234_F0.9240.18
69_L72_T0.9230.18
123_A328_R0.9230.18
334_I345_L0.9190.18
96_P100_K0.9160.18
91_A308_T0.9140.18
110_A273_G0.9140.18
193_W199_V0.9110.18
103_W147_L0.9110.18
62_T66_S0.9090.18
103_W329_E0.9080.18
296_Q362_M0.9080.18
285_K321_K0.9030.18
229_Y274_K0.8970.17
137_R153_D0.8950.17
352_K355_D0.8910.17
276_E297_L0.8910.17
67_Q333_G0.8880.17
181_I292_E0.8850.17
106_I119_L0.8850.17
99_S182_A0.8840.17
141_V329_E0.8810.17
133_S171_V0.8760.17
112_R163_T0.8730.17
316_Q320_T0.8720.17
28_P58_K0.8710.17
248_N322_T0.8630.17
110_A120_V0.8630.17
67_Q189_K0.8590.17
156_N225_S0.8570.17
273_G326_L0.8560.17
94_A142_R0.8520.16
289_S295_R0.8500.16
113_M265_I0.8490.16
136_E271_E0.8440.16
16_L140_S0.8430.16
152_D198_T0.8360.16
192_P207_R0.8290.16
119_L154_L0.8290.16
191_Y327_P0.8290.16
88_N266_R0.8290.16
133_S282_L0.8170.16
194_K254_S0.8160.16
48_A325_S0.8130.16
315_Y328_R0.8120.16
274_K295_R0.8110.16
296_Q304_S0.8100.16
209_G350_F0.8080.15
123_A131_G0.8060.15
146_Q288_M0.8060.15
103_W121_H0.7990.15
98_L278_A0.7960.15
198_T291_S0.7960.15
131_G345_L0.7940.15
93_P143_T0.7900.15
339_P353_R0.7900.15
133_S138_L0.7890.15
62_T257_K0.7870.15
73_L80_L0.7790.15
75_N282_L0.7770.15
290_D295_R0.7740.15
83_A268_D0.7740.15
122_T167_S0.7710.15
279_T314_V0.7710.15
83_A209_G0.7700.15
152_D265_I0.7690.15
251_S257_K0.7690.15
228_I331_L0.7690.15
97_G360_R0.7690.15
266_R269_S0.7680.15
13_L319_E0.7670.15
12_L273_G0.7660.15
57_A209_G0.7650.15
49_S89_Y0.7640.15
91_A248_N0.7640.15
163_T270_K0.7620.15
336_L346_T0.7610.15
205_S304_S0.7610.15
289_S292_E0.7600.15
76_V155_I0.7550.14
83_A301_D0.7540.14
192_P204_F0.7540.14
20_G37_D0.7520.14
35_A54_D0.7500.14
140_S146_Q0.7490.14
42_V324_K0.7490.14
25_A91_A0.7490.14
156_N189_K0.7450.14
39_A215_Y0.7430.14
257_K355_D0.7410.14
137_R151_F0.7410.14
187_H223_S0.7410.14
67_Q201_Q0.7390.14
265_I298_E0.7380.14
265_I355_D0.7370.14
28_P73_L0.7350.14
20_G309_A0.7340.14
236_A240_A0.7330.14
144_E209_G0.7320.14
173_T209_G0.7320.14
219_N238_W0.7320.14
37_D103_W0.7310.14
18_L21_C0.7310.14
214_T352_K0.7260.14
181_I214_T0.7220.14
84_Q356_E0.7180.14
83_A88_N0.7170.14
336_L345_L0.7170.14
37_D337_E0.7170.14
335_Q358_R0.7160.14
267_Y320_T0.7120.14
131_G334_I0.7120.14
99_S292_E0.7110.14
166_G265_I0.7110.14
89_Y227_P0.7100.14
83_A265_I0.7060.13
246_F314_V0.7050.13
216_H238_W0.7040.13
338_S342_T0.7040.13
167_S291_S0.7030.13
147_L294_R0.7000.13
105_E161_G0.6990.13
181_I234_F0.6970.13
334_I341_I0.6950.13
162_Q257_K0.6940.13
171_V356_E0.6930.13
122_T140_S0.6930.13
250_V289_S0.6920.13
169_N245_A0.6920.13
116_P204_F0.6910.13
158_V161_G0.6900.13
33_E358_R0.6890.13
46_M76_V0.6880.13
136_E187_H0.6870.13
117_A234_F0.6870.13
68_G281_K0.6830.13
212_F318_A0.6800.13
92_D146_Q0.6770.13
204_F328_R0.6740.13
33_E41_V0.6740.13
139_D344_N0.6730.13
15_V253_A0.6720.13
228_I311_Y0.6720.13
181_I273_G0.6670.13
142_R307_E0.6670.13
176_P212_F0.6650.13
68_G234_F0.6650.13
64_F103_W0.6610.13
118_F300_G0.6610.13
78_S227_P0.6600.13
49_S132_K0.6580.13
260_L333_G0.6510.12
107_D150_I0.6510.12
108_R333_G0.6410.12
39_A61_A0.6410.12
104_Q352_K0.6410.12
64_F129_P0.6400.12
33_E215_Y0.6400.12
45_K253_A0.6390.12
69_L253_A0.6360.12
271_E320_T0.6340.12
17_V156_N0.6330.12
100_K210_L0.6300.12
127_K288_M0.6300.12
303_F313_K0.6290.12
88_N267_Y0.6280.12
120_V172_R0.6270.12
270_K313_K0.6270.12
306_E311_Y0.6260.12
265_I301_D0.6250.12
91_A294_R0.6250.12
271_E313_K0.6230.12
271_E290_D0.6220.12
20_G23_S0.6210.12
68_G189_K0.6210.12
192_P212_F0.6210.12
325_S329_E0.6200.12
92_D355_D0.6180.12
36_I257_K0.6170.12
19_A279_T0.6140.12
127_K199_V0.6120.12
54_D133_S0.6100.12
181_I293_I0.6080.12
83_A292_E0.6080.12
205_S225_S0.6070.12
123_A134_Y0.6070.12
20_G298_E0.6050.12
26_P112_R0.6020.12
250_V274_K0.5990.12
34_K62_T0.5980.12
142_R359_A0.5970.12
143_T335_Q0.5960.12
92_D149_A0.5950.12
80_L88_N0.5950.12
154_L250_V0.5950.12
130_N308_T0.5950.12
131_G204_F0.5940.12
148_S204_F0.5930.12
227_P306_E0.5910.11
66_S281_K0.5900.11
50_V330_M0.5890.11
58_K112_R0.5880.11
15_V24_Q0.5880.11
79_V348_A0.5870.11
288_M337_E0.5860.11
105_E108_R0.5860.11
126_I157_M0.5840.11
216_H300_G0.5840.11
46_M72_T0.5820.11
210_L324_K0.5810.11
109_R165_F0.5800.11
39_A58_K0.5790.11
72_T221_P0.5770.11
76_V117_A0.5770.11
78_S187_H0.5760.11
68_G76_V0.5760.11
15_V274_K0.5760.11
13_L37_D0.5750.11
313_K317_L0.5720.11
308_T320_T0.5700.11
129_P251_S0.5690.11
103_W215_Y0.5680.11
341_I345_L0.5670.11
359_A363_K0.5670.11
128_S137_R0.5670.11
271_E289_S0.5670.11
45_K210_L0.5650.11
255_G258_L0.5650.11
15_V252_K0.5630.11
101_I338_S0.5630.11
192_P318_A0.5630.11
14_A335_Q0.5610.11
38_V108_R0.5580.11
36_I359_A0.5570.11
343_R353_R0.5560.11
73_L362_M0.5560.11
139_D329_E0.5560.11
112_R194_K0.5550.11
254_S335_Q0.5540.11
52_D207_R0.5520.11
50_V279_T0.5520.11
211_W248_N0.5520.11
17_V62_T0.5520.11
123_A204_F0.5510.11
66_S118_F0.5510.11
189_K215_Y0.5480.11
51_K362_M0.5470.11
204_F341_I0.5460.11
51_K151_F0.5460.11
108_R238_W0.5460.11
58_K306_E0.5460.11
90_Q143_T0.5440.11
253_A307_E0.5440.11
69_L226_A0.5440.11
58_K214_T0.5430.11
68_G252_K0.5430.11
150_I158_V0.5410.11
58_K312_K0.5410.11
46_M319_E0.5400.11
119_L259_A0.5400.11
194_K256_V0.5390.11
41_V138_L0.5390.11
268_D325_S0.5380.11
276_E280_R0.5350.11
308_T326_L0.5340.11
36_I363_K0.5340.11
44_Q337_E0.5330.11
51_K94_A0.5330.11
48_A352_K0.5320.11
71_P313_K0.5320.11
24_Q320_T0.5310.11
289_S359_A0.5310.11
250_V307_E0.5310.11
141_V337_E0.5290.11
116_P249_A0.5280.11
83_A283_A0.5270.10
37_D316_Q0.5260.10
116_P353_R0.5250.10
115_I303_F0.5230.10
103_W133_S0.5230.10
203_V318_A0.5200.10
133_S270_K0.5200.10
66_S89_Y0.5190.10
60_L142_R0.5190.10
61_A308_T0.5190.10
254_S257_K0.5190.10
116_P212_F0.5180.10
134_Y158_V0.5180.10
127_K299_K0.5160.10
205_S250_V0.5160.10
188_T199_V0.5140.10
145_K234_F0.5140.10
136_E185_E0.5120.10
114_H119_L0.5120.10
50_V54_D0.5120.10
259_A333_G0.5110.10
34_K43_R0.5110.10
155_I189_K0.5110.10
126_I160_M0.5110.10
42_V92_D0.5110.10
132_K194_K0.5100.10
62_T65_E0.5080.10
20_G303_F0.5080.10
145_K205_S0.5080.10
66_S344_N0.5040.10
206_R245_A0.5030.10
266_R308_T0.5020.10
236_A334_I0.5020.10
135_S253_A0.5010.10
95_V170_P0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w6bA 1 0.4231 90.9 0.969 Contact Map
1gbsA 1 0.4753 89.7 0.969 Contact Map
4g9sA 1 0.4478 87 0.971 Contact Map
4hjzA 1 0.4588 86.4 0.971 Contact Map
3gxrA 1 0.4863 84.9 0.972 Contact Map
1qsaA 1 0.5604 82.1 0.973 Contact Map
4fdyA 1 0.4918 79.7 0.973 Contact Map
4hpeA 1 0.4835 75.8 0.974 Contact Map
3zbiC 1 0.0742 72.4 0.975 Contact Map
4xp8A 1 0.228 66.6 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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