DXS - ECOLI - GREMLIN Contacts

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DXS - 1-deoxy-D-xylulose-5-phosphate synthase

UniProt:	P77488	Sequences: MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGNAVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDEALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELGLDAAGMEAKIKAWLA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13612
Length:	620 (579)
Sequences:	12169 (6244)
Seq/√Len:	259.5

ECOLI - DXS TKT1 TKT2
BACSU - DXS TKT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
506_L	615_I	4.045	1.00
528_T	616_K	3.707	1.00
198_Q	201_S	3.623	1.00
467_Y	470_G	3.514	1.00
377_A	389_V	3.470	1.00
334_A	358_K	3.319	1.00
608_A	612_E	3.234	1.00
449_M	460_M	3.204	1.00
386_K	413_P	2.902	1.00
214_K	217_S	2.888	1.00
607_D	610_G	2.842	1.00
583_L	614_K	2.797	1.00
39_L	84_P	2.789	1.00
208_L	236_M	2.782	1.00
228_R	234_K	2.584	1.00
291_A	295_P	2.521	1.00
228_R	233_I	2.510	1.00
602_A	607_D	2.452	1.00
552_A	557_E	2.438	1.00
277_F	281_M	2.430	1.00
505_K	526_N	2.386	1.00
67_Y	219_V	2.374	1.00
500_K	522_A	2.362	1.00
101_K	599_E	2.360	1.00
195_H	198_Q	2.322	1.00
380_L	385_Y	2.283	1.00
173_D	176_V	2.255	1.00
544_L	576_H	2.218	1.00
599_E	602_A	2.213	1.00
520_K	523_E	2.131	1.00
258_D	261_G	2.128	1.00
407_V	416_F	2.122	1.00
508_I	518_A	2.116	1.00
602_A	609_A	2.108	1.00
446_M	473_A	2.107	1.00
289_E	293_K	2.103	1.00
164_M	200_L	2.087	1.00
206_S	236_M	2.074	1.00
295_P	299_H	2.072	1.00
101_K	595_G	2.059	1.00
544_L	577_R	2.058	1.00
510_N	515_M	2.051	1.00
66_V	219_V	2.044	1.00
596_T	599_E	2.035	1.00
130_G	148_C	2.014	1.00
267_K	271_D	2.001	1.00
319_P	327_D	1.980	1.00
610_G	614_K	1.966	1.00
52_S	81_Q	1.960	1.00
296_I	300_A	1.945	1.00
496_K	537_P	1.941	1.00
161_F	203_K	1.937	1.00
564_G	584_N	1.934	1.00
447_V	470_G	1.925	1.00
540_E	544_L	1.922	1.00
438_S	559_N	1.872	1.00
394_T	436_D	1.830	1.00
520_K	608_A	1.823	1.00
206_S	228_R	1.802	1.00
101_K	603_E	1.782	1.00
59_L	177_I	1.778	1.00
216_F	219_V	1.776	1.00
274_G	278_L	1.769	1.00
519_A	529_L	1.755	1.00
118_L	129_A	1.754	1.00
93_D	96_G	1.744	1.00
548_A	552_A	1.713	1.00
83_Y	90_G	1.710	1.00
151_G	154_A	1.707	1.00
319_P	324_I	1.702	1.00
597_Q	601_R	1.702	1.00
374_V	416_F	1.697	1.00
197_A	201_S	1.697	1.00
243_F	252_G	1.692	1.00
462_Y	466_H	1.691	1.00
140_E	385_Y	1.673	1.00
332_T	339_L	1.673	1.00
266_L	269_M	1.654	1.00
354_E	357_R	1.653	1.00
44_S	263_I	1.652	1.00
443_I	446_M	1.643	1.00
411_K	445_E	1.642	1.00
510_N	518_A	1.641	1.00
191_A	194_N	1.629	1.00
517_E	608_A	1.628	1.00
331_E	334_A	1.627	1.00
85_H	90_G	1.626	1.00
440_L	473_A	1.620	1.00
540_E	572_V	1.619	1.00
516_P	520_K	1.617	1.00
518_A	556_V	1.608	1.00
528_T	550_H	1.602	1.00
216_F	220_P	1.593	1.00
570_N	586_G	1.591	1.00
505_K	531_D	1.588	1.00
69_T	115_Y	1.588	1.00
374_V	418_I	1.585	1.00
94_K	97_T	1.577	1.00
83_Y	86_K	1.572	1.00
436_D	475_R	1.571	1.00
477_P	481_A	1.551	1.00
612_E	616_K	1.549	1.00
505_K	551_E	1.549	1.00
85_H	89_T	1.545	1.00
84_P	90_G	1.539	1.00
447_V	539_D	1.537	1.00
37_R	40_L	1.536	1.00
403_V	446_M	1.527	1.00
354_E	358_K	1.524	1.00
208_L	224_E	1.518	1.00
135_V	376_F	1.510	1.00
524_S	527_A	1.509	1.00
86_K	90_G	1.507	1.00
32_C	61_V	1.506	1.00
570_N	574_M	1.505	1.00
137_A	144_R	1.501	1.00
281_M	285_G	1.500	1.00
587_L	590_F	1.498	1.00
521_V	612_E	1.496	1.00
139_K	340_M	1.482	1.00
524_S	612_E	1.481	1.00
223_K	227_K	1.471	1.00
490_E	493_P	1.470	1.00
283_K	286_R	1.466	1.00
560_A	581_P	1.464	1.00
275_P	278_L	1.448	1.00
415_L	464_G	1.441	1.00
105_H	113_S	1.436	1.00
223_K	226_L	1.428	1.00
497_G	542_L	1.427	1.00
522_A	529_L	1.422	1.00
290_P	293_K	1.419	1.00
40_L	266_L	1.414	1.00
318_L	480_N	1.414	1.00
578_K	584_N	1.412	1.00
579_P	582_V	1.406	1.00
128_S	372_H	1.403	1.00
381_A	414_V	1.401	1.00
67_Y	226_L	1.396	1.00
381_A	387_P	1.396	1.00
145_R	173_D	1.393	1.00
323_K	327_D	1.388	1.00
159_M	371_Q	1.385	1.00
257_H	260_L	1.383	1.00
381_A	412_L	1.383	1.00
83_Y	89_T	1.383	1.00
610_G	613_A	1.382	1.00
411_K	469_D	1.380	1.00
497_G	501_R	1.380	1.00
452_S	515_M	1.370	1.00
378_A	407_V	1.366	1.00
166_H	170_I	1.351	1.00
514_L	517_E	1.349	1.00
595_G	600_M	1.348	1.00
208_L	221_P	1.347	1.00
508_I	615_I	1.343	1.00
86_K	89_T	1.338	1.00
400_Y	439_Y	1.337	1.00
377_A	414_V	1.336	1.00
570_N	584_N	1.334	1.00
52_S	56_T	1.334	1.00
525_L	529_L	1.328	1.00
546_M	549_S	1.326	1.00
106_P	109_W	1.323	1.00
144_R	383_G	1.322	1.00
164_M	203_K	1.321	1.00
329_L	388_I	1.319	1.00
447_V	467_Y	1.316	1.00
517_E	520_K	1.312	1.00
180_D	239_P	1.310	1.00
305_D	308_S	1.308	1.00
501_R	523_E	1.305	1.00
197_A	239_P	1.305	1.00
449_M	472_S	1.301	1.00
263_I	267_K	1.300	1.00
418_I	473_A	1.294	1.00
262_L	265_T	1.293	1.00
494_I	497_G	1.288	1.00
282_T	285_G	1.284	1.00
323_K	351_G	1.283	1.00
299_H	303_K	1.280	1.00
257_H	261_G	1.278	1.00
437_L	475_R	1.268	1.00
507_A	550_H	1.268	1.00
133_I	383_G	1.268	1.00
434_A	587_L	1.267	1.00
493_P	496_K	1.258	1.00
374_V	399_A	1.256	1.00
328_W	458_R	1.253	1.00
113_S	116_D	1.247	1.00
212_G	242_L	1.240	1.00
313_K	316_G	1.237	1.00
334_A	359_F	1.237	1.00
441_R	568_G	1.236	1.00
602_A	610_G	1.234	1.00
137_A	146_T	1.226	1.00
87_I	90_G	1.225	1.00
566_G	573_L	1.225	1.00
75_I	133_I	1.221	1.00
274_G	277_F	1.220	1.00
590_F	603_E	1.218	1.00
176_V	248_F	1.214	1.00
297_T	300_A	1.212	1.00
537_P	540_E	1.203	1.00
276_Q	280_I	1.201	1.00
145_R	176_V	1.197	1.00
126_S	150_I	1.197	1.00
490_E	494_I	1.191	1.00
323_K	480_N	1.189	1.00
341_A	388_I	1.186	1.00
324_I	454_E	1.181	1.00
393_S	440_L	1.180	1.00
567_S	571_E	1.179	1.00
506_L	532_M	1.176	1.00
134_A	146_T	1.176	1.00
319_P	323_K	1.173	1.00
139_K	385_Y	1.172	1.00
396_L	418_I	1.171	1.00
110_R	382_I	1.169	1.00
105_H	109_W	1.169	1.00
477_P	513_T	1.166	1.00
135_V	364_F	1.160	1.00
219_V	223_K	1.158	1.00
177_I	222_I	1.154	1.00
262_L	266_L	1.150	1.00
102_G	603_E	1.150	1.00
609_A	613_A	1.150	1.00
396_L	439_Y	1.149	1.00
377_A	390_A	1.149	1.00
85_H	88_L	1.147	1.00
42_S	95_I	1.144	1.00
470_G	545_E	1.143	1.00
393_S	475_R	1.143	1.00
403_V	418_I	1.139	1.00
600_M	604_L	1.132	1.00
268_N	271_D	1.131	1.00
544_L	572_V	1.130	1.00
530_V	546_M	1.128	1.00
526_N	532_M	1.127	1.00
386_K	415_L	1.126	1.00
501_R	533_R	1.122	1.00
546_M	550_H	1.122	1.00
308_S	311_L	1.121	1.00
265_T	268_N	1.121	1.00
447_V	472_S	1.120	1.00
342_I	377_A	1.120	1.00
332_T	465_Y	1.120	1.00
83_Y	91_R	1.117	1.00
288_Y	292_E	1.117	1.00
75_I	130_G	1.114	1.00
228_R	232_H	1.114	1.00
145_R	175_L	1.112	1.00
500_K	523_E	1.111	1.00
83_Y	87_I	1.109	1.00
83_Y	88_L	1.108	1.00
85_H	91_R	1.105	1.00
138_E	173_D	1.103	1.00
253_P	256_G	1.102	1.00
540_E	576_H	1.102	1.00
166_H	376_F	1.102	1.00
587_L	604_L	1.100	1.00
127_I	164_M	1.099	1.00
467_Y	472_S	1.098	1.00
251_I	255_D	1.098	1.00
336_D	386_K	1.095	1.00
264_T	268_N	1.094	1.00
84_P	88_L	1.094	1.00
197_A	207_S	1.092	1.00
564_G	570_N	1.092	1.00
104_L	107_F	1.089	1.00
509_L	537_P	1.089	1.00
599_E	603_E	1.089	1.00
413_P	470_G	1.088	1.00
258_D	262_L	1.083	1.00
38_Y	42_S	1.081	1.00
590_F	604_L	1.081	1.00
197_A	209_R	1.080	1.00
350_S	390_A	1.078	1.00
263_I	266_L	1.078	1.00
457_C	476_Y	1.076	1.00
135_V	170_I	1.073	1.00
399_A	403_V	1.069	1.00
248_F	269_M	1.068	1.00
277_F	280_I	1.067	1.00
438_S	568_G	1.066	1.00
340_M	385_Y	1.064	1.00
510_N	514_L	1.062	1.00
178_L	197_A	1.062	1.00
374_V	407_V	1.060	1.00
68_N	71_F	1.057	1.00
182_E	241_T	1.057	1.00
292_E	296_I	1.055	1.00
293_K	296_I	1.048	1.00
86_K	91_R	1.046	1.00
498_I	501_R	1.046	1.00
498_I	531_D	1.043	1.00
136_A	383_G	1.042	1.00
169_D	193_N	1.042	1.00
490_E	496_K	1.040	1.00
265_T	269_M	1.038	1.00
584_N	587_L	1.037	1.00
539_D	542_L	1.033	1.00
463_T	493_P	1.033	1.00
570_N	589_D	1.032	1.00
447_V	542_L	1.030	1.00
171_R	357_R	1.028	1.00
118_L	382_I	1.027	1.00
408_A	591_F	1.025	1.00
259_V	263_I	1.022	1.00
330_C	358_K	1.021	1.00
278_L	282_T	1.018	1.00
282_T	286_R	1.013	1.00
482_V	516_P	1.010	1.00
33_D	37_R	1.007	1.00
464_G	472_S	1.005	1.00
108_P	120_V	1.003	1.00
40_L	269_M	1.003	1.00
299_H	302_P	1.002	1.00
145_R	226_L	1.002	1.00
300_A	304_F	0.999	1.00
86_K	115_Y	0.999	1.00
452_S	531_D	0.995	1.00
52_S	149_V	0.992	1.00
437_L	559_N	0.990	1.00
35_L	84_P	0.989	1.00
601_R	606_L	0.989	1.00
606_L	610_G	0.989	1.00
257_H	262_L	0.989	1.00
275_P	279_H	0.989	1.00
42_S	96_G	0.987	1.00
222_I	226_L	0.987	1.00
532_M	565_A	0.986	1.00
201_S	209_R	0.986	1.00
278_L	281_M	0.983	1.00
518_A	565_A	0.981	1.00
220_P	224_E	0.981	1.00
39_L	53_G	0.980	1.00
78_V	151_G	0.979	1.00
128_S	375_T	0.979	1.00
454_E	483_G	0.976	1.00
331_E	458_R	0.975	1.00
449_M	534_F	0.973	1.00
84_P	89_T	0.971	1.00
459_Q	492_L	0.968	1.00
423_I	600_M	0.966	1.00
74_L	149_V	0.965	1.00
87_I	277_F	0.964	1.00
158_G	162_E	0.964	1.00
524_S	608_A	0.963	1.00
403_V	416_F	0.960	1.00
491_K	495_G	0.960	1.00
298_F	302_P	0.952	1.00
107_F	110_R	0.950	1.00
426_A	596_T	0.949	1.00
556_V	611_M	0.949	1.00
538_L	543_I	0.948	1.00
509_L	532_M	0.943	1.00
491_K	497_G	0.941	1.00
177_I	266_L	0.941	1.00
344_P	350_S	0.940	1.00
93_D	97_T	0.939	1.00
441_R	571_E	0.937	1.00
304_F	309_G	0.937	1.00
301_V	305_D	0.936	1.00
177_I	240_G	0.935	1.00
504_E	526_N	0.933	1.00
376_F	380_L	0.931	1.00
341_A	363_Y	0.931	1.00
521_V	615_I	0.931	1.00
497_G	500_K	0.926	1.00
548_A	557_E	0.926	1.00
103_G	106_P	0.926	1.00
88_L	91_R	0.922	1.00
407_V	414_V	0.920	1.00
463_T	466_H	0.919	1.00
56_T	59_L	0.919	1.00
200_L	237_V	0.918	1.00
332_T	462_Y	0.917	1.00
321_Y	481_A	0.917	1.00
275_P	280_I	0.915	1.00
563_G	585_I	0.914	1.00
568_G	571_E	0.912	1.00
340_M	380_L	0.909	1.00
53_G	84_P	0.906	1.00
353_V	356_S	0.905	1.00
186_S	347_R	0.903	1.00
105_H	108_P	0.901	1.00
256_G	259_V	0.900	1.00
110_R	119_S	0.900	1.00
490_E	497_G	0.898	1.00
61_V	65_Y	0.897	1.00
87_I	91_R	0.896	1.00
347_R	365_D	0.892	1.00
106_P	110_R	0.892	1.00
295_P	298_F	0.888	1.00
312_P	315_S	0.888	1.00
585_I	614_K	0.885	1.00
289_E	292_E	0.885	1.00
250_Y	268_N	0.882	1.00
260_L	266_L	0.882	1.00
285_G	289_E	0.881	1.00
312_P	316_G	0.879	1.00
501_R	522_A	0.877	1.00
371_Q	402_Q	0.873	1.00
342_I	373_A	0.872	1.00
70_P	91_R	0.872	1.00
583_L	615_I	0.871	1.00
388_I	465_Y	0.871	1.00
281_M	284_K	0.871	1.00
186_S	348_E	0.870	1.00
84_P	91_R	0.870	1.00
127_I	167_A	0.865	1.00
228_R	236_M	0.864	1.00
492_L	497_G	0.863	1.00
493_P	497_G	0.861	1.00
146_T	174_M	0.861	1.00
127_I	148_C	0.860	1.00
184_S	368_I	0.859	1.00
159_M	375_T	0.858	1.00
518_A	529_L	0.858	1.00
400_Y	442_C	0.858	1.00
217_S	220_P	0.857	1.00
492_L	496_K	0.856	1.00
501_R	504_E	0.855	1.00
517_E	601_R	0.853	0.99
325_F	461_L	0.853	0.99
276_Q	279_H	0.852	0.99
84_P	87_I	0.852	0.99
62_A	67_Y	0.852	0.99
61_V	88_L	0.851	0.99
298_F	309_G	0.850	0.99
64_H	85_H	0.849	0.99
302_P	309_G	0.848	0.99
224_E	227_K	0.847	0.99
356_S	359_F	0.844	0.99
541_A	545_E	0.844	0.99
316_G	483_G	0.841	0.99
462_Y	489_L	0.840	0.99
613_A	616_K	0.840	0.99
259_V	262_L	0.840	0.99
499_V	542_L	0.838	0.99
209_R	241_T	0.837	0.99
338_K	385_Y	0.836	0.99
279_H	282_T	0.835	0.99
103_G	107_F	0.834	0.99
69_T	290_P	0.834	0.99
353_V	357_R	0.832	0.99
150_I	155_I	0.832	0.99
103_G	108_P	0.830	0.99
58_E	61_V	0.827	0.99
127_I	160_A	0.826	0.99
547_A	553_L	0.825	0.99
241_T	244_E	0.824	0.99
38_Y	46_S	0.822	0.99
572_V	576_H	0.822	0.99
330_C	359_F	0.821	0.99
417_A	476_Y	0.821	0.99
507_A	546_M	0.819	0.99
67_Y	223_K	0.818	0.99
492_L	498_I	0.817	0.99
491_K	494_I	0.816	0.99
574_M	584_N	0.815	0.99
545_E	549_S	0.814	0.99
563_G	615_I	0.813	0.99
419_D	476_Y	0.811	0.99
544_L	548_A	0.811	0.99
548_A	551_E	0.810	0.99
521_V	585_I	0.808	0.99
306_P	309_G	0.807	0.99
590_F	593_P	0.807	0.99
121_G	124_S	0.805	0.99
209_R	239_P	0.804	0.99
73_Q	144_R	0.802	0.99
520_K	609_A	0.802	0.99
489_L	493_P	0.801	0.99
506_L	552_A	0.799	0.99
336_D	339_L	0.798	0.99
563_G	614_K	0.795	0.99
153_G	184_S	0.795	0.99
517_E	611_M	0.795	0.99
156_T	184_S	0.795	0.99
397_Q	400_Y	0.794	0.99
511_F	537_P	0.793	0.99
542_L	546_M	0.790	0.99
320_S	323_K	0.789	0.99
165_N	192_L	0.789	0.99
284_K	290_P	0.786	0.99
564_G	578_K	0.786	0.99
125_T	375_T	0.786	0.99
63_L	74_L	0.783	0.99
509_L	555_T	0.783	0.99
489_L	492_L	0.781	0.99
251_I	265_T	0.780	0.99
279_H	283_K	0.779	0.99
173_D	233_I	0.777	0.99
411_K	470_G	0.776	0.99
389_V	416_F	0.776	0.99
304_F	308_S	0.776	0.99
429_Q	432_Q	0.775	0.99
133_I	379_G	0.774	0.99
507_A	530_V	0.773	0.99
495_G	499_V	0.772	0.99
136_A	380_L	0.772	0.99
38_Y	87_I	0.772	0.99
124_S	157_A	0.771	0.99
521_V	611_M	0.770	0.99
496_K	500_K	0.770	0.99
325_F	390_A	0.770	0.99
305_D	309_G	0.768	0.99
439_Y	443_I	0.768	0.99
284_K	291_A	0.767	0.99
508_I	554_V	0.767	0.99
328_W	462_Y	0.767	0.99
37_R	41_D	0.766	0.99
235_G	238_V	0.765	0.99
598_E	602_A	0.763	0.99
62_A	215_V	0.763	0.99
450_T	513_T	0.760	0.99
437_L	448_I	0.758	0.99
586_G	589_D	0.758	0.99
510_N	529_L	0.758	0.99
524_S	609_A	0.757	0.99
377_A	380_L	0.757	0.99
353_V	358_K	0.757	0.99
460_M	492_L	0.757	0.99
500_K	519_A	0.755	0.99
595_G	599_E	0.755	0.99
138_E	360_P	0.755	0.99
514_L	556_V	0.755	0.99
78_V	149_V	0.755	0.99
224_E	228_R	0.754	0.99
561_I	586_G	0.752	0.99
506_L	527_A	0.749	0.99
511_F	535_V	0.749	0.99
72_D	77_D	0.749	0.99
570_N	582_V	0.748	0.99
296_I	299_H	0.747	0.99
104_L	109_W	0.747	0.99
494_I	498_I	0.746	0.99
530_V	542_L	0.744	0.99
355_F	360_P	0.744	0.99
314_S	317_G	0.744	0.99
128_S	163_A	0.744	0.99
54_L	269_M	0.744	0.99
597_Q	600_M	0.743	0.99
452_S	498_I	0.742	0.99
501_R	526_N	0.741	0.99
530_V	616_K	0.739	0.99
539_D	543_I	0.739	0.99
609_A	612_E	0.738	0.99
287_G	290_P	0.736	0.99
578_K	581_P	0.735	0.99
261_G	264_T	0.735	0.99
210_E	217_S	0.735	0.99
403_V	440_L	0.731	0.98
65_Y	263_I	0.731	0.98
267_K	270_R	0.730	0.98
523_E	527_A	0.728	0.98
171_R	233_I	0.727	0.98
447_V	541_A	0.727	0.98
73_Q	133_I	0.726	0.98
257_H	270_R	0.725	0.98
488_P	493_P	0.725	0.98
208_L	225_L	0.723	0.98
488_P	491_K	0.723	0.98
400_Y	418_I	0.722	0.98
380_L	387_P	0.722	0.98
52_S	78_V	0.721	0.98
52_S	55_G	0.719	0.98
199_L	203_K	0.719	0.98
436_D	565_A	0.718	0.98
161_F	164_M	0.718	0.98
327_D	354_E	0.717	0.98
328_W	331_E	0.717	0.98
438_S	571_E	0.717	0.98
297_T	301_V	0.714	0.98
333_A	339_L	0.713	0.98
137_A	383_G	0.713	0.98
287_G	291_A	0.712	0.98
45_R	96_G	0.712	0.98
326_G	351_G	0.711	0.98
582_V	587_L	0.710	0.98
459_Q	462_Y	0.708	0.98
495_G	498_I	0.706	0.98
106_P	115_Y	0.706	0.98
354_E	359_F	0.703	0.98
129_A	410_Q	0.702	0.98
97_T	100_Q	0.702	0.98
571_E	574_M	0.702	0.98
460_M	474_V	0.701	0.98
207_S	239_P	0.700	0.98
44_S	266_L	0.700	0.98
542_L	545_E	0.698	0.98
104_L	108_P	0.698	0.98
413_P	468_N	0.696	0.98
585_I	611_M	0.696	0.98
611_M	614_K	0.696	0.98
56_T	81_Q	0.693	0.98
120_V	124_S	0.693	0.98
408_A	443_I	0.690	0.98
544_L	551_E	0.689	0.98
507_A	556_V	0.689	0.98
307_S	311_L	0.689	0.98
552_A	558_E	0.688	0.98
286_R	290_P	0.687	0.98
484_V	519_A	0.686	0.98
137_A	142_K	0.686	0.98
397_Q	436_D	0.686	0.98
488_P	492_L	0.682	0.98
125_T	371_Q	0.682	0.98
73_Q	383_G	0.682	0.98
355_F	359_F	0.681	0.98
155_I	160_A	0.680	0.98
374_V	389_V	0.679	0.97
326_G	330_C	0.678	0.97
272_L	276_Q	0.678	0.97
439_Y	442_C	0.678	0.97
561_I	584_N	0.678	0.97
524_S	528_T	0.678	0.97
206_S	224_E	0.676	0.97
140_E	383_G	0.675	0.97
62_A	219_V	0.674	0.97
256_G	262_L	0.672	0.97
438_S	572_V	0.671	0.97
509_L	543_I	0.671	0.97
245_E	256_G	0.670	0.97
489_L	495_G	0.669	0.97
266_L	270_R	0.669	0.97
34_E	37_R	0.667	0.97
149_V	177_I	0.667	0.97
497_G	530_V	0.666	0.97
490_E	498_I	0.666	0.97
505_K	532_M	0.665	0.97
87_I	92_R	0.665	0.97
301_V	306_P	0.665	0.97
605_G	610_G	0.664	0.97
79_G	108_P	0.662	0.97
592_I	604_L	0.661	0.97
252_G	255_D	0.661	0.97
463_T	467_Y	0.661	0.97
159_M	163_A	0.660	0.97
560_A	580_V	0.659	0.97
347_R	363_Y	0.659	0.97
440_L	443_I	0.658	0.97
447_V	463_T	0.658	0.97
366_V	377_A	0.657	0.97
79_G	179_N	0.655	0.97
101_K	600_M	0.655	0.97
578_K	582_V	0.654	0.97
459_Q	489_L	0.653	0.97
515_M	529_L	0.653	0.97
503_G	526_N	0.652	0.97
147_V	175_L	0.652	0.97
42_S	46_S	0.651	0.97
256_G	260_L	0.651	0.97
456_E	531_D	0.650	0.97
423_I	604_L	0.648	0.97
415_L	472_S	0.648	0.97
63_L	147_V	0.644	0.97
103_G	113_S	0.641	0.96
248_F	268_N	0.639	0.96
306_P	310_C	0.639	0.96
507_A	555_T	0.639	0.96
284_K	288_Y	0.638	0.96
131_I	167_A	0.638	0.96
536_K	539_D	0.637	0.96
323_K	326_G	0.636	0.96
415_L	461_L	0.635	0.96
62_A	66_V	0.635	0.96
449_M	463_T	0.635	0.96
73_Q	137_A	0.634	0.96
182_E	188_N	0.634	0.96
593_P	603_E	0.634	0.96
39_L	43_V	0.633	0.96
559_N	562_M	0.633	0.96
502_R	526_N	0.632	0.96
552_A	555_T	0.632	0.96
529_L	534_F	0.630	0.96
502_R	531_D	0.629	0.96
612_E	615_I	0.627	0.96
496_K	532_M	0.627	0.96
150_I	154_A	0.627	0.96
419_D	474_V	0.625	0.96
56_T	60_T	0.624	0.96
225_L	236_M	0.624	0.96
491_K	498_I	0.623	0.96
166_H	372_H	0.622	0.96
78_V	81_Q	0.621	0.96
221_P	225_L	0.621	0.96
554_V	615_I	0.621	0.96
446_M	471_P	0.620	0.96
519_A	523_E	0.619	0.96
423_I	601_R	0.619	0.96
448_I	475_R	0.618	0.96
533_R	538_L	0.618	0.96
173_D	273_K	0.617	0.96
348_E	365_D	0.617	0.96
499_V	528_T	0.616	0.96
44_S	262_L	0.616	0.96
423_I	587_L	0.615	0.96
111_G	411_K	0.615	0.96
396_L	440_L	0.615	0.96
303_K	307_S	0.613	0.95
490_E	495_G	0.611	0.95
313_K	318_L	0.611	0.95
508_I	556_V	0.609	0.95
261_G	265_T	0.609	0.95
102_G	107_F	0.608	0.95
70_P	89_T	0.608	0.95
222_I	238_V	0.602	0.95
517_E	607_D	0.601	0.95
507_A	559_N	0.601	0.95
211_G	214_K	0.601	0.95
159_M	402_Q	0.600	0.95
534_F	539_D	0.600	0.95
496_K	499_V	0.600	0.95
524_S	529_L	0.600	0.95
324_I	457_C	0.599	0.95
118_L	410_Q	0.599	0.95
102_G	106_P	0.599	0.95
135_V	166_H	0.598	0.95
567_S	573_L	0.598	0.95
488_P	495_G	0.597	0.95
333_A	355_F	0.597	0.95
555_T	566_G	0.597	0.95
262_L	270_R	0.596	0.95
490_E	501_R	0.595	0.95
462_Y	493_P	0.594	0.95
327_D	331_E	0.594	0.95
328_W	332_T	0.593	0.95
131_I	163_A	0.593	0.95
415_L	465_Y	0.593	0.95
540_E	577_R	0.593	0.95
138_E	172_P	0.592	0.95
121_G	126_S	0.591	0.94
210_E	218_G	0.591	0.94
307_S	310_C	0.591	0.94
243_F	247_G	0.590	0.94
508_I	527_A	0.589	0.94
243_F	253_P	0.589	0.94
272_L	275_P	0.588	0.94
58_E	62_A	0.588	0.94
222_I	227_K	0.588	0.94
505_K	530_V	0.586	0.94
232_H	235_G	0.585	0.94
291_A	294_D	0.584	0.94
497_G	503_G	0.584	0.94
336_D	465_Y	0.584	0.94
447_V	545_E	0.582	0.94
252_G	257_H	0.581	0.94
206_S	233_I	0.580	0.94
382_I	412_L	0.579	0.94
58_E	213_K	0.574	0.94
59_L	149_V	0.574	0.94
355_F	358_K	0.574	0.94
354_E	365_D	0.573	0.94
330_C	334_A	0.573	0.94
245_E	248_F	0.573	0.94
300_A	303_K	0.571	0.93
481_A	513_T	0.570	0.93
585_I	606_L	0.570	0.93
60_T	85_H	0.569	0.93
275_P	282_T	0.568	0.93
102_G	105_H	0.567	0.93
102_G	593_P	0.565	0.93
330_C	363_Y	0.562	0.93
178_L	239_P	0.562	0.93
45_R	100_Q	0.561	0.93
522_A	526_N	0.561	0.93
120_V	125_T	0.560	0.93
377_A	387_P	0.559	0.93
243_F	248_F	0.559	0.93
280_I	284_K	0.559	0.93
298_F	301_V	0.558	0.93
129_A	382_I	0.558	0.93
563_G	583_L	0.557	0.93
235_G	239_P	0.556	0.93
269_M	278_L	0.555	0.92
264_T	267_K	0.555	0.92
319_P	454_E	0.554	0.92
587_L	600_M	0.552	0.92
133_I	382_I	0.549	0.92
366_V	372_H	0.547	0.92
409_I	429_Q	0.547	0.92
401_D	407_V	0.547	0.92
555_T	558_E	0.546	0.92
568_G	573_L	0.546	0.92
147_V	226_L	0.544	0.92
364_F	376_F	0.544	0.92
125_T	403_V	0.541	0.91
145_R	174_M	0.540	0.91
555_T	559_N	0.540	0.91
388_I	461_L	0.540	0.91
163_A	372_H	0.540	0.91
569_V	572_V	0.539	0.91
166_H	367_A	0.537	0.91
593_P	596_T	0.537	0.91
285_G	288_Y	0.537	0.91
379_G	382_I	0.536	0.91
413_P	469_D	0.536	0.91
387_P	413_P	0.536	0.91
247_G	250_Y	0.535	0.91
489_L	497_G	0.535	0.91
491_K	501_R	0.534	0.91
125_T	399_A	0.534	0.91
292_E	295_P	0.533	0.91
374_V	403_V	0.533	0.91
117_V	133_I	0.532	0.91
62_A	218_G	0.531	0.91
324_I	328_W	0.531	0.91
71_F	143_N	0.531	0.91
491_K	496_K	0.530	0.91
332_T	336_D	0.529	0.91
139_K	380_L	0.527	0.90
328_W	461_L	0.526	0.90
564_G	574_M	0.525	0.90
454_E	481_A	0.525	0.90
587_L	606_L	0.524	0.90
583_L	587_L	0.523	0.90
112_E	593_P	0.522	0.90
127_I	130_G	0.521	0.90
205_Y	237_V	0.521	0.90
53_G	56_T	0.520	0.90
341_A	355_F	0.520	0.90
135_V	139_K	0.520	0.90
415_L	474_V	0.518	0.90
493_P	501_R	0.517	0.90
526_N	531_D	0.517	0.90
508_I	565_A	0.517	0.90
492_L	500_K	0.517	0.90
564_G	573_L	0.517	0.90
274_G	279_H	0.516	0.89
437_L	511_F	0.515	0.89
94_K	104_L	0.515	0.89
241_T	245_E	0.515	0.89
552_A	556_V	0.514	0.89
110_R	410_Q	0.514	0.89
459_Q	463_T	0.514	0.89
565_A	611_M	0.513	0.89
150_I	160_A	0.513	0.89
92_R	96_G	0.513	0.89
250_Y	254_V	0.512	0.89
250_Y	255_D	0.512	0.89
100_Q	596_T	0.512	0.89
502_R	549_S	0.510	0.89
434_A	560_A	0.509	0.89
211_G	217_S	0.509	0.89
580_V	583_L	0.509	0.89
102_G	112_E	0.509	0.89
492_L	501_R	0.508	0.89
496_K	540_E	0.508	0.89
133_I	146_T	0.507	0.89
507_A	528_T	0.507	0.89
406_D	409_I	0.506	0.89
399_A	402_Q	0.506	0.89
46_S	98_I	0.505	0.88
104_L	110_R	0.504	0.88
371_Q	401_D	0.504	0.88
492_L	495_G	0.503	0.88
56_T	78_V	0.503	0.88
109_W	112_E	0.503	0.88
329_L	333_A	0.503	0.88
375_T	402_Q	0.502	0.88
489_L	496_K	0.501	0.88
215_V	218_G	0.500	0.88
173_D	206_S	0.500	0.88
500_K	526_N	0.500	0.88
107_F	113_S	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2o1sA	2	0.8645	100	0.241	Contact Map
2o1xA	2	0.9226	100	0.244	Contact Map
1r9jA	2	0.9355	100	0.268	Contact Map
1itzA	2	0.9387	100	0.279	Contact Map
3rimA	2	0.9548	100	0.281	Contact Map
4kxvA	2	0.9435	100	0.289	Contact Map
1gpuA	2	0.9306	100	0.29	Contact Map
3uk1A	2	0.9339	100	0.29	Contact Map
2r8oA	2	0.9339	100	0.298	Contact Map
2qtcA	2	0.9548	100	0.3	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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