GREMLIN Database
ALLD - Ureidoglycolate dehydrogenase (NAD(+))
UniProt: P77555 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13624
Length: 349 (331)
Sequences: 2100 (1564)
Seq/√Len: 85.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
315_K319_E4.0871.00
68_R82_D3.7371.00
124_V160_A3.6861.00
81_A89_A3.4081.00
291_N307_Q3.3751.00
200_A214_V3.1081.00
202_D206_V2.9741.00
62_N82_D2.9431.00
102_Q130_A2.7861.00
194_S209_T2.6721.00
149_G293_I2.6571.00
325_D329_Q2.6041.00
95_E126_Q2.5471.00
9_H31_E2.4841.00
110_G240_L2.4611.00
94_M127_A2.3851.00
210_D213_A2.3411.00
194_S211_P2.3111.00
75_C104_N2.2861.00
16_L49_V2.2781.00
128_A162_A2.2631.00
295_P302_V2.2361.00
74_P104_N2.1601.00
72_T100_T2.1481.00
17_C23_R2.1401.00
269_N272_F2.1391.00
301_Q311_I2.1241.00
298_G301_Q2.1181.00
42_H316_A2.1171.00
161_F231_M2.0831.00
314_R318_V2.0581.00
99_K103_Q2.0441.00
38_A316_A2.0131.00
96_H99_K2.0031.00
37_D42_H1.9891.00
13_E27_A1.9881.00
313_Q317_A1.9811.00
165_G284_S1.9681.00
65_P82_D1.9571.00
8_L46_A1.9571.00
117_S120_I1.9521.00
197_D209_T1.8971.00
13_E17_C1.8761.00
316_A322_E1.8751.00
145_V216_A1.8511.00
173_F227_G1.7771.00
30_A34_V1.7761.00
125_Q129_R1.7751.00
189_R212_F1.7741.00
90_A265_H1.7591.00
10_Q14_N1.7361.00
180_Q199_W1.7091.00
98_I130_A1.7011.00
70_E80_H1.6611.00
97_A107_A1.6391.00
97_A267_V1.6341.00
131_G280_R1.6271.00
117_S136_S1.6211.00
202_D213_A1.6191.00
48_R183_G1.6171.00
328_Y332_I1.5891.00
127_A267_V1.5861.00
5_R38_A1.5691.00
102_Q132_F1.5621.00
156_T177_T1.5541.00
145_V201_V1.5531.00
80_H113_R1.5481.00
74_P100_T1.5421.00
162_A172_T1.5351.00
62_N65_P1.5251.00
132_F270_P1.5181.00
201_V216_A1.5131.00
77_A109_V1.5021.00
77_A107_A1.4980.99
134_G162_A1.4790.99
195_I199_W1.4740.99
13_E23_R1.4330.99
29_V85_A1.4190.99
39_R313_Q1.4170.99
144_V178_T1.4100.99
297_P301_Q1.4090.99
329_Q333_S1.4070.99
181_A184_K1.3990.99
11_L335_A1.3960.99
134_G267_V1.3860.99
94_M126_Q1.3810.99
108_V266_I1.3690.99
91_K126_Q1.3690.99
106_V266_I1.3690.99
151_E293_I1.3680.99
291_N301_Q1.3460.99
242_L262_G1.3460.99
159_L232_I1.3440.99
195_I214_V1.3410.99
65_P84_A1.3350.99
135_I266_I1.3280.99
28_T91_K1.3250.99
97_A109_V1.3240.99
234_V283_L1.3160.99
83_N113_R1.3090.99
77_A96_H1.3020.99
94_M267_V1.2990.99
208_T214_V1.2920.98
23_R27_A1.2900.98
188_A195_I1.2890.98
169_E314_R1.2770.98
69_L79_L1.2660.98
114_M263_Q1.2640.98
107_A267_V1.2580.98
96_H100_T1.2560.98
15_K53_A1.2550.98
25_H88_V1.2540.98
69_L77_A1.2510.98
98_I132_F1.2470.98
38_A317_A1.2460.98
243_P260_N1.2460.98
44_H116_H1.2330.98
12_I49_V1.2010.98
32_V87_Q1.1970.98
73_G272_F1.1940.97
21_L85_A1.1900.97
195_I200_A1.1860.97
101_A107_A1.1820.97
108_V264_L1.1820.97
200_A208_T1.1610.97
19_A53_A1.1520.97
61_T115_G1.1500.97
80_H112_S1.1420.97
236_S262_G1.1410.97
14_N17_C1.1400.97
270_P275_S1.1260.96
288_R292_A1.1260.96
101_A132_F1.1250.96
43_S184_K1.1200.96
312_K316_A1.1180.96
324_V327_I1.1140.96
311_I315_K1.1130.96
56_I63_R1.1130.96
171_L230_M1.1110.96
113_R260_N1.1080.96
303_Y309_Q1.1070.96
276_S280_R1.1010.96
12_I16_L1.1000.96
138_C263_Q1.0990.96
78_I112_S1.0900.96
77_A97_A1.0900.96
76_S273_F1.0820.95
166_E281_Q1.0800.95
98_I101_A1.0790.95
77_A100_T1.0790.95
303_Y308_D1.0780.95
70_E78_I1.0690.95
163_A231_M1.0660.95
108_V268_I1.0650.95
98_I102_Q1.0620.95
16_L29_V1.0600.95
4_S7_T1.0590.95
188_A193_M1.0560.95
189_R211_P1.0550.95
329_Q332_I1.0520.95
287_M291_N1.0420.94
303_Y311_I1.0400.94
5_R34_V1.0380.94
102_Q269_N1.0340.94
9_H27_A1.0260.94
53_A334_D1.0260.94
12_I30_A1.0130.94
98_I127_A1.0090.93
54_E58_K1.0070.93
124_V136_S1.0070.93
124_V162_A1.0060.93
312_K315_K1.0050.93
284_S288_R1.0040.93
159_L228_L1.0000.93
8_L321_I0.9930.93
92_M95_E0.9920.93
167_G284_S0.9910.93
137_M232_I0.9900.93
185_V214_V0.9900.93
323_I328_Y0.9880.93
194_S210_D0.9840.93
308_D312_K0.9810.92
146_P293_I0.9770.92
25_H66_E0.9750.92
136_S265_H0.9740.92
67_F82_D0.9700.92
108_V273_F0.9670.92
297_P300_N0.9640.92
175_M227_G0.9520.91
185_V273_F0.9480.91
154_Y229_M0.9470.91
143_M182_W0.9470.91
121_S124_V0.9460.91
22_K64_E0.9440.91
166_E284_S0.9400.91
12_I46_A0.9350.91
5_R317_A0.9350.91
27_A31_E0.9340.90
73_G269_N0.9340.90
125_Q172_T0.9330.90
19_A57_S0.9320.90
95_E99_K0.9310.90
140_S155_G0.9290.90
94_M134_G0.9240.90
166_E280_R0.9210.90
116_H183_G0.9180.90
140_S143_M0.9180.90
69_L92_M0.9150.90
314_R317_A0.9080.89
66_E92_M0.9050.89
93_G109_V0.9020.89
35_Y313_Q0.9020.89
144_V177_T0.9010.89
22_K25_H0.9000.89
167_G288_R0.8990.89
147_F226_Y0.8990.89
81_A111_I0.8980.89
26_A30_A0.8970.89
146_P226_Y0.8940.88
69_L96_H0.8930.88
6_E10_Q0.8920.88
8_L323_I0.8900.88
180_Q184_K0.8900.88
247_Q289_E0.8830.88
171_L287_M0.8830.88
31_E122_Y0.8780.88
9_H13_E0.8720.87
11_L15_K0.8720.87
197_D207_P0.8680.87
284_S287_M0.8660.87
165_G168_D0.8590.86
117_S263_Q0.8590.86
153_Y293_I0.8540.86
230_M286_T0.8490.86
208_T213_A0.8490.86
46_A327_I0.8470.86
287_M304_Y0.8460.86
127_A134_G0.8380.85
226_Y230_M0.8330.85
5_R321_I0.8290.84
198_T218_L0.8270.84
154_Y230_M0.8250.84
111_I263_Q0.8240.84
68_R80_H0.8190.84
153_Y289_E0.8180.84
322_E325_D0.8160.83
201_V218_L0.8060.83
190_S330_Y0.8060.83
125_Q313_Q0.8030.82
39_R125_Q0.8000.82
95_E130_A0.7910.81
83_N260_N0.7880.81
226_Y304_Y0.7870.81
81_A114_M0.7870.81
110_G264_L0.7850.81
89_A111_I0.7840.81
163_A279_F0.7840.81
94_M98_I0.7810.81
175_M228_L0.7740.80
67_F79_L0.7730.80
96_H109_V0.7730.80
100_T107_A0.7720.80
101_A267_V0.7720.80
35_Y122_Y0.7700.80
131_G276_S0.7690.80
90_A117_S0.7690.80
67_F89_A0.7680.80
150_A204_N0.7680.80
177_T220_A0.7680.80
295_P301_Q0.7660.79
270_P274_S0.7660.79
302_V307_Q0.7640.79
144_V219_P0.7620.79
168_D288_R0.7610.79
47_V186_L0.7600.79
233_D237_G0.7570.79
165_G287_M0.7570.79
21_L29_V0.7550.78
206_V297_P0.7540.78
44_H183_G0.7520.78
198_T209_T0.7480.78
137_M264_L0.7480.78
161_F232_I0.7470.78
5_R9_H0.7470.78
144_V216_A0.7450.77
136_S263_Q0.7450.77
79_L109_V0.7420.77
97_A127_A0.7390.77
7_T10_Q0.7380.77
71_E103_Q0.7370.77
76_S272_F0.7350.77
52_Y118_G0.7340.76
79_L93_G0.7270.76
37_D316_A0.7220.75
274_S282_H0.7220.75
48_R116_H0.7170.75
19_A56_I0.7150.75
135_I161_F0.7130.74
149_G226_Y0.7130.74
79_L92_M0.7110.74
39_R119_A0.7110.74
91_K95_E0.7100.74
307_Q311_I0.7050.73
28_T88_V0.7040.73
164_P170_I0.7040.73
311_I314_R0.6970.73
187_D191_R0.6970.73
40_G306_G0.6960.73
196_P199_W0.6960.73
15_K49_V0.6960.73
144_V229_M0.6950.72
271_N276_S0.6920.72
304_Y307_Q0.6920.72
11_L331_L0.6910.72
177_T229_M0.6900.72
179_V222_G0.6890.72
179_V199_W0.6880.72
73_G104_N0.6860.71
79_L96_H0.6840.71
13_E30_A0.6830.71
94_M97_A0.6790.71
78_I110_G0.6770.70
50_E330_Y0.6760.70
307_Q310_D0.6740.70
48_R186_L0.6720.70
156_T198_T0.6710.70
31_E91_K0.6650.69
327_I330_Y0.6650.69
181_A188_A0.6640.69
124_V128_A0.6630.69
14_N18_Q0.6610.69
67_F92_M0.6580.68
161_F235_L0.6560.68
6_E9_H0.6540.68
326_D330_Y0.6530.68
72_T104_N0.6510.67
203_K318_V0.6510.67
154_Y286_T0.6510.67
171_L305_P0.6500.67
71_E100_T0.6490.67
203_K213_A0.6460.67
43_S116_H0.6460.67
168_D291_N0.6440.67
132_F267_V0.6440.67
59_G211_P0.6430.67
32_V119_A0.6410.66
37_D46_A0.6410.66
36_A118_G0.6400.66
185_V217_L0.6390.66
133_I235_L0.6380.66
66_E82_D0.6380.66
139_Q242_L0.6360.66
29_V88_V0.6350.66
24_E27_A0.6310.65
192_N212_F0.6290.65
46_A323_I0.6290.65
275_S278_L0.6270.65
9_H317_A0.6260.64
165_G170_I0.6260.64
111_I265_H0.6240.64
271_N275_S0.6180.63
117_S309_Q0.6160.63
179_V218_L0.6140.63
29_V87_Q0.6120.63
182_W200_A0.6120.63
177_T226_Y0.6110.63
52_Y116_H0.6100.62
14_N318_V0.6080.62
232_I261_L0.6070.62
53_A57_S0.6070.62
291_N304_Y0.6060.62
83_N259_R0.6060.62
24_E66_E0.6030.62
32_V122_Y0.6030.62
283_L287_M0.6020.61
186_L190_S0.6010.61
244_F285_Q0.6000.61
251_M261_L0.6000.61
114_M117_S0.5990.61
140_S200_A0.5980.61
33_L49_V0.5980.61
330_Y333_S0.5980.61
100_T104_N0.5970.61
185_V195_I0.5940.60
48_R182_W0.5940.60
133_I268_I0.5940.60
25_H64_E0.5920.60
78_I272_F0.5900.60
23_R66_E0.5900.60
11_L14_N0.5880.60
312_K322_E0.5880.60
4_S321_I0.5860.59
186_L189_R0.5860.59
129_R169_E0.5820.59
124_V172_T0.5820.59
157_N232_I0.5810.59
137_M144_V0.5800.59
195_I209_T0.5800.59
25_H85_A0.5790.58
220_A228_L0.5790.58
144_V182_W0.5780.58
70_E112_S0.5760.58
203_K208_T0.5740.58
24_E92_M0.5720.58
246_R289_E0.5710.57
74_P103_Q0.5700.57
8_L34_V0.5690.57
39_R309_Q0.5670.57
235_L264_L0.5660.57
163_A234_V0.5650.57
99_K130_A0.5650.57
120_I263_Q0.5640.57
72_T77_A0.5640.57
92_M96_H0.5640.57
203_K215_H0.5630.56
131_G166_E0.5630.56
3_I328_Y0.5630.56
119_A139_Q0.5620.56
42_H46_A0.5610.56
49_V159_L0.5600.56
8_L279_F0.5600.56
239_L268_I0.5590.56
47_V190_S0.5590.56
15_K19_A0.5570.56
84_A87_Q0.5570.56
42_H322_E0.5560.55
234_V279_F0.5560.55
70_E100_T0.5530.55
35_Y39_R0.5520.55
290_L302_V0.5510.55
277_E281_Q0.5500.55
32_V36_A0.5490.55
173_F231_M0.5480.54
27_A64_E0.5480.54
114_M139_Q0.5480.54
27_A206_V0.5460.54
99_K194_S0.5460.54
72_T76_S0.5440.54
141_D182_W0.5430.54
153_Y290_L0.5390.53
231_M264_L0.5380.53
249_S265_H0.5370.53
32_V123_F0.5370.53
230_M290_L0.5350.53
151_E292_A0.5340.53
144_V156_T0.5310.52
62_N84_A0.5300.52
194_S197_D0.5300.52
143_M179_V0.5300.52
93_G111_I0.5290.52
291_N302_V0.5280.52
190_S327_I0.5280.52
325_D328_Y0.5270.52
43_S187_D0.5270.52
86_G123_F0.5260.51
295_P298_G0.5260.51
290_L293_I0.5250.51
81_A226_Y0.5220.51
62_N83_N0.5220.51
98_I126_Q0.5210.51
9_H34_V0.5200.51
163_A171_L0.5200.51
147_F223_P0.5200.51
303_Y307_Q0.5190.50
142_P249_S0.5190.50
43_S138_C0.5180.50
90_A111_I0.5170.50
55_R115_G0.5160.50
154_Y163_A0.5160.50
238_V246_R0.5140.50
178_T229_M0.5130.50
192_N197_D0.5130.50
115_G251_M0.5120.50
296_A301_Q0.5120.50
268_I273_F0.5100.49
72_T96_H0.5100.49
281_Q285_Q0.5090.49
20_G101_A0.5090.49
124_V134_G0.5090.49
148_G303_Y0.5090.49
5_R8_L0.5080.49
156_T262_G0.5070.49
211_P335_A0.5070.49
251_M259_R0.5040.48
44_H48_R0.5040.48
18_Q329_Q0.5030.48
220_A263_Q0.5030.48
12_I34_V0.5030.48
48_R190_S0.5030.48
36_A183_G0.5020.48
204_N318_V0.5010.48
10_Q194_S0.5010.48
144_V154_Y0.5010.48
314_R333_S0.5000.48
84_A89_A0.5000.48
101_A105_G0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vbiA 2 0.9742 100 0.062 Contact Map
1z2iA 2 0.9885 100 0.063 Contact Map
3i0pA 2 0.9828 100 0.064 Contact Map
4h8aA 2 0.9656 100 0.068 Contact Map
1v9nA 2 0.937 100 0.069 Contact Map
3uoeA 2 0.9484 100 0.073 Contact Map
2x06A 2 0.9742 100 0.073 Contact Map
2g8yA 2 0.9828 100 0.078 Contact Map
1nxuA 2 0.9456 100 0.082 Contact Map
1wtjA 2 0.9427 100 0.084 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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