YAGR - ECOLI - GREMLIN Contacts

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YAGR - Putative xanthine dehydrogenase YagR molybdenum-binding subunit

UniProt:	P77489	Sequences: MKFDKPAGENPIDQLKVVGRPHDRIDGPLKTTGTARYAYEWHEEAPNAAYGYIVGSAIAKGRLTALDTDAAQKAPGVLAVITASNAGALGKGDKNTARLLGGPTIEHYHQAIALVVAETFEQARAAASLVQAHYRRNKGAYSLADEKQAVNQPPEDTPDKNVGDFDGAFTSAAVKIDATYTTPDQSHMAMEPHASMAVWDGNKLTLWTSNQMIDWCRTDLAKTLKVPVENVRIISPYIGGGFGGKLFLRSDALLAALAARAVKRPVKVMLPRPSIPNNTTHRPATLQHLRIGADQSGKITAISHESWSGNLPGGTPETAVQQSELLYAGANRHTGLRLATLDLPEGNAMRAPGEAPGLMALEIAIDELAEKAGIDPVEFRILNDTQVDPADPTRCFSRRQLIECLRTGADKFGWKQRNATPGQVRDGEWLVGHGVAAGFRNNLLEKSGARVHLEQNGTVTVETDMTDIGTGSYTILAQTAAEMLGVPLEQVAVHLGDSSFPVSAGSGGQWGANTSTSGVYAACMKLREMIASAVGFDPEQSQFADGKITNGTRSATLHEATAGGRLTAEESIEFGTLSKEYQQSTFAGHFVEVGVHSATGEVRVRRMLAVCAAGRILNPKTARSQVIGAMTMGMGAALMEELAVDDRLGYFVNHDMAGYEVPVHADIPKQEVIFLDDTDPISSPMKAKGVGELGLCGVSAAIANAVYNATGIRVRDYPITLDKLLDKLPDVV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13557
Length:	732 (707)
Sequences:	5620 (3697)
Seq/√Len:	139.0

ECOLI - YAGR XDHD XDHA
BACSU - XDHD
SULSO - Q7LX54 Q97V74 Q97VI4 Q97UK2 Q97TZ2 Q7LXA2 Q97UR0 Q97YU6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
74_A	129_L	4.567	1.00
177_D	290_R	4.259	1.00
54_V	130_V	4.204	1.00
49_A	78_L	4.031	1.00
119_T	122_Q	3.812	1.00
70_A	131_Q	3.644	1.00
381_I	406_R	3.604	1.00
58_I	61_G	3.575	1.00
179_T	288_H	3.539	1.00
413_G	416_Q	3.407	1.00
294_D	298_K	3.403	1.00
293_A	368_L	3.327	1.00
303_S	333_H	3.316	1.00
480_A	519_V	3.239	1.00
64_T	133_H	3.175	1.00
173_A	295_Q	3.136	1.00
374_I	382_L	3.122	1.00
173_A	294_D	3.122	1.00
74_A	122_Q	3.104	1.00
62_R	135_R	3.096	1.00
299_I	365_I	3.027	1.00
167_G	171_S	2.996	1.00
459_V	486_V	2.982	1.00
164_D	167_G	2.925	1.00
54_V	127_A	2.904	1.00
78_L	118_E	2.895	1.00
177_D	288_H	2.885	1.00
305_E	335_G	2.826	1.00
483_M	524_M	2.821	1.00
58_I	136_R	2.811	1.00
61_G	134_Y	2.808	1.00
378_E	382_L	2.621	1.00
290_R	303_S	2.615	1.00
116_V	258_A	2.606	1.00
65_A	133_H	2.603	1.00
60_K	137_N	2.593	1.00
547_K	554_S	2.589	1.00
206_L	220_L	2.572	1.00
328_A	389_P	2.521	1.00
118_E	122_Q	2.511	1.00
520_Y	524_M	2.472	1.00
205_T	234_I	2.444	1.00
51_G	268_V	2.433	1.00
64_T	135_R	2.420	1.00
298_K	382_L	2.392	1.00
606_R	671_E	2.391	1.00
716_D	723_K	2.349	1.00
118_E	264_R	2.313	1.00
232_R	497_D	2.294	1.00
198_V	207_W	2.254	1.00
203_K	499_S	2.242	1.00
703_A	719_I	2.230	1.00
305_E	337_R	2.223	1.00
68_T	72_Q	2.222	1.00
144_A	286_L	2.214	1.00
412_F	590_F	2.197	1.00
169_F	292_G	2.194	1.00
374_I	379_F	2.189	1.00
309_G	343_L	2.175	1.00
594_G	605_R	2.169	1.00
706_V	719_I	2.100	1.00
51_G	114_L	2.100	1.00
368_L	379_F	2.091	1.00
291_I	364_A	2.058	1.00
407_T	410_D	2.050	1.00
53_I	254_L	2.033	1.00
145_D	148_Q	2.030	1.00
407_T	673_I	2.020	1.00
458_T	490_Q	2.010	1.00
172_A	292_G	2.007	1.00
181_T	716_D	1.985	1.00
408_G	590_F	1.965	1.00
174_V	293_A	1.950	1.00
631_T	667_I	1.946	1.00
378_E	381_I	1.938	1.00
298_K	328_A	1.935	1.00
381_I	409_A	1.931	1.00
458_T	492_A	1.913	1.00
451_V	461_V	1.903	1.00
174_V	295_Q	1.899	1.00
68_T	80_V	1.895	1.00
630_M	670_Q	1.890	1.00
67_D	131_Q	1.877	1.00
71_A	130_V	1.876	1.00
22_H	488_L	1.872	1.00
453_L	526_L	1.861	1.00
406_R	410_D	1.858	1.00
57_A	112_I	1.852	1.00
386_Q	402_I	1.851	1.00
289_L	364_A	1.845	1.00
39_Y	267_K	1.839	1.00
142_S	145_D	1.830	1.00
479_T	516_T	1.824	1.00
62_R	103_P	1.817	1.00
69_D	72_Q	1.811	1.00
161_N	333_H	1.809	1.00
62_R	104_T	1.793	1.00
386_Q	389_P	1.787	1.00
556_T	559_E	1.780	1.00
377_V	409_A	1.773	1.00
116_V	262_V	1.756	1.00
194_A	269_M	1.747	1.00
512_A	617_L	1.732	1.00
454_E	460_T	1.726	1.00
70_A	129_L	1.712	1.00
117_A	123_A	1.709	1.00
203_K	230_N	1.704	1.00
411_K	671_E	1.694	1.00
477_A	493_V	1.689	1.00
294_D	300_T	1.686	1.00
58_I	134_Y	1.683	1.00
78_L	264_R	1.675	1.00
487_P	490_Q	1.670	1.00
645_D	648_L	1.668	1.00
45_A	48_A	1.666	1.00
114_L	258_A	1.659	1.00
438_G	587_A	1.657	1.00
51_G	266_V	1.657	1.00
622_A	690_V	1.654	1.00
454_E	458_T	1.648	1.00
602_V	724_L	1.646	1.00
429_W	594_G	1.639	1.00
400_Q	403_E	1.631	1.00
451_V	523_C	1.630	1.00
79_A	261_A	1.625	1.00
188_M	656_M	1.614	1.00
407_T	411_K	1.612	1.00
23_D	620_K	1.607	1.00
189_A	244_G	1.606	1.00
172_A	300_T	1.605	1.00
179_T	286_L	1.601	1.00
591_V	607_M	1.591	1.00
169_F	290_R	1.576	1.00
77_V	117_A	1.569	1.00
720_T	723_K	1.563	1.00
459_V	484_L	1.563	1.00
607_M	630_M	1.554	1.00
381_I	402_I	1.553	1.00
616_I	674_F	1.553	1.00
174_V	371_K	1.547	1.00
291_I	368_L	1.547	1.00
461_V	480_A	1.546	1.00
370_E	707_Y	1.541	1.00
60_K	104_T	1.540	1.00
589_H	607_M	1.536	1.00
537_D	540_Q	1.534	1.00
74_A	126_A	1.533	1.00
70_A	73_K	1.532	1.00
428_E	596_H	1.525	1.00
291_I	299_I	1.524	1.00
613_A	616_I	1.522	1.00
288_H	305_E	1.521	1.00
483_M	685_M	1.515	1.00
615_R	676_D	1.505	1.00
166_D	333_H	1.503	1.00
127_A	130_V	1.503	1.00
72_Q	79_A	1.503	1.00
114_L	254_L	1.496	1.00
402_I	406_R	1.495	1.00
622_A	674_F	1.483	1.00
449_A	519_V	1.457	1.00
38_A	194_A	1.455	1.00
44_E	48_A	1.444	1.00
151_N	154_P	1.444	1.00
521_A	525_K	1.435	1.00
205_T	232_R	1.432	1.00
411_K	673_I	1.424	1.00
409_A	415_K	1.423	1.00
635_G	662_P	1.418	1.00
227_P	230_N	1.417	1.00
181_T	286_L	1.416	1.00
174_V	294_D	1.414	1.00
221_A	231_V	1.412	1.00
45_A	198_V	1.410	1.00
175_K	290_R	1.402	1.00
604_V	634_M	1.401	1.00
299_I	329_G	1.373	1.00
174_V	368_L	1.372	1.00
226_V	231_V	1.371	1.00
483_M	520_Y	1.365	1.00
430_L	597_S	1.365	1.00
166_D	170_T	1.365	1.00
81_I	258_A	1.364	1.00
481_A	491_V	1.363	1.00
633_G	698_V	1.363	1.00
544_A	549_T	1.363	1.00
408_G	588_G	1.363	1.00
81_I	262_V	1.362	1.00
152_Q	155_E	1.362	1.00
48_A	267_K	1.362	1.00
53_I	268_V	1.360	1.00
431_V	594_G	1.357	1.00
84_S	103_P	1.353	1.00
525_K	528_E	1.352	1.00
39_Y	269_M	1.345	1.00
63_L	66_L	1.339	1.00
169_F	301_A	1.334	1.00
125_A	129_L	1.330	1.00
49_A	264_R	1.324	1.00
174_V	372_A	1.323	1.00
476_L	519_V	1.320	1.00
404_C	588_G	1.320	1.00
224_L	256_A	1.315	1.00
220_L	231_V	1.315	1.00
296_S	382_L	1.312	1.00
541_S	548_I	1.312	1.00
202_N	230_N	1.308	1.00
218_T	228_V	1.298	1.00
168_A	301_A	1.294	1.00
168_A	331_N	1.292	1.00
418_N	421_P	1.287	1.00
178_A	367_E	1.287	1.00
475_I	512_A	1.272	1.00
608_L	671_E	1.271	1.00
165_F	168_A	1.267	1.00
204_L	256_A	1.264	1.00
366_D	704_N	1.263	1.00
35_A	237_Y	1.260	1.00
362_E	380_R	1.259	1.00
122_Q	126_A	1.257	1.00
542_Q	549_T	1.254	1.00
63_L	132_A	1.254	1.00
25_I	477_A	1.252	1.00
349_M	632_M	1.250	1.00
197_A	206_L	1.249	1.00
479_T	512_A	1.246	1.00
165_F	169_F	1.243	1.00
258_A	266_V	1.242	1.00
45_A	196_M	1.241	1.00
52_Y	127_A	1.240	1.00
412_F	608_L	1.240	1.00
411_K	610_V	1.239	1.00
616_I	622_A	1.235	1.00
29_L	34_T	1.235	1.00
287_Q	360_A	1.233	1.00
197_A	259_A	1.233	1.00
197_A	255_A	1.231	1.00
204_L	226_V	1.230	1.00
370_E	708_N	1.229	1.00
293_A	372_A	1.229	1.00
100_L	254_L	1.223	1.00
643_A	653_N	1.218	1.00
280_T	347_N	1.216	1.00
372_A	379_F	1.214	1.00
450_R	462_E	1.210	1.00
593_V	706_V	1.209	1.00
428_E	598_A	1.208	1.00
610_V	673_I	1.203	1.00
408_G	610_V	1.198	1.00
307_W	337_R	1.197	1.00
60_K	138_K	1.192	1.00
166_D	303_S	1.191	1.00
106_E	110_Q	1.188	1.00
366_D	376_P	1.188	1.00
112_I	132_A	1.186	1.00
25_I	474_T	1.185	1.00
55_G	274_S	1.180	1.00
284_A	309_G	1.175	1.00
428_E	597_S	1.175	1.00
207_W	234_I	1.173	0.99
169_F	175_K	1.170	0.99
188_M	661_V	1.167	0.99
178_A	371_K	1.166	0.99
517_S	520_Y	1.166	0.99
626_V	630_M	1.166	0.99
57_A	134_Y	1.165	0.99
525_K	529_M	1.163	0.99
62_R	137_N	1.162	0.99
104_T	137_N	1.158	0.99
77_V	126_A	1.157	0.99
52_Y	120_F	1.155	0.99
82_T	100_L	1.154	0.99
83_A	102_G	1.151	0.99
52_Y	124_R	1.149	0.99
367_E	715_R	1.149	0.99
60_K	342_D	1.146	0.99
600_G	724_L	1.146	0.99
638_L	702_I	1.145	0.99
241_G	468_I	1.143	0.99
602_V	638_L	1.140	0.99
167_G	170_T	1.138	0.99
293_A	379_F	1.131	0.99
28_P	32_T	1.126	0.99
378_E	415_K	1.125	0.99
478_Q	618_N	1.121	0.99
189_A	275_I	1.121	0.99
595_V	602_V	1.120	0.99
359_M	703_A	1.119	0.99
549_T	554_S	1.118	0.99
126_A	129_L	1.115	0.99
151_N	155_E	1.111	0.99
462_E	494_H	1.111	0.99
52_Y	123_A	1.109	0.99
171_S	300_T	1.109	0.99
150_V	153_P	1.108	0.99
477_A	488_L	1.107	0.99
200_D	205_T	1.104	0.99
714_V	719_I	1.098	0.99
104_T	156_D	1.096	0.99
77_V	123_A	1.095	0.99
180_Y	364_A	1.095	0.99
86_A	257_L	1.091	0.99
410_D	415_K	1.090	0.99
570_E	573_E	1.089	0.99
384_D	405_L	1.089	0.99
320_V	334_T	1.089	0.99
407_T	610_V	1.086	0.99
291_I	302_I	1.086	0.99
591_V	604_V	1.085	0.99
66_L	132_A	1.076	0.99
199_W	260_R	1.076	0.99
79_A	262_V	1.071	0.99
535_G	540_Q	1.070	0.99
65_A	131_Q	1.069	0.99
429_W	603_R	1.065	0.99
524_M	528_E	1.064	0.99
48_A	196_M	1.064	0.99
404_C	610_V	1.059	0.99
403_E	407_T	1.053	0.99
112_I	134_Y	1.052	0.99
602_V	706_V	1.050	0.99
460_T	494_H	1.043	0.99
78_L	122_Q	1.040	0.99
480_A	523_C	1.036	0.99
316_P	336_L	1.036	0.99
157_T	335_G	1.035	0.99
120_F	124_R	1.035	0.99
74_A	125_A	1.035	0.99
490_Q	546_G	1.034	0.99
17_V	482_E	1.034	0.99
157_T	161_N	1.033	0.99
644_V	651_F	1.029	0.99
44_E	267_K	1.029	0.99
722_D	726_D	1.028	0.99
293_A	299_I	1.027	0.99
429_W	596_H	1.026	0.99
292_G	301_A	1.026	0.99
176_I	371_K	1.025	0.99
81_I	261_A	1.024	0.99
47_N	264_R	1.021	0.99
168_A	292_G	1.021	0.99
53_I	114_L	1.016	0.99
171_S	294_D	1.014	0.99
612_A	677_D	1.011	0.98
54_V	132_A	1.009	0.98
143_L	307_W	1.009	0.98
365_I	379_F	1.009	0.98
144_A	181_T	1.006	0.98
307_W	339_A	1.004	0.98
49_A	262_V	1.003	0.98
195_S	255_A	0.997	0.98
105_I	134_Y	0.997	0.98
634_M	667_I	0.994	0.98
572_I	575_G	0.993	0.98
198_V	205_T	0.992	0.98
483_M	523_C	0.990	0.98
645_D	650_Y	0.988	0.98
536_F	540_Q	0.988	0.98
176_I	293_A	0.987	0.98
147_K	339_A	0.987	0.98
528_E	538_P	0.987	0.98
292_G	300_T	0.985	0.98
419_A	423_Q	0.982	0.98
60_K	139_G	0.982	0.98
199_W	259_A	0.981	0.98
61_G	137_N	0.980	0.98
165_F	303_S	0.980	0.98
572_I	576_T	0.979	0.98
115_V	127_A	0.978	0.98
530_I	560_A	0.976	0.98
461_V	491_V	0.975	0.98
187_H	244_G	0.974	0.98
417_R	592_E	0.974	0.98
226_V	230_N	0.967	0.98
186_S	642_L	0.967	0.98
719_I	723_K	0.967	0.98
173_A	300_T	0.965	0.98
78_L	116_V	0.965	0.98
209_S	245_K	0.965	0.98
200_D	203_K	0.964	0.98
719_I	724_L	0.964	0.98
169_F	303_S	0.963	0.98
641_E	723_K	0.962	0.98
83_A	103_P	0.960	0.98
543_F	548_I	0.960	0.98
113_A	130_V	0.959	0.98
226_V	260_R	0.957	0.98
63_L	112_I	0.957	0.98
431_V	592_E	0.952	0.98
165_F	331_N	0.952	0.98
51_G	258_A	0.949	0.98
639_M	666_D	0.949	0.98
68_T	130_V	0.949	0.98
283_P	356_P	0.946	0.98
384_D	402_I	0.945	0.98
655_D	658_G	0.940	0.98
217_R	228_V	0.940	0.98
238_I	468_I	0.939	0.98
633_G	695_L	0.938	0.98
421_P	425_R	0.937	0.98
113_A	132_A	0.935	0.97
148_Q	151_N	0.935	0.97
61_G	132_A	0.935	0.97
474_T	478_Q	0.934	0.97
198_V	259_A	0.934	0.97
403_E	406_R	0.930	0.97
21_P	623_R	0.927	0.97
165_F	301_A	0.927	0.97
367_E	713_R	0.925	0.97
176_I	291_I	0.925	0.97
363_I	703_A	0.920	0.97
405_L	435_V	0.918	0.97
285_T	319_A	0.917	0.97
66_L	130_V	0.914	0.97
76_G	126_A	0.912	0.97
88_A	92_G	0.909	0.97
483_M	527_R	0.907	0.97
81_I	257_L	0.904	0.97
530_I	557_L	0.902	0.97
53_I	111_A	0.902	0.97
623_R	627_I	0.901	0.97
211_Q	241_G	0.900	0.97
147_K	307_W	0.899	0.97
366_D	380_R	0.898	0.97
123_A	127_A	0.897	0.97
199_W	202_N	0.895	0.97
667_I	670_Q	0.895	0.97
75_P	118_E	0.895	0.97
80_V	113_A	0.895	0.97
452_H	462_E	0.895	0.97
255_A	268_V	0.893	0.97
29_L	473_Y	0.891	0.97
403_E	675_L	0.891	0.97
377_V	405_L	0.886	0.97
204_L	260_R	0.886	0.97
285_T	308_S	0.885	0.97
609_A	630_M	0.883	0.96
232_R	499_S	0.880	0.96
591_V	697_G	0.879	0.96
377_V	435_V	0.878	0.96
591_V	701_A	0.878	0.96
465_M	511_G	0.877	0.96
140_A	146_E	0.876	0.96
607_M	698_V	0.876	0.96
110_Q	313_G	0.876	0.96
651_F	654_H	0.875	0.96
157_T	337_R	0.875	0.96
521_A	524_M	0.875	0.96
559_E	562_A	0.873	0.96
54_V	113_A	0.872	0.96
273_P	654_H	0.871	0.96
593_V	604_V	0.869	0.96
159_D	335_G	0.868	0.96
231_V	256_A	0.867	0.96
460_T	492_A	0.866	0.96
613_A	622_A	0.865	0.96
50_Y	267_K	0.863	0.96
478_Q	619_P	0.863	0.96
303_S	335_G	0.863	0.96
480_A	491_V	0.859	0.96
592_E	606_R	0.857	0.96
29_L	237_Y	0.856	0.96
327_Y	362_E	0.856	0.96
571_S	574_F	0.855	0.96
246_L	507_G	0.852	0.96
465_M	472_S	0.851	0.96
327_Y	380_R	0.849	0.96
490_Q	558_H	0.848	0.96
144_A	179_T	0.848	0.96
63_L	134_Y	0.846	0.95
81_I	116_V	0.845	0.95
72_Q	84_S	0.845	0.95
168_A	300_T	0.844	0.95
165_F	333_H	0.843	0.95
209_S	238_I	0.843	0.95
623_R	674_F	0.842	0.95
175_K	292_G	0.841	0.95
68_T	82_T	0.840	0.95
290_R	333_H	0.839	0.95
17_V	488_L	0.838	0.95
570_E	574_F	0.837	0.95
76_G	118_E	0.835	0.95
18_V	482_E	0.832	0.95
431_V	605_R	0.828	0.95
180_Y	367_E	0.828	0.95
645_D	652_V	0.828	0.95
164_D	331_N	0.827	0.95
155_E	340_T	0.827	0.95
50_Y	120_F	0.827	0.95
69_D	73_K	0.827	0.95
432_G	436_A	0.827	0.95
193_H	275_I	0.824	0.95
84_S	102_G	0.824	0.95
21_P	620_K	0.823	0.95
470_T	506_S	0.820	0.95
471_G	621_T	0.819	0.95
451_V	522_A	0.818	0.95
172_A	301_A	0.816	0.95
180_Y	715_R	0.813	0.94
30_K	37_Y	0.813	0.94
311_L	345_E	0.813	0.94
543_F	557_L	0.813	0.94
149_A	154_P	0.813	0.94
391_D	394_R	0.809	0.94
453_L	557_L	0.809	0.94
149_A	152_Q	0.807	0.94
547_K	556_T	0.807	0.94
300_T	331_N	0.807	0.94
66_L	112_I	0.806	0.94
707_Y	713_R	0.804	0.94
143_L	286_L	0.804	0.94
141_Y	649_G	0.801	0.94
180_Y	363_I	0.801	0.94
534_V	555_A	0.801	0.94
142_S	286_L	0.800	0.94
606_R	669_K	0.799	0.94
68_T	71_A	0.798	0.94
85_N	261_A	0.798	0.94
168_A	172_A	0.798	0.94
293_A	364_A	0.797	0.94
527_R	543_F	0.797	0.94
533_A	563_G	0.797	0.94
486_V	490_Q	0.797	0.94
258_A	262_V	0.797	0.94
425_R	432_G	0.797	0.94
61_G	105_I	0.796	0.94
634_M	702_I	0.796	0.94
613_A	690_V	0.796	0.94
475_I	617_L	0.795	0.94
475_I	621_T	0.795	0.94
374_I	378_E	0.794	0.94
22_H	477_A	0.794	0.94
177_D	303_S	0.793	0.94
453_L	459_V	0.791	0.94
479_T	617_L	0.791	0.94
202_N	260_R	0.790	0.94
423_Q	427_G	0.789	0.93
150_V	155_E	0.787	0.93
117_A	126_A	0.786	0.93
287_Q	304_H	0.786	0.93
596_H	601_E	0.785	0.93
270_L	275_I	0.785	0.93
224_L	257_L	0.783	0.93
169_F	300_T	0.783	0.93
459_V	526_L	0.780	0.93
232_R	498_S	0.780	0.93
55_G	278_N	0.779	0.93
210_N	216_C	0.776	0.93
451_V	526_L	0.775	0.93
101_G	105_I	0.775	0.93
59_A	139_G	0.775	0.93
192_P	269_M	0.775	0.93
316_P	338_L	0.773	0.93
124_R	271_P	0.773	0.93
324_E	332_R	0.773	0.93
122_Q	125_A	0.772	0.93
120_F	271_P	0.770	0.93
359_M	717_Y	0.768	0.93
163_G	168_A	0.767	0.93
656_M	661_V	0.766	0.92
138_K	145_D	0.764	0.92
297_G	374_I	0.764	0.92
58_I	105_I	0.762	0.92
595_V	724_L	0.762	0.92
642_L	651_F	0.761	0.92
361_L	364_A	0.761	0.92
555_A	563_G	0.758	0.92
196_M	267_K	0.758	0.92
612_A	678_T	0.757	0.92
364_A	368_L	0.757	0.92
426_D	594_G	0.756	0.92
72_Q	126_A	0.756	0.92
141_Y	145_D	0.755	0.92
216_C	220_L	0.754	0.92
456_N	492_A	0.753	0.92
591_V	702_I	0.751	0.92
168_A	171_S	0.751	0.92
447_S	515_S	0.751	0.92
523_C	526_L	0.749	0.92
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217_R	498_S	0.749	0.92
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429_W	597_S	0.747	0.92
199_W	204_L	0.746	0.91
593_V	705_A	0.746	0.91
375_D	414_W	0.746	0.91
208_T	216_C	0.746	0.91
149_A	155_E	0.745	0.91
25_I	488_L	0.745	0.91
214_D	498_S	0.744	0.91
405_L	437_A	0.743	0.91
204_L	231_V	0.741	0.91
36_R	41_W	0.740	0.91
121_E	125_A	0.740	0.91
74_A	77_V	0.740	0.91
683_S	687_A	0.739	0.91
140_A	342_D	0.739	0.91
364_A	367_E	0.738	0.91
611_C	626_V	0.738	0.91
482_E	615_R	0.737	0.91
312_P	342_D	0.736	0.91
424_V	432_G	0.735	0.91
409_A	414_W	0.734	0.91
359_M	363_I	0.734	0.91
302_I	329_G	0.734	0.91
289_L	360_A	0.733	0.91
430_L	595_V	0.733	0.91
150_V	154_P	0.728	0.90
480_A	483_M	0.726	0.90
106_E	313_G	0.725	0.90
108_Y	650_Y	0.725	0.90
306_S	319_A	0.725	0.90
310_N	338_L	0.724	0.90
367_E	371_K	0.723	0.90
66_L	80_V	0.722	0.90
627_I	672_V	0.722	0.90
67_D	70_A	0.722	0.90
169_F	172_A	0.721	0.90
468_I	506_S	0.721	0.90
47_N	265_P	0.721	0.90
451_V	480_A	0.719	0.90
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695_L	699_S	0.716	0.90
38_A	41_W	0.716	0.90
506_S	511_G	0.716	0.90
59_A	108_Y	0.714	0.90
319_A	357_G	0.713	0.90
185_Q	636_A	0.713	0.90
213_I	498_S	0.713	0.90
301_A	331_N	0.712	0.89
63_L	105_I	0.712	0.89
714_V	727_K	0.710	0.89
379_F	382_L	0.710	0.89
262_V	266_V	0.708	0.89
299_I	379_F	0.707	0.89
406_R	409_A	0.707	0.89
299_I	368_L	0.705	0.89
158_P	161_N	0.704	0.89
18_V	478_Q	0.704	0.89
44_E	196_M	0.704	0.89
45_A	207_W	0.703	0.89
101_G	110_Q	0.702	0.89
435_V	590_F	0.702	0.89
178_A	715_R	0.702	0.89
17_V	20_R	0.701	0.89
384_D	399_R	0.701	0.89
71_A	77_V	0.699	0.89
162_V	332_R	0.697	0.88
543_F	547_K	0.696	0.88
41_W	207_W	0.695	0.88
428_E	432_G	0.695	0.88
105_I	132_A	0.693	0.88
260_R	263_K	0.692	0.88
302_I	361_L	0.691	0.88
208_T	252_A	0.690	0.88
704_N	713_R	0.690	0.88
400_Q	675_L	0.688	0.88
223_T	253_L	0.688	0.88
291_I	379_F	0.687	0.88
423_Q	426_D	0.686	0.88
292_G	303_S	0.685	0.88
724_L	727_K	0.685	0.88
181_T	284_A	0.685	0.88
571_S	575_G	0.684	0.88
177_D	371_K	0.683	0.87
390_A	393_T	0.681	0.87
533_A	555_A	0.681	0.87
60_K	154_P	0.681	0.87
623_R	672_V	0.680	0.87
72_Q	85_N	0.680	0.87
414_W	590_F	0.676	0.87
564_G	568_A	0.676	0.87
51_G	255_A	0.675	0.87
116_V	266_V	0.674	0.87
144_A	307_W	0.674	0.87
309_G	341_L	0.673	0.87
643_A	652_V	0.672	0.87
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71_A	76_G	0.670	0.86
217_R	499_S	0.670	0.86
104_T	154_P	0.667	0.86
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517_S	683_S	0.667	0.86
56_S	108_Y	0.667	0.86
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424_V	433_H	0.666	0.86
38_A	269_M	0.666	0.86
608_L	673_I	0.665	0.86
329_G	332_R	0.664	0.86
437_A	588_G	0.664	0.86
136_R	648_L	0.663	0.86
409_A	590_F	0.663	0.86
414_W	417_R	0.663	0.86
147_K	286_L	0.663	0.86
530_I	548_I	0.658	0.85
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24_R	30_K	0.658	0.85
354_E	440_R	0.658	0.85
82_T	85_N	0.658	0.85
427_G	430_L	0.657	0.85
271_P	274_S	0.657	0.85
58_I	112_I	0.657	0.85
573_E	576_T	0.656	0.85
472_S	511_G	0.656	0.85
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534_V	541_S	0.654	0.85
445_E	510_W	0.652	0.85
193_H	244_G	0.650	0.85
195_S	208_T	0.650	0.85
173_A	296_S	0.650	0.85
427_G	597_S	0.650	0.85
589_H	698_V	0.649	0.85
388_D	391_D	0.649	0.85
304_H	360_A	0.649	0.85
294_D	382_L	0.648	0.85
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560_A	564_G	0.648	0.85
173_A	298_K	0.648	0.85
83_A	87_G	0.646	0.84
125_A	128_S	0.646	0.84
45_A	265_P	0.646	0.84
449_A	518_G	0.646	0.84
487_P	546_G	0.646	0.84
65_A	69_D	0.645	0.84
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68_T	74_A	0.643	0.84
79_A	116_V	0.641	0.84
182_T	285_T	0.641	0.84
389_P	392_P	0.640	0.84
54_V	57_A	0.640	0.84
126_A	130_V	0.639	0.84
376_P	704_N	0.638	0.84
153_P	156_D	0.637	0.84
97_A	101_G	0.637	0.84
106_E	312_P	0.637	0.84
180_Y	360_A	0.637	0.84
67_D	71_A	0.637	0.84
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387_V	402_I	0.637	0.84
115_V	130_V	0.636	0.83
609_A	626_V	0.636	0.83
639_M	660_E	0.636	0.83
549_T	552_T	0.634	0.83
413_G	606_R	0.632	0.83
136_R	139_G	0.632	0.83
602_V	702_I	0.632	0.83
289_L	368_L	0.632	0.83
29_L	35_A	0.631	0.83
41_W	236_P	0.631	0.83
478_Q	488_L	0.631	0.83
555_A	558_H	0.631	0.83
570_E	576_T	0.630	0.83
308_S	338_L	0.629	0.83
511_G	515_S	0.628	0.83
32_T	35_A	0.628	0.83
80_V	84_S	0.627	0.83
613_A	674_F	0.625	0.82
565_R	568_A	0.625	0.82
454_E	492_A	0.624	0.82
308_S	319_A	0.624	0.82
154_P	342_D	0.623	0.82
183_P	284_A	0.621	0.82
115_V	126_A	0.620	0.82
71_A	126_A	0.620	0.82
188_M	642_L	0.620	0.82
275_I	279_T	0.619	0.82
21_P	478_Q	0.619	0.82
302_I	323_S	0.618	0.82
548_I	560_A	0.618	0.82
414_W	435_V	0.618	0.82
182_T	636_A	0.617	0.82
358_L	700_A	0.617	0.82
424_V	431_V	0.617	0.82
197_A	266_V	0.616	0.81
343_L	644_V	0.616	0.81
30_K	237_Y	0.615	0.81
425_R	430_L	0.615	0.81
48_A	265_P	0.615	0.81
368_L	371_K	0.615	0.81
195_S	251_D	0.613	0.81
217_R	221_A	0.613	0.81
476_L	493_V	0.612	0.81
105_I	108_Y	0.611	0.81
385_T	399_R	0.610	0.81
213_I	466_T	0.610	0.81
531_A	535_G	0.609	0.81
432_G	435_V	0.609	0.81
432_G	708_N	0.609	0.81
182_T	359_M	0.609	0.81
519_V	523_C	0.609	0.81
358_L	696_C	0.609	0.81
55_G	111_A	0.608	0.81
308_S	316_P	0.608	0.81
707_Y	710_T	0.606	0.80
186_S	276_P	0.606	0.80
451_V	459_V	0.604	0.80
595_V	600_G	0.604	0.80
300_T	379_F	0.603	0.80
176_I	368_L	0.603	0.80
465_M	515_S	0.603	0.80
590_F	608_L	0.603	0.80
63_L	101_G	0.603	0.80
415_K	419_A	0.602	0.80
626_V	674_F	0.602	0.80
512_A	687_A	0.602	0.80
112_I	130_V	0.601	0.80
68_T	84_S	0.601	0.80
98_R	102_G	0.601	0.80
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174_V	379_F	0.599	0.80
167_G	295_Q	0.599	0.80
147_K	337_R	0.599	0.80
504_A	507_G	0.599	0.80
284_A	346_G	0.598	0.80
216_C	252_A	0.598	0.80
182_T	287_Q	0.598	0.80
484_L	523_C	0.598	0.80
555_A	560_A	0.597	0.79
146_E	151_N	0.596	0.79
422_G	426_D	0.595	0.79
436_A	440_R	0.595	0.79
97_A	110_Q	0.595	0.79
144_A	147_K	0.594	0.79
98_R	101_G	0.594	0.79
304_H	323_S	0.594	0.79
142_S	307_W	0.594	0.79
19_G	478_Q	0.594	0.79
429_W	432_G	0.593	0.79
544_A	554_S	0.592	0.79
476_L	480_A	0.592	0.79
485_G	527_R	0.592	0.79
77_V	80_V	0.592	0.79
63_L	83_A	0.592	0.79
41_W	196_M	0.592	0.79
363_I	713_R	0.592	0.79
596_H	599_T	0.592	0.79
535_G	538_P	0.591	0.79
626_V	672_V	0.590	0.79
416_Q	419_A	0.590	0.79
467_D	473_Y	0.589	0.79
164_D	168_A	0.589	0.79
447_S	503_S	0.589	0.79
610_V	675_L	0.588	0.78
408_G	608_L	0.588	0.78
286_L	307_W	0.587	0.78
390_A	394_R	0.586	0.78
550_N	553_R	0.585	0.78
660_E	663_V	0.585	0.78
432_G	440_R	0.584	0.78
141_Y	343_L	0.584	0.78
122_Q	129_L	0.584	0.78
442_N	583_Q	0.583	0.78
384_D	437_A	0.583	0.78
165_F	173_A	0.583	0.78
27_G	30_K	0.582	0.78
27_G	31_T	0.581	0.78
157_T	162_V	0.580	0.77
52_Y	274_S	0.580	0.77
178_A	364_A	0.579	0.77
679_D	682_S	0.579	0.77
561_T	569_E	0.578	0.77
65_A	295_Q	0.577	0.77
328_A	386_Q	0.577	0.77
159_D	162_V	0.575	0.77
49_A	79_A	0.575	0.77
370_E	713_R	0.574	0.77
176_I	379_F	0.573	0.77
220_L	225_K	0.572	0.77
476_L	515_S	0.572	0.77
65_A	70_A	0.571	0.76
484_L	491_V	0.571	0.76
551_G	554_S	0.571	0.76
168_A	330_A	0.571	0.76
723_K	726_D	0.570	0.76
616_I	619_P	0.570	0.76
324_E	434_G	0.569	0.76
557_L	561_T	0.569	0.76
429_W	605_R	0.567	0.76
115_V	123_A	0.566	0.76
207_W	236_P	0.566	0.76
426_D	431_V	0.565	0.76
80_V	115_V	0.565	0.76
184_D	642_L	0.565	0.76
290_R	305_E	0.565	0.76
195_S	252_A	0.564	0.76
50_Y	269_M	0.564	0.76
570_E	575_G	0.564	0.76
159_D	333_H	0.564	0.76
561_T	564_G	0.563	0.75
373_G	376_P	0.563	0.75
571_S	576_T	0.563	0.75
26_D	237_Y	0.562	0.75
100_L	111_A	0.562	0.75
38_A	196_M	0.561	0.75
604_V	607_M	0.560	0.75
544_A	547_K	0.560	0.75
704_N	707_Y	0.559	0.75
523_C	527_R	0.558	0.75
424_V	427_G	0.557	0.75
600_G	725_L	0.555	0.74
185_Q	282_R	0.555	0.74
209_S	216_C	0.555	0.74
411_K	608_L	0.554	0.74
503_S	515_S	0.554	0.74
71_A	113_A	0.554	0.74
485_G	543_F	0.554	0.74
602_V	721_L	0.552	0.74
420_T	592_E	0.552	0.74
315_T	356_P	0.552	0.74
410_D	413_G	0.551	0.74
632_M	635_G	0.551	0.74
418_N	425_R	0.551	0.74
553_R	559_E	0.551	0.74
418_N	433_H	0.550	0.74
476_L	479_T	0.550	0.74
631_T	634_M	0.550	0.74
712_I	724_L	0.550	0.74
140_A	152_Q	0.549	0.74
276_P	656_M	0.549	0.74
75_P	122_Q	0.548	0.73
285_T	356_P	0.548	0.73
146_E	150_V	0.548	0.73
432_G	438_G	0.548	0.73
67_D	133_H	0.548	0.73
449_A	463_T	0.547	0.73
310_N	346_G	0.547	0.73
146_E	149_A	0.547	0.73
472_S	506_S	0.547	0.73
114_L	268_V	0.546	0.73
96_T	314_G	0.546	0.73
526_L	530_I	0.545	0.73
206_L	256_A	0.545	0.73
425_R	428_E	0.545	0.73
59_A	645_D	0.545	0.73
447_S	514_T	0.544	0.73
368_L	374_I	0.543	0.73
376_P	380_R	0.543	0.73
433_H	708_N	0.543	0.73
108_Y	651_F	0.542	0.73
563_G	567_T	0.542	0.73
66_L	134_Y	0.542	0.73
634_M	639_M	0.542	0.73
18_V	617_L	0.541	0.72
75_P	78_L	0.541	0.72
633_G	637_A	0.541	0.72
72_Q	261_A	0.539	0.72
297_G	379_F	0.539	0.72
587_A	611_C	0.538	0.72
531_A	541_S	0.538	0.72
41_W	45_A	0.538	0.72
408_G	412_F	0.537	0.72
142_S	339_A	0.537	0.72
606_R	670_Q	0.537	0.72
212_M	215_W	0.536	0.72
420_T	423_Q	0.536	0.72
689_G	694_G	0.536	0.72
387_V	400_Q	0.536	0.72
57_A	105_I	0.535	0.72
284_A	343_L	0.535	0.72
700_A	703_A	0.535	0.72
145_D	150_V	0.535	0.72
436_A	701_A	0.534	0.72
133_H	136_R	0.534	0.72
417_R	606_R	0.534	0.72
79_A	258_A	0.533	0.71
314_G	340_T	0.533	0.71
97_A	100_L	0.532	0.71
479_T	685_M	0.532	0.71
498_S	502_V	0.532	0.71
234_I	497_D	0.532	0.71
527_R	548_I	0.532	0.71
710_T	727_K	0.531	0.71
169_F	173_A	0.531	0.71
473_Y	495_L	0.531	0.71
193_H	279_T	0.531	0.71
293_A	371_K	0.531	0.71
426_D	429_W	0.531	0.71
417_R	421_P	0.530	0.71
379_F	383_N	0.530	0.71
400_Q	677_D	0.530	0.71
412_F	588_G	0.530	0.71
513_N	682_S	0.530	0.71
168_A	173_A	0.529	0.71
167_G	331_N	0.529	0.71
556_T	562_A	0.527	0.71
186_S	281_H	0.527	0.71
371_K	713_R	0.526	0.70
160_K	163_G	0.526	0.70
398_R	586_F	0.524	0.70
220_L	253_L	0.524	0.70
468_I	472_S	0.524	0.70
452_H	460_T	0.524	0.70
451_V	491_V	0.523	0.70
424_V	429_W	0.523	0.70
635_G	639_M	0.523	0.70
418_N	435_V	0.523	0.70
352_P	508_G	0.521	0.70
412_F	415_K	0.521	0.70
209_S	241_G	0.521	0.70
161_N	164_D	0.520	0.70
188_M	275_I	0.520	0.70
589_H	609_A	0.519	0.69
157_T	160_K	0.519	0.69
626_V	694_G	0.519	0.69
428_E	434_G	0.518	0.69
467_D	472_S	0.517	0.69
611_C	693_L	0.517	0.69
463_T	476_L	0.516	0.69
215_W	246_L	0.516	0.69
26_D	30_K	0.516	0.69
450_R	575_G	0.516	0.69
257_L	262_V	0.516	0.69
653_N	658_G	0.516	0.69
589_H	697_G	0.514	0.69
143_L	339_A	0.513	0.69
99_L	241_G	0.513	0.69
528_E	531_A	0.513	0.69
199_W	231_V	0.513	0.69
296_S	300_T	0.513	0.69
161_N	166_D	0.513	0.69
425_R	597_S	0.512	0.68
592_E	605_R	0.512	0.68
639_M	661_V	0.511	0.68
366_D	713_R	0.510	0.68
318_T	322_Q	0.510	0.68
185_Q	349_M	0.510	0.68
300_T	330_A	0.509	0.68
106_E	340_T	0.509	0.68
723_K	727_K	0.509	0.68
397_S	679_D	0.509	0.68
50_Y	119_T	0.509	0.68
89_L	225_K	0.509	0.68
73_K	131_Q	0.508	0.68
127_A	131_Q	0.508	0.68
508_G	629_A	0.507	0.68
139_G	342_D	0.507	0.68
186_S	189_A	0.507	0.68
418_N	708_N	0.507	0.68
369_A	379_F	0.506	0.67
298_K	378_E	0.506	0.67
372_A	382_L	0.505	0.67
710_T	714_V	0.505	0.67
517_S	684_P	0.504	0.67
615_R	678_T	0.504	0.67
63_L	71_A	0.504	0.67
520_Y	685_M	0.504	0.67
536_F	541_S	0.503	0.67
315_T	352_P	0.503	0.67
377_V	414_W	0.503	0.67
22_H	474_T	0.503	0.67
323_S	334_T	0.503	0.67
159_D	337_R	0.503	0.67
49_A	266_V	0.503	0.67
270_L	279_T	0.501	0.67
427_G	432_G	0.501	0.67
398_R	688_K	0.501	0.67
173_A	293_A	0.500	0.67
426_D	597_S	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1t3qB	2	0.9863	100	0.12	Contact Map
1rm6A	2	0.9645	100	0.123	Contact Map
1ffvB	2	0.9836	100	0.127	Contact Map
1n62B	2	0.9891	100	0.129	Contact Map
2w3sB	2	0.9727	100	0.141	Contact Map
3uncA	2	0.9863	100	0.148	Contact Map
1dgjA	1	0.9604	100	0.158	Contact Map
3nvzC	2	0.9686	100	0.158	Contact Map
4usaA	2	0.9617	100	0.159	Contact Map
3zyvA	3	0.9795	100	0.16	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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