DPIB - ECOLI - GREMLIN Contacts

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DPIB - Sensor histidine kinase DpiB

UniProt:	P77510	Sequences: MLQLNENKQFAFFQRLAFPLRIFLLILVFSIFVIAALAQYFTASFEDYLTLHVRDMAMNQAKIIASNDSVISAVKTRDYKRLATIANKLQRDTDFDYVVIGDRHSIRLYHPNPEKIGYPMQFTKQGALEKGESYFITGKGSMGMAMRAKTPIFDDDGKVIGVVSIGYLVSKIDSWRAEFLLPMAGVFVVLLGILMLLSWFLAAHIRRQMMGMEPKQIARVVRQQEALFSSVYEGLIAVDPHGYITAINRNARKMLGLSSPGRQWLGKPIVEVVRPADFFTEQIDEKRQDVVANFNGLSVIANREAIRSGDDLLGAIISFRSKDEISTLNAQLTQIKQYVESLRTLRHEHLNWMSTLNGLLQMKEYDRVLAMVQGESQAQQQLIDSLREAFADRQVAGLLFGKVQRARELGLKMIIVPGSQLSQLPPGLDSTEFAAIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIYIPKVKPNDSSINPIDR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13646
Length:	552 (509)
Sequences:	9870 (8686)
Seq/√Len:	385.0

ECOLI - DPIB DCUS ATOS RCSC RCSD BARA ARCB NARX EVGS TORS NARQ PHOR ZRAS CREC PHOQ CUSS QSEC NTRB ENVZ BAES GLRK
BACSU - DCTS MALK CITS YYCG RESE PHOR KINE KINA KINC KIND YCLK CSSS YKOH
HALSA - Q9HQ16 O51970 Q9HR10 Q9HRE4 Q9HQG5 Q9HRG1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
474_A	532_L	4.256	1.00
526_N	529_C	4.194	1.00
360_L	372_V	3.859	1.00
485_R	523_L	3.784	1.00
511_A	515_T	3.553	1.00
393_R	428_L	3.472	1.00
414_I	457_I	3.373	1.00
416_V	461_F	3.369	1.00
448_S	476_Q	3.268	1.00
522_T	534_S	3.209	1.00
468_D	536_Y	3.161	1.00
436_I	513_Y	3.072	1.00
233_E	320_R	3.019	1.00
514_V	535_I	3.017	1.00
239_D	243_Y	2.935	1.00
221_V	225_E	2.894	1.00
510_I	521_I	2.813	1.00
481_P	484_L	2.807	1.00
461_F	472_E	2.805	1.00
459_E	474_A	2.799	1.00
472_E	532_L	2.798	1.00
523_L	533_F	2.775	1.00
414_I	459_E	2.723	1.00
392_D	427_G	2.689	1.00
250_N	253_K	2.670	1.00
220_V	223_Q	2.670	1.00
428_L	517_C	2.629	1.00
471_I	535_I	2.611	1.00
472_E	534_S	2.602	1.00
470_V	536_Y	2.579	1.00
416_V	459_E	2.545	1.00
480_V	484_L	2.536	1.00
457_I	476_Q	2.516	1.00
465_E	470_V	2.514	1.00
461_F	474_A	2.499	1.00
475_D	479_G	2.493	1.00
394_Q	397_G	2.487	1.00
464_D	539_K	2.455	1.00
463_S	470_V	2.454	1.00
336_K	339_V	2.430	1.00
513_Y	517_C	2.395	1.00
448_S	456_K	2.386	1.00
524_E	532_L	2.382	1.00
325_I	329_N	2.233	1.00
525_D	531_T	2.208	1.00
436_I	514_V	2.197	1.00
412_K	457_I	2.184	1.00
437_V	471_I	2.174	1.00
485_R	525_D	2.131	1.00
391_A	430_S	2.129	1.00
514_V	519_G	2.119	1.00
456_K	476_Q	2.110	1.00
215_K	218_A	2.110	1.00
470_V	534_S	2.099	1.00
448_S	458_V	2.089	1.00
102_D	106_I	2.087	1.00
329_N	333_T	2.064	1.00
436_I	510_I	2.060	1.00
489_F	521_I	2.059	1.00
267_K	271_E	2.054	1.00
401_G	434_A	1.992	1.00
396_A	462_L	1.975	1.00
357_N	376_S	1.963	1.00
326_S	329_N	1.961	1.00
236_I	251_A	1.951	1.00
218_A	221_V	1.923	1.00
487_K	490_E	1.905	1.00
336_K	340_E	1.903	1.00
524_E	534_S	1.903	1.00
429_D	432_E	1.900	1.00
520_V	536_Y	1.884	1.00
220_V	225_E	1.863	1.00
234_G	319_F	1.860	1.00
125_Q	128_L	1.853	1.00
359_L	368_V	1.849	1.00
234_G	254_M	1.848	1.00
447_A	494_S	1.835	1.00
463_S	472_E	1.833	1.00
480_V	488_I	1.814	1.00
231_V	235_L	1.807	1.00
198_S	202_A	1.796	1.00
205_I	208_Q	1.726	1.00
357_N	377_Q	1.710	1.00
332_L	335_I	1.687	1.00
515_T	520_V	1.657	1.00
216_Q	220_V	1.656	1.00
289_D	292_A	1.638	1.00
525_D	528_P	1.636	1.00
281_E	285_E	1.618	1.00
525_D	529_C	1.611	1.00
236_I	317_I	1.595	1.00
428_L	433_F	1.594	1.00
417_P	462_L	1.585	1.00
482_E	485_R	1.580	1.00
288_Q	326_S	1.575	1.00
437_V	441_L	1.563	1.00
432_E	513_Y	1.560	1.00
327_T	331_Q	1.560	1.00
519_G	537_I	1.552	1.00
217_I	220_V	1.550	1.00
432_E	435_A	1.547	1.00
484_L	493_V	1.523	1.00
257_L	294_F	1.517	1.00
220_V	224_Q	1.509	1.00
522_T	536_Y	1.508	1.00
214_P	218_A	1.500	1.00
394_Q	423_Q	1.494	1.00
324_E	327_T	1.479	1.00
300_I	320_R	1.467	1.00
484_L	487_K	1.443	1.00
488_I	523_L	1.437	1.00
236_I	244_I	1.437	1.00
61_A	65_A	1.433	1.00
39_Q	43_A	1.432	1.00
249_R	253_K	1.432	1.00
225_E	229_S	1.428	1.00
446_E	496_R	1.426	1.00
252_R	259_S	1.424	1.00
268_P	271_E	1.422	1.00
53_V	57_A	1.421	1.00
381_Q	431_T	1.419	1.00
224_Q	228_F	1.407	1.00
221_V	224_Q	1.374	1.00
468_D	520_V	1.372	1.00
327_T	330_A	1.356	1.00
442_D	446_E	1.351	1.00
459_E	476_Q	1.351	1.00
481_P	527_D	1.348	1.00
437_V	473_V	1.345	1.00
487_K	493_V	1.338	1.00
399_L	462_L	1.336	1.00
380_Q	384_D	1.333	1.00
119_P	122_F	1.330	1.00
433_F	517_C	1.312	1.00
291_V	294_F	1.310	1.00
337_Q	340_E	1.309	1.00
118_Y	122_F	1.305	1.00
308_S	311_D	1.304	1.00
444_A	458_V	1.303	1.00
360_L	373_Q	1.301	1.00
358_G	362_M	1.300	1.00
355_T	359_L	1.293	1.00
469_V	539_K	1.290	1.00
87_N	90_Q	1.286	1.00
490_E	493_V	1.285	1.00
237_A	314_G	1.282	1.00
370_A	374_G	1.278	1.00
373_Q	377_Q	1.274	1.00
489_F	523_L	1.273	1.00
403_V	415_I	1.272	1.00
252_R	258_S	1.264	1.00
436_I	535_I	1.263	1.00
251_A	255_L	1.262	1.00
224_Q	227_L	1.255	1.00
395_V	471_I	1.251	1.00
61_A	64_I	1.248	1.00
65_A	69_S	1.242	1.00
440_L	535_I	1.235	1.00
422_S	464_D	1.235	1.00
247_I	252_R	1.234	1.00
234_G	248_N	1.233	1.00
402_K	434_A	1.227	1.00
57_A	61_A	1.226	1.00
421_L	462_L	1.225	1.00
151_P	161_G	1.225	1.00
356_L	372_V	1.221	1.00
398_L	402_K	1.215	1.00
50_T	54_R	1.207	1.00
331_Q	334_Q	1.205	1.00
249_R	252_R	1.205	1.00
366_D	370_A	1.202	1.00
401_G	430_S	1.195	1.00
489_F	533_F	1.194	1.00
346_R	351_N	1.193	1.00
482_E	526_N	1.191	1.00
247_I	264_W	1.191	1.00
390_F	427_G	1.187	1.00
484_L	495_T	1.185	1.00
238_V	317_I	1.179	1.00
355_T	375_E	1.176	1.00
289_D	296_G	1.168	1.00
397_G	401_G	1.158	1.00
432_E	516_R	1.158	1.00
488_I	533_F	1.152	1.00
119_P	123_T	1.145	1.00
441_L	460_L	1.139	1.00
161_G	168_L	1.139	1.00
514_V	521_I	1.137	1.00
330_A	333_T	1.135	1.00
418_G	463_S	1.133	1.00
247_I	251_A	1.130	1.00
305_A	312_L	1.121	1.00
288_Q	291_V	1.118	1.00
202_A	206_R	1.113	1.00
396_A	400_F	1.112	1.00
234_G	251_A	1.109	1.00
402_K	441_L	1.101	1.00
307_R	312_L	1.101	1.00
305_A	314_G	1.100	1.00
216_Q	221_V	1.097	1.00
57_A	60_Q	1.095	1.00
203_A	207_R	1.093	1.00
300_I	325_I	1.089	1.00
480_V	523_L	1.085	1.00
120_M	123_T	1.083	1.00
301_A	319_F	1.080	1.00
215_K	220_V	1.076	1.00
523_L	531_T	1.071	1.00
448_S	451_S	1.068	1.00
400_F	415_I	1.067	1.00
257_L	263_Q	1.061	1.00
81_R	84_T	1.061	1.00
399_L	460_L	1.059	1.00
360_L	369_L	1.056	1.00
56_M	59_N	1.056	1.00
406_A	445_F	1.055	1.00
41_F	45_F	1.055	1.00
435_A	513_Y	1.052	1.00
78_D	81_R	1.045	1.00
138_G	141_S	1.044	1.00
462_L	471_I	1.040	1.00
218_A	222_R	1.037	1.00
127_A	131_G	1.034	1.00
390_F	428_L	1.032	1.00
345_L	386_L	1.032	1.00
333_T	336_K	1.023	1.00
248_N	251_A	1.020	1.00
465_E	536_Y	1.014	1.00
49_L	52_H	1.009	1.00
326_S	330_A	1.007	1.00
440_L	473_V	1.007	1.00
60_Q	63_I	1.004	1.00
349_H	352_W	1.003	1.00
228_F	246_A	1.003	1.00
125_Q	129_E	1.003	1.00
390_F	517_C	0.998	1.00
52_H	55_D	0.996	1.00
505_I	509_L	0.995	1.00
119_P	124_K	0.991	1.00
396_A	417_P	0.991	1.00
322_K	326_S	0.989	1.00
238_V	244_I	0.987	1.00
42_T	46_E	0.985	1.00
359_L	371_M	0.984	1.00
405_R	438_G	0.983	1.00
204_H	208_Q	0.977	1.00
397_G	400_F	0.975	1.00
153_F	161_G	0.973	1.00
328_L	332_L	0.968	1.00
440_L	533_F	0.967	1.00
181_L	185_G	0.966	1.00
329_N	332_L	0.965	1.00
158_K	161_G	0.965	1.00
218_A	223_Q	0.965	1.00
514_V	537_I	0.962	1.00
436_I	517_C	0.956	1.00
480_V	525_D	0.956	1.00
38_A	42_T	0.954	1.00
293_N	297_L	0.954	1.00
149_K	162_V	0.953	1.00
496_R	501_G	0.952	1.00
248_N	323_D	0.948	1.00
406_A	458_V	0.945	1.00
355_T	371_M	0.943	1.00
252_R	264_W	0.940	1.00
434_A	438_G	0.934	1.00
348_E	351_N	0.928	1.00
121_Q	124_K	0.926	1.00
522_T	535_I	0.925	1.00
99_V	107_R	0.925	1.00
359_L	372_V	0.924	1.00
480_V	531_T	0.922	1.00
258_S	263_Q	0.921	1.00
120_M	124_K	0.920	1.00
371_M	375_E	0.917	1.00
406_A	413_M	0.917	1.00
115_K	119_P	0.916	1.00
433_F	535_I	0.915	1.00
349_H	353_M	0.914	1.00
399_L	415_I	0.914	1.00
291_V	296_G	0.912	1.00
194_L	198_S	0.911	1.00
399_L	402_K	0.910	1.00
468_D	538_P	0.908	1.00
292_A	295_N	0.905	1.00
237_A	316_I	0.902	1.00
350_L	380_Q	0.900	1.00
52_H	56_M	0.900	1.00
478_C	531_T	0.899	1.00
208_Q	212_M	0.897	1.00
349_H	379_Q	0.895	1.00
480_V	485_R	0.894	1.00
299_V	302_N	0.894	1.00
348_E	352_W	0.889	1.00
446_E	494_S	0.887	1.00
302_N	305_A	0.885	1.00
430_S	434_A	0.885	1.00
339_V	343_R	0.884	1.00
460_L	473_V	0.884	1.00
46_E	50_T	0.882	1.00
153_F	159_V	0.882	1.00
43_A	47_D	0.882	1.00
390_F	393_R	0.881	1.00
467_D	539_K	0.881	1.00
116_I	119_P	0.880	1.00
49_L	53_V	0.878	1.00
350_L	379_Q	0.878	1.00
427_G	540_V	0.878	1.00
356_L	376_S	0.877	1.00
343_R	348_E	0.877	1.00
298_S	326_S	0.876	1.00
54_R	58_M	0.876	1.00
341_S	346_R	0.872	1.00
118_Y	121_Q	0.871	1.00
215_K	219_R	0.870	1.00
411_L	448_S	0.869	1.00
97_Y	166_G	0.868	1.00
325_I	328_L	0.867	1.00
157_G	161_G	0.865	1.00
372_V	376_S	0.864	1.00
51_L	54_R	0.864	1.00
491_Q	512_S	0.863	1.00
441_L	458_V	0.863	1.00
400_F	404_Q	0.862	1.00
440_L	510_I	0.860	1.00
220_V	227_L	0.857	1.00
161_G	165_I	0.854	1.00
97_Y	110_H	0.854	1.00
403_V	413_M	0.851	1.00
341_S	351_N	0.850	1.00
297_L	321_S	0.848	1.00
43_A	46_E	0.847	1.00
399_L	437_V	0.847	1.00
138_G	149_K	0.846	1.00
250_N	254_M	0.843	1.00
420_Q	464_D	0.841	1.00
367_R	371_M	0.840	1.00
237_A	246_A	0.838	1.00
482_E	486_D	0.838	1.00
143_G	147_R	0.834	1.00
117_G	120_M	0.832	1.00
328_L	331_Q	0.832	1.00
351_N	358_G	0.830	1.00
214_P	220_V	0.830	1.00
360_L	376_S	0.830	1.00
58_M	62_K	0.829	1.00
303_R	306_I	0.828	1.00
128_L	131_G	0.827	1.00
85_I	89_L	0.826	1.00
235_L	318_S	0.825	1.00
343_R	382_L	0.822	1.00
395_V	469_V	0.822	1.00
229_S	249_R	0.819	1.00
388_E	432_E	0.818	1.00
349_H	383_I	0.818	1.00
258_S	262_R	0.818	1.00
126_G	129_E	0.815	1.00
87_N	91_R	0.814	1.00
263_Q	294_F	0.812	1.00
303_R	315_A	0.811	1.00
354_S	357_N	0.811	1.00
65_A	68_D	0.810	1.00
115_K	118_Y	0.810	1.00
332_L	339_V	0.810	1.00
357_N	380_Q	0.809	1.00
367_R	370_A	0.809	1.00
235_L	248_N	0.808	1.00
51_L	55_D	0.808	1.00
332_L	338_Y	0.808	1.00
35_A	39_Q	0.805	1.00
40_Y	44_S	0.805	1.00
196_L	200_F	0.805	1.00
219_R	223_Q	0.804	1.00
451_S	456_K	0.803	1.00
228_F	235_L	0.799	1.00
351_N	447_A	0.796	1.00
364_E	368_V	0.796	1.00
239_D	245_T	0.794	1.00
398_L	403_V	0.793	1.00
53_V	56_M	0.793	1.00
274_R	277_D	0.792	1.00
350_L	387_R	0.791	1.00
244_I	248_N	0.791	1.00
218_A	224_Q	0.790	1.00
145_A	148_A	0.789	1.00
168_L	171_K	0.789	1.00
290_V	293_N	0.789	1.00
361_Q	373_Q	0.788	1.00
368_V	371_M	0.788	1.00
298_S	323_D	0.785	1.00
374_G	401_G	0.785	1.00
362_M	368_V	0.784	1.00
385_S	432_E	0.784	1.00
177_A	180_L	0.783	1.00
416_V	463_S	0.783	1.00
410_G	450_R	0.780	1.00
214_P	217_I	0.780	1.00
148_A	151_P	0.780	1.00
102_D	108_L	0.779	1.00
132_E	136_I	0.777	1.00
397_G	430_S	0.777	1.00
60_Q	68_D	0.777	1.00
107_R	110_H	0.776	1.00
347_H	439_N	0.770	1.00
62_K	65_A	0.769	1.00
357_N	361_Q	0.768	1.00
344_T	491_Q	0.768	1.00
82_L	86_A	0.766	1.00
397_G	402_K	0.763	1.00
280_T	284_D	0.761	1.00
350_L	384_D	0.761	1.00
151_P	160_I	0.759	1.00
237_A	248_N	0.759	1.00
335_I	338_Y	0.757	1.00
357_N	360_L	0.756	1.00
290_V	295_N	0.756	1.00
446_E	495_T	0.754	1.00
169_V	173_D	0.752	1.00
127_A	132_E	0.752	1.00
245_T	314_G	0.751	1.00
480_V	486_D	0.750	1.00
465_E	468_D	0.749	1.00
348_E	509_L	0.747	1.00
243_Y	268_P	0.747	1.00
223_Q	246_A	0.746	1.00
481_P	488_I	0.745	1.00
375_E	378_A	0.745	1.00
216_Q	223_Q	0.744	1.00
243_Y	266_G	0.744	1.00
402_K	405_R	0.741	1.00
289_D	294_F	0.733	1.00
303_R	317_I	0.732	1.00
60_Q	65_A	0.732	1.00
447_A	478_C	0.731	1.00
116_I	120_M	0.730	1.00
102_D	105_S	0.729	1.00
307_R	310_D	0.729	1.00
64_I	67_N	0.728	1.00
389_A	491_Q	0.727	1.00
381_Q	385_S	0.727	1.00
107_R	111_P	0.726	1.00
510_I	514_V	0.726	1.00
475_D	530_G	0.720	1.00
215_K	225_E	0.719	1.00
126_G	130_K	0.719	1.00
325_I	331_Q	0.718	1.00
60_Q	64_I	0.718	1.00
233_E	250_N	0.717	1.00
512_S	515_T	0.715	1.00
447_A	496_R	0.715	1.00
251_A	319_F	0.714	1.00
47_D	50_T	0.713	1.00
180_L	184_A	0.712	1.00
342_L	345_L	0.711	1.00
348_E	435_A	0.710	1.00
146_M	149_K	0.709	1.00
393_R	398_L	0.709	1.00
141_S	145_A	0.708	1.00
86_A	90_Q	0.708	1.00
365_Y	368_V	0.708	1.00
376_S	380_Q	0.707	1.00
435_A	509_L	0.707	1.00
398_L	428_L	0.706	1.00
289_D	293_N	0.705	1.00
331_Q	335_I	0.705	1.00
161_G	164_S	0.700	1.00
349_H	382_L	0.699	1.00
389_A	512_S	0.699	1.00
217_I	221_V	0.697	0.99
223_Q	227_L	0.697	0.99
66_S	69_S	0.696	0.99
234_G	255_L	0.695	0.99
352_W	379_Q	0.695	0.99
494_S	503_H	0.695	0.99
496_R	499_E	0.695	0.99
290_V	296_G	0.694	0.99
334_Q	338_Y	0.693	0.99
393_R	433_F	0.693	0.99
411_L	445_F	0.692	0.99
519_G	538_P	0.690	0.99
61_A	165_I	0.690	0.99
37_L	41_F	0.690	0.99
127_A	130_K	0.690	0.99
259_S	262_R	0.690	0.99
231_V	234_G	0.689	0.99
400_F	403_V	0.688	0.99
54_R	57_A	0.685	0.99
251_A	254_M	0.685	0.99
56_M	60_Q	0.685	0.99
290_V	294_F	0.682	0.99
199_W	203_A	0.680	0.99
147_R	166_G	0.678	0.99
279_F	282_Q	0.678	0.99
411_L	476_Q	0.677	0.99
128_L	162_V	0.676	0.99
346_R	447_A	0.676	0.99
105_S	109_Y	0.673	0.99
341_S	387_R	0.673	0.99
215_K	223_Q	0.671	0.99
535_I	538_P	0.670	0.99
228_F	248_N	0.670	0.99
393_R	402_K	0.669	0.99
221_V	227_L	0.668	0.99
215_K	221_V	0.667	0.99
282_Q	286_K	0.667	0.99
145_A	149_K	0.665	0.99
480_V	507_L	0.665	0.99
343_R	349_H	0.663	0.99
154_D	158_K	0.663	0.99
50_T	53_V	0.663	0.99
411_L	458_V	0.661	0.99
298_S	322_K	0.661	0.99
437_V	535_I	0.659	0.99
128_L	134_Y	0.658	0.99
304_E	316_I	0.658	0.99
187_F	191_L	0.657	0.99
242_G	248_N	0.657	0.99
347_H	351_N	0.657	0.99
112_N	115_K	0.656	0.99
236_I	248_N	0.656	0.99
181_L	184_A	0.654	0.99
352_W	492_G	0.654	0.99
93_T	96_D	0.653	0.99
381_Q	384_D	0.653	0.99
365_Y	371_M	0.652	0.99
433_F	514_V	0.650	0.99
76_T	79_Y	0.649	0.99
101_G	107_R	0.648	0.99
149_K	164_S	0.647	0.99
345_L	349_H	0.647	0.99
39_Q	42_T	0.641	0.99
432_E	436_I	0.640	0.99
308_S	313_L	0.639	0.99
352_W	383_I	0.638	0.99
348_E	382_L	0.638	0.99
288_Q	296_G	0.638	0.99
125_Q	131_G	0.638	0.99
435_A	438_G	0.636	0.99
292_A	296_G	0.635	0.99
83_A	87_N	0.635	0.99
64_I	68_D	0.634	0.99
223_Q	228_F	0.634	0.99
88_K	92_D	0.632	0.99
358_G	376_S	0.631	0.99
385_S	503_H	0.630	0.99
138_G	145_A	0.630	0.99
341_S	494_S	0.629	0.99
172_I	176_R	0.628	0.99
267_K	272_V	0.628	0.99
231_V	318_S	0.628	0.99
150_T	153_F	0.627	0.99
216_Q	224_Q	0.625	0.99
182_P	185_G	0.625	0.99
281_E	286_K	0.624	0.99
289_D	295_N	0.624	0.99
379_Q	385_S	0.624	0.99
346_R	350_L	0.624	0.99
177_A	181_L	0.623	0.99
117_G	122_F	0.621	0.99
333_T	337_Q	0.620	0.99
387_R	503_H	0.619	0.99
56_M	61_A	0.619	0.99
375_E	379_Q	0.618	0.99
278_F	283_I	0.618	0.99
147_R	150_T	0.617	0.99
133_S	137_T	0.617	0.99
468_D	539_K	0.615	0.99
521_I	535_I	0.614	0.99
353_M	359_L	0.614	0.99
153_F	157_G	0.612	0.99
342_L	354_S	0.611	0.99
494_S	501_G	0.611	0.99
140_G	147_R	0.609	0.99
399_L	417_P	0.608	0.99
77_R	81_R	0.608	0.99
81_R	85_I	0.608	0.99
221_V	228_F	0.608	0.99
30_S	33_V	0.608	0.99
214_P	221_V	0.608	0.99
290_V	298_S	0.607	0.99
343_R	351_N	0.607	0.99
234_G	321_S	0.606	0.99
413_M	458_V	0.606	0.99
298_S	304_E	0.605	0.99
55_D	59_N	0.604	0.99
330_A	334_Q	0.603	0.99
40_Y	43_A	0.602	0.99
214_P	225_E	0.601	0.99
342_L	351_N	0.600	0.98
399_L	403_V	0.600	0.98
103_R	109_Y	0.599	0.98
451_S	476_Q	0.599	0.98
215_K	224_Q	0.599	0.98
325_I	332_L	0.598	0.98
368_V	372_V	0.597	0.98
236_I	319_F	0.596	0.98
107_R	112_N	0.596	0.98
237_A	251_A	0.595	0.98
432_E	517_C	0.595	0.98
378_A	382_L	0.595	0.98
232_Y	235_L	0.595	0.98
238_V	242_G	0.594	0.98
363_K	366_D	0.594	0.98
369_L	372_V	0.594	0.98
47_D	51_L	0.592	0.98
170_S	174_S	0.591	0.98
359_L	375_E	0.591	0.98
142_M	145_A	0.591	0.98
188_V	192_G	0.591	0.98
334_Q	337_Q	0.591	0.98
105_S	111_P	0.591	0.98
300_I	303_R	0.590	0.98
105_S	108_L	0.590	0.98
514_V	517_C	0.589	0.98
351_N	362_M	0.588	0.98
351_N	387_R	0.587	0.98
101_G	164_S	0.587	0.98
447_A	495_T	0.586	0.98
486_D	490_E	0.586	0.98
217_I	224_Q	0.586	0.98
84_T	87_N	0.585	0.98
353_M	383_I	0.585	0.98
288_Q	295_N	0.585	0.98
343_R	346_R	0.584	0.98
244_I	266_G	0.583	0.98
117_G	121_Q	0.583	0.98
354_S	491_Q	0.583	0.98
237_A	245_T	0.583	0.98
377_Q	381_Q	0.582	0.98
293_N	296_G	0.581	0.98
118_Y	124_K	0.581	0.98
142_M	147_R	0.581	0.98
344_T	389_A	0.581	0.98
118_Y	123_T	0.581	0.98
132_E	137_T	0.580	0.98
409_L	445_F	0.580	0.98
470_V	522_T	0.579	0.98
283_I	286_K	0.579	0.98
299_V	303_R	0.579	0.98
127_A	133_S	0.578	0.98
351_N	355_T	0.578	0.98
48_Y	52_H	0.578	0.98
62_K	66_S	0.577	0.98
352_W	509_L	0.577	0.98
351_N	379_Q	0.577	0.98
484_L	496_R	0.576	0.98
444_A	473_V	0.575	0.98
421_L	426_P	0.575	0.98
144_M	147_R	0.575	0.98
281_E	284_D	0.573	0.98
138_G	147_R	0.571	0.98
314_G	319_F	0.570	0.98
146_M	172_I	0.570	0.98
75_K	79_Y	0.570	0.98
146_M	150_T	0.567	0.98
278_F	281_E	0.565	0.98
346_R	446_E	0.565	0.98
282_Q	315_A	0.564	0.98
398_L	434_A	0.564	0.98
348_E	501_G	0.562	0.98
350_L	354_S	0.562	0.98
297_L	302_N	0.562	0.98
222_R	226_A	0.560	0.98
433_F	537_I	0.560	0.98
59_N	63_I	0.560	0.98
363_K	367_R	0.559	0.98
147_R	153_F	0.557	0.98
492_G	505_I	0.556	0.98
282_Q	305_A	0.556	0.98
139_K	153_F	0.555	0.98
348_E	439_N	0.555	0.98
257_L	264_W	0.553	0.97
138_G	142_M	0.553	0.97
289_D	301_A	0.553	0.97
308_S	312_L	0.552	0.97
195_M	199_W	0.551	0.97
489_F	511_A	0.549	0.97
406_A	411_L	0.549	0.97
228_F	237_A	0.549	0.97
157_G	163_V	0.548	0.97
479_G	530_G	0.548	0.97
235_L	316_I	0.548	0.97
88_K	91_R	0.547	0.97
266_G	272_V	0.547	0.97
411_L	415_I	0.546	0.97
488_I	508_Y	0.546	0.97
218_A	225_E	0.546	0.97
402_K	438_G	0.546	0.97
464_D	469_V	0.545	0.97
141_S	147_R	0.544	0.97
375_E	380_Q	0.544	0.97
351_N	446_E	0.544	0.97
75_K	78_D	0.543	0.97
323_D	327_T	0.542	0.97
507_L	533_F	0.541	0.97
151_P	159_V	0.541	0.97
349_H	359_L	0.541	0.97
345_L	354_S	0.540	0.97
85_I	88_K	0.540	0.97
344_T	354_S	0.540	0.97
443_N	506_G	0.539	0.97
351_N	383_I	0.537	0.97
251_A	317_I	0.537	0.97
351_N	496_R	0.535	0.97
206_R	209_M	0.535	0.97
227_L	231_V	0.535	0.97
255_L	319_F	0.534	0.97
375_E	387_R	0.534	0.97
341_S	345_L	0.533	0.97
63_I	67_N	0.533	0.97
223_Q	226_A	0.532	0.97
347_H	352_W	0.531	0.97
125_Q	130_K	0.531	0.97
345_L	355_T	0.530	0.97
130_K	134_Y	0.529	0.97
480_V	533_F	0.528	0.97
192_G	196_L	0.528	0.97
96_D	110_H	0.527	0.97
472_E	524_E	0.527	0.97
236_I	247_I	0.526	0.97
178_E	182_P	0.526	0.97
55_D	58_M	0.525	0.97
376_S	379_Q	0.524	0.96
223_Q	237_A	0.524	0.96
35_A	40_Y	0.524	0.96
472_E	535_I	0.523	0.96
340_E	344_T	0.523	0.96
168_L	173_D	0.522	0.96
390_F	518_G	0.522	0.96
394_Q	398_L	0.521	0.96
340_E	491_Q	0.521	0.96
151_P	162_V	0.519	0.96
48_Y	51_L	0.519	0.96
353_M	379_Q	0.518	0.96
448_S	478_C	0.518	0.96
202_A	205_I	0.518	0.96
166_G	169_V	0.517	0.96
348_E	510_I	0.517	0.96
322_K	325_I	0.515	0.96
282_Q	285_E	0.515	0.96
226_A	230_S	0.514	0.96
354_S	375_E	0.514	0.96
356_L	375_E	0.513	0.96
348_E	375_E	0.512	0.96
139_K	145_A	0.512	0.96
344_T	351_N	0.512	0.96
49_L	54_R	0.511	0.96
498_D	501_G	0.511	0.96
491_Q	505_I	0.511	0.96
227_L	230_S	0.510	0.96
269_I	303_R	0.509	0.96
418_G	421_L	0.508	0.96
165_I	172_I	0.508	0.96
255_L	291_V	0.507	0.96
412_K	415_I	0.507	0.96
291_V	295_N	0.506	0.96
409_L	413_M	0.506	0.96
101_G	105_S	0.506	0.96
492_G	508_Y	0.502	0.96
441_L	445_F	0.501	0.95
384_D	388_E	0.501	0.95
108_L	111_P	0.500	0.95
19_P	203_A	0.500	0.95
491_Q	508_Y	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.587	100	0.467	Contact Map
4gczA	2	0.5924	100	0.486	Contact Map
3a0rA	2	0.5507	100	0.498	Contact Map
4r3aA	1	0.5326	100	0.582	Contact Map
2c2aA	2	0.3895	100	0.617	Contact Map
3jz3A	2	0.2518	100	0.619	Contact Map
2q8gA	2	0.5254	100	0.624	Contact Map
4q20A	2	0.3804	100	0.629	Contact Map
4mpcA	2	0.5344	100	0.629	Contact Map
4e01A	3	0.4891	100	0.63	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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