GREMLIN Database
YDJL - Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjL
UniProt: P77539 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13488
Length: 358 (303)
Sequences: 52680 (36393)
Seq/√Len: 2090.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_K150_Y2.9771.00
32_E68_A2.9081.00
334_Q337_E2.8411.00
34_K66_C2.8381.00
7_F17_I2.5741.00
30_V68_A2.5591.00
149_D152_D2.4281.00
78_K81_Q2.4061.00
29_V141_L2.3971.00
81_Q143_E2.3381.00
195_R224_T2.3271.00
82_R144_I2.2911.00
21_Q126_Y2.2741.00
151_E329_R2.2501.00
177_D200_V2.2481.00
237_R240_Q2.2181.00
330_I341_A2.2161.00
32_E66_C2.2031.00
7_F15_K2.1801.00
32_E126_Y2.1681.00
329_R353_T2.1681.00
328_H341_A2.1431.00
178_V194_A2.1111.00
173_L176_Q2.0801.00
26_P72_E2.0631.00
5_A17_I2.0411.00
215_F219_K2.0401.00
26_P73_K2.0181.00
76_D131_G2.0151.00
147_G316_A2.0091.00
25_G28_D2.0031.00
313_R317_S1.9811.00
331_G334_Q1.9671.00
63_F85_S1.9631.00
216_P220_E1.9511.00
63_F122_G1.9211.00
191_V223_A1.8921.00
27_E73_K1.8911.00
30_V128_L1.8841.00
340_D344_D1.8801.00
68_A126_Y1.8701.00
47_N343_V1.8681.00
64_A150_Y1.8341.00
216_P219_K1.8291.00
82_R150_Y1.8141.00
196_I319_A1.7831.00
159_I189_F1.7611.00
209_E216_P1.7181.00
179_V205_V1.7141.00
23_M69_Q1.6981.00
248_G268_R1.6971.00
341_A346_T1.6891.00
272_E296_S1.6841.00
337_E340_D1.6801.00
215_F226_V1.6761.00
179_V247_L1.6671.00
144_I150_Y1.6201.00
337_E341_A1.6181.00
203_V247_L1.6141.00
217_V220_E1.6101.00
225_A241_I1.6031.00
272_E298_I1.5891.00
206_G215_F1.5801.00
152_D323_K1.5511.00
330_I338_G1.5321.00
30_V126_Y1.5241.00
151_E353_T1.5241.00
4_L335_W1.5171.00
69_Q79_V1.5061.00
144_I153_A1.4971.00
66_C82_R1.4931.00
267_L273_V1.4921.00
70_V79_V1.4911.00
209_E231_T1.4871.00
28_D130_P1.4691.00
267_L295_K1.4671.00
181_I263_A1.4651.00
232_E237_R1.4601.00
176_Q272_E1.4491.00
77_W143_E1.4461.00
77_W81_Q1.4391.00
27_E130_P1.4321.00
170_S249_L1.4241.00
24_C128_L1.4211.00
250_V267_L1.4171.00
336_R340_D1.4171.00
233_D236_A1.4031.00
71_G74_V1.3961.00
209_E228_N1.3951.00
267_L271_G1.3951.00
33_I63_F1.3931.00
28_D128_L1.3861.00
30_V69_Q1.3791.00
228_N231_T1.3701.00
207_L229_G1.3661.00
123_F339_F1.3631.00
200_V225_A1.3581.00
250_V263_A1.3581.00
35_A353_T1.3561.00
24_C30_V1.3491.00
82_R146_D1.3441.00
35_A151_E1.3321.00
327_T341_A1.3131.00
183_T204_V1.3081.00
67_I77_W1.2961.00
200_V224_T1.2941.00
313_R316_A1.2941.00
29_V77_W1.2901.00
3_A19_V1.2901.00
236_A240_Q1.2901.00
196_I314_L1.2871.00
177_D203_V1.2761.00
66_C150_Y1.2631.00
208_Q213_V1.2581.00
191_V204_V1.2531.00
190_S251_I1.2301.00
4_L16_M1.2001.00
34_K82_R1.1991.00
156_L315_L1.1961.00
181_I205_V1.1911.00
46_Y339_F1.1901.00
77_W141_L1.1791.00
168_Q307_S1.1761.00
237_R241_I1.1751.00
21_Q30_V1.1701.00
33_I127_C1.1631.00
220_E324_P1.1541.00
27_E131_G1.1271.00
305_S309_R1.1271.00
219_K226_V1.1261.00
8_G13_G1.1221.00
177_D248_G1.1171.00
183_T206_G1.1121.00
207_L230_S1.1031.00
168_Q310_N1.0951.00
314_L319_A1.0871.00
172_F199_A1.0851.00
215_F228_N1.0841.00
265_E289_D1.0821.00
310_N313_R1.0731.00
235_V265_E1.0731.00
331_G353_T1.0701.00
335_W352_M1.0651.00
129_V141_L1.0561.00
31_I65_G1.0541.00
176_Q248_G1.0391.00
31_I83_V1.0351.00
233_D237_R1.0301.00
68_A79_V1.0291.00
16_M333_S1.0271.00
164_K307_S1.0191.00
5_A19_V1.0181.00
203_V225_A1.0171.00
38_I338_G1.0011.00
162_A190_S1.0001.00
217_V347_A0.9981.00
24_C28_D0.9971.00
169_Q296_S0.9961.00
172_F176_Q0.9921.00
46_Y343_V0.9901.00
132_E140_A0.9881.00
35_A150_Y0.9861.00
36_A123_F0.9841.00
170_S274_V0.9821.00
254_S259_A0.9781.00
204_V223_A0.9731.00
309_R313_R0.9721.00
4_L332_L0.9721.00
235_V262_Q0.9651.00
194_A199_A0.9621.00
262_Q265_E0.9601.00
209_E215_F0.9601.00
231_T237_R0.9601.00
341_A350_V0.9581.00
340_D343_V0.9511.00
289_D293_W0.9491.00
74_V131_G0.9481.00
163_Y310_N0.9331.00
34_K64_A0.9311.00
123_F335_W0.9281.00
219_K225_A0.9241.00
165_S276_V0.9201.00
204_V218_A0.9181.00
159_I311_A0.9151.00
148_V153_A0.9151.00
235_V239_Q0.9141.00
162_A193_M0.9141.00
75_K131_G0.9111.00
208_Q228_N0.9101.00
261_K265_E0.9071.00
191_V202_I0.8981.00
310_N314_L0.8941.00
43_M342_M0.8851.00
165_S251_I0.8851.00
330_I334_Q0.8831.00
179_V266_M0.8831.00
238_C247_L0.8811.00
5_A58_I0.8791.00
35_A351_I0.8771.00
8_G12_G0.8721.00
57_S120_G0.8711.00
21_Q69_Q0.8711.00
213_V216_P0.8681.00
39_C62_E0.8641.00
214_R347_A0.8611.00
205_V229_G0.8611.00
36_A122_G0.8601.00
203_V227_V0.8601.00
188_L217_V0.8581.00
242_C246_N0.8531.00
84_V312_I0.8531.00
176_Q249_L0.8511.00
32_E125_K0.8471.00
180_V194_A0.8461.00
252_E255_G0.8451.00
70_V74_V0.8441.00
180_V190_S0.8431.00
21_Q68_A0.8331.00
181_I250_V0.8321.00
78_K143_E0.8321.00
7_F13_G0.8301.00
290_I297_I0.8291.00
3_A58_I0.8291.00
206_G226_V0.8271.00
208_Q214_R0.8261.00
70_V78_K0.8241.00
169_Q298_I0.8201.00
306_T310_N0.8181.00
4_L14_Y0.8151.00
193_M311_A0.8091.00
37_A62_E0.8081.00
63_F127_C0.8081.00
270_N294_N0.8081.00
258_I262_Q0.8081.00
177_D247_L0.8041.00
207_L215_F0.8031.00
123_F352_M0.8011.00
160_C307_S0.7961.00
23_M30_V0.7951.00
146_D316_A0.7941.00
39_C61_H0.7931.00
178_V199_A0.7891.00
38_I342_M0.7831.00
203_V241_I0.7811.00
306_T309_R0.7801.00
234_V262_Q0.7791.00
250_V273_V0.7781.00
209_E213_V0.7761.00
236_A239_Q0.7741.00
166_I194_A0.7721.00
181_I259_A0.7681.00
183_T218_A0.7671.00
142_W309_R0.7661.00
263_A273_V0.7611.00
314_L317_S0.7601.00
171_K272_E0.7591.00
193_M314_L0.7501.00
197_M310_N0.7501.00
19_V58_I0.7501.00
290_I299_G0.7491.00
29_V131_G0.7481.00
218_A223_A0.7481.00
25_G128_L0.7461.00
261_K282_P0.7361.00
19_V120_G0.7351.00
328_H337_E0.7341.00
194_A202_I0.7331.00
16_M332_L0.7321.00
203_V238_C0.7291.00
85_S129_V0.7291.00
342_M350_V0.7281.00
233_D262_Q0.7271.00
330_I350_V0.7261.00
235_V266_M0.7251.00
122_G127_C0.7251.00
83_V141_L0.7241.00
24_C69_Q0.7241.00
165_S190_S0.7231.00
27_E71_G0.7221.00
84_V144_I0.7191.00
330_I352_M0.7191.00
341_A344_D0.7181.00
162_A189_F0.7171.00
148_V315_L0.7171.00
41_A61_H0.7141.00
202_I224_T0.7111.00
200_V203_V0.7081.00
172_F249_L0.7061.00
314_L318_G0.7051.00
27_E72_E0.7051.00
171_K296_S0.7041.00
199_A249_L0.7021.00
275_R297_I0.7001.00
253_C276_V0.6991.00
290_I295_K0.6981.00
247_L250_V0.6931.00
64_A154_A0.6911.00
76_D305_S0.6891.00
163_Y311_A0.6851.00
164_K294_N0.6851.00
145_P316_A0.6841.00
39_C42_D0.6841.00
171_K298_I0.6831.00
312_I316_A0.6751.00
142_W308_W0.6751.00
163_Y314_L0.6721.00
282_P286_S0.6711.00
180_V204_V0.6711.00
326_I329_R0.6701.00
27_E132_E0.6671.00
4_L336_R0.6661.00
328_H350_V0.6591.00
249_L274_V0.6571.00
217_V221_L0.6561.00
286_S289_D0.6541.00
6_R13_G0.6521.00
163_Y307_S0.6501.00
269_P293_W0.6501.00
162_A186_L0.6491.00
260_L273_V0.6461.00
43_M343_V0.6451.00
53_D57_S0.6441.00
29_V67_I0.6441.00
33_I36_A0.6431.00
34_K353_T0.6421.00
206_G218_A0.6421.00
199_A202_I0.6421.00
252_E273_V0.6381.00
12_G340_D0.6381.00
54_E57_S0.6381.00
64_A144_I0.6371.00
81_Q146_D0.6341.00
11_F340_D0.6321.00
22_P128_L0.6291.00
8_G11_F0.6291.00
175_G200_V0.6291.00
24_C71_G0.6291.00
261_K289_D0.6291.00
191_V221_L0.6251.00
162_A166_I0.6251.00
193_M197_M0.6251.00
31_I85_S0.6251.00
256_A259_A0.6241.00
35_A64_A0.6241.00
31_I141_L0.6241.00
192_Q221_L0.6231.00
195_R202_I0.6231.00
238_C266_M0.6231.00
223_A226_V0.6211.00
84_V157_D0.6211.00
225_A237_R0.6201.00
294_N304_D0.6181.00
142_W312_I0.6161.00
177_D245_D0.6151.00
8_G15_K0.6151.00
161_N186_L0.6131.00
44_K49_D0.6081.00
41_A45_H0.6061.00
64_A82_R0.6061.00
245_D268_R0.6051.00
282_P285_F0.6021.00
158_P185_P0.6021.00
82_R147_G0.6011.00
158_P189_F0.6001.00
35_A329_R0.5961.00
168_Q197_M0.5961.00
188_L325_M0.5951.00
155_V351_I0.5941.00
215_F218_A0.5941.00
156_L311_A0.5931.00
76_D79_V0.5921.00
328_H347_A0.5911.00
38_I123_F0.5911.00
190_S276_V0.5901.00
191_V218_A0.5891.00
39_C158_P0.5891.00
22_P126_Y0.5861.00
170_S272_E0.5861.00
261_K284_D0.5841.00
142_W305_S0.5831.00
206_G229_G0.5811.00
85_S141_L0.5801.00
183_T191_V0.5781.00
249_L272_E0.5731.00
76_D143_E0.5721.00
247_L266_M0.5721.00
220_E323_K0.5711.00
217_V325_M0.5711.00
179_V250_V0.5701.00
234_V238_C0.5691.00
86_D142_W0.5671.00
178_V249_L0.5661.00
339_F343_V0.5661.00
43_M47_N0.5641.00
75_K78_K0.5641.00
70_V81_Q0.5591.00
40_G44_K0.5591.00
327_T348_I0.5551.00
39_C349_K0.5511.00
41_A44_K0.5511.00
227_V241_I0.5491.00
243_G246_N0.5481.00
45_H50_S0.5461.00
165_S274_V0.5461.00
36_A352_M0.5451.00
250_V266_M0.5421.00
174_P198_G0.5421.00
130_P140_A0.5401.00
21_Q128_L0.5391.00
239_Q246_N0.5381.00
289_D295_K0.5381.00
183_T214_R0.5381.00
174_P197_M0.5371.00
161_N276_V0.5351.00
289_D292_A0.5351.00
259_A263_A0.5341.00
300_H303_Y0.5331.00
22_P28_D0.5331.00
227_V237_R0.5321.00
13_G336_R0.5321.00
239_Q242_C0.5311.00
14_Y339_F0.5311.00
177_D242_C0.5301.00
188_L221_L0.5291.00
205_V227_V0.5281.00
38_I352_M0.5281.00
338_G352_M0.5271.00
307_S310_N0.5261.00
60_G123_F0.5251.00
165_S300_H0.5251.00
274_V300_H0.5241.00
64_A153_A0.5231.00
149_D153_A0.5221.00
258_I261_K0.5221.00
192_Q320_I0.5211.00
77_W131_G0.5201.00
189_F193_M0.5191.00
180_V191_V0.5181.00
166_I193_M0.5161.00
308_W312_I0.5151.00
62_E349_K0.5131.00
20_P23_M0.5131.00
288_N291_T0.5131.00
85_S122_G0.5101.00
163_Y197_M0.5091.00
350_V353_T0.5061.00
168_Q306_T0.5061.00
218_A226_V0.5061.00
214_R346_T0.5051.00
206_G228_N0.5041.00
58_I121_G0.5031.00
40_G184_G0.5021.00
252_E277_G0.5001.00
242_C247_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ej6A 1 0.9358 100 0.156 Contact Map
2dq4A 4 0.9441 100 0.158 Contact Map
3ukoA 4 0.9553 100 0.162 Contact Map
4ilkA 2 0.9274 100 0.164 Contact Map
1e3iA 2 0.9469 100 0.166 Contact Map
1cdoA 2 0.9497 100 0.168 Contact Map
1vj0A 4 0.9553 100 0.169 Contact Map
3ip1A 4 0.9497 100 0.172 Contact Map
1f8fA 4 0.9469 100 0.174 Contact Map
4oh1A 4 0.9302 100 0.174 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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