GREMLIN Database
YDJH - Uncharacterized sugar kinase YdjH
UniProt: P77493 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13484
Length: 315 (280)
Sequences: 22581 (16821)
Seq/√Len: 1005.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_H268_A3.1601.00
138_S168_C2.7961.00
74_L89_Q2.6951.00
59_A83_D2.5271.00
228_T234_F2.5161.00
235_I280_A2.5141.00
7_I134_A2.4901.00
269_A274_K2.3781.00
275_N278_E2.3281.00
233_C262_F2.2611.00
158_T189_Y2.2281.00
71_Q89_Q2.1471.00
63_R90_D2.0771.00
51_I56_H2.0391.00
217_L236_K2.0111.00
197_F228_T2.0041.00
8_C48_A1.9881.00
269_A282_F1.9681.00
53_R80_E1.9571.00
157_F167_I1.9551.00
168_C267_I1.9521.00
160_A165_M1.9221.00
242_M277_R1.8891.00
63_R125_D1.8831.00
302_N305_L1.8691.00
261_N286_T1.8621.00
49_T80_E1.8581.00
136_L166_I1.8381.00
194_F263_A1.8211.00
272_E303_R1.8201.00
274_K278_E1.8011.00
210_D241_T1.7861.00
235_I242_M1.7581.00
166_I191_D1.7491.00
78_R84_I1.7441.00
213_A236_K1.7271.00
50_I264_S1.7271.00
233_C284_N1.7231.00
191_D222_K1.7221.00
258_A291_V1.6751.00
287_A291_V1.6721.00
136_L168_C1.6701.00
234_F243_K1.6581.00
74_L78_R1.6551.00
76_H79_K1.6501.00
75_D79_K1.6491.00
266_F279_C1.6331.00
293_S305_L1.6141.00
192_Y223_T1.6031.00
265_G286_T1.5961.00
154_T185_E1.5961.00
277_R281_R1.5951.00
215_C219_C1.5881.00
6_V51_I1.5751.00
228_T243_K1.5721.00
159_Q163_R1.5531.00
225_V266_F1.5491.00
51_I268_A1.5251.00
247_V285_A1.5201.00
12_A62_S1.5111.00
155_E158_T1.5081.00
223_T237_R1.5031.00
254_D295_G1.4891.00
235_I276_L1.4771.00
136_L267_I1.4651.00
170_D227_K1.4641.00
38_M72_F1.4631.00
215_C218_A1.4531.00
250_I292_L1.4511.00
237_R240_M1.4511.00
154_T158_T1.4481.00
66_K71_Q1.4431.00
265_G282_F1.4331.00
228_T231_D1.4331.00
155_E159_Q1.4211.00
161_K191_D1.4211.00
244_V280_A1.4181.00
71_Q75_D1.4151.00
190_V193_L1.3531.00
40_T73_I1.3491.00
208_T211_E1.3451.00
66_K89_Q1.3411.00
122_N125_D1.3311.00
45_I77_C1.3211.00
210_D214_D1.3181.00
14_V72_F1.3171.00
132_S163_R1.3111.00
70_G95_T1.3101.00
166_I192_Y1.3071.00
93_I120_K1.3061.00
159_Q162_A1.3051.00
57_R83_D1.3011.00
74_L87_L1.3011.00
206_K215_C1.3001.00
161_K189_Y1.2901.00
214_D218_A1.2841.00
247_V281_R1.2651.00
16_I36_I1.2501.00
244_V284_N1.2491.00
19_Q35_R1.2431.00
265_G283_A1.2381.00
268_A272_E1.2351.00
217_L238_G1.2261.00
214_D241_T1.2201.00
233_C280_A1.2091.00
76_H80_E1.2031.00
247_V284_N1.2021.00
266_F270_L1.2021.00
223_T270_L1.1991.00
40_T76_H1.1981.00
123_I155_E1.1981.00
227_K262_F1.1951.00
223_T276_L1.1901.00
223_T266_F1.1891.00
166_I222_K1.1871.00
110_F113_N1.1871.00
72_F75_D1.1751.00
214_D236_K1.1751.00
236_K241_T1.1711.00
90_D93_I1.1711.00
269_A279_C1.1691.00
228_T232_G1.1681.00
278_E281_R1.1571.00
184_C219_C1.1571.00
71_Q74_L1.1541.00
194_F227_K1.1521.00
16_I38_M1.1501.00
109_T112_T1.1471.00
266_F283_A1.1401.00
54_L265_G1.1351.00
52_S82_I1.1311.00
200_A226_I1.1311.00
131_F134_A1.1301.00
47_E138_S1.1211.00
137_L160_A1.1191.00
56_H271_L1.1101.00
252_A291_V1.1091.00
75_D78_R1.0921.00
289_I292_L1.0861.00
197_F231_D1.0811.00
206_K211_E1.0801.00
48_A58_T1.0771.00
51_I58_T1.0771.00
289_I293_S1.0731.00
139_L167_I1.0661.00
109_T113_N1.0631.00
127_D155_E1.0551.00
12_A73_I1.0541.00
68_A71_Q1.0501.00
66_K92_S1.0491.00
269_A272_E1.0471.00
192_Y266_F1.0431.00
252_A255_T1.0411.00
200_A212_I1.0341.00
138_S267_I1.0341.00
223_T235_I1.0291.00
49_T53_R1.0281.00
158_T162_A1.0261.00
211_E214_D1.0161.00
284_N287_A1.0061.00
192_Y270_L1.0051.00
56_H272_E1.0031.00
137_L165_M1.0021.00
50_I261_N0.9891.00
261_N290_S0.9841.00
247_V288_A0.9801.00
250_I291_V0.9791.00
51_I264_S0.9781.00
266_F276_L0.9781.00
16_I97_I0.9761.00
59_A134_A0.9731.00
59_A130_R0.9731.00
151_K155_E0.9711.00
52_S81_N0.9661.00
59_A86_S0.9561.00
64_I70_G0.9551.00
246_A284_N0.9541.00
169_A190_V0.9531.00
279_C283_A0.9501.00
194_F266_F0.9491.00
213_A226_I0.9451.00
204_T212_I0.9441.00
138_S263_A0.9381.00
139_L157_F0.9381.00
40_T72_F0.9371.00
222_K238_G0.9331.00
9_I137_L0.9321.00
171_M195_P0.9321.00
64_I74_L0.9281.00
54_L286_T0.9281.00
108_R112_T0.9281.00
65_G95_T0.9231.00
17_P39_T0.9221.00
72_F76_H0.9211.00
281_R285_A0.9211.00
8_C44_A0.9191.00
268_A303_R0.9171.00
90_D120_K0.9171.00
18_L99_V0.9161.00
19_Q37_A0.9151.00
6_V271_L0.9121.00
268_A282_F0.9111.00
16_I69_A0.9101.00
240_M277_R0.9101.00
129_A132_S0.9081.00
12_A60_L0.9061.00
67_D95_T0.9051.00
52_S57_R0.9001.00
274_K282_F0.8991.00
64_I87_L0.8991.00
179_T182_D0.8981.00
197_F201_K0.8861.00
134_A165_M0.8851.00
84_I87_L0.8841.00
74_L84_I0.8761.00
7_I61_M0.8741.00
139_L153_L0.8681.00
252_A292_L0.8671.00
270_L279_C0.8601.00
231_D243_K0.8561.00
12_A45_I0.8551.00
9_I156_I0.8551.00
232_G246_A0.8431.00
251_T292_L0.8331.00
253_I294_V0.8291.00
275_N279_C0.8271.00
196_N199_E0.8261.00
45_I297_T0.8241.00
63_R88_K0.8231.00
195_P200_A0.8211.00
234_F241_T0.8171.00
64_I89_Q0.8171.00
73_I95_T0.8101.00
158_T185_E0.8021.00
7_I59_A0.8021.00
152_A156_I0.8011.00
213_A224_V0.8011.00
242_M280_A0.7961.00
261_N265_G0.7941.00
187_L190_V0.7941.00
47_E263_A0.7941.00
261_N287_A0.7911.00
262_F284_N0.7901.00
131_F165_M0.7891.00
88_K125_D0.7851.00
74_L88_K0.7831.00
265_G269_A0.7801.00
13_I96_S0.7741.00
107_E113_N0.7721.00
52_S58_T0.7671.00
214_D217_L0.7661.00
244_V281_R0.7661.00
211_E215_C0.7651.00
115_N118_L0.7641.00
237_R276_L0.7581.00
170_D194_F0.7481.00
284_N288_A0.7421.00
170_D195_P0.7341.00
14_V38_M0.7331.00
6_V136_L0.7311.00
141_S169_A0.7261.00
285_A289_I0.7251.00
136_L271_L0.7241.00
101_L109_T0.7241.00
26_F29_D0.7211.00
154_T189_Y0.7191.00
225_V235_I0.7181.00
7_I130_R0.7181.00
15_D41_G0.7181.00
244_V277_R0.7171.00
168_C194_F0.7161.00
48_A60_L0.7161.00
130_R134_A0.7131.00
14_V69_A0.7121.00
157_F189_Y0.7101.00
28_V31_Y0.7081.00
59_A85_Q0.7051.00
200_A216_F0.6961.00
125_D128_F0.6951.00
107_E110_F0.6911.00
100_G256_I0.6911.00
213_A217_L0.6891.00
287_A290_S0.6861.00
282_F303_R0.6851.00
181_D184_C0.6831.00
121_L126_V0.6821.00
168_C192_Y0.6821.00
237_R242_M0.6801.00
38_M69_A0.6761.00
262_F283_A0.6701.00
289_I305_L0.6681.00
185_E188_S0.6661.00
209_L228_T0.6651.00
106_G113_N0.6651.00
217_L237_R0.6641.00
37_A294_V0.6631.00
123_I151_K0.6631.00
69_A97_I0.6601.00
54_L268_A0.6591.00
54_L282_F0.6581.00
76_H297_T0.6581.00
124_D127_D0.6571.00
213_A241_T0.6571.00
262_F280_A0.6561.00
210_D236_K0.6551.00
49_T297_T0.6511.00
100_G110_F0.6471.00
232_G243_K0.6401.00
210_D243_K0.6401.00
137_L156_I0.6391.00
160_A167_I0.6391.00
230_K249_G0.6371.00
106_G109_T0.6371.00
48_A82_I0.6351.00
212_I216_F0.6331.00
206_K212_I0.6311.00
121_L125_D0.6311.00
86_S130_R0.6291.00
262_F287_A0.6291.00
19_Q104_E0.6291.00
41_G46_N0.6281.00
119_W122_N0.6251.00
6_V56_H0.6221.00
210_D234_F0.6211.00
80_E302_N0.6201.00
123_I152_A0.6191.00
33_L111_V0.6171.00
274_K279_C0.6161.00
151_K154_T0.6151.00
250_I288_A0.6131.00
270_L273_G0.6131.00
107_E112_T0.6131.00
154_T157_F0.6121.00
107_E111_V0.6101.00
247_V250_I0.6041.00
123_I127_D0.6031.00
96_S118_L0.6001.00
168_C263_A0.6001.00
27_D107_E0.5991.00
62_S87_L0.5941.00
57_R135_K0.5931.00
200_A209_L0.5921.00
19_Q294_V0.5911.00
136_L192_Y0.5901.00
180_L184_C0.5901.00
103_T107_E0.5891.00
51_I267_I0.5881.00
280_A284_N0.5881.00
233_C244_V0.5821.00
244_V247_V0.5821.00
184_C188_S0.5811.00
67_D70_G0.5791.00
45_I60_L0.5731.00
8_C51_I0.5711.00
18_L36_I0.5671.00
193_L224_V0.5641.00
230_K252_A0.5631.00
11_A142_I0.5621.00
130_R133_Q0.5581.00
57_R271_L0.5571.00
220_G224_V0.5571.00
210_D213_A0.5561.00
217_L239_D0.5551.00
18_L33_L0.5551.00
225_V262_F0.5531.00
264_S268_A0.5521.00
194_F225_V0.5511.00
136_L270_L0.5491.00
135_K165_M0.5461.00
278_E282_F0.5451.00
124_D128_F0.5411.00
170_D260_D0.5401.00
54_L264_S0.5391.00
101_L111_V0.5391.00
27_D103_T0.5391.00
71_Q78_R0.5391.00
108_R111_V0.5351.00
16_I99_V0.5351.00
217_L221_V0.5341.00
276_L279_C0.5331.00
52_S80_E0.5331.00
68_A72_F0.5331.00
167_I190_V0.5321.00
188_S219_C0.5311.00
86_S89_Q0.5311.00
106_G112_T0.5291.00
103_T109_T0.5281.00
98_N112_T0.5281.00
40_T297_T0.5281.00
44_A48_A0.5251.00
47_E51_I0.5241.00
12_A77_C0.5241.00
229_G255_T0.5211.00
256_I296_A0.5211.00
217_L220_G0.5201.00
221_V224_V0.5191.00
128_F159_Q0.5191.00
96_S101_L0.5191.00
47_E267_I0.5151.00
8_C58_T0.5151.00
93_I117_S0.5141.00
276_L280_A0.5131.00
198_A202_L0.5131.00
43_D142_I0.5131.00
77_C82_I0.5131.00
19_Q102_V0.5121.00
28_V33_L0.5111.00
85_Q130_R0.5111.00
46_N296_A0.5091.00
88_K128_F0.5091.00
106_G110_F0.5091.00
127_D159_Q0.5061.00
123_I126_V0.5051.00
135_K166_I0.5051.00
121_L127_D0.5051.00
209_L212_I0.5041.00
204_T215_C0.5021.00
30_S43_D0.5011.00
85_Q88_K0.5001.00
47_E264_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rbcA 2 0.9556 100 0.154 Contact Map
3h49A 2 0.9778 100 0.174 Contact Map
3vasA 1 0.9492 100 0.179 Contact Map
2fv7A 2 0.9429 100 0.181 Contact Map
3ljsA 2 0.9619 100 0.182 Contact Map
3iq0A 2 0.9683 100 0.182 Contact Map
1rkdA 2 0.9492 100 0.184 Contact Map
4k8kA 2 0.9778 100 0.186 Contact Map
3hj6A 2 0.8667 100 0.191 Contact Map
4xdaA 2 0.9492 100 0.194 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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