GREMLIN Database
YCJS - Uncharacterized oxidoreductase YcjS
UniProt: P77503 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13916
Length: 351 (315)
Sequences: 25648 (19340)
Seq/√Len: 1089.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_Q91_M3.1441.00
133_R192_D2.8471.00
90_L118_T2.8121.00
86_Y114_E2.8121.00
11_R36_E2.7731.00
205_S242_E2.7671.00
45_L49_Q2.7031.00
152_E272_D2.7001.00
113_R330_Y2.6891.00
140_Q143_E2.6871.00
94_E118_T2.6721.00
204_K244_H2.4891.00
90_L94_E2.4281.00
80_S88_H2.4131.00
13_A67_M2.4031.00
142_R146_T2.4021.00
86_Y111_Q2.3961.00
90_L114_E2.3861.00
98_H125_V2.3321.00
239_G339_L2.2641.00
93_L124_K2.2181.00
63_D66_A2.2001.00
39_A61_W2.1681.00
84_F88_H2.1111.00
9_P36_E2.0951.00
117_D121_K2.0621.00
314_N318_G2.0591.00
59_S70_A2.0251.00
143_E147_N2.0101.00
120_R327_E1.9991.00
86_Y90_L1.9851.00
89_T101_C1.9771.00
140_Q144_Q1.9481.00
49_Q53_E1.9261.00
75_V312_F1.9081.00
93_L119_A1.8651.00
113_R334_Q1.8641.00
80_S84_F1.8541.00
113_R117_D1.8491.00
118_T122_L1.8401.00
87_E91_M1.8311.00
150_L271_G1.7811.00
98_H124_K1.7791.00
243_F249_L1.7691.00
94_E122_L1.7561.00
13_A73_P1.7551.00
109_P337_A1.7151.00
12_V75_V1.7101.00
44_R47_Q1.7081.00
76_V92_A1.6961.00
29_Y77_S1.6651.00
108_T111_Q1.6551.00
89_T115_M1.6441.00
34_D317_Q1.6361.00
35_L313_I1.6141.00
68_L92_A1.6061.00
126_L326_A1.5931.00
73_P97_C1.5921.00
62_D66_A1.5821.00
69_L95_A1.5741.00
210_S343_A1.5741.00
142_R196_Y1.5661.00
32_R310_E1.5521.00
129_D308_S1.5441.00
141_L276_A1.5421.00
204_K242_E1.5231.00
94_E121_K1.5171.00
64_P91_M1.5141.00
125_V319_K1.5111.00
116_C330_Y1.4751.00
107_M111_Q1.4691.00
144_Q149_V1.4681.00
116_C326_A1.4671.00
50_A54_K1.4571.00
154_Y272_D1.4481.00
61_W70_A1.4471.00
331_I334_Q1.4471.00
118_T121_K1.4381.00
66_A69_L1.4331.00
65_Q69_L1.4321.00
157_T268_S1.4281.00
23_K54_K1.4191.00
86_Y115_M1.4101.00
91_M94_E1.3901.00
45_L62_D1.3871.00
93_L122_L1.3741.00
61_W67_M1.3681.00
106_A115_M1.3531.00
106_A112_A1.3511.00
198_L247_G1.3491.00
11_R38_V1.3471.00
314_N320_P1.3431.00
268_S277_T1.3311.00
11_R74_D1.3281.00
200_F244_H1.3171.00
203_V243_F1.3101.00
209_H242_E1.3001.00
112_A330_Y1.2881.00
109_P334_Q1.2851.00
109_P113_R1.2841.00
91_M95_A1.2831.00
200_F245_N1.2791.00
150_L274_A1.2751.00
48_A60_V1.2751.00
311_A315_H1.2741.00
195_M331_I1.2721.00
41_C64_P1.2691.00
17_A40_V1.2591.00
66_A70_A1.2351.00
195_M243_F1.2291.00
78_V88_H1.2241.00
92_A99_V1.2151.00
46_S49_Q1.2061.00
41_C67_M1.2001.00
153_I269_F1.1991.00
114_E117_D1.1971.00
50_A53_E1.1961.00
191_L335_L1.1891.00
157_T252_E1.1871.00
96_G122_L1.1811.00
39_A67_M1.1731.00
311_A323_I1.1681.00
64_P88_H1.1631.00
78_V89_T1.1601.00
93_L118_T1.1491.00
52_A60_V1.1461.00
144_Q147_N1.1401.00
105_P112_A1.1381.00
116_C327_E1.1351.00
325_D328_Q1.1271.00
195_M328_Q1.1251.00
310_E314_N1.1211.00
207_N240_T1.1151.00
337_A341_Q1.1111.00
98_H319_K1.1111.00
31_T306_L1.1101.00
338_A341_Q1.1061.00
67_M73_P1.1011.00
313_I317_Q1.0971.00
266_N277_T1.0971.00
64_P68_L1.0931.00
112_A333_Q1.0931.00
114_E118_T1.0881.00
100_M129_D1.0871.00
72_K97_C1.0841.00
71_V97_C1.0821.00
12_V35_L1.0791.00
81_P84_F1.0791.00
117_D120_R1.0781.00
10_L75_V1.0611.00
83_R178_Q1.0611.00
100_M308_S1.0581.00
138_T196_Y1.0581.00
10_L316_V1.0561.00
194_A249_L1.0521.00
68_L91_M1.0471.00
116_C120_R1.0421.00
156_T198_L1.0391.00
150_L276_A1.0361.00
39_A73_P1.0221.00
48_A62_D1.0221.00
111_Q114_E1.0201.00
68_L95_A1.0161.00
90_L115_M1.0121.00
15_I88_H1.0111.00
143_E146_T1.0101.00
101_C126_L1.0091.00
311_A320_P1.0041.00
150_L153_I1.0011.00
110_E113_R0.9961.00
70_A73_P0.9941.00
25_H77_S0.9931.00
10_L317_Q0.9911.00
134_F311_A0.9891.00
156_T249_L0.9891.00
307_R310_E0.9721.00
106_A111_Q0.9711.00
27_S31_T0.9671.00
98_H316_V0.9641.00
338_A342_S0.9621.00
341_Q344_E0.9551.00
139_Q323_I0.9531.00
311_A314_N0.9511.00
47_Q50_A0.9501.00
59_S72_K0.9471.00
105_P326_A0.9391.00
203_V241_I0.9391.00
89_T99_V0.9361.00
115_M126_L0.9341.00
314_N319_K0.9291.00
61_W66_A0.9291.00
306_L310_E0.9291.00
141_L278_L0.9271.00
46_S50_A0.9271.00
133_R328_Q0.9251.00
110_E114_E0.9251.00
153_I198_L0.9241.00
175_K178_Q0.9211.00
48_A52_A0.9201.00
285_T288_N0.9181.00
88_H91_M0.9161.00
17_A42_D0.9101.00
109_P330_Y0.9081.00
209_H248_I0.9041.00
153_I271_G0.9031.00
27_S54_K0.8981.00
131_H304_R0.8971.00
9_P34_D0.8961.00
321_V325_D0.8901.00
105_P126_L0.8861.00
86_Y106_A0.8851.00
45_L48_A0.8811.00
327_E331_I0.8761.00
52_A57_N0.8721.00
200_F331_I0.8711.00
34_D310_E0.8701.00
127_A312_F0.8661.00
49_Q60_V0.8641.00
119_A122_L0.8621.00
40_V51_L0.8621.00
340_Y344_E0.8531.00
78_V92_A0.8501.00
158_A267_V0.8471.00
42_D48_A0.8451.00
238_F250_W0.8451.00
284_Y289_G0.8451.00
77_S309_M0.8441.00
49_Q52_A0.8431.00
38_V72_K0.8411.00
334_Q338_A0.8401.00
207_N342_S0.8391.00
45_L60_V0.8351.00
84_F87_E0.8351.00
119_A126_L0.8341.00
93_L99_V0.8301.00
125_V316_V0.8261.00
113_R116_C0.8261.00
101_C105_P0.8231.00
151_G271_G0.8191.00
34_D314_N0.8191.00
13_A39_A0.8181.00
89_T93_L0.8171.00
315_H318_G0.8071.00
13_A41_C0.8071.00
42_D47_Q0.8031.00
29_Y309_M0.8021.00
203_V335_L0.8011.00
200_F203_V0.7991.00
156_T269_F0.7971.00
25_H309_M0.7961.00
12_V29_Y0.7951.00
195_M332_I0.7951.00
11_R73_P0.7911.00
268_S275_G0.7891.00
139_Q143_E0.7891.00
125_V315_H0.7881.00
101_C115_M0.7871.00
208_A339_L0.7861.00
38_V59_S0.7831.00
156_T194_A0.7821.00
191_L336_V0.7801.00
29_Y35_L0.7741.00
119_A124_K0.7741.00
157_T250_W0.7721.00
15_I64_P0.7701.00
151_G274_A0.7681.00
315_H322_M0.7681.00
175_K232_S0.7661.00
119_A326_A0.7631.00
145_V271_G0.7631.00
181_G234_E0.7621.00
203_V244_H0.7601.00
287_N290_E0.7571.00
21_A79_C0.7521.00
158_A190_M0.7511.00
127_A315_H0.7481.00
20_V305_H0.7481.00
315_H320_P0.7461.00
330_Y334_Q0.7441.00
112_A116_C0.7421.00
32_R35_L0.7421.00
266_N279_F0.7421.00
182_P253_T0.7411.00
14_I26_A0.7411.00
70_A97_C0.7381.00
82_N185_D0.7381.00
75_V98_H0.7361.00
241_I249_L0.7321.00
21_A27_S0.7321.00
93_L126_L0.7311.00
15_I80_S0.7311.00
20_V79_C0.7301.00
38_V73_P0.7241.00
20_V25_H0.7241.00
128_Y329_G0.7221.00
152_E273_K0.7161.00
194_A243_F0.7141.00
311_A322_M0.7081.00
312_F316_V0.7051.00
51_L54_K0.7051.00
38_V70_A0.7041.00
15_I41_C0.7031.00
287_N292_M0.7011.00
86_Y118_T0.6981.00
130_F188_I0.6981.00
188_I332_I0.6981.00
183_L336_V0.6981.00
13_A76_V0.6961.00
209_H240_T0.6961.00
240_T248_I0.6961.00
176_E232_S0.6941.00
146_T199_G0.6911.00
159_R252_E0.6901.00
328_Q331_I0.6881.00
234_E340_Y0.6821.00
172_F175_K0.6811.00
26_A37_L0.6811.00
105_P128_Y0.6801.00
205_S209_H0.6781.00
139_Q307_R0.6741.00
96_G124_K0.6741.00
152_E245_N0.6741.00
85_H101_C0.6721.00
158_A194_A0.6711.00
285_T289_G0.6711.00
333_Q337_A0.6711.00
138_T193_A0.6691.00
211_F242_E0.6681.00
101_C128_Y0.6671.00
11_R72_K0.6671.00
93_L115_M0.6661.00
198_L243_F0.6641.00
285_T291_L0.6631.00
17_A48_A0.6631.00
132_H135_A0.6621.00
90_L93_L0.6611.00
12_V313_I0.6611.00
288_N291_L0.6601.00
187_G253_T0.6591.00
145_V269_F0.6571.00
270_C275_G0.6571.00
192_D332_I0.6561.00
185_D255_F0.6551.00
130_F192_D0.6541.00
243_F247_G0.6531.00
305_H308_S0.6511.00
197_V269_F0.6501.00
155_V248_I0.6481.00
87_E114_E0.6471.00
239_G251_L0.6471.00
26_A51_L0.6431.00
51_L55_Y0.6431.00
326_A329_G0.6421.00
187_G190_M0.6421.00
18_G21_A0.6401.00
44_R49_Q0.6391.00
142_R197_V0.6371.00
100_M127_A0.6341.00
242_E248_I0.6331.00
130_F332_I0.6311.00
183_L237_L0.6311.00
76_V97_C0.6301.00
133_R196_Y0.6281.00
23_K27_S0.6231.00
34_D313_I0.6231.00
107_M179_G0.6231.00
284_Y288_N0.6171.00
75_V316_V0.6161.00
64_P92_A0.6161.00
67_M70_A0.6151.00
208_A239_G0.6141.00
125_V321_V0.6131.00
159_R266_N0.6121.00
12_V77_S0.6101.00
97_C124_K0.6091.00
235_D256_A0.6071.00
131_H305_H0.6061.00
89_T126_L0.6061.00
208_A237_L0.6021.00
36_E58_A0.6001.00
65_Q87_E0.5971.00
103_K189_H0.5931.00
254_S257_L0.5921.00
192_D196_Y0.5891.00
286_D289_G0.5871.00
285_T290_E0.5851.00
153_I247_G0.5841.00
32_R313_I0.5841.00
207_N242_E0.5821.00
213_K235_D0.5781.00
127_A311_A0.5781.00
210_S237_L0.5751.00
176_E344_E0.5751.00
195_M335_L0.5741.00
20_V102_E0.5711.00
284_Y291_L0.5711.00
25_H29_Y0.5711.00
191_L339_L0.5691.00
145_V197_V0.5671.00
132_H192_D0.5671.00
155_V270_C0.5671.00
87_E90_L0.5661.00
17_A51_L0.5651.00
77_S100_M0.5641.00
141_L197_V0.5631.00
194_A251_L0.5631.00
21_A51_L0.5601.00
39_A59_S0.5591.00
40_V60_V0.5591.00
290_E293_T0.5581.00
184_I337_A0.5571.00
139_Q196_Y0.5551.00
78_V85_H0.5541.00
148_G152_E0.5531.00
35_L75_V0.5511.00
236_S254_S0.5511.00
240_T250_W0.5471.00
160_A186_I0.5461.00
314_N317_Q0.5461.00
195_M200_F0.5461.00
102_E129_D0.5451.00
27_S30_C0.5451.00
286_D290_E0.5451.00
116_C119_A0.5441.00
164_C168_G0.5421.00
241_I251_L0.5401.00
37_L57_N0.5391.00
10_L35_L0.5391.00
161_L252_E0.5381.00
125_V312_F0.5381.00
286_D291_L0.5381.00
285_T292_M0.5381.00
103_K185_D0.5361.00
83_R107_M0.5361.00
332_I336_V0.5361.00
183_L239_G0.5351.00
80_S85_H0.5331.00
41_C61_W0.5331.00
336_V340_Y0.5311.00
155_V250_W0.5301.00
149_V152_E0.5291.00
89_T119_A0.5281.00
18_G79_C0.5261.00
180_G184_I0.5251.00
43_S80_S0.5251.00
61_W71_V0.5251.00
303_N306_L0.5211.00
173_T185_D0.5191.00
108_T337_A0.5181.00
15_I76_V0.5171.00
19_Q24_V0.5161.00
189_H192_D0.5141.00
65_Q95_A0.5131.00
134_F324_A0.5131.00
296_Q299_I0.5111.00
289_G292_M0.5111.00
79_C102_E0.5101.00
94_E114_E0.5101.00
238_F252_E0.5101.00
271_G276_A0.5091.00
148_G271_G0.5081.00
128_Y189_H0.5081.00
288_N293_T0.5061.00
125_V322_M0.5051.00
15_I78_V0.5051.00
136_L307_R0.5041.00
283_I289_G0.5021.00
179_G233_V0.5011.00
14_I37_L0.5011.00
302_D306_L0.5001.00
53_E60_V0.5001.00
273_K287_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h6dA 8 0.9544 100 0.171 Contact Map
1zh8A 2 0.9003 100 0.178 Contact Map
3dtyA 4 0.9088 100 0.186 Contact Map
2nvwA 3 0.9601 100 0.195 Contact Map
3v5nA 4 0.8832 100 0.199 Contact Map
3moiA 2 0.9259 100 0.212 Contact Map
3oqbA 4 0.963 100 0.212 Contact Map
3q2iA 4 0.9316 100 0.212 Contact Map
4mkxA 4 0.9288 100 0.213 Contact Map
4gqaA 4 0.963 100 0.215 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0099 seconds.