GREMLIN Database
YFHR - Uncharacterized protein YfhR
UniProt: P77538 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13453
Length: 284 (222)
Sequences: 25437 (18500)
Seq/√Len: 1241.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_V176_A4.0501.00
114_R131_D3.4341.00
166_I177_V2.9801.00
53_E61_R2.6641.00
225_K252_P2.6271.00
239_Y246_K2.4931.00
104_R273_V2.4601.00
249_I271_Q2.4261.00
66_F107_N2.3581.00
232_W250_L2.3231.00
55_T61_R2.3071.00
251_I271_Q2.2961.00
69_S107_N2.1781.00
179_L182_T2.1561.00
57_K134_S2.0951.00
247_R271_Q2.0401.00
225_K250_L2.0341.00
138_V142_R1.9621.00
80_T107_N1.9611.00
162_I177_V1.9491.00
52_V64_G1.8811.00
151_V276_I1.8311.00
84_A132_T1.8081.00
125_Q128_L1.7951.00
214_V217_I1.7471.00
133_Q165_V1.7421.00
236_E250_L1.7271.00
152_L162_I1.7081.00
247_R278_S1.6841.00
133_Q137_N1.6251.00
68_P107_N1.5961.00
67_I110_M1.5791.00
61_R120_K1.5781.00
219_L242_A1.5551.00
163_L179_L1.5531.00
220_L275_F1.5301.00
210_Y213_S1.5171.00
137_N173_G1.5091.00
232_W236_E1.5011.00
85_H116_F1.4951.00
133_Q169_G1.4941.00
109_F135_A1.4611.00
136_I150_L1.4541.00
149_R175_R1.4341.00
223_H232_W1.4281.00
65_W91_M1.4261.00
271_Q274_D1.4201.00
78_I107_N1.4101.00
104_R277_L1.4091.00
164_D168_R1.4001.00
236_E240_S1.3851.00
66_F109_F1.3841.00
50_E68_P1.3801.00
267_V271_Q1.3771.00
63_Q118_K1.3721.00
153_F180_D1.3701.00
159_G182_T1.3611.00
270_E274_D1.3591.00
100_W104_R1.3581.00
140_R173_G1.3541.00
124_S128_L1.3471.00
132_T165_V1.3411.00
133_Q168_R1.3311.00
225_K253_D1.3181.00
178_I272_M1.3131.00
84_A113_Y1.3071.00
251_I254_G1.3061.00
84_A162_I1.2941.00
80_T145_V1.2891.00
51_S63_Q1.2891.00
239_Y248_L1.2811.00
146_N149_R1.2791.00
86_G156_S1.2781.00
178_I276_I1.2651.00
81_I106_F1.2651.00
225_K232_W1.2471.00
85_H113_Y1.2451.00
212_A241_L1.2411.00
98_V110_M1.2351.00
138_V141_H1.2321.00
83_H153_F1.2301.00
134_S137_N1.2291.00
106_F277_L1.2271.00
181_S227_D1.2161.00
111_F135_A1.2131.00
223_H235_S1.2121.00
220_L249_I1.2101.00
54_F135_A1.2091.00
155_Q181_S1.2071.00
169_G173_G1.2001.00
273_V277_L1.2001.00
79_A149_R1.1991.00
99_S103_E1.1871.00
236_E248_L1.1871.00
180_D268_Y1.1781.00
251_I267_V1.1711.00
84_A111_F1.1711.00
80_T109_F1.1441.00
109_F139_V1.1431.00
60_T120_K1.1281.00
53_E63_Q1.1261.00
137_N169_G1.1131.00
52_V138_V1.1041.00
151_V178_I1.1011.00
100_W269_R1.0921.00
54_F64_G1.0921.00
79_A106_F1.0871.00
237_K241_L1.0871.00
124_S127_G1.0841.00
151_V175_R1.0831.00
130_D168_R1.0761.00
87_N157_I1.0711.00
226_A253_D1.0701.00
193_M197_S1.0611.00
80_T139_V1.0541.00
97_L269_R1.0351.00
63_Q112_D1.0351.00
177_V219_L1.0341.00
123_P128_L1.0261.00
178_I220_L1.0231.00
100_W273_V1.0201.00
101_L153_F1.0061.00
100_W103_E1.0051.00
91_M118_K0.9911.00
179_L221_L0.9891.00
169_G172_E0.9871.00
136_I174_I0.9841.00
235_S248_L0.9801.00
98_V102_P0.9731.00
165_V169_G0.9711.00
60_T114_R0.9671.00
268_Y272_M0.9661.00
91_M110_M0.9651.00
64_G109_F0.9651.00
57_K130_D0.9651.00
88_A156_S0.9641.00
155_Q180_D0.9601.00
177_V217_I0.9581.00
63_Q119_S0.9491.00
166_I217_I0.9481.00
222_I251_I0.9471.00
88_A157_I0.9461.00
167_G210_Y0.9431.00
222_I268_Y0.9411.00
221_L239_Y0.9411.00
164_D167_G0.9371.00
67_I102_P0.9301.00
178_I222_I0.9291.00
222_I249_I0.9221.00
102_P108_V0.9201.00
51_S118_K0.9201.00
267_V270_E0.9201.00
129_L164_D0.9181.00
221_L238_L0.9131.00
127_G130_D0.9091.00
62_L119_S0.9071.00
135_A139_V0.8991.00
249_I267_V0.8981.00
123_P127_G0.8951.00
64_G135_A0.8931.00
164_D210_Y0.8921.00
266_D270_E0.8861.00
56_A60_T0.8841.00
81_I108_V0.8831.00
58_D114_R0.8791.00
133_Q173_G0.8781.00
84_A152_L0.8761.00
163_L182_T0.8741.00
206_S209_N0.8671.00
243_K246_K0.8611.00
63_Q91_M0.8511.00
237_K240_S0.8501.00
112_D117_G0.8481.00
201_L204_S0.8461.00
113_Y157_I0.8441.00
81_I153_F0.8381.00
168_R210_Y0.8261.00
68_P102_P0.8261.00
254_G258_D0.8251.00
181_S258_D0.8201.00
136_I165_V0.8191.00
94_H97_L0.8181.00
83_H108_V0.8151.00
152_L165_V0.8141.00
137_N140_R0.8081.00
233_Q236_E0.8071.00
126_A130_D0.8051.00
242_A246_K0.8031.00
95_W99_S0.8031.00
203_E207_G0.7961.00
111_F132_T0.7951.00
137_N141_H0.7941.00
254_G262_D0.7921.00
152_L174_I0.7811.00
274_D278_S0.7801.00
80_T150_L0.7801.00
113_Y161_N0.7781.00
106_F151_V0.7781.00
221_L235_S0.7761.00
235_S239_Y0.7731.00
67_I98_V0.7731.00
69_S78_I0.7721.00
83_H98_V0.7691.00
160_A183_F0.7651.00
181_S257_I0.7581.00
203_E209_N0.7571.00
159_G179_L0.7561.00
113_Y116_F0.7521.00
82_I136_I0.7491.00
81_I101_L0.7361.00
181_S224_G0.7361.00
156_S256_H0.7301.00
180_D222_I0.7281.00
247_R274_D0.7251.00
82_I109_F0.7221.00
79_A151_V0.7171.00
176_A276_I0.7091.00
49_A67_I0.7081.00
181_S223_H0.6981.00
228_H255_E0.6971.00
56_A59_G0.6921.00
153_F272_M0.6821.00
239_Y243_K0.6821.00
87_N116_F0.6811.00
51_S65_W0.6811.00
223_H250_L0.6801.00
274_D277_L0.6801.00
56_A114_R0.6781.00
150_L174_I0.6751.00
188_T234_H0.6751.00
106_F276_I0.6671.00
236_E239_Y0.6651.00
132_T161_N0.6641.00
55_T59_G0.6641.00
155_Q257_I0.6571.00
105_N273_V0.6551.00
176_A218_P0.6541.00
75_D78_I0.6511.00
54_F134_S0.6481.00
56_A134_S0.6471.00
83_H110_M0.6441.00
69_S102_P0.6441.00
221_L242_A0.6431.00
140_R147_P0.6431.00
83_H94_H0.6411.00
93_A96_P0.6401.00
154_G162_I0.6391.00
159_G230_I0.6281.00
165_V174_I0.6281.00
91_M112_D0.6191.00
88_A116_F0.6151.00
153_F178_I0.6131.00
148_Q175_R0.6131.00
159_G183_F0.6131.00
183_F230_I0.6101.00
81_I151_V0.6101.00
162_I166_I0.6091.00
130_D133_Q0.6091.00
232_W248_L0.6081.00
112_D119_S0.6071.00
166_I214_V0.6071.00
154_G166_I0.6041.00
129_L133_Q0.6021.00
258_D261_S0.6021.00
223_H248_L0.6011.00
234_H237_K0.5991.00
100_W266_D0.5971.00
50_E142_R0.5971.00
176_A275_F0.5971.00
96_P99_S0.5951.00
172_E215_S0.5951.00
135_A138_V0.5951.00
157_I161_N0.5921.00
67_I108_V0.5911.00
80_T106_F0.5891.00
202_D205_Y0.5891.00
49_A65_W0.5871.00
188_T237_K0.5841.00
93_A97_L0.5781.00
209_N212_A0.5771.00
101_L108_V0.5761.00
220_L247_R0.5761.00
127_G131_D0.5751.00
163_L238_L0.5711.00
256_H259_A0.5711.00
269_R272_M0.5691.00
99_S102_P0.5691.00
154_G159_G0.5671.00
185_S188_T0.5651.00
223_H230_I0.5631.00
160_A163_L0.5601.00
221_L248_L0.5601.00
233_Q237_K0.5591.00
101_L272_M0.5591.00
71_T78_I0.5591.00
130_D134_S0.5581.00
180_D259_A0.5581.00
182_T223_H0.5571.00
66_F69_S0.5531.00
180_D258_D0.5531.00
50_E66_F0.5521.00
185_S206_S0.5501.00
107_N145_V0.5491.00
245_P278_S0.5451.00
211_I214_V0.5431.00
241_L244_E0.5421.00
65_W92_S0.5421.00
126_A129_L0.5401.00
133_Q136_I0.5401.00
211_I238_L0.5391.00
140_R145_V0.5381.00
167_G214_V0.5341.00
180_D272_M0.5331.00
142_R145_V0.5331.00
145_V148_Q0.5331.00
184_A238_L0.5321.00
255_E258_D0.5301.00
100_W270_E0.5271.00
136_I141_H0.5231.00
79_A148_Q0.5231.00
89_G93_A0.5211.00
82_I111_F0.5201.00
65_W110_M0.5201.00
136_I173_G0.5191.00
156_S257_I0.5191.00
123_P126_A0.5171.00
167_G213_S0.5161.00
203_E206_S0.5131.00
64_G138_V0.5051.00
56_A62_L0.5041.00
182_T230_I0.5031.00
126_A168_R0.5021.00
98_V108_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ns4A 1 0.7923 100 0.378 Contact Map
3pe6A 1 0.8239 100 0.383 Contact Map
2wtmA 2 0.7852 100 0.384 Contact Map
2hdwA 2 0.8486 100 0.386 Contact Map
1k8qA 1 0.8838 100 0.39 Contact Map
2y6uA 2 0.8732 100 0.391 Contact Map
1zoiA 3 0.7394 100 0.4 Contact Map
4q1vA 2 0.9683 100 0.404 Contact Map
1mtzA 1 0.757 100 0.407 Contact Map
2ecfA 2 0.9789 100 0.409 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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