GREMLIN Database
YFCF - Glutathione S-transferase YfcF
UniProt: P77544 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14109
Length: 214 (194)
Sequences: 21123 (14458)
Seq/√Len: 1038.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_T36_K3.3191.00
77_E103_R3.1421.00
28_E199_R3.0481.00
81_D99_R2.9041.00
27_Q204_R2.7961.00
10_S19_V2.7651.00
26_L33_F2.7471.00
67_F97_E2.7351.00
7_T34_H2.6651.00
191_D195_F2.6041.00
51_Q57_R2.5091.00
147_A186_P2.4631.00
158_P195_F2.3091.00
63_Q68_E2.3051.00
150_E188_R2.2221.00
7_T63_Q2.1831.00
154_V188_R2.0551.00
10_S35_I2.0151.00
9_W63_Q1.9701.00
39_D42_S1.9051.00
27_Q33_F1.8881.00
164_W169_T1.8851.00
25_A76_A1.8241.00
95_D98_N1.7821.00
190_V194_T1.7571.00
28_E201_S1.7481.00
53_Y63_Q1.6821.00
29_K80_E1.6561.00
48_P52_G1.6391.00
53_Y61_L1.6351.00
81_D103_R1.6351.00
64_I78_Y1.6331.00
172_A196_Q1.6201.00
101_R104_Q1.6021.00
136_A140_A1.5891.00
49_T52_G1.5721.00
24_V202_V1.5281.00
105_I152_L1.5231.00
9_W38_I1.4911.00
50_W61_L1.4901.00
31_L83_F1.4711.00
44_E47_Q1.4131.00
188_R191_D1.4091.00
193_A197_W1.3961.00
139_K143_E1.3721.00
50_W53_Y1.3701.00
158_P162_G1.3621.00
63_Q66_D1.3591.00
64_I67_F1.3531.00
147_A151_H1.3491.00
200_A204_R1.3481.00
164_W199_R1.3261.00
25_A29_K1.3241.00
107_A110_R1.3131.00
132_A136_A1.3131.00
194_T198_Q1.2911.00
92_Y102_A1.2761.00
93_P102_A1.2551.00
70_S104_Q1.2541.00
97_E101_R1.2491.00
77_E107_A1.2381.00
46_L57_R1.2351.00
161_F165_C1.2211.00
198_Q203_Q1.2111.00
6_I62_L1.1971.00
86_P90_R1.1941.00
152_L157_Q1.1931.00
160_L171_L1.1801.00
69_L100_A1.1781.00
143_E186_P1.1681.00
21_S72_S1.1551.00
25_A91_I1.1541.00
22_A76_A1.1291.00
141_S144_K1.1271.00
8_L26_L1.1251.00
150_E154_V1.1211.00
82_R96_L1.1171.00
131_K134_L1.1131.00
150_E187_E1.1081.00
164_W196_Q1.1071.00
172_A197_W1.0951.00
107_A111_S1.0881.00
140_A144_K1.0861.00
179_V193_A1.0751.00
159_N196_Q1.0651.00
151_H154_V1.0601.00
56_T108_W1.0511.00
76_A170_D1.0461.00
148_M152_L1.0341.00
28_E164_W1.0311.00
10_S23_W1.0261.00
106_Q170_D1.0261.00
136_A139_K1.0251.00
158_P161_F1.0241.00
64_I82_R1.0221.00
144_K147_A1.0131.00
109_L171_L1.0091.00
73_S107_A1.0001.00
67_F101_R0.9981.00
98_N101_R0.9971.00
140_A143_E0.9941.00
91_I169_T0.9861.00
6_I83_F0.9801.00
64_I83_F0.9791.00
22_A75_I0.9781.00
76_A166_I0.9741.00
53_Y68_E0.9681.00
143_E147_A0.9641.00
137_E141_S0.9621.00
58_R71_E0.9591.00
102_A161_F0.9581.00
195_F198_Q0.9481.00
119_E123_D0.9471.00
19_V59_V0.9431.00
146_F186_P0.9331.00
6_I31_L0.9311.00
29_K79_L0.9201.00
96_L100_A0.9201.00
102_A165_C0.9181.00
150_E186_P0.9161.00
98_N163_E0.9141.00
172_A202_V0.9121.00
61_L68_E0.9111.00
101_R152_L0.9071.00
148_M151_H0.9041.00
54_G61_L0.9031.00
90_R163_E0.8931.00
24_V169_T0.8921.00
99_R103_R0.8921.00
182_G185_V0.8911.00
106_Q166_I0.8881.00
192_Y196_Q0.8871.00
194_T197_W0.8841.00
56_T70_S0.8811.00
176_N197_W0.8801.00
73_S170_D0.8791.00
48_P51_Q0.8791.00
73_S110_R0.8751.00
23_W35_I0.8741.00
175_I193_A0.8611.00
21_S170_D0.8591.00
28_E169_T0.8551.00
133_P136_A0.8551.00
158_P191_D0.8511.00
50_W54_G0.8501.00
78_Y82_R0.8491.00
21_S76_A0.8481.00
102_A166_I0.8391.00
23_W27_Q0.8361.00
46_L51_Q0.8321.00
108_W145_L0.8261.00
67_F100_A0.8261.00
191_D194_T0.8211.00
160_L167_A0.8161.00
90_R94_L0.8131.00
159_N195_F0.8061.00
132_A135_T0.8051.00
74_A104_Q0.8041.00
29_K86_P0.8031.00
137_E140_A0.7961.00
61_L70_S0.7951.00
150_E189_L0.7951.00
123_D127_A0.7951.00
11_D14_F0.7911.00
6_I64_I0.7911.00
186_P189_L0.7861.00
79_L83_F0.7851.00
11_D15_F0.7801.00
102_A167_A0.7711.00
8_L23_W0.7671.00
77_E81_D0.7611.00
159_N162_G0.7581.00
200_A203_Q0.7541.00
85_P90_R0.7541.00
101_R105_I0.7511.00
146_F189_L0.7491.00
25_A80_E0.7441.00
16_S19_V0.7431.00
176_N202_V0.7421.00
179_V197_W0.7371.00
135_T139_K0.7361.00
149_A171_L0.7361.00
25_A169_T0.7341.00
74_A100_A0.7341.00
29_K84_A0.7311.00
175_I192_Y0.7231.00
116_I119_E0.7121.00
92_Y103_R0.7111.00
24_V201_S0.7051.00
20_L205_F0.7031.00
152_L156_G0.6961.00
9_W36_K0.6921.00
100_A103_R0.6901.00
101_R157_Q0.6891.00
26_L79_L0.6881.00
93_P98_N0.6851.00
120_R123_D0.6851.00
14_F37_T0.6781.00
80_E92_Y0.6741.00
118_E122_T0.6741.00
142_A146_F0.6671.00
187_E191_D0.6661.00
29_K83_F0.6651.00
130_K133_P0.6641.00
116_I145_L0.6641.00
98_N161_F0.6621.00
23_W205_F0.6611.00
24_V172_A0.6601.00
38_I44_E0.6601.00
138_G141_S0.6561.00
69_L75_I0.6491.00
81_D96_L0.6481.00
159_N164_W0.6481.00
130_K135_T0.6481.00
104_Q152_L0.6471.00
108_W148_M0.6471.00
10_S37_T0.6461.00
119_E141_S0.6461.00
8_L62_L0.6431.00
27_Q205_F0.6411.00
84_A90_R0.6361.00
42_S47_Q0.6331.00
117_R121_P0.6231.00
105_I161_F0.6221.00
196_Q202_V0.6191.00
105_I108_W0.6191.00
190_V193_A0.6181.00
80_E166_I0.6141.00
156_G188_R0.6101.00
24_V173_L0.6091.00
81_D100_A0.6081.00
62_L79_L0.6071.00
71_E112_D0.6061.00
152_L160_L0.6021.00
21_S73_S0.6001.00
122_T133_P0.5991.00
39_D44_E0.5931.00
131_K135_T0.5931.00
47_Q51_Q0.5911.00
27_Q30_G0.5901.00
187_E190_V0.5901.00
96_L99_R0.5881.00
25_A166_I0.5871.00
82_R97_E0.5871.00
160_L192_Y0.5861.00
109_L113_L0.5851.00
101_R161_F0.5841.00
73_S106_Q0.5831.00
18_Y21_S0.5791.00
120_R124_V0.5771.00
20_L176_N0.5761.00
133_P137_E0.5761.00
157_Q161_F0.5741.00
134_L137_E0.5741.00
27_Q201_S0.5711.00
92_Y166_I0.5691.00
159_N168_D0.5691.00
56_T148_M0.5691.00
9_W53_Y0.5681.00
80_E90_R0.5681.00
41_D44_E0.5671.00
147_A150_E0.5661.00
64_I97_E0.5661.00
18_Y114_M0.5631.00
99_R102_A0.5631.00
119_E122_T0.5611.00
134_L138_G0.5581.00
176_N193_A0.5571.00
66_D97_E0.5511.00
115_P119_E0.5511.00
157_Q162_G0.5511.00
117_R142_A0.5461.00
9_W61_L0.5431.00
21_S110_R0.5421.00
81_D92_Y0.5381.00
105_I160_L0.5371.00
149_A189_L0.5351.00
29_K85_P0.5281.00
92_Y99_R0.5271.00
83_F86_P0.5271.00
161_F167_A0.5271.00
65_D97_E0.5241.00
62_L75_I0.5191.00
179_V190_V0.5151.00
84_A94_L0.5061.00
120_R139_K0.5041.00
20_L23_W0.5031.00
162_G168_D0.5021.00
77_E92_Y0.5011.00
144_K148_M0.5011.00
74_A107_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mp4A 2 0.9065 100 0.192 Contact Map
4isdA 2 0.8785 100 0.21 Contact Map
4jbbA 2 0.9626 100 0.214 Contact Map
1e6bA 2 0.8692 100 0.233 Contact Map
3n5oA 3 0.9579 100 0.238 Contact Map
4ri6A 2 0.9626 100 0.239 Contact Map
1k0dA 2 0.9673 100 0.245 Contact Map
2cz2A 2 0.9393 100 0.25 Contact Map
3qavA 2 0.9579 100 0.25 Contact Map
2v6kA 2 0.9626 100 0.25 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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