GREMLIN Database
YDJN - Uncharacterized symporter YdjN
UniProt: P77529 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13990
Length: 463 (394)
Sequences: 6261 (3711)
Seq/√Len: 187.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_A181_G4.6651.00
213_E217_A3.6851.00
210_P213_E3.2331.00
128_N372_I3.1811.00
126_V270_G3.1131.00
39_M242_L3.0851.00
107_L444_L3.0271.00
228_K231_R3.0041.00
170_F192_I2.9821.00
85_F194_A2.8671.00
66_N70_N2.8281.00
89_L219_I2.7411.00
313_I335_A2.6481.00
318_E322_R2.6441.00
43_F242_L2.6341.00
32_K235_Q2.6141.00
71_G171_I2.5791.00
214_R221_T2.5671.00
327_P446_Q2.5581.00
442_Q449_K2.4641.00
68_V243_A2.4581.00
131_G135_E2.4571.00
85_F89_L2.4371.00
368_D371_W2.4321.00
322_R328_E2.4071.00
86_A222_L2.4051.00
209_A212_G2.3011.00
327_P441_S2.2901.00
300_L431_S2.2781.00
197_L225_W2.2581.00
268_Y424_G2.2351.00
283_G286_G2.1921.00
126_V273_I2.1451.00
28_S31_K2.1191.00
111_T436_A2.1091.00
265_V269_L2.0921.00
115_T281_L2.0741.00
165_Q169_S2.0661.00
299_V319_A2.0451.00
107_L443_W2.0061.00
130_F266_A1.9631.00
173_K177_A1.9561.00
365_N368_D1.9291.00
42_V46_A1.9051.00
215_V218_A1.8941.00
121_L125_L1.8881.00
34_L38_V1.8801.00
214_R217_A1.8671.00
326_V438_T1.8621.00
358_V410_L1.8531.00
86_A226_V1.8501.00
271_L424_G1.8411.00
94_R220_D1.8171.00
125_L129_L1.8061.00
318_E323_R1.8011.00
127_T356_V1.7981.00
36_G242_L1.7971.00
320_Q434_M1.7971.00
106_F110_G1.7961.00
211_K224_S1.7721.00
418_E425_R1.7631.00
186_S189_S1.7581.00
79_I233_V1.7441.00
132_L360_P1.7361.00
282_L435_T1.7341.00
215_V221_T1.7331.00
201_A225_W1.7261.00
175_P193_F1.7211.00
273_I276_A1.7171.00
130_F269_L1.6741.00
334_A437_G1.6621.00
285_N442_Q1.6611.00
203_K228_K1.6591.00
215_V225_W1.6591.00
103_K444_L1.6581.00
326_V441_S1.6551.00
258_I262_S1.6291.00
176_F180_T1.6231.00
295_K324_L1.6011.00
127_T353_M1.5891.00
291_K294_R1.5711.00
358_V406_L1.5641.00
176_F179_L1.5571.00
296_V434_M1.5521.00
316_N434_M1.5431.00
181_G186_S1.5391.00
126_V266_A1.5311.00
271_L428_L1.5181.00
422_D426_T1.5061.00
71_G168_L1.5061.00
36_G40_G1.4861.00
270_G349_L1.4751.00
362_V410_L1.4751.00
93_A216_L1.4691.00
27_W31_K1.4651.00
43_F47_L1.4471.00
261_G265_V1.4351.00
310_A388_G1.4341.00
77_Q173_K1.4331.00
300_L427_A1.4281.00
295_K323_R1.4211.00
203_K232_L1.4081.00
220_D224_S1.4001.00
200_A229_L1.3981.00
70_N74_Q1.3831.00
218_A221_T1.3711.00
92_V195_A1.3631.00
365_N370_M1.3611.00
138_V363_G1.3591.00
317_V331_A1.3571.00
84_V187_I1.3431.00
169_S186_S1.3421.00
31_K35_V1.3341.00
85_F179_L1.3311.00
290_L294_R1.3221.00
78_M193_F1.3151.00
441_S447_T1.3121.00
330_I441_S1.2921.00
90_S219_I1.2901.00
214_R218_A1.2811.00
171_I192_I1.2801.00
37_L245_M1.2781.00
281_L439_L1.2771.00
124_V372_I1.2741.00
204_L212_G1.2731.00
74_Q173_K1.2691.00
288_S291_K1.2611.00
108_T334_A1.2561.00
327_P330_I1.2491.00
340_T343_Q1.2411.00
27_W35_V1.2381.00
296_V431_S1.2291.00
201_A215_V1.2291.00
369_P373_A1.2261.00
316_N335_A1.2221.00
280_I283_G1.2101.00
197_L222_L1.2071.00
282_L287_V1.1971.00
196_F229_L1.1951.00
79_I230_V1.1891.00
264_V417_V1.1851.00
441_S445_K1.1781.00
279_G293_F1.1761.00
110_G114_F1.1751.00
232_L236_L1.1701.00
266_A353_M1.1581.00
259_K262_S1.1571.00
375_L404_M1.1551.00
355_A375_L1.1521.00
200_A232_L1.1501.00
286_G442_Q1.1491.00
303_A426_T1.1441.00
100_Q329_S1.1431.00
350_Y418_E1.1421.00
195_A199_V1.1331.00
283_G288_S1.1301.00
162_S165_Q1.1281.00
276_A280_I1.1231.00
112_L334_A1.1171.00
32_K36_G1.1151.00
133_T360_P1.1141.00
81_M190_V1.1101.00
344_N383_S1.1071.00
125_L128_N1.1061.00
394_T415_I1.0951.00
298_P323_R1.0941.00
231_R318_E1.0931.00
121_L376_V1.0891.00
292_Y296_V1.0881.00
42_V45_L1.0881.00
226_V230_V1.0821.00
262_S265_V1.0781.00
204_L221_T1.0751.00
316_N430_V1.0741.00
39_M43_F1.0691.00
204_L225_W1.0671.00
71_G75_L1.0641.00
115_T344_N1.0561.00
313_I339_A1.0551.00
365_N371_W1.0551.00
86_A90_S1.0521.00
138_V141_G1.0521.00
287_V447_T1.0491.00
103_K107_L1.0481.00
217_A221_T1.0481.00
312_S316_N1.0451.00
175_P180_T1.0361.00
247_K251_G1.0341.00
274_M277_V1.0291.00
373_A377_G1.0261.00
441_S446_Q1.0261.00
66_N247_K1.0251.00
68_V236_L1.0231.00
138_V142_A1.0181.00
236_L239_Y1.0131.00
307_R419_P1.0111.00
215_V219_I1.0091.00
123_G352_A1.0070.99
104_I330_I1.0060.99
442_Q445_K1.0060.99
276_A279_G1.0050.99
88_I191_V0.9970.99
320_Q335_A0.9910.99
69_G244_L0.9860.99
350_Y425_R0.9840.99
213_E216_L0.9840.99
175_P182_A0.9830.99
177_A180_T0.9800.99
121_L373_A0.9790.99
50_I64_W0.9790.99
346_C393_A0.9760.99
158_V161_L0.9750.99
114_F118_I0.9680.99
320_Q326_V0.9680.99
264_V420_L0.9680.99
38_V42_V0.9640.99
228_K232_L0.9600.99
48_H250_A0.9580.99
217_A220_D0.9540.99
362_V409_T0.9450.99
326_V331_A0.9420.99
174_N178_D0.9380.99
126_V130_F0.9370.99
192_I196_F0.9360.99
49_T63_Q0.9350.99
342_G433_S0.9320.99
122_V273_I0.9320.99
113_L117_L0.9300.99
43_F246_T0.9270.99
161_L165_Q0.9240.99
312_S315_L0.9240.99
278_H282_L0.9230.99
390_G422_D0.9220.99
79_I229_L0.9210.99
274_M349_L0.9170.99
275_F279_G0.9150.99
272_L275_F0.9130.99
117_L121_L0.9120.99
304_F423_M0.9120.99
356_V372_I0.9110.99
369_P372_I0.9100.99
47_L65_F0.9090.99
287_V291_K0.9080.99
163_V167_V0.9050.99
255_Q258_I0.9030.99
319_A323_R0.9030.99
47_L50_I0.9030.99
294_R297_W0.8990.99
28_S32_K0.8970.99
97_N100_Q0.8950.99
196_F232_L0.8910.99
267_S421_I0.8900.99
74_Q77_Q0.8880.99
295_K319_A0.8860.99
164_P168_L0.8850.99
258_I261_G0.8770.99
267_S353_M0.8740.99
351_P397_A0.8720.99
295_K299_V0.8700.99
124_V128_N0.8640.98
197_L229_L0.8630.98
262_S360_P0.8590.98
382_S400_V0.8560.98
26_Q31_K0.8550.98
309_S429_N0.8550.98
269_L273_I0.8530.98
43_F65_F0.8510.98
168_L172_P0.8500.98
86_A219_I0.8470.98
350_Y421_I0.8440.98
27_W32_K0.8440.98
283_G289_P0.8440.98
199_V203_K0.8430.98
299_V316_N0.8400.98
175_P178_D0.8400.98
178_D193_F0.8380.98
343_Q433_S0.8360.98
46_A50_I0.8330.98
242_L246_T0.8330.98
212_G221_T0.8300.98
297_W301_T0.8300.98
264_V421_I0.8250.98
212_G216_L0.8240.98
320_Q331_A0.8230.98
90_S220_D0.8200.98
292_Y434_M0.8200.98
70_N168_L0.8200.98
367_L371_W0.8190.98
246_T250_A0.8180.98
268_Y272_L0.8130.98
302_F312_S0.8130.98
104_I440_T0.8110.98
159_S162_S0.8090.98
194_A198_G0.8060.98
64_W67_I0.8040.98
398_L411_V0.8030.97
89_L201_A0.8000.97
339_A433_S0.7930.97
394_T411_V0.7920.97
299_V312_S0.7920.97
65_F246_T0.7900.97
341_I384_A0.7890.97
118_I277_V0.7890.97
223_Q227_M0.7890.97
201_A219_I0.7890.97
174_N193_F0.7840.97
69_G240_G0.7810.97
302_F315_L0.7760.97
65_F243_A0.7740.97
89_L194_A0.7730.97
330_I334_A0.7700.97
354_L414_L0.7690.97
171_I174_N0.7660.97
72_Y237_T0.7640.97
269_L272_L0.7640.97
161_L169_S0.7620.97
98_A199_V0.7610.97
193_F197_L0.7600.97
441_S448_D0.7600.97
351_P394_T0.7590.96
226_V233_V0.7570.96
93_A202_L0.7550.96
165_Q168_L0.7550.96
87_S223_Q0.7540.96
231_R235_Q0.7540.96
131_G360_P0.7530.96
355_A400_V0.7520.96
282_L285_N0.7520.96
442_Q447_T0.7520.96
89_L197_L0.7480.96
263_F353_M0.7470.96
40_G246_T0.7470.96
247_K250_A0.7440.96
126_V269_L0.7400.96
47_L246_T0.7390.96
266_A269_L0.7390.96
237_T240_G0.7390.96
95_L104_I0.7380.96
218_A222_L0.7360.96
307_R422_D0.7350.96
123_G353_M0.7350.96
263_F421_I0.7330.96
291_K295_K0.7310.96
213_E218_A0.7310.96
372_I376_V0.7280.96
394_T421_I0.7270.96
75_L171_I0.7270.96
122_V277_V0.7270.96
64_W68_V0.7260.95
166_L172_P0.7250.95
264_V268_Y0.7240.95
303_A430_V0.7220.95
263_F350_Y0.7220.95
275_F280_I0.7200.95
192_I236_L0.7200.95
337_F341_I0.7200.95
32_K239_Y0.7190.95
299_V315_L0.7180.95
75_L196_F0.7160.95
33_V237_T0.7130.95
167_V171_I0.7130.95
263_F271_L0.7110.95
166_L169_S0.7060.95
398_L402_P0.7040.95
263_F414_L0.7030.95
209_A213_E0.7010.95
168_L171_I0.7010.95
99_S102_G0.7010.95
302_F306_S0.7010.95
72_Y236_L0.6990.94
157_K160_D0.6950.94
282_L439_L0.6950.94
117_L380_T0.6940.94
267_S271_L0.6880.94
210_P217_A0.6860.94
316_N433_S0.6860.94
178_D182_A0.6850.94
122_V270_G0.6840.94
123_G349_L0.6830.94
169_S172_P0.6800.94
346_C386_V0.6770.93
162_S166_L0.6750.93
260_L263_F0.6740.93
179_L193_F0.6730.93
379_V396_A0.6730.93
224_S228_K0.6730.93
370_M374_T0.6730.93
136_G139_Q0.6700.93
237_T306_S0.6690.93
96_H99_S0.6670.93
374_T404_M0.6660.93
278_H432_G0.6660.93
204_L224_S0.6640.93
370_M373_A0.6610.93
74_Q169_S0.6600.93
100_Q446_Q0.6590.93
179_L189_S0.6580.92
446_Q449_K0.6580.92
62_V250_A0.6580.92
89_L222_L0.6570.92
48_H63_Q0.6570.92
359_A364_I0.6510.92
292_Y438_T0.6510.92
155_V158_V0.6510.92
355_A359_A0.6480.92
100_Q103_K0.6470.92
119_A274_M0.6450.92
335_A437_G0.6450.92
197_L215_V0.6410.92
346_C351_P0.6410.92
275_F282_L0.6400.91
62_V247_K0.6390.91
230_V304_F0.6390.91
128_N369_P0.6380.91
63_Q250_A0.6380.91
212_G225_W0.6360.91
378_I403_A0.6360.91
384_A433_S0.6350.91
386_V396_A0.6340.91
126_V265_V0.6330.91
112_L274_M0.6330.91
241_V390_G0.6330.91
108_T440_T0.6310.91
110_G113_L0.6310.91
388_G391_G0.6300.91
287_V295_K0.6280.91
133_T136_G0.6270.91
97_N105_S0.6270.91
328_E332_S0.6250.90
49_T250_A0.6220.90
239_Y243_A0.6200.90
240_G244_L0.6190.90
138_V143_E0.6190.90
339_A343_Q0.6180.90
376_V379_V0.6180.90
296_V316_N0.6170.90
367_L375_L0.6160.90
71_G192_I0.6150.90
355_A358_V0.6150.90
220_D223_Q0.6140.90
351_P386_V0.6140.90
118_I122_V0.6120.90
263_F354_L0.6100.89
68_V239_Y0.6090.89
284_I439_L0.6090.89
139_Q142_A0.6060.89
270_G353_M0.6060.89
292_Y324_L0.6050.89
221_T224_S0.6050.89
351_P355_A0.6050.89
270_G274_M0.6020.89
113_L384_A0.6000.89
40_G44_G0.6000.89
120_A380_T0.6000.89
126_V129_L0.5980.88
388_G392_G0.5960.88
215_V222_L0.5960.88
112_L433_S0.5960.88
343_Q386_V0.5930.88
317_V335_A0.5920.88
262_S266_A0.5920.88
136_G262_S0.5910.88
172_P175_P0.5910.88
119_A349_L0.5910.88
112_L436_A0.5890.88
294_R298_P0.5870.88
135_E139_Q0.5850.87
352_A379_V0.5830.87
310_A339_A0.5810.87
330_I446_Q0.5780.87
221_T225_W0.5750.86
228_K235_Q0.5740.86
156_G159_S0.5730.86
90_S216_L0.5730.86
274_M344_N0.5730.86
265_V268_Y0.5730.86
75_L233_V0.5730.86
362_V407_P0.5720.86
287_V448_D0.5720.86
393_A400_V0.5720.86
100_Q105_S0.5720.86
83_L191_V0.5710.86
324_L438_T0.5710.86
116_T347_A0.5710.86
78_M229_L0.5690.86
325_G448_D0.5690.86
410_L413_L0.5670.86
312_S339_A0.5660.86
40_G245_M0.5660.86
358_V396_A0.5650.85
114_F281_L0.5640.85
191_V362_V0.5630.85
81_M179_L0.5620.85
327_P331_A0.5610.85
80_V392_G0.5610.85
118_I121_L0.5600.85
90_S94_R0.5600.85
81_M187_I0.5600.85
344_N432_G0.5580.85
216_L220_D0.5580.85
172_P176_F0.5570.85
235_Q239_Y0.5570.85
115_T119_A0.5550.84
123_G350_Y0.5520.84
260_L264_V0.5510.84
204_L228_K0.5510.84
140_G143_E0.5500.84
37_L423_M0.5490.84
312_S430_V0.5480.84
35_V39_M0.5460.84
201_A216_L0.5460.84
75_L236_L0.5460.84
132_L136_G0.5450.83
131_G356_V0.5450.83
407_P410_L0.5440.83
439_L443_W0.5440.83
76_L302_F0.5430.83
278_H281_L0.5420.83
130_F262_S0.5410.83
346_C392_G0.5400.83
437_G441_S0.5400.83
398_L408_V0.5390.83
112_L338_G0.5390.83
104_I444_L0.5380.83
383_S395_F0.5380.83
124_V376_V0.5380.83
103_K106_F0.5370.83
303_A422_D0.5360.82
346_C425_R0.5360.82
157_K161_L0.5360.82
43_F50_I0.5360.82
141_G144_T0.5350.82
95_L437_G0.5350.82
315_L318_E0.5350.82
307_R311_A0.5350.82
128_N356_V0.5350.82
408_V411_V0.5340.82
48_H62_V0.5330.82
155_V159_S0.5320.82
29_L32_K0.5320.82
174_N180_T0.5320.82
431_S435_T0.5310.82
109_I341_I0.5310.82
36_G246_T0.5300.82
376_V380_T0.5300.82
154_Y157_K0.5300.82
211_K217_A0.5300.82
268_Y271_L0.5300.82
227_M263_F0.5270.81
346_C422_D0.5270.81
354_L418_E0.5260.81
326_V437_G0.5260.81
45_L254_L0.5240.81
445_K449_K0.5240.81
173_K181_G0.5240.81
386_V393_A0.5230.81
37_L241_V0.5220.81
281_L284_I0.5220.81
303_A427_A0.5210.81
211_K214_R0.5210.81
180_T186_S0.5200.80
292_Y431_S0.5200.80
322_R331_A0.5190.80
43_F46_A0.5190.80
83_L226_V0.5190.80
106_F109_I0.5180.80
405_G409_T0.5180.80
200_A204_L0.5180.80
178_D181_G0.5170.80
327_P445_K0.5160.80
429_N433_S0.5160.80
29_L35_V0.5150.80
43_F48_H0.5140.80
371_W374_T0.5140.80
345_G428_L0.5130.80
365_N369_P0.5100.79
277_V281_L0.5080.79
292_Y435_T0.5070.79
200_A225_W0.5070.79
174_N177_A0.5070.79
201_A221_T0.5060.79
419_P423_M0.5050.79
296_V324_L0.5050.79
98_A105_S0.5030.78
166_L170_F0.5010.78
329_S446_Q0.5010.78
338_G437_G0.5010.78
179_L190_V0.5000.78
374_T378_I0.5000.78
186_S190_V0.5000.78
296_V300_L0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.8488 100 0.128 Contact Map
4bgnA 3 0.4233 22.7 0.97 Contact Map
2zy9A 2 0.2635 6.2 0.977 Contact Map
4gofA 2 0.1123 4.4 0.979 Contact Map
1ji6A 1 0.1901 3.8 0.979 Contact Map
2m8rA 1 0.1123 3.6 0.979 Contact Map
4czbA 2 0.5745 3.1 0.98 Contact Map
2gsvA 3 0.0972 2.6 0.981 Contact Map
2c9kA 1 0.1965 2.6 0.981 Contact Map
4n8fA 3 0.1706 2.5 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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