GREMLIN Database
SUFB - FeS cluster assembly protein SufB
UniProt: P77522 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13965
Length: 495 (417)
Sequences: 3036 (1599)
Seq/√Len: 78.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_R247_Y5.2321.00
213_K244_E4.9751.00
307_C312_S4.6401.00
213_K243_D4.4811.00
242_A279_V4.3901.00
275_K310_E4.3311.00
242_A246_S4.2171.00
244_E275_K3.9851.00
454_S457_D3.6351.00
276_N311_N3.6131.00
166_F209_I3.5931.00
273_I277_A3.5731.00
244_E274_H3.3571.00
349_T382_S3.3491.00
367_N398_N3.3081.00
247_Y278_E3.1921.00
168_S171_E3.1691.00
273_I314_M3.1391.00
210_Y243_D3.1371.00
248_V279_V3.1251.00
455_E459_I3.0381.00
305_A314_M3.0211.00
245_D276_N2.9821.00
337_D367_N2.9641.00
311_N338_N2.9291.00
273_I312_S2.8561.00
182_K274_H2.8011.00
54_E58_E2.7401.00
337_D366_K2.7141.00
271_V279_V2.6881.00
347_A376_G2.6761.00
362_I393_M2.6291.00
157_E161_E2.5651.00
278_E313_K2.5421.00
397_T426_N2.4681.00
199_N237_R2.4391.00
165_I210_Y2.3691.00
63_A200_A2.3341.00
340_I369_K2.3111.00
398_N428_S2.2871.00
363_H370_S2.2701.00
449_L455_E2.2701.00
222_S253_G2.2651.00
65_R69_E2.2631.00
306_L335_R2.2341.00
214_G245_D2.2191.00
59_F200_A2.2191.00
381_H413_N2.2071.00
242_A277_A2.1981.00
273_I279_V2.1821.00
383_Q415_G2.1671.00
383_Q417_H2.1301.00
313_K340_I2.1181.00
187_V272_I2.1031.00
242_A248_V2.0581.00
310_E337_D2.0491.00
240_L250_Y2.0371.00
335_R364_I2.0311.00
378_S382_S2.0281.00
211_V248_V2.0091.00
402_F432_E1.9991.00
263_Q297_I1.9371.00
273_I307_C1.8551.00
337_D365_G1.8431.00
275_K308_E1.8151.00
84_N87_D1.8021.00
56_M173_I1.7921.00
221_L248_V1.7891.00
371_T400_R1.6411.00
168_S205_D1.6361.00
333_I362_I1.6331.00
334_L368_T1.6321.00
64_Y68_L1.6241.00
364_I393_M1.5911.00
323_S326_T1.5871.00
352_H381_H1.5771.00
310_E338_N1.5751.00
281_Y314_M1.5660.99
339_S365_G1.5580.99
165_I212_P1.5570.99
392_I431_L1.5420.99
58_E62_N1.5240.99
57_L61_L1.5190.99
399_A429_A1.5030.99
162_Q218_P1.4920.99
185_G270_E1.4910.99
397_T428_S1.4860.99
170_G205_D1.4740.99
349_T355_A1.4720.99
440_I462_I1.4620.99
188_V268_V1.4550.99
351_G380_G1.4360.99
209_I221_L1.4330.99
405_C418_T1.4260.99
122_E125_A1.4010.99
210_Y241_V1.3750.99
418_T435_A1.3750.99
338_N367_N1.3750.99
148_S228_N1.3720.99
384_N416_A1.3720.99
246_S279_V1.3670.99
339_S368_T1.3650.99
55_W181_R1.3530.98
51_N174_H1.3530.98
164_I211_V1.3500.98
66_A69_E1.3480.98
217_C248_V1.3330.98
62_N65_R1.3300.98
346_V467_C1.3260.98
172_A208_F1.3240.98
171_E175_D1.3090.98
308_E336_G1.3080.98
345_S374_S1.3000.98
308_E335_R1.2970.98
387_R419_F1.2900.98
369_K400_R1.2900.98
186_T272_I1.2880.98
354_Q385_S1.2800.98
377_I467_C1.2780.98
275_K311_N1.2760.98
396_A399_A1.2700.98
276_N338_N1.2640.98
157_E160_A1.2530.97
392_I399_A1.2490.97
65_R68_L1.2380.97
357_T374_S1.2360.97
249_S280_K1.2350.97
216_R245_D1.2220.97
249_S282_S1.2190.97
287_W299_N1.2190.97
185_G199_N1.2180.97
395_T426_N1.2170.97
225_F254_C1.2150.97
72_E195_F1.2130.97
453_I461_M1.1970.97
325_I354_Q1.1950.97
274_H308_E1.1750.96
183_Y272_I1.1640.96
365_G368_T1.1450.96
329_Y358_G1.1400.96
86_Q354_Q1.1310.95
378_S416_A1.1280.95
211_V242_A1.1260.95
308_E312_S1.1250.95
307_C332_C1.1080.95
177_P181_R1.1080.95
183_Y241_V1.1040.95
418_T437_T1.1000.95
279_V314_M1.0990.95
165_I208_F1.0960.95
167_C172_A1.0920.94
145_I152_A1.0890.94
332_C341_G1.0890.94
385_S419_F1.0860.94
62_N66_A1.0860.94
424_C429_A1.0800.94
237_R268_V1.0760.94
56_M203_A1.0760.94
319_S482_A1.0760.94
66_A70_M1.0740.94
211_V217_C1.0720.94
390_V401_N1.0680.94
161_E164_I1.0620.94
328_K357_T1.0560.93
167_C171_E1.0500.93
252_E281_Y1.0450.93
66_A190_G1.0420.93
172_A180_V1.0350.93
317_T344_Y1.0330.93
146_F151_V1.0310.93
200_A237_R1.0300.92
54_E57_L1.0200.92
185_G237_R1.0190.92
422_V431_L1.0150.92
226_R255_S1.0140.92
199_N268_V1.0110.92
235_F266_A1.0070.92
280_K315_S1.0020.91
306_L333_I1.0010.91
86_Q325_I0.9990.91
59_F62_N0.9970.91
184_L239_I0.9970.91
391_K425_R0.9960.91
145_I148_S0.9960.91
164_I215_V0.9960.91
71_E194_F0.9950.91
214_G276_N0.9930.91
212_P241_V0.9830.91
241_V272_I0.9820.91
358_G387_R0.9810.91
243_D274_H0.9790.90
366_K397_T0.9780.90
193_N329_Y0.9750.90
212_P215_V0.9740.90
474_L480_V0.9740.90
307_C314_M0.9720.90
184_L203_A0.9700.90
183_Y239_I0.9700.90
281_Y316_W0.9680.90
132_V135_R0.9670.90
407_S418_T0.9610.90
333_I364_I0.9580.89
307_C341_G0.9570.89
166_F221_L0.9570.89
392_I423_E0.9550.89
169_F173_I0.9470.89
368_T399_A0.9420.89
392_I403_T0.9400.89
242_A273_I0.9360.88
378_S384_N0.9290.88
480_V483_Q0.9280.88
334_L365_G0.9270.88
329_Y387_R0.9140.87
338_N365_G0.9110.87
362_I391_K0.9100.87
275_K338_N0.9100.87
56_M184_L0.9090.87
61_L65_R0.9020.86
169_F180_V0.9010.86
67_W194_F0.8920.86
365_G395_T0.8880.86
121_K125_A0.8850.85
85_Y195_F0.8800.85
283_T301_V0.8800.85
225_F238_T0.8760.85
403_T431_L0.8700.84
66_A191_N0.8700.84
453_I458_A0.8650.84
358_G407_S0.8640.84
310_E336_G0.8610.84
387_R421_Y0.8560.83
167_C175_D0.8530.83
208_F241_V0.8490.83
359_T374_S0.8470.83
421_Y432_E0.8440.83
324_A352_H0.8440.83
240_L271_V0.8440.83
426_N429_A0.8430.82
147_D228_N0.8410.82
350_S380_G0.8390.82
310_E367_N0.8370.82
379_A411_G0.8360.82
81_D327_W0.8360.82
213_K275_K0.8360.82
448_C453_I0.8350.82
421_Y425_R0.8340.82
283_T299_N0.8330.82
254_C299_N0.8330.82
403_T422_V0.8280.81
239_I270_E0.8270.81
225_F252_E0.8270.81
185_G239_I0.8270.81
448_C462_I0.8240.81
389_L421_Y0.8230.81
283_T287_W0.8230.81
64_Y202_V0.8220.81
163_G215_V0.8180.81
389_L403_T0.8170.80
270_E304_R0.8150.80
302_T331_S0.8140.80
198_L477_E0.8110.80
252_E283_T0.8100.80
322_G326_T0.8090.80
58_E61_L0.8070.80
334_L438_S0.8030.79
367_N397_T0.8000.79
146_F225_F0.7990.79
142_V219_M0.7990.79
392_I424_C0.7970.79
288_F296_G0.7970.79
343_F361_M0.7930.78
74_H77_K0.7890.78
372_I390_V0.7870.78
392_I400_R0.7850.78
244_E276_N0.7830.78
180_V208_F0.7820.77
335_R365_G0.7820.77
360_K391_K0.7790.77
366_K372_I0.7790.77
349_T378_S0.7770.77
236_E267_A0.7700.76
381_H414_C0.7670.76
148_S203_A0.7660.76
125_A128_E0.7650.76
424_C428_S0.7630.76
359_T372_I0.7600.75
72_E80_Y0.7590.75
151_V156_R0.7580.75
214_G244_E0.7580.75
410_I446_F0.7540.75
240_L248_V0.7530.75
276_N310_E0.7520.75
63_A197_A0.7510.75
424_C431_L0.7480.74
345_S357_T0.7470.74
179_L210_Y0.7470.74
397_T427_N0.7440.74
354_Q374_S0.7440.74
271_V314_M0.7430.74
408_M415_G0.7420.74
63_A201_A0.7400.73
60_R197_A0.7340.73
285_Q353_Q0.7340.73
350_S353_Q0.7320.73
69_E186_T0.7320.73
400_R430_Q0.7280.72
238_T269_V0.7280.72
185_G200_A0.7280.72
387_R416_A0.7260.72
377_I408_M0.7250.72
263_Q287_W0.7250.72
372_I375_K0.7240.72
63_A190_G0.7240.72
354_Q383_Q0.7230.72
165_I183_Y0.7220.72
176_H179_L0.7210.72
381_H411_G0.7200.71
124_E127_F0.7180.71
162_Q217_C0.7150.71
176_H208_F0.7140.71
401_N407_S0.7100.70
389_L423_E0.7100.70
184_L209_I0.7090.70
303_K330_P0.7090.70
392_I429_A0.7080.70
248_V273_I0.7080.70
390_V399_A0.7070.70
380_G411_G0.7070.70
397_T430_Q0.7050.70
164_I217_C0.7040.70
147_D151_V0.7030.70
200_A268_V0.7030.70
332_C343_F0.7020.70
144_A149_V0.7000.69
176_H212_P0.6990.69
155_Y239_I0.6990.69
227_I234_Q0.6980.69
343_F401_N0.6950.69
119_L127_F0.6940.69
272_I306_L0.6930.69
269_V281_Y0.6920.68
62_N190_G0.6900.68
143_D150_S0.6890.68
265_H287_W0.6890.68
143_D153_T0.6880.68
435_A463_V0.6840.68
373_I441_G0.6830.67
366_K396_A0.6830.67
387_R407_S0.6780.67
120_S123_V0.6780.67
285_Q318_Q0.6770.67
328_K374_S0.6770.67
239_I272_I0.6760.67
401_N405_C0.6760.67
114_G117_A0.6760.67
158_K161_E0.6750.67
398_N426_N0.6740.66
127_F130_L0.6730.66
289_P351_G0.6730.66
152_A155_Y0.6720.66
394_P425_R0.6710.66
440_I459_I0.6710.66
179_L182_K0.6710.66
199_N266_A0.6690.66
348_L486_L0.6670.66
376_G405_C0.6640.65
120_S163_G0.6590.65
165_I176_H0.6590.65
477_E481_E0.6590.65
197_A270_E0.6590.65
192_D196_A0.6580.65
340_I371_T0.6580.65
311_N337_D0.6580.65
432_E438_S0.6570.64
59_F181_R0.6560.64
358_G467_C0.6560.64
314_M332_C0.6560.64
305_A312_S0.6550.64
425_R438_S0.6550.64
145_I149_V0.6540.64
326_T355_A0.6530.64
394_P397_T0.6520.64
54_E161_E0.6520.64
285_Q323_S0.6520.64
127_F142_V0.6500.64
477_E480_V0.6480.63
394_P413_N0.6470.63
272_I308_E0.6470.63
358_G401_N0.6460.63
227_I297_I0.6450.63
468_K483_Q0.6440.63
424_C427_N0.6430.63
282_S475_P0.6430.63
304_R435_A0.6430.63
285_Q322_G0.6400.62
180_V239_I0.6400.62
237_R270_E0.6390.62
274_H312_S0.6390.62
334_L339_S0.6390.62
142_V148_S0.6370.62
339_S366_K0.6360.62
332_C438_S0.6350.62
342_E371_T0.6340.62
193_N302_T0.6320.61
337_D398_N0.6320.61
115_A118_F0.6300.61
84_N88_Y0.6290.61
306_L332_C0.6280.61
275_K339_S0.6270.61
419_F432_E0.6260.61
358_G405_C0.6240.60
438_S441_G0.6230.60
72_E88_Y0.6230.60
275_K312_S0.6230.60
195_F300_F0.6220.60
399_A431_L0.6200.60
186_T270_E0.6170.60
273_I332_C0.6160.59
408_M463_V0.6160.59
398_N427_N0.6150.59
124_E128_E0.6110.59
426_N436_T0.6110.59
396_A426_N0.6110.59
284_V321_T0.6080.58
59_F63_A0.6080.58
216_R340_I0.6080.58
350_S448_C0.6070.58
344_Y473_E0.6070.58
183_Y270_E0.6060.58
431_L441_G0.6060.58
75_W87_D0.6050.58
375_K486_L0.6050.58
179_L208_F0.6040.58
220_E408_M0.6040.58
159_L218_P0.6040.58
192_D304_R0.6020.58
85_Y403_T0.6000.57
81_D397_T0.5990.57
173_I176_H0.5990.57
254_C283_T0.5970.57
229_A232_T0.5960.57
280_K475_P0.5940.57
52_E61_L0.5940.57
145_I224_Y0.5920.56
327_W434_E0.5920.56
161_E218_P0.5910.56
363_H393_M0.5910.56
164_I410_I0.5910.56
172_A179_L0.5910.56
225_F444_Q0.5900.56
328_K438_S0.5890.56
338_N369_K0.5890.56
307_C339_S0.5880.56
329_Y403_T0.5870.56
289_P296_G0.5850.56
113_T251_I0.5850.56
361_M370_S0.5840.55
427_N430_Q0.5840.55
419_F426_N0.5830.55
212_P243_D0.5830.55
408_M492_H0.5820.55
305_A332_C0.5820.55
207_T225_F0.5820.55
244_E312_S0.5810.55
159_L217_C0.5790.55
378_S414_C0.5790.55
173_I180_V0.5780.55
363_H425_R0.5770.55
350_S379_A0.5770.55
88_Y91_Y0.5760.54
143_D224_Y0.5760.54
209_I217_C0.5760.54
77_K80_Y0.5760.54
59_F190_G0.5740.54
374_S387_R0.5740.54
280_K317_T0.5720.54
426_N434_E0.5720.54
321_T489_S0.5710.54
83_L86_Q0.5710.54
386_Y419_F0.5700.54
476_L479_A0.5700.54
113_T117_A0.5690.54
407_S439_R0.5680.53
206_G238_T0.5670.53
219_M248_V0.5670.53
60_R63_A0.5660.53
431_L434_E0.5660.53
163_G211_V0.5660.53
218_P240_L0.5650.53
86_Q385_S0.5640.53
256_A263_Q0.5640.53
117_A481_E0.5630.53
320_E347_A0.5630.53
233_G375_K0.5630.53
460_S487_A0.5620.53
144_A148_S0.5620.53
407_S437_T0.5620.53
399_A426_N0.5610.53
373_I470_V0.5610.53
301_V318_Q0.5610.53
98_N113_T0.5600.52
358_G418_T0.5590.52
163_G212_P0.5590.52
90_Y226_R0.5590.52
393_M418_T0.5580.52
220_E249_S0.5560.52
364_I391_K0.5560.52
431_L462_I0.5560.52
391_K423_E0.5530.51
422_V429_A0.5530.51
393_M425_R0.5530.51
154_T484_K0.5530.51
65_R230_E0.5530.51
61_L118_F0.5530.51
146_F207_T0.5530.51
144_A151_V0.5520.51
227_I265_H0.5520.51
392_I427_N0.5520.51
231_K261_S0.5510.51
216_R367_N0.5500.51
436_T467_C0.5500.51
285_Q320_E0.5500.51
448_C489_S0.5490.51
67_W71_E0.5490.51
160_A163_G0.5480.51
467_C470_V0.5480.51
454_S464_N0.5480.51
392_I426_N0.5480.51
253_G286_N0.5470.51
353_Q380_G0.5460.51
339_S364_I0.5460.51
409_L416_A0.5460.51
262_Y351_G0.5460.51
64_Y171_E0.5450.50
96_C298_L0.5440.50
369_K432_E0.5430.50
364_I395_T0.5430.50
250_Y269_V0.5420.50
316_W435_A0.5420.50
414_C448_C0.5410.50
276_N313_K0.5410.50
407_S419_F0.5410.50
348_L379_A0.5400.50
63_A66_A0.5400.50
133_P202_V0.5380.50
348_L489_S0.5370.49
203_A266_A0.5370.49
153_T156_R0.5360.49
120_S124_E0.5360.49
363_H423_E0.5350.49
169_F203_A0.5340.49
133_P219_M0.5340.49
269_V317_T0.5340.49
383_Q414_C0.5330.49
56_M169_F0.5310.49
372_I403_T0.5300.49
201_A277_A0.5300.49
436_T469_D0.5290.48
67_W197_A0.5280.48
162_Q211_V0.5280.48
387_R418_T0.5280.48
453_I457_D0.5280.48
235_F264_L0.5270.48
327_W354_Q0.5270.48
315_S475_P0.5260.48
334_L465_G0.5260.48
347_A357_T0.5260.48
97_G113_T0.5260.48
241_V270_E0.5260.48
198_L235_F0.5250.48
247_Y280_K0.5240.48
401_N422_V0.5230.48
237_R438_S0.5220.48
371_T392_I0.5220.48
300_F318_Q0.5210.47
214_G364_I0.5210.47
409_L419_F0.5200.47
199_N462_I0.5200.47
258_V445_L0.5180.47
128_E131_G0.5150.47
83_L422_V0.5150.47
357_T378_S0.5150.47
85_Y415_G0.5140.46
315_S342_E0.5140.46
286_N485_L0.5140.46
265_H299_N0.5140.46
372_I421_Y0.5130.46
141_A159_L0.5130.46
448_C461_M0.5120.46
133_P352_H0.5120.46
187_V270_E0.5120.46
147_D152_A0.5120.46
164_I221_L0.5110.46
441_G444_Q0.5110.46
303_K328_K0.5110.46
468_K471_F0.5100.46
167_C176_H0.5100.46
415_G486_L0.5090.46
384_N392_I0.5090.46
417_H437_T0.5090.46
401_N444_Q0.5090.46
245_D278_E0.5080.46
260_D296_G0.5070.46
92_S371_T0.5070.46
374_S405_C0.5070.46
384_N459_I0.5070.46
146_F205_D0.5050.45
300_F304_R0.5050.45
347_A439_R0.5040.45
88_Y356_D0.5040.45
129_Q133_P0.5040.45
230_E261_S0.5040.45
321_T471_F0.5040.45
119_L124_E0.5040.45
116_N119_L0.5040.45
145_I156_R0.5030.45
85_Y199_N0.5030.45
467_C490_L0.5020.45
457_D460_S0.5020.45
298_L324_A0.5020.45
89_S383_Q0.5010.45
207_T238_T0.5010.45
330_P333_I0.5000.45
305_A440_I0.5000.45
318_Q357_T0.5000.45
419_F427_N0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vh4A 2 0.8263 100 0.279 Contact Map
4dn7A 2 0.8182 100 0.312 Contact Map
4xfmA 2 0.1434 63.2 0.971 Contact Map
3dqqA 2 0.1535 32.4 0.976 Contact Map
1yzyA 1 0.1394 24.6 0.978 Contact Map
4v0qA 2 0.1192 22.4 0.978 Contact Map
4k6mA 2 0.1212 20.2 0.979 Contact Map
1ifyA 1 0.0869 18.6 0.979 Contact Map
4xg0A 2 0.1475 18.3 0.979 Contact Map
1wjiA 1 0.1131 17.8 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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