PRPE - ECOLI - GREMLIN Contacts

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PRPE - Propionate--CoA ligase

UniProt:	P77495	Sequences: MSFSEFYQRSINEPEQFWAEQARRIDWQTPFTQTLDHSNPPFARWFCEGRTNLCHNAIDRWLEKQPEALALIAVSSETEEERTFTFRQLHDEVNAVASMLRSLGVQRGDRVLVYMPMIAEAHITLLACARIGAIHSVVFGGFASHSVAARIDDAKPVLIVSADAGARGGKIIPYKKLLDDAISQAQHQPRHVLLVDRGLAKMARVSGRDVDFASLRHQHIGARVPVAWLESNETSCILYTSGTTGKPKGVQRDVGGYAVALATSMDTIFGGKAGSVFFCASDIGWVVGHSYIVYAPLLAGMATIVYEGLPTWPDCGVWWTIVEKYQVSRMFSAPTAIRVLKKFPTAEIRKHDLSSLEVLYLAGEPLDEPTASWVSNTLDVPVIDNYWQTESGWPIMAIARGLDDRPTRLGSPGVPMYGYNVQLLNEVTGEPCGVNEKGMLVVEGPLPPGCIQTIWGDDGRFVKTYWSLFSRPVYATFDWGIRDADGYHFILGRTDDVINVAGHRLGTREIEESISSHPGVAEVAVVGVKDALKGQVAVAFVIPKESDSLEDRDVAHSQEKAIMALVDSQIGNFGRPAHVWFVSQLPKTRSGKMLRRTIQAICEGRDPGDLTTIDDPASLDQIRQAMEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13604
Length:	628 (501)
Sequences:	68474 (48728)
Seq/√Len:	2177.0

ECOLI - PRPE ACSA ENTF AAS FADK LCFA CAIC ENTE MENE PAAK
BACSU - PPSE SRFAC PPSB PPSC ACSA YNGI LCFA LCFB DHBE YDAB YTCI MENE DLTA YHFT DHBF PKSJ SRFAA SRFAB PPSD PKSN PPSA
HALSA - Q9HRY8 Q9HQU8 Q9HSM3 Q9HNK0 Q9HQ43 Q9HQN8
SULSO - Q97UX8 Q97WQ9 Q97U22 Q97WQ0 Q97YK9 Q97VT6 Q97UW7 Q97VU7 Q97WK0 Q97UF6 Q97XW4 Q97V27 Q97WS5 Q980E4 Q97X52 Q97XW5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
234_T	251_Q	4.027	1.00
440_L	480_G	3.297	1.00
517_H	565_L	3.147	1.00
153_D	239_Y	3.005	1.00
94_N	130_R	2.949	1.00
457_D	460_R	2.935	1.00
420_N	443_E	2.912	1.00
105_V	133_A	2.911	1.00
253_D	452_Q	2.814	1.00
109_D	157_V	2.764	1.00
112_L	156_P	2.742	1.00
90_H	130_R	2.717	1.00
481_I	489_F	2.628	1.00
72_I	302_A	2.557	1.00
110_R	136_S	2.501	1.00
155_K	456_G	2.427	1.00
69_L	83_T	2.424	1.00
276_V	302_A	2.407	1.00
522_E	587_K	2.364	1.00
439_M	475_A	2.357	1.00
499_N	504_R	2.334	1.00
437_K	479_W	2.304	1.00
59_D	90_H	2.302	1.00
425_N	430_E	2.301	1.00
65_Q	68_A	2.291	1.00
424_L	441_V	2.267	1.00
515_S	523_V	2.231	1.00
99_M	103_L	2.231	1.00
422_Q	431_P	2.230	1.00
514_I	539_A	2.204	1.00
124_T	160_V	2.181	1.00
320_T	324_K	2.160	1.00
153_D	457_D	2.146	1.00
61_W	65_Q	2.137	1.00
92_E	123_I	2.110	1.00
275_S	357_E	2.083	1.00
149_A	246_K	2.076	1.00
516_S	569_Q	2.073	1.00
73_A	119_A	2.061	1.00
441_V	475_A	2.014	1.00
230_E	233_E	2.013	1.00
90_H	94_N	2.003	1.00
460_R	463_K	1.978	1.00
538_V	580_W	1.969	1.00
483_D	489_F	1.958	1.00
594_L	597_T	1.945	1.00
96_V	123_I	1.934	1.00
411_S	489_F	1.927	1.00
107_R	233_E	1.921	1.00
425_N	428_T	1.905	1.00
157_V	190_R	1.905	1.00
275_S	328_S	1.892	1.00
128_C	133_A	1.870	1.00
67_E	87_R	1.868	1.00
148_A	152_D	1.861	1.00
496_D	595_R	1.853	1.00
458_D	462_V	1.853	1.00
108_G	233_E	1.848	1.00
101_R	131_I	1.796	1.00
483_D	487_Y	1.793	1.00
93_V	130_R	1.782	1.00
368_E	372_S	1.779	1.00
72_I	83_T	1.775	1.00
106_Q	109_D	1.733	1.00
482_R	488_H	1.731	1.00
500_V	505_L	1.724	1.00
437_K	491_L	1.694	1.00
87_R	91_D	1.693	1.00
304_I	327_V	1.690	1.00
481_I	491_L	1.689	1.00
72_I	325_Y	1.688	1.00
60_R	64_K	1.686	1.00
422_Q	441_V	1.676	1.00
511_E	525_V	1.669	1.00
597_T	600_A	1.668	1.00
253_D	256_G	1.661	1.00
116_P	162_A	1.656	1.00
326_Q	355_S	1.655	1.00
52_N	60_R	1.654	1.00
122_H	293_V	1.635	1.00
423_L	480_G	1.635	1.00
509_E	574_G	1.633	1.00
434_V	482_R	1.633	1.00
521_A	544_K	1.625	1.00
234_T	452_Q	1.618	1.00
129_A	235_S	1.615	1.00
515_S	522_E	1.592	1.00
103_L	191_H	1.588	1.00
148_A	184_Q	1.583	1.00
525_V	539_A	1.571	1.00
540_F	598_I	1.569	1.00
519_G	561_A	1.562	1.00
112_L	138_V	1.556	1.00
459_G	463_K	1.548	1.00
542_I	585_L	1.539	1.00
94_N	98_S	1.533	1.00
381_P	399_A	1.529	1.00
433_G	436_E	1.512	1.00
317_V	320_T	1.510	1.00
395_I	442_V	1.507	1.00
59_D	130_R	1.504	1.00
84_F	123_I	1.504	1.00
85_T	88_Q	1.502	1.00
99_M	215_L	1.499	1.00
61_W	64_K	1.496	1.00
526_V	540_F	1.492	1.00
73_A	80_E	1.491	1.00
232_N	255_G	1.487	1.00
68_A	274_G	1.486	1.00
256_G	392_G	1.481	1.00
565_L	569_Q	1.476	1.00
372_S	376_N	1.470	1.00
154_A	239_Y	1.468	1.00
332_S	337_I	1.465	1.00
69_L	302_A	1.460	1.00
296_P	301_M	1.450	1.00
69_L	72_I	1.448	1.00
66_P	87_R	1.443	1.00
513_S	569_Q	1.442	1.00
543_P	581_F	1.440	1.00
560_K	564_A	1.430	1.00
237_I	455_W	1.426	1.00
425_N	432_C	1.421	1.00
62_L	90_H	1.417	1.00
541_V	581_F	1.414	1.00
563_M	579_V	1.410	1.00
251_Q	453_T	1.406	1.00
111_V	128_C	1.406	1.00
278_F	327_V	1.406	1.00
408_R	485_D	1.406	1.00
421_V	442_V	1.405	1.00
84_F	119_A	1.398	1.00
111_V	133_A	1.398	1.00
70_A	89_L	1.397	1.00
480_G	490_I	1.392	1.00
541_V	579_V	1.389	1.00
335_T	364_E	1.384	1.00
275_S	329_R	1.382	1.00
239_Y	249_G	1.380	1.00
426_E	494_T	1.379	1.00
272_K	275_S	1.378	1.00
588_T	594_L	1.377	1.00
563_M	567_D	1.376	1.00
396_M	421_V	1.375	1.00
443_E	473_V	1.374	1.00
451_I	465_Y	1.373	1.00
110_R	134_I	1.372	1.00
461_F	465_Y	1.370	1.00
323_E	351_H	1.365	1.00
266_D	299_A	1.359	1.00
388_Q	474_Y	1.358	1.00
151_I	156_P	1.358	1.00
529_K	535_Q	1.347	1.00
108_G	452_Q	1.345	1.00
337_I	359_L	1.338	1.00
267_T	417_Y	1.331	1.00
251_Q	455_W	1.330	1.00
153_D	456_G	1.328	1.00
112_L	151_I	1.328	1.00
519_G	547_D	1.314	1.00
96_V	127_A	1.313	1.00
276_V	327_V	1.310	1.00
314_D	317_V	1.308	1.00
306_Y	321_I	1.308	1.00
464_T	474_Y	1.306	1.00
437_K	481_I	1.303	1.00
127_A	131_I	1.299	1.00
105_V	111_V	1.295	1.00
564_A	568_S	1.294	1.00
110_R	237_I	1.292	1.00
134_I	234_T	1.290	1.00
83_T	325_Y	1.289	1.00
110_R	455_W	1.288	1.00
322_V	355_S	1.287	1.00
231_S	255_G	1.280	1.00
73_A	82_R	1.275	1.00
498_I	507_T	1.271	1.00
276_V	304_I	1.267	1.00
136_S	154_A	1.264	1.00
105_V	109_D	1.262	1.00
479_W	494_T	1.259	1.00
144_S	180_D	1.255	1.00
321_I	325_Y	1.255	1.00
361_L	366_L	1.252	1.00
530_D	536_V	1.248	1.00
408_R	487_Y	1.233	1.00
540_F	582_V	1.232	1.00
113_V	124_T	1.224	1.00
211_D	214_S	1.218	1.00
126_L	297_L	1.212	1.00
149_A	153_D	1.210	1.00
414_V	487_Y	1.208	1.00
91_D	95_A	1.208	1.00
138_V	147_V	1.203	1.00
567_D	575_R	1.202	1.00
92_E	95_A	1.200	1.00
163_D	196_D	1.199	1.00
287_V	331_F	1.194	1.00
90_H	224_V	1.192	1.00
528_V	538_V	1.191	1.00
567_D	572_N	1.185	1.00
330_M	356_L	1.169	1.00
158_L	191_H	1.162	1.00
538_V	578_H	1.159	1.00
240_T	250_V	1.158	1.00
460_R	464_T	1.157	1.00
565_L	568_S	1.156	1.00
89_L	126_L	1.155	1.00
342_K	373_W	1.151	1.00
256_G	450_C	1.149	1.00
153_D	246_K	1.149	1.00
539_A	579_V	1.147	1.00
508_R	512_E	1.138	1.00
440_L	490_I	1.136	1.00
540_F	599_Q	1.134	1.00
229_L	233_E	1.133	1.00
251_Q	452_Q	1.132	1.00
144_S	148_A	1.132	1.00
96_V	160_V	1.132	1.00
88_Q	91_D	1.130	1.00
527_G	535_Q	1.128	1.00
522_E	542_I	1.128	1.00
152_D	246_K	1.126	1.00
503_H	573_F	1.121	1.00
432_C	436_E	1.121	1.00
105_V	158_L	1.120	1.00
374_V	378_L	1.115	1.00
415_P	421_V	1.114	1.00
59_D	94_N	1.112	1.00
398_I	487_Y	1.108	1.00
329_R	358_V	1.105	1.00
92_E	120_E	1.105	1.00
237_I	249_G	1.101	1.00
53_L	56_N	1.101	1.00
252_R	256_G	1.101	1.00
99_M	102_S	1.098	1.00
255_G	445_P	1.093	1.00
422_Q	473_V	1.088	1.00
550_E	561_A	1.084	1.00
93_V	127_A	1.083	1.00
536_V	577_A	1.077	1.00
582_V	585_L	1.070	1.00
82_R	119_A	1.070	1.00
439_M	494_T	1.069	1.00
115_M	195_V	1.068	1.00
121_A	283_I	1.065	1.00
566_V	575_R	1.064	1.00
304_I	321_I	1.061	1.00
419_Y	449_G	1.060	1.00
275_S	301_M	1.054	1.00
149_A	239_Y	1.054	1.00
232_N	253_D	1.052	1.00
84_F	92_E	1.051	1.00
144_S	177_L	1.046	1.00
513_S	566_V	1.045	1.00
316_G	343_F	1.044	1.00
72_I	304_I	1.044	1.00
97_A	130_R	1.043	1.00
70_A	86_F	1.042	1.00
540_F	602_C	1.041	1.00
114_Y	147_V	1.040	1.00
367_D	370_T	1.031	1.00
497_V	506_G	1.030	1.00
396_M	488_H	1.026	1.00
109_D	133_A	1.024	1.00
536_V	578_H	1.024	1.00
89_L	123_I	1.023	1.00
582_V	601_I	1.021	1.00
412_P	490_I	1.019	1.00
496_D	508_R	1.017	1.00
146_S	574_G	1.015	1.00
52_N	56_N	1.013	1.00
511_E	595_R	1.012	1.00
469_F	475_A	1.011	1.00
423_L	432_C	1.011	1.00
442_V	476_T	1.003	1.00
338_R	370_T	1.002	1.00
517_H	561_A	1.001	1.00
398_I	411_S	1.001	1.00
571_G	574_G	1.000	1.00
277_F	296_P	0.999	1.00
517_H	562_I	0.996	1.00
69_L	85_T	0.995	1.00
259_V	418_G	0.992	1.00
501_A	533_K	0.991	1.00
68_A	302_A	0.991	1.00
193_L	197_R	0.991	1.00
585_L	593_M	0.987	1.00
524_A	585_L	0.986	1.00
241_S	590_S	0.986	1.00
564_A	567_D	0.986	1.00
304_I	325_Y	0.985	1.00
373_W	377_T	0.985	1.00
276_V	328_S	0.983	1.00
238_L	389_T	0.979	1.00
281_S	287_V	0.979	1.00
596_R	600_A	0.976	1.00
82_R	92_E	0.975	1.00
421_V	440_L	0.973	1.00
250_V	451_I	0.972	1.00
162_A	165_G	0.969	1.00
341_K	373_W	0.969	1.00
528_V	578_H	0.966	1.00
561_A	564_A	0.966	1.00
513_S	516_S	0.964	1.00
441_V	473_V	0.959	1.00
479_W	492_G	0.959	1.00
421_V	488_H	0.952	1.00
100_L	128_C	0.950	1.00
260_A	393_W	0.949	1.00
562_I	579_V	0.949	1.00
110_R	155_K	0.947	1.00
516_S	565_L	0.945	1.00
498_I	537_A	0.945	1.00
58_I	62_L	0.945	1.00
366_L	371_A	0.943	1.00
71_L	122_H	0.943	1.00
259_V	445_P	0.942	1.00
105_V	131_I	0.941	1.00
84_F	89_L	0.936	1.00
296_P	303_T	0.936	1.00
597_T	601_I	0.932	1.00
500_V	527_G	0.929	1.00
81_E	324_K	0.928	1.00
142_F	150_R	0.921	1.00
112_L	159_I	0.917	1.00
521_A	542_I	0.917	1.00
80_E	307_E	0.915	1.00
98_S	225_P	0.913	1.00
90_H	93_V	0.911	1.00
91_D	222_A	0.911	1.00
89_L	93_V	0.908	1.00
145_H	569_Q	0.907	1.00
444_G	450_C	0.905	1.00
101_R	225_P	0.904	1.00
103_L	158_L	0.902	1.00
443_E	471_R	0.898	1.00
96_V	124_T	0.897	1.00
145_H	148_A	0.894	1.00
278_F	306_Y	0.891	1.00
73_A	81_E	0.888	1.00
98_S	101_R	0.887	1.00
425_N	436_E	0.883	1.00
369_P	373_W	0.881	1.00
149_A	457_D	0.880	1.00
119_A	123_I	0.880	1.00
139_F	284_G	0.879	1.00
360_Y	385_N	0.878	1.00
261_L	298_L	0.874	1.00
115_M	118_I	0.871	1.00
423_L	488_H	0.871	1.00
102_S	218_Q	0.866	1.00
101_R	106_Q	0.864	1.00
411_S	487_Y	0.863	1.00
55_H	229_L	0.863	1.00
149_A	152_D	0.860	1.00
98_S	221_G	0.860	1.00
440_L	488_H	0.857	1.00
529_K	532_L	0.857	1.00
391_S	474_Y	0.857	1.00
60_R	63_E	0.856	1.00
252_R	392_G	0.853	1.00
313_P	336_A	0.853	1.00
331_F	394_P	0.850	1.00
71_L	119_A	0.849	1.00
373_W	376_N	0.848	1.00
100_L	160_V	0.848	1.00
424_L	431_P	0.844	1.00
72_I	276_V	0.841	1.00
274_G	328_S	0.839	1.00
462_V	465_Y	0.837	1.00
339_V	532_L	0.834	1.00
561_A	565_L	0.834	1.00
519_G	544_K	0.832	1.00
145_H	149_A	0.832	1.00
159_I	178_L	0.831	1.00
234_T	253_D	0.831	1.00
125_L	135_H	0.830	1.00
286_V	388_Q	0.825	1.00
235_S	254_V	0.824	1.00
116_P	164_A	0.818	1.00
338_R	367_D	0.817	1.00
82_R	120_E	0.808	1.00
68_A	273_A	0.807	1.00
543_P	549_L	0.807	1.00
408_R	483_D	0.805	1.00
356_L	359_L	0.805	1.00
429_G	441_V	0.803	1.00
113_V	135_H	0.803	1.00
123_I	127_A	0.802	1.00
457_D	461_F	0.801	1.00
337_I	374_V	0.800	1.00
88_Q	92_E	0.797	1.00
524_A	598_I	0.797	1.00
128_C	135_H	0.796	1.00
252_R	451_I	0.793	1.00
120_E	123_I	0.793	1.00
235_S	257_Y	0.789	1.00
122_H	305_V	0.787	1.00
280_A	336_A	0.786	1.00
136_S	156_P	0.786	1.00
57_A	262_A	0.786	1.00
163_D	197_R	0.782	1.00
286_V	393_W	0.778	1.00
276_V	326_Q	0.778	1.00
459_G	462_V	0.778	1.00
58_I	126_L	0.777	1.00
62_L	66_P	0.776	1.00
465_Y	475_A	0.773	1.00
540_F	601_I	0.773	1.00
519_G	543_P	0.770	1.00
123_I	212_F	0.770	1.00
59_D	63_E	0.769	1.00
97_A	131_I	0.766	1.00
112_L	136_S	0.764	1.00
56_N	60_R	0.761	1.00
89_L	122_H	0.761	1.00
150_R	249_G	0.760	1.00
69_L	73_A	0.759	1.00
369_P	372_S	0.757	1.00
55_H	254_V	0.756	1.00
65_Q	87_R	0.756	1.00
391_S	442_V	0.755	1.00
391_S	450_C	0.754	1.00
358_V	383_I	0.754	1.00
461_F	464_T	0.753	1.00
125_L	289_H	0.753	1.00
333_A	336_A	0.752	1.00
236_C	252_R	0.751	1.00
421_V	480_G	0.748	1.00
514_I	523_V	0.748	1.00
344_P	348_I	0.748	1.00
444_G	449_G	0.745	1.00
291_Y	331_F	0.744	1.00
366_L	382_V	0.744	1.00
337_I	361_L	0.743	1.00
538_V	602_C	0.743	1.00
426_E	439_M	0.743	1.00
470_S	475_A	0.743	1.00
435_N	484_A	0.741	1.00
541_V	562_I	0.741	1.00
551_D	560_K	0.739	1.00
323_E	352_D	0.739	1.00
229_L	254_V	0.739	1.00
529_K	534_G	0.736	1.00
124_T	128_C	0.735	1.00
529_K	533_K	0.735	1.00
500_V	577_A	0.732	1.00
420_N	473_V	0.731	1.00
57_A	61_W	0.730	1.00
271_G	329_R	0.730	1.00
316_G	320_T	0.730	1.00
600_A	603_E	0.726	1.00
81_E	325_Y	0.725	1.00
524_A	593_M	0.722	1.00
128_C	131_I	0.722	1.00
507_T	525_V	0.721	1.00
551_D	581_F	0.721	1.00
351_H	354_S	0.720	1.00
328_S	357_E	0.719	1.00
161_S	194_L	0.717	1.00
271_G	275_S	0.716	1.00
260_A	291_Y	0.716	1.00
55_H	129_A	0.714	1.00
102_S	220_I	0.713	1.00
95_A	99_M	0.713	1.00
422_Q	443_E	0.711	1.00
98_S	222_A	0.711	1.00
114_Y	159_I	0.711	1.00
56_N	59_D	0.711	1.00
563_M	575_R	0.708	1.00
323_E	354_S	0.708	1.00
95_A	222_A	0.707	1.00
145_H	246_K	0.706	1.00
115_M	160_V	0.706	1.00
500_V	537_A	0.706	1.00
135_H	289_H	0.705	1.00
67_E	85_T	0.704	1.00
560_K	563_M	0.703	1.00
161_S	165_G	0.702	1.00
285_W	503_H	0.700	1.00
98_S	223_R	0.700	1.00
434_V	484_A	0.697	1.00
278_F	321_I	0.696	1.00
526_V	602_C	0.696	1.00
115_M	121_A	0.695	1.00
58_I	90_H	0.694	1.00
331_F	385_N	0.694	1.00
385_N	394_P	0.693	1.00
155_K	455_W	0.692	1.00
167_R	177_L	0.692	1.00
96_V	100_L	0.689	1.00
287_V	362_A	0.689	1.00
480_G	488_H	0.688	1.00
338_R	373_W	0.688	1.00
542_I	584_Q	0.688	1.00
260_A	392_G	0.688	1.00
358_V	381_P	0.687	1.00
306_Y	318_W	0.687	1.00
322_V	327_V	0.686	1.00
359_L	374_V	0.685	1.00
112_L	154_A	0.685	1.00
480_G	491_L	0.683	1.00
271_G	301_M	0.682	1.00
563_M	566_V	0.681	1.00
423_L	482_R	0.681	1.00
106_Q	157_V	0.681	1.00
280_A	333_A	0.681	1.00
391_S	395_I	0.681	1.00
566_V	570_I	0.680	1.00
86_F	301_M	0.680	1.00
546_S	549_L	0.678	1.00
114_Y	165_G	0.677	1.00
320_T	323_E	0.676	1.00
214_S	217_H	0.676	1.00
384_D	410_G	0.674	1.00
83_T	302_A	0.674	1.00
423_L	440_L	0.674	1.00
496_D	511_E	0.673	1.00
55_H	59_D	0.668	1.00
416_M	419_Y	0.667	1.00
111_V	158_L	0.667	1.00
101_R	227_A	0.666	1.00
345_T	373_W	0.666	1.00
513_S	565_L	0.665	1.00
317_V	321_I	0.664	1.00
98_S	220_I	0.663	1.00
153_D	455_W	0.662	1.00
475_A	494_T	0.661	1.00
61_W	300_G	0.660	1.00
92_E	119_A	0.659	1.00
97_A	127_A	0.658	1.00
543_P	547_D	0.657	1.00
386_Y	395_I	0.655	1.00
94_N	224_V	0.653	1.00
508_R	511_E	0.653	1.00
528_V	536_V	0.653	1.00
507_T	595_R	0.652	1.00
383_I	399_A	0.652	1.00
118_I	162_A	0.652	1.00
443_E	472_P	0.651	1.00
51_T	255_G	0.648	1.00
429_G	475_A	0.648	1.00
260_A	394_P	0.646	1.00
101_R	226_V	0.646	1.00
520_V	541_V	0.645	1.00
322_V	330_M	0.641	1.00
104_G	133_A	0.641	1.00
106_Q	133_A	0.641	1.00
161_S	192_V	0.640	1.00
144_S	184_Q	0.639	1.00
110_R	456_G	0.639	1.00
338_R	342_K	0.638	1.00
100_L	158_L	0.637	1.00
521_A	543_P	0.634	1.00
495_D	535_Q	0.633	1.00
134_I	237_I	0.632	1.00
266_D	295_A	0.632	1.00
224_V	227_A	0.631	1.00
125_L	129_A	0.630	1.00
158_L	193_L	0.628	1.00
338_R	369_P	0.628	1.00
186_Q	189_P	0.627	1.00
572_N	575_R	0.625	1.00
256_G	452_Q	0.624	1.00
442_V	450_C	0.622	1.00
323_E	355_S	0.621	1.00
320_T	351_H	0.621	1.00
63_E	90_H	0.621	1.00
107_R	229_L	0.619	1.00
57_A	258_A	0.618	1.00
101_R	224_V	0.618	1.00
365_P	490_I	0.618	1.00
279_C	292_I	0.617	1.00
268_I	417_Y	0.617	1.00
278_F	322_V	0.617	1.00
292_I	331_F	0.616	1.00
95_A	220_I	0.616	1.00
98_S	224_V	0.615	1.00
115_M	124_T	0.614	1.00
451_I	464_T	0.613	1.00
120_E	162_A	0.613	1.00
272_K	357_E	0.613	1.00
126_L	294_Y	0.613	1.00
96_V	99_M	0.613	1.00
53_L	254_V	0.612	1.00
107_R	227_A	0.610	1.00
530_D	533_K	0.610	1.00
232_N	452_Q	0.609	1.00
535_Q	599_Q	0.608	1.00
245_G	506_G	0.605	1.00
520_V	523_V	0.604	1.00
529_K	603_E	0.604	1.00
330_M	359_L	0.603	1.00
153_D	249_G	0.603	1.00
73_A	307_E	0.602	1.00
469_F	472_P	0.601	1.00
281_S	331_F	0.600	1.00
349_R	377_T	0.600	1.00
96_V	212_F	0.600	1.00
277_F	301_M	0.600	1.00
396_M	412_P	0.599	1.00
313_P	318_W	0.597	1.00
302_A	325_Y	0.596	1.00
424_L	473_V	0.596	1.00
282_D	285_W	0.595	1.00
125_L	293_V	0.595	1.00
134_I	455_W	0.595	1.00
57_A	298_L	0.594	1.00
277_F	329_R	0.592	1.00
65_Q	273_A	0.591	1.00
92_E	216_R	0.591	1.00
450_C	474_Y	0.591	1.00
500_V	533_K	0.591	1.00
331_F	362_A	0.591	1.00
457_D	463_K	0.590	1.00
65_Q	300_G	0.589	1.00
388_Q	391_S	0.588	1.00
521_A	545_E	0.587	1.00
524_A	595_R	0.587	1.00
318_W	322_V	0.587	1.00
69_L	276_V	0.586	1.00
115_M	162_A	0.584	1.00
465_Y	469_F	0.584	1.00
510_I	537_A	0.582	1.00
526_V	599_Q	0.582	1.00
580_W	601_I	0.581	1.00
404_D	407_T	0.580	1.00
514_I	525_V	0.580	1.00
136_S	239_Y	0.580	1.00
84_F	88_Q	0.579	1.00
540_F	580_W	0.577	1.00
93_V	97_A	0.574	1.00
110_R	156_P	0.574	1.00
600_A	604_G	0.574	1.00
586_P	598_I	0.573	1.00
93_V	96_V	0.572	1.00
291_Y	394_P	0.572	1.00
279_C	303_T	0.572	1.00
412_P	480_G	0.572	1.00
94_N	101_R	0.571	1.00
137_V	238_L	0.571	1.00
424_L	429_G	0.569	1.00
375_S	381_P	0.568	1.00
513_S	570_I	0.567	1.00
453_T	458_D	0.566	1.00
361_L	382_V	0.566	1.00
319_W	353_L	0.565	1.00
551_D	579_V	0.564	1.00
437_K	494_T	0.563	1.00
105_V	157_V	0.563	1.00
366_L	384_D	0.562	1.00
71_L	303_T	0.562	1.00
522_E	585_L	0.562	1.00
95_A	98_S	0.561	1.00
125_L	294_Y	0.560	1.00
385_N	397_A	0.560	1.00
100_L	133_A	0.559	1.00
246_K	457_D	0.559	1.00
261_L	294_Y	0.559	1.00
115_M	161_S	0.558	1.00
321_I	324_K	0.557	1.00
374_V	382_V	0.556	1.00
236_C	289_H	0.554	1.00
143_A	146_S	0.554	1.00
236_C	257_Y	0.554	1.00
161_S	166_A	0.554	1.00
146_S	509_E	0.553	1.00
322_V	326_Q	0.550	1.00
154_A	237_I	0.550	1.00
237_I	251_Q	0.550	1.00
500_V	535_Q	0.549	1.00
99_M	216_R	0.549	1.00
458_D	461_F	0.548	1.00
180_D	183_S	0.548	1.00
279_C	305_V	0.547	1.00
145_H	184_Q	0.547	1.00
71_L	84_F	0.547	1.00
183_S	186_Q	0.546	1.00
370_T	373_W	0.545	1.00
511_E	539_A	0.545	1.00
345_T	350_K	0.544	1.00
523_V	566_V	0.542	1.00
514_I	566_V	0.542	1.00
163_D	194_L	0.542	1.00
517_H	520_V	0.542	1.00
372_S	375_S	0.541	1.00
519_G	565_L	0.540	1.00
362_A	385_N	0.539	1.00
99_M	220_I	0.539	1.00
432_C	435_N	0.538	1.00
388_Q	476_T	0.536	1.00
55_H	130_R	0.536	1.00
545_E	548_S	0.536	1.00
362_A	394_P	0.535	1.00
492_G	507_T	0.534	1.00
454_I	461_F	0.534	1.00
71_L	89_L	0.534	1.00
113_V	128_C	0.533	1.00
512_E	516_S	0.533	1.00
420_N	471_R	0.533	1.00
262_A	266_D	0.532	1.00
260_A	265_M	0.530	1.00
287_V	360_Y	0.530	1.00
59_D	224_V	0.530	1.00
280_A	332_S	0.529	1.00
72_I	81_E	0.527	1.00
136_S	150_R	0.525	1.00
95_A	221_G	0.525	1.00
113_V	121_A	0.524	1.00
161_S	178_L	0.523	1.00
154_A	249_G	0.523	1.00
499_N	506_G	0.521	1.00
431_P	482_R	0.521	1.00
465_Y	474_Y	0.520	1.00
86_F	297_L	0.520	1.00
431_P	441_V	0.520	1.00
287_V	393_W	0.519	1.00
142_F	284_G	0.518	1.00
284_G	503_H	0.516	1.00
575_R	579_V	0.516	1.00
507_T	527_G	0.516	1.00
441_V	469_F	0.514	1.00
272_K	328_S	0.512	1.00
160_V	193_L	0.511	1.00
334_P	364_E	0.511	1.00
261_L	295_A	0.511	1.00
435_N	481_I	0.511	1.00
108_G	133_A	0.509	1.00
341_K	370_T	0.508	1.00
279_C	288_G	0.508	1.00
182_I	185_A	0.508	1.00
138_V	151_I	0.508	1.00
291_Y	385_N	0.507	1.00
460_R	465_Y	0.507	1.00
313_P	339_V	0.506	1.00
262_A	298_L	0.506	1.00
580_W	605_R	0.506	1.00
445_P	449_G	0.506	1.00
436_E	481_I	0.505	1.00
56_N	228_W	0.504	1.00
268_I	399_A	0.504	1.00
157_V	191_H	0.504	1.00
359_L	380_V	0.504	1.00
108_G	234_T	0.503	1.00
566_V	569_Q	0.503	1.00
142_F	573_F	0.502	1.00
260_A	395_I	0.501	1.00
278_F	318_W	0.501	1.00
510_I	570_I	0.500	1.00
116_P	165_G	0.500	1.00
469_F	473_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pg4A	1	0.9777	100	0.146	Contact Map
1ry2A	1	0.9586	100	0.155	Contact Map
4wd1A	1	0.9522	100	0.16	Contact Map
3tsyA	2	0.7134	100	0.183	Contact Map
2vsqA	1	0.9029	100	0.185	Contact Map
3etcA	2	0.8424	100	0.201	Contact Map
1mdbA	1	0.8487	100	0.214	Contact Map
3g7sA	2	0.7755	100	0.214	Contact Map
3ni2A	1	0.8264	100	0.214	Contact Map
2d1sA	1	0.8408	100	0.217	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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