GREMLIN Database
RZPR - Putative Rz endopeptidase from lambdoid prophage Rac (Fragment)
UniProt: P77551 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13366
Length: 147 (140)
Sequences: 437 (274)
Seq/√Len: 23.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_D136_G4.3961.00
130_M134_L3.8411.00
102_S136_G3.4951.00
111_R117_E2.8780.99
130_M133_Q2.4990.98
37_L40_A2.2960.97
131_Q134_L2.2870.97
102_S105_D2.1690.96
115_T126_R2.1050.95
118_R126_R2.0590.95
120_Y123_L2.0460.94
9_V12_L2.0460.94
46_E50_R1.9970.94
114_D126_R1.9470.93
7_C10_V1.9210.92
58_D62_T1.9120.92
124_R127_L1.8750.91
78_D84_R1.8510.91
71_E76_R1.8450.91
139_Q143_E1.8140.90
23_A26_Y1.8110.90
117_E120_Y1.6440.85
79_V82_G1.5950.83
70_A74_A1.5590.81
80_A84_R1.5370.80
57_L61_Y1.5050.79
122_T126_R1.5030.79
130_M135_E1.4850.78
134_L141_I1.4660.77
114_D118_R1.4610.77
79_V121_F1.4560.76
123_L133_Q1.4410.76
78_D85_R1.4140.74
78_D83_R1.3920.73
130_M136_G1.3860.73
5_V8_I1.3810.73
111_R126_R1.3440.70
64_E82_G1.2940.67
22_N26_Y1.2500.65
110_P123_L1.2480.65
16_V19_Y1.2300.63
110_P120_Y1.2240.63
10_V13_S1.2210.63
26_Y29_Q1.2200.63
120_Y133_Q1.2190.63
30_R34_A1.2170.63
106_N113_A1.2130.62
131_Q135_E1.2040.62
23_A27_K1.1980.61
127_L130_M1.1900.61
8_I13_S1.1790.60
6_I14_W1.1760.60
111_R114_D1.1740.60
19_Y23_A1.1610.59
122_T133_Q1.1500.58
133_Q136_G1.1490.58
117_E133_Q1.1360.57
73_D84_R1.1290.57
20_R24_I1.1110.55
33_N36_E1.1080.55
117_E126_R1.0950.54
36_E40_A1.0940.54
129_M136_G1.0870.54
12_L16_V1.0840.54
7_C11_C1.0830.53
5_V9_V1.0660.52
126_R130_M1.0620.52
37_L41_N1.0540.51
32_K36_E1.0350.50
7_C14_W1.0350.50
123_L134_L1.0180.49
105_D134_L1.0110.48
28_E32_K1.0000.48
110_P130_M0.9970.47
113_A127_L0.9920.47
74_A77_D0.9770.46
26_Y30_R0.9730.46
6_I11_C0.9690.46
10_V14_W0.9680.45
29_Q34_A0.9680.45
127_L137_A0.9610.45
63_K67_D0.9610.45
71_E74_A0.9510.44
9_V16_V0.9300.43
117_E130_M0.9250.43
106_N127_L0.9170.42
79_V86_L0.9160.42
23_A29_Q0.9130.42
13_S16_V0.9040.41
24_I27_K0.9020.41
67_D101_A0.9010.41
126_R136_G0.8970.41
10_V15_G0.8890.40
103_G116_A0.8840.40
117_E123_L0.8800.39
123_L126_R0.8780.39
47_M51_Q0.8650.38
8_I11_C0.8620.38
13_S17_N0.8510.38
60_K64_E0.8500.37
14_W18_H0.8440.37
72_N85_R0.8420.37
27_K31_D0.8410.37
25_A33_N0.8380.37
79_V122_T0.8360.37
81_A91_V0.8320.36
105_D128_V0.8230.36
15_G20_R0.8220.36
94_S97_E0.8220.36
32_K35_R0.8140.35
58_D66_A0.8120.35
126_R134_L0.8110.35
127_L135_E0.8020.34
44_I47_M0.8020.34
29_Q32_K0.7870.33
37_L48_Q0.7870.33
128_V133_Q0.7820.33
110_P117_E0.7730.33
50_R144_Q0.7690.32
40_A52_R0.7560.32
25_A28_E0.7520.31
77_D80_A0.7510.31
14_W17_N0.7450.31
103_G136_G0.7420.31
30_R33_N0.7400.31
110_P133_Q0.7400.31
121_F128_V0.7370.30
9_V15_G0.7310.30
119_D126_R0.7310.30
97_E108_A0.7260.30
120_Y130_M0.7250.30
12_L15_G0.7220.30
47_M61_Y0.7200.29
46_E53_D0.7140.29
85_R90_A0.7110.29
128_V136_G0.7110.29
72_N76_R0.7080.29
35_R38_K0.7070.29
102_S134_L0.6920.28
19_Y22_N0.6760.27
21_D25_A0.6690.27
56_A60_K0.6590.26
12_L20_R0.6590.26
24_I33_N0.6550.26
124_R138_Q0.6540.26
22_N31_D0.6480.25
72_N84_R0.6460.25
115_T118_R0.6440.25
79_V83_R0.6420.25
112_L116_A0.6370.25
111_R123_L0.6370.25
87_H121_F0.6320.25
117_E121_F0.6310.25
40_A48_Q0.6240.24
124_R141_I0.6230.24
127_L134_L0.6160.24
74_A80_A0.6150.24
129_M134_L0.6130.24
22_N27_K0.6120.24
111_R120_Y0.6120.24
84_R87_H0.6080.23
128_V131_Q0.6070.23
126_R129_M0.6030.23
123_L131_Q0.6030.23
114_D122_T0.6010.23
20_R25_A0.6010.23
105_D130_M0.5990.23
83_R86_L0.5960.23
8_I12_L0.5960.23
35_R100_T0.5960.23
123_L129_M0.5940.23
130_M137_A0.5940.23
123_L130_M0.5930.23
9_V21_D0.5880.22
59_A63_K0.5870.22
120_Y136_G0.5870.22
113_A130_M0.5820.22
10_V18_H0.5810.22
61_Y132_A0.5790.22
76_R85_R0.5780.22
112_L122_T0.5770.22
115_T127_L0.5730.22
5_V35_R0.5730.22
6_I35_R0.5710.22
60_K66_A0.5680.21
132_A135_E0.5670.21
7_C15_G0.5620.21
85_R110_P0.5500.21
74_A83_R0.5490.21
33_N42_A0.5420.20
113_A128_V0.5410.20
132_A141_I0.5400.20
8_I16_V0.5390.20
37_L50_R0.5370.20
18_H28_E0.5340.20
31_D34_A0.5330.20
16_V24_I0.5310.20
97_E103_G0.5280.20
62_T65_L0.5230.19
79_V88_I0.5220.19
78_D90_A0.5180.19
139_Q144_Q0.5160.19
83_R90_A0.5160.19
52_R55_A0.5150.19
13_S18_H0.5100.19
7_C16_V0.5100.19
17_N21_D0.5030.19
19_Y44_I0.5030.19
28_E35_R0.5010.18
73_D77_D0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cgkA 3 0.6122 83.7 0.906 Contact Map
4q4gX 1 0 80.1 0.909 Contact Map
3rvyA 3 0.1565 34.9 0.933 Contact Map
3vp9A 3 0.4422 26.2 0.937 Contact Map
3hnwA 2 0.5578 26.1 0.937 Contact Map
4gipD 3 0.3673 21.4 0.939 Contact Map
4k1pA 1 0.8163 21 0.94 Contact Map
4rsiA 1 0.4422 17.5 0.942 Contact Map
4bgnA 3 0.2449 16.7 0.942 Contact Map
1fzcA 1 0.1905 15.8 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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