GREMLIN Database
YDHQ - Uncharacterized protein YdhQ
UniProt: P77552 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13951
Length: 418 (343)
Sequences: 316 (283)
Seq/√Len: 15.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
390_I406_P6.0981.00
356_L362_I4.8881.00
409_D412_G4.7461.00
356_L386_I4.2831.00
362_I386_I4.0321.00
373_P404_L3.8691.00
397_T403_K3.5530.99
382_V414_T3.4990.99
397_T404_L3.4720.99
395_R403_K3.1390.99
388_V407_D2.8290.97
189_T193_G2.6080.95
364_L406_P2.5240.94
367_S412_G2.4870.94
356_L397_T2.4660.94
275_R280_L2.4630.94
341_L364_L2.4370.93
386_I404_L2.2590.90
362_I397_T2.1900.89
368_A392_D2.1680.88
395_R404_L2.1670.88
382_V409_D2.1480.88
371_I397_T2.1120.87
273_E294_I2.1090.87
229_T232_L2.0560.85
337_G341_L2.0050.84
371_I404_L1.9660.82
366_T373_P1.9190.81
398_L403_K1.8790.79
381_E409_D1.8790.79
71_L77_A1.8620.79
356_L404_L1.8570.78
377_N410_G1.8480.78
341_L349_V1.8330.78
398_L404_L1.8130.77
411_I414_T1.8010.76
307_V317_G1.7820.75
356_L382_V1.7740.75
393_A397_T1.7570.74
227_G258_I1.7360.73
388_V406_P1.7240.73
392_D397_T1.7160.73
92_L95_L1.7000.72
356_L371_I1.6990.72
71_L79_A1.6980.72
364_L388_V1.6970.72
367_S397_T1.6940.72
79_A82_I1.6920.71
362_I373_P1.6880.71
362_I367_S1.6660.70
381_E412_G1.6460.69
362_I414_T1.6430.69
371_I403_K1.6280.68
375_F405_Q1.6150.68
406_P412_G1.6000.67
382_V386_I1.5940.67
382_V412_G1.5800.66
356_L405_Q1.5750.66
391_T409_D1.5740.66
371_I395_R1.5690.65
411_I416_Q1.5660.65
367_S404_L1.5510.65
109_V114_A1.5440.64
216_L219_D1.5390.64
332_I339_L1.5320.64
379_K410_G1.5210.63
313_L321_K1.5210.63
258_I283_S1.5100.62
257_V262_P1.5070.62
362_I404_L1.4850.61
71_L74_S1.4820.61
72_S91_S1.4720.60
109_V131_H1.4650.60
307_V385_D1.4640.60
397_T409_D1.4530.59
367_S403_K1.4510.59
362_I382_V1.4380.58
372_S397_T1.4370.58
88_G92_L1.4320.58
77_A82_I1.4320.58
167_G174_I1.4130.57
403_K409_D1.4070.57
200_G212_S1.4020.56
397_T405_Q1.3990.56
364_L397_T1.3950.56
386_I397_T1.3800.55
159_G163_V1.3790.55
92_L119_L1.3550.54
403_K412_G1.3550.54
356_L393_A1.3370.53
307_V339_L1.3350.53
356_L395_R1.3210.52
393_A412_G1.3190.52
393_A403_K1.3120.51
150_T153_V1.3110.51
362_I412_G1.2970.51
148_G161_L1.2910.50
319_T366_T1.2880.50
148_G178_G1.2800.50
349_V368_A1.2770.49
73_V92_L1.2710.49
331_N355_R1.2620.49
382_V411_I1.2570.48
248_E257_V1.2550.48
356_L403_K1.2540.48
395_R412_G1.2510.48
316_D365_Q1.2450.48
197_N200_G1.2400.47
189_T197_N1.2340.47
364_L407_D1.2310.47
404_L411_I1.2240.46
406_P409_D1.2200.46
186_A193_G1.2200.46
363_C386_I1.2140.46
356_L367_S1.2130.46
257_V260_L1.2110.46
131_H136_I1.2030.45
382_V413_A1.1990.45
370_E393_A1.1970.45
355_R382_V1.1960.45
90_I97_T1.1950.45
357_R373_P1.1890.44
109_V118_L1.1890.44
388_V399_C1.1880.44
105_G122_G1.1880.44
97_T100_G1.1870.44
249_N256_T1.1840.44
386_I412_G1.1830.44
393_A396_Q1.1740.44
367_S409_D1.1660.43
386_I403_K1.1660.43
275_R283_S1.1570.43
362_I403_K1.1560.43
186_A189_T1.1550.43
111_K124_N1.1540.43
395_R399_C1.1500.42
362_I379_K1.1240.41
388_V412_G1.1120.40
375_F403_K1.1110.40
81_D87_G1.1060.40
371_I386_I1.1020.40
366_T385_D1.0960.39
393_A409_D1.0890.39
73_V95_L1.0840.39
313_L319_T1.0830.39
404_L412_G1.0790.38
305_I407_D1.0790.38
255_G348_H1.0780.38
369_K397_T1.0780.38
276_A298_A1.0650.38
319_T363_C1.0610.37
377_N409_D1.0570.37
350_Q393_A1.0570.37
148_G153_V1.0540.37
388_V411_I1.0530.37
343_T349_V1.0520.37
356_L412_G1.0500.37
350_Q375_F1.0470.37
356_L399_C1.0460.37
267_E290_A1.0430.37
373_P386_I1.0390.36
302_Q321_K1.0360.36
379_K411_I1.0350.36
386_I396_Q1.0300.36
195_T205_D1.0290.36
350_Q365_Q1.0220.35
123_G127_V1.0170.35
373_P397_T1.0150.35
399_C404_L1.0130.35
257_V283_S1.0110.35
63_T71_L1.0010.34
271_V275_R1.0010.34
163_V167_G0.9990.34
364_L376_I0.9860.34
409_D414_T0.9830.33
395_R398_L0.9800.33
134_E142_G0.9780.33
369_K395_R0.9780.33
365_Q391_T0.9770.33
378_V409_D0.9690.33
382_V397_T0.9680.33
141_E173_E0.9660.33
142_G178_G0.9600.32
177_G181_M0.9600.32
71_L161_L0.9590.32
256_T261_S0.9550.32
380_G411_I0.9540.32
284_V294_I0.9520.32
397_T412_G0.9490.32
74_S87_G0.9490.32
386_I395_R0.9490.32
90_I211_G0.9480.32
256_T259_L0.9420.31
214_Y217_G0.9390.31
350_Q377_N0.9370.31
379_K414_T0.9370.31
141_E186_A0.9370.31
306_T311_G0.9300.31
92_L97_T0.9290.31
337_G373_P0.9230.30
155_V171_N0.9220.30
388_V409_D0.9210.30
286_L341_L0.9200.30
158_G171_N0.9180.30
366_T405_Q0.9160.30
362_I393_A0.9160.30
276_A321_K0.9120.30
88_G207_I0.9110.30
153_V171_N0.9040.30
219_D339_L0.9040.30
405_Q408_E0.9040.30
121_N124_N0.9010.29
73_V77_A0.9000.29
411_I415_L0.8950.29
318_S337_G0.8920.29
186_A198_N0.8910.29
287_L290_A0.8900.29
149_T168_E0.8890.29
73_V76_G0.8850.29
163_V169_A0.8840.29
403_K411_I0.8820.29
155_V345_A0.8810.28
354_K393_A0.8750.28
377_N408_E0.8750.28
141_E321_K0.8730.28
63_T77_A0.8710.28
349_V392_D0.8710.28
362_I371_I0.8640.28
133_A211_G0.8640.28
313_L348_H0.8570.27
315_L351_L0.8520.27
364_L367_S0.8490.27
364_L371_I0.8490.27
314_I413_A0.8480.27
363_C396_Q0.8460.27
219_D223_L0.8450.27
334_L397_T0.8430.27
364_L416_Q0.8390.27
367_S395_R0.8330.26
167_G179_V0.8300.26
300_L392_D0.8240.26
159_G167_G0.8230.26
248_E255_G0.8210.26
333_N359_E0.8190.26
163_V173_E0.8170.26
95_L247_L0.8160.26
230_Q234_V0.8140.25
356_L414_T0.8110.25
194_G199_L0.8110.25
302_Q386_I0.8110.25
158_G174_I0.8100.25
395_R409_D0.8100.25
123_G177_G0.8070.25
72_S88_G0.8050.25
76_G82_I0.7960.25
255_G259_L0.7960.25
289_G376_I0.7960.25
386_I414_T0.7940.25
65_Y69_G0.7920.25
352_K377_N0.7910.25
166_G171_N0.7910.25
228_K232_L0.7890.24
370_E378_V0.7880.24
311_G316_D0.7850.24
148_G159_G0.7830.24
189_T196_M0.7830.24
357_R362_I0.7820.24
85_S103_P0.7810.24
218_T226_S0.7750.24
141_E242_V0.7730.24
381_E407_D0.7640.23
388_V393_A0.7640.23
109_V146_V0.7640.23
368_A403_K0.7590.23
152_A159_G0.7550.23
259_L262_P0.7520.23
282_G360_G0.7520.23
284_V292_M0.7500.23
69_G142_G0.7480.23
65_Y95_L0.7480.23
87_G91_S0.7470.23
353_V376_I0.7450.23
307_V334_L0.7440.23
198_N203_D0.7350.22
309_Q315_L0.7340.22
100_G114_A0.7330.22
171_N174_I0.7320.22
349_V377_N0.7320.22
85_S132_R0.7320.22
398_L411_I0.7310.22
121_N126_R0.7290.22
256_T260_L0.7270.22
254_G257_V0.7260.22
163_V179_V0.7240.22
141_E162_L0.7240.22
377_N412_G0.7230.22
364_L409_D0.7220.22
364_L404_L0.7210.22
383_T402_L0.7210.22
305_I364_L0.7200.22
167_G194_G0.7180.22
166_G353_V0.7170.22
262_P291_S0.7160.22
355_R414_T0.7160.22
353_V409_D0.7130.21
125_L210_N0.7110.21
133_A139_D0.7110.21
375_F397_T0.7100.21
226_S339_L0.7090.21
76_G274_D0.7080.21
373_P382_V0.7080.21
82_I90_I0.7080.21
169_A183_A0.7080.21
269_F287_L0.7060.21
376_I394_S0.7060.21
138_L142_G0.7060.21
142_G307_V0.7050.21
413_A416_Q0.7050.21
340_W403_K0.7040.21
317_G366_T0.7040.21
135_K142_G0.7020.21
307_V311_G0.7010.21
334_L360_G0.7010.21
388_V403_K0.7000.21
278_V376_I0.6980.21
367_S388_V0.6970.21
336_G340_W0.6970.21
368_A375_F0.6970.21
367_S391_T0.6950.21
79_A84_Q0.6930.21
405_Q412_G0.6930.21
141_E211_G0.6920.21
99_N339_L0.6910.21
198_N214_Y0.6900.21
194_G210_N0.6900.21
305_I341_L0.6890.20
348_H369_K0.6880.20
365_Q395_R0.6870.20
350_Q370_E0.6850.20
387_H412_G0.6820.20
379_K386_I0.6810.20
91_S131_H0.6810.20
234_V334_L0.6790.20
351_L384_G0.6770.20
129_E133_A0.6760.20
111_K167_G0.6760.20
365_Q388_V0.6750.20
99_N124_N0.6750.20
228_K246_T0.6720.20
201_G206_T0.6720.20
260_L271_V0.6710.20
139_D170_S0.6670.20
227_G346_A0.6650.20
166_G174_I0.6650.20
158_G161_L0.6630.20
77_A247_L0.6610.19
125_L353_V0.6600.19
382_V403_K0.6590.19
119_L124_N0.6590.19
92_L315_L0.6590.19
373_P409_D0.6580.19
364_L412_G0.6580.19
370_E403_K0.6570.19
223_L342_I0.6560.19
375_F392_D0.6560.19
59_I63_T0.6520.19
349_V364_L0.6520.19
280_L366_T0.6510.19
129_E136_I0.6500.19
362_I388_V0.6500.19
372_S403_K0.6470.19
130_G138_L0.6470.19
255_G262_P0.6460.19
88_G184_G0.6460.19
373_P395_R0.6460.19
313_L374_D0.6450.19
284_V353_V0.6430.19
367_S371_I0.6430.19
159_G205_D0.6420.19
221_L269_F0.6420.19
405_Q411_I0.6410.19
289_G292_M0.6400.19
404_L409_D0.6400.19
316_D319_T0.6400.19
97_T165_P0.6400.19
294_I334_L0.6390.19
95_L198_N0.6360.19
377_N404_L0.6340.19
399_C409_D0.6340.19
373_P391_T0.6320.18
342_I349_V0.6310.18
377_N411_I0.6300.18
373_P405_Q0.6270.18
399_C403_K0.6260.18
309_Q319_T0.6250.18
355_R410_G0.6230.18
291_S315_L0.6230.18
87_G337_G0.6210.18
368_A393_A0.6210.18
386_I409_D0.6200.18
356_L385_D0.6190.18
186_A191_L0.6180.18
74_S117_L0.6180.18
371_I382_V0.6150.18
379_K404_L0.6130.18
247_L273_E0.6100.18
380_G409_D0.6080.18
176_Q184_G0.6070.18
176_Q385_D0.6060.18
371_I398_L0.6060.18
250_A256_T0.6060.18
93_S383_T0.6050.18
87_G103_P0.6040.18
394_S416_Q0.6040.18
172_C175_N0.6030.17
283_S296_Y0.6010.17
306_T333_N0.5970.17
372_S404_L0.5940.17
82_I92_L0.5930.17
366_T404_L0.5920.17
201_G205_D0.5920.17
357_R383_T0.5920.17
151_S169_A0.5910.17
245_G390_I0.5900.17
365_Q411_I0.5890.17
115_C119_L0.5890.17
72_S191_L0.5890.17
362_I377_N0.5890.17
295_G309_Q0.5860.17
352_K409_D0.5850.17
382_V404_L0.5830.17
234_V237_G0.5830.17
273_E368_A0.5820.17
262_P301_Q0.5810.17
355_R386_I0.5790.17
367_S386_I0.5780.17
365_Q392_D0.5780.17
356_L373_P0.5760.17
373_P403_K0.5760.17
269_F352_K0.5760.17
107_F188_D0.5760.17
311_G319_T0.5760.17
317_G365_Q0.5740.17
313_L318_S0.5680.16
369_K393_A0.5680.16
150_T278_V0.5660.16
348_H393_A0.5660.16
396_Q409_D0.5640.16
284_V305_I0.5640.16
273_E278_V0.5620.16
229_T233_S0.5620.16
221_L271_V0.5600.16
83_V191_L0.5590.16
276_A355_R0.5580.16
387_H409_D0.5570.16
113_Y117_L0.5550.16
367_S393_A0.5540.16
300_L345_A0.5530.16
88_G139_D0.5530.16
333_N390_I0.5510.16
336_G342_I0.5480.16
362_I395_R0.5480.16
258_I261_S0.5470.16
89_A98_V0.5470.16
249_N257_V0.5440.16
360_G397_T0.5430.16
175_N179_V0.5410.16
130_G166_G0.5400.16
280_L294_I0.5390.15
72_S92_L0.5380.15
167_G175_N0.5370.15
287_L321_K0.5360.15
364_L396_Q0.5360.15
364_L410_G0.5360.15
249_N255_G0.5360.15
283_S321_K0.5360.15
131_H138_L0.5340.15
408_E417_P0.5340.15
70_T91_S0.5340.15
319_T403_K0.5320.15
100_G107_F0.5320.15
136_I208_V0.5320.15
152_A353_V0.5320.15
367_S405_Q0.5310.15
318_S410_G0.5300.15
343_T366_T0.5280.15
168_E390_I0.5280.15
373_P398_L0.5270.15
396_Q403_K0.5260.15
69_G77_A0.5250.15
62_C67_N0.5250.15
154_V180_F0.5230.15
184_G188_D0.5190.15
357_R396_Q0.5190.15
374_D394_S0.5180.15
184_G249_N0.5180.15
68_N80_T0.5160.15
381_E390_I0.5160.15
311_G336_G0.5150.15
132_R136_I0.5140.15
286_L303_S0.5100.15
146_V352_K0.5100.15
377_N397_T0.5070.15
167_G406_P0.5070.15
356_L396_Q0.5060.15
234_V242_V0.5050.15
127_V148_G0.5040.14
405_Q409_D0.5030.14
373_P412_G0.5030.14
311_G315_L0.5020.14
307_V332_I0.5020.14
365_Q404_L0.5010.14
111_K357_R0.5010.14
126_R136_I0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dabA 5 0.9234 100 0.619 Contact Map
4om9A 1 0.9378 100 0.619 Contact Map
3szeA 1 0.9378 100 0.632 Contact Map
3syjA 2 0.9306 100 0.652 Contact Map
1wxrA 1 0.8756 100 0.656 Contact Map
3h09A 1 0.9211 100 0.661 Contact Map
4kh3A 1 0.756 99.9 0.707 Contact Map
4q1qA 1 0.5861 99.9 0.729 Contact Map
3ml3A 1 0.2775 99.8 0.757 Contact Map
4meeA 1 0 99.7 0.778 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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