GREMLIN Database
YFCG - Disulfide-bond oxidoreductase YfcG
UniProt: P77526 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14110
Length: 215 (193)
Sequences: 22130 (15083)
Seq/√Len: 1085.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_E196_R3.5851.00
77_L98_L3.2791.00
3_D29_I3.1401.00
81_E94_R3.0611.00
188_N192_R3.0111.00
19_L26_Y2.9041.00
6_F12_G2.8531.00
20_E201_Q2.6821.00
142_H183_Y2.5941.00
67_L92_R2.5351.00
3_D27_R2.4371.00
20_E26_Y2.3921.00
44_L50_N2.2281.00
145_N185_A2.1611.00
152_P192_R2.1591.00
149_E185_A2.1541.00
56_V59_S2.0901.00
3_D56_V2.0401.00
56_V68_S2.0171.00
22_A80_A1.9971.00
90_E93_E1.9051.00
21_E198_A1.8691.00
57_D78_Y1.8591.00
6_F28_L1.8591.00
138_Q182_M1.8581.00
5_Y56_V1.8511.00
57_D67_L1.8011.00
18_F76_L1.7751.00
46_I56_V1.7221.00
159_Y164_I1.7221.00
41_P45_R1.6921.00
187_K191_E1.6891.00
152_P157_E1.6821.00
96_A99_Q1.6491.00
127_P131_E1.6471.00
81_E98_L1.6291.00
131_E135_V1.6291.00
46_I54_A1.5661.00
57_D82_K1.5611.00
167_W193_I1.5531.00
59_S67_L1.5401.00
17_L199_T1.5311.00
185_A188_N1.5281.00
100_W147_R1.5241.00
42_E45_R1.5141.00
24_L83_T1.4821.00
43_F54_A1.4601.00
142_H146_K1.4421.00
191_E195_S1.4391.00
37_G40_R1.4321.00
5_Y31_V1.4231.00
88_S97_T1.3991.00
159_Y196_R1.3691.00
155_G160_S1.3661.00
43_F46_I1.3491.00
154_L166_C1.2891.00
87_L97_T1.2741.00
70_F99_Q1.2461.00
147_R151_S1.2441.00
14_K72_S1.2371.00
195_S200_G1.2331.00
102_F105_V1.2321.00
39_F50_N1.2301.00
134_Q138_Q1.2231.00
4_L19_L1.2201.00
77_L102_F1.2061.00
18_F22_A1.2041.00
18_F86_F1.2011.00
181_A187_K1.1951.00
190_H194_R1.1731.00
57_D83_T1.1721.00
153_W193_I1.1631.00
69_L95_A1.1371.00
15_I76_L1.1271.00
82_K91_T1.1241.00
159_Y193_I1.1201.00
39_F44_L1.1121.00
145_N149_E1.1071.00
142_H182_M1.1051.00
136_E139_R1.1031.00
197_P201_Q1.0901.00
21_E159_Y1.0811.00
92_R96_A1.0741.00
200_G204_L1.0731.00
167_W194_R1.0671.00
51_K71_E1.0661.00
138_Q183_Y1.0651.00
101_L165_A1.0531.00
104_Q166_C1.0461.00
22_A79_L1.0431.00
135_V139_R1.0401.00
76_L161_I1.0311.00
86_F164_I1.0281.00
191_E194_R1.0211.00
6_F16_T1.0181.00
14_K165_A1.0171.00
126_I129_A1.0021.00
93_E96_A0.9891.00
146_K149_E0.9841.00
22_A84_G0.9791.00
21_E164_I0.9681.00
145_N184_P0.9681.00
43_F47_S0.9621.00
152_P188_N0.9551.00
131_E134_Q0.9491.00
96_A147_R0.9361.00
12_G52_I0.9331.00
91_T95_A0.9331.00
49_N103_W0.9301.00
102_F106_G0.9271.00
146_K150_N0.9231.00
76_L165_A0.9201.00
153_W192_R0.9131.00
32_D38_Q0.9111.00
174_T190_H0.8981.00
47_S54_A0.8971.00
97_T161_I0.8961.00
170_V189_W0.8871.00
139_R142_H0.8851.00
189_W193_I0.8771.00
93_E158_N0.8741.00
135_V138_Q0.8711.00
147_R150_N0.8701.00
79_L83_T0.8691.00
167_W199_T0.8611.00
101_L161_I0.8571.00
138_Q142_H0.8561.00
143_V147_R0.8551.00
46_I68_S0.8541.00
197_P200_G0.8531.00
128_Y131_E0.8531.00
192_R195_S0.8521.00
188_N191_E0.8381.00
15_I75_I0.8381.00
14_K76_L0.8351.00
8_P30_K0.8321.00
179_D182_M0.8311.00
97_T160_S0.8291.00
87_L98_L0.8261.00
41_P44_L0.8221.00
88_S93_E0.8221.00
67_L95_A0.8211.00
73_G102_F0.8181.00
97_T155_G0.8181.00
17_L164_I0.8181.00
132_R136_E0.8121.00
16_T28_L0.8111.00
127_P130_I0.8051.00
40_R44_L0.8041.00
154_L189_W0.8041.00
118_F122_A0.8031.00
171_N194_R0.7941.00
132_R135_V0.7911.00
9_T12_G0.7861.00
16_T20_E0.7821.00
54_A68_S0.7801.00
33_L38_Q0.7691.00
49_N70_F0.7681.00
145_N183_Y0.7671.00
78_Y82_K0.7671.00
22_A85_L0.7661.00
174_T194_R0.7651.00
151_S157_E0.7641.00
96_A100_W0.7631.00
103_W140_L0.7601.00
143_V146_K0.7601.00
77_L81_E0.7591.00
73_G105_V0.7581.00
85_L158_N0.7561.00
96_A151_S0.7551.00
67_L96_A0.7531.00
18_F164_I0.7531.00
154_L162_A0.7521.00
111_M114_Q0.7491.00
40_R43_F0.7471.00
74_A99_Q0.7471.00
94_R98_L0.7431.00
100_W103_W0.7411.00
73_G165_A0.7371.00
85_L89_H0.7361.00
125_T130_I0.7301.00
4_L16_T0.7241.00
128_Y132_R0.7231.00
17_L168_P0.7191.00
31_V37_G0.7121.00
129_A132_R0.7101.00
97_T162_A0.7101.00
182_M187_K0.7091.00
80_A85_L0.7061.00
145_N186_V0.7031.00
170_V190_H0.7011.00
55_I79_L0.7001.00
22_A83_T0.6981.00
183_Y186_V0.6941.00
171_N199_T0.6931.00
18_F80_A0.6931.00
5_Y29_I0.6871.00
126_I130_I0.6861.00
74_A95_A0.6831.00
153_W159_Y0.6801.00
71_E107_G0.6791.00
17_L167_W0.6761.00
54_A70_F0.6701.00
111_M140_L0.6681.00
117_H128_Y0.6671.00
57_D92_R0.6661.00
17_L198_A0.6651.00
142_H145_N0.6641.00
144_L166_C0.6621.00
87_L161_I0.6591.00
11_N14_K0.6551.00
13_H202_A0.6431.00
3_D58_H0.6421.00
144_L186_V0.6411.00
150_N185_A0.6401.00
125_T128_Y0.6331.00
57_D69_L0.6331.00
59_S92_R0.6301.00
113_G117_H0.6261.00
130_I134_Q0.6251.00
93_E155_G0.6241.00
133_Y136_E0.6211.00
29_I37_G0.6101.00
147_R154_L0.6061.00
80_A84_G0.6031.00
152_P155_G0.6021.00
184_P187_K0.6021.00
141_Y186_V0.5961.00
14_K73_G0.5941.00
155_G162_A0.5941.00
81_E91_T0.5921.00
156_G163_D0.5911.00
198_A201_Q0.5901.00
16_T202_A0.5851.00
118_F121_A0.5811.00
58_H67_L0.5801.00
119_N122_A0.5761.00
4_L55_I0.5751.00
94_R97_T0.5731.00
74_A102_F0.5721.00
141_Y183_Y0.5721.00
5_Y46_I0.5681.00
98_L102_F0.5661.00
129_A133_Y0.5621.00
82_K92_R0.5611.00
20_E23_E0.5551.00
99_Q147_R0.5551.00
110_P114_Q0.5551.00
19_L24_L0.5531.00
80_A87_L0.5531.00
4_L15_I0.5531.00
100_W155_G0.5531.00
73_G101_L0.5531.00
69_L75_I0.5511.00
174_T187_K0.5461.00
112_L137_T0.5451.00
153_W156_G0.5451.00
14_K105_V0.5391.00
11_N109_G0.5391.00
96_A155_G0.5391.00
32_D37_G0.5371.00
100_W154_L0.5371.00
104_Q108_L0.5361.00
103_W143_V0.5351.00
151_S192_R0.5251.00
151_S185_A0.5251.00
7_A32_D0.5251.00
20_E25_D0.5221.00
81_E95_A0.5211.00
22_A86_F0.5201.00
18_F161_I0.5191.00
184_P188_N0.5181.00
115_N134_Q0.5171.00
20_E202_A0.5141.00
95_A98_L0.5141.00
144_L154_L0.5111.00
77_L87_L0.5111.00
76_L80_A0.5081.00
11_N51_K0.5081.00
5_Y54_A0.5081.00
49_N143_V0.5071.00
164_I168_P0.5061.00
31_V40_R0.5061.00
7_A52_I0.5031.00
74_A77_L0.5031.00
6_F30_K0.5021.00
193_I199_T0.5021.00
19_L79_L0.5011.00
81_E87_L0.5011.00
201_Q204_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gx0A 2 0.9488 100 0.184 Contact Map
1k0dA 2 0.9395 100 0.226 Contact Map
4l8eA 2 0.9256 100 0.232 Contact Map
4ecjA 2 0.9442 100 0.233 Contact Map
4kdxA 1 0.9302 100 0.235 Contact Map
4mf5A 2 0.9628 100 0.237 Contact Map
2v6kA 2 0.9488 100 0.238 Contact Map
3c8eA 2 0.9814 100 0.24 Contact Map
4ivfA 4 0.9814 100 0.24 Contact Map
4ri6A 2 0.9395 100 0.241 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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