GREMLIN Database
CUSS - Sensor kinase CusS
UniProt: P77485 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13642
Length: 480 (438)
Sequences: 52368 (45118)
Seq/√Len: 2155.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
413_E473_R4.0631.00
414_N418_P3.9221.00
453_K457_V3.7061.00
336_L371_G3.7011.00
407_L477_T3.6781.00
284_T304_N3.6341.00
464_A475_V3.5581.00
411_I473_R3.1651.00
400_R411_I3.0081.00
404_V409_Q3.0031.00
424_L467_S3.0011.00
409_Q477_T2.8341.00
411_I475_V2.8151.00
371_G459_H2.8091.00
361_R398_V2.7961.00
420_A423_H2.7381.00
402_Q409_Q2.7381.00
409_Q475_V2.7331.00
288_L305_L2.6991.00
391_T415_P2.6781.00
398_V413_E2.6541.00
335_M370_A2.6381.00
465_V474_F2.5931.00
288_L302_Y2.5701.00
452_V463_V2.5671.00
281_I309_T2.5651.00
396_T415_P2.5561.00
379_A456_V2.5381.00
361_R396_T2.5091.00
400_R413_E2.4641.00
402_Q411_I2.4591.00
466_T475_V2.4521.00
456_V461_G2.4341.00
466_T473_R2.4191.00
424_L465_V2.3911.00
428_F463_V2.3381.00
419_I427_L2.3341.00
337_N340_D2.3191.00
335_M368_Q2.2941.00
467_S472_T2.2681.00
423_H426_R2.2431.00
344_K377_R2.2431.00
281_I308_L2.2281.00
239_I242_E2.2001.00
334_K373_P2.1751.00
462_T477_T2.1551.00
294_Q297_L2.1331.00
456_V476_I2.0761.00
349_F381_S2.0641.00
359_E396_T2.0071.00
421_P424_L1.9701.00
379_A455_I1.9561.00
379_A452_V1.9361.00
312_A316_S1.9031.00
333_K370_A1.8891.00
281_I312_A1.8831.00
371_G376_L1.8581.00
426_R429_D1.8351.00
419_I423_H1.8251.00
455_I459_H1.8231.00
353_A388_L1.8141.00
464_A477_T1.8101.00
285_E305_L1.7981.00
264_N268_D1.7971.00
426_R432_Y1.7951.00
252_I255_I1.7951.00
423_H432_Y1.7621.00
260_T264_N1.7491.00
385_S389_R1.7321.00
92_D96_K1.7301.00
251_M255_I1.7241.00
380_L410_V1.7201.00
238_P242_E1.6991.00
457_V462_T1.6991.00
241_L245_V1.6971.00
410_V476_I1.6821.00
293_S297_L1.6791.00
33_W37_H1.6681.00
283_Q300_V1.6581.00
372_D375_M1.6541.00
284_T305_L1.6501.00
391_T395_E1.6181.00
256_E259_F1.6151.00
404_V477_T1.6041.00
288_L298_E1.5961.00
287_A301_L1.5891.00
248_F251_M1.5771.00
419_I472_T1.5681.00
339_A401_C1.5681.00
245_V249_N1.5581.00
423_H434_V1.5491.00
339_A343_G1.5331.00
395_E415_P1.5251.00
398_V415_P1.5231.00
280_L308_L1.5221.00
414_N471_G1.5201.00
262_Q266_S1.5171.00
305_L309_T1.5031.00
222_N227_D1.5011.00
249_N252_I1.4491.00
429_D432_Y1.4481.00
217_S221_Q1.4431.00
379_A476_I1.4401.00
382_N452_V1.4391.00
344_K373_P1.4351.00
348_F377_R1.4321.00
428_F465_V1.4211.00
375_M378_R1.4201.00
456_V463_V1.4151.00
293_S296_E1.3961.00
280_L304_N1.3941.00
424_L428_F1.3921.00
467_S470_R1.3881.00
281_I305_L1.3871.00
337_N366_K1.3851.00
279_N307_E1.3791.00
390_Y433_R1.3611.00
373_P377_R1.3501.00
185_N189_M1.3491.00
337_N368_Q1.3391.00
350_E354_E1.3161.00
287_A297_L1.3161.00
290_Q297_L1.3151.00
214_R217_S1.3051.00
352_L355_D1.2971.00
252_I256_E1.2901.00
279_N283_Q1.2881.00
407_L462_T1.2731.00
375_M458_A1.2681.00
454_S457_V1.2671.00
202_V206_V1.2671.00
217_S243_Q1.2631.00
220_I223_I1.2581.00
259_F262_Q1.2551.00
236_T242_E1.2461.00
433_R442_G1.2411.00
268_D430_R1.2341.00
427_L465_V1.2311.00
346_F362_F1.2291.00
375_M455_I1.2291.00
341_E345_V1.2281.00
272_E378_R1.2191.00
302_Y306_E1.2171.00
257_D261_R1.2151.00
331_P372_D1.2141.00
428_F474_F1.2061.00
465_V472_T1.2051.00
284_T308_L1.2041.00
283_Q303_S1.1941.00
461_G478_L1.1891.00
391_T397_I1.1691.00
363_V400_R1.1651.00
223_I252_I1.1641.00
313_K374_L1.1601.00
265_F269_I1.1591.00
241_L244_L1.1551.00
343_G362_F1.1441.00
216_V220_I1.1441.00
342_V401_C1.1271.00
73_L77_E1.1221.00
333_K459_H1.1141.00
404_V407_L1.1131.00
419_I424_L1.1061.00
284_T288_L1.1051.00
294_Q298_E1.1041.00
367_C408_V1.0951.00
247_S250_H1.0941.00
284_T301_L1.0931.00
217_S220_I1.0921.00
206_V210_H1.0881.00
382_N385_S1.0871.00
345_V349_F1.0821.00
413_E468_D1.0791.00
282_T286_I1.0751.00
428_F453_K1.0741.00
231_R253_E1.0721.00
319_L322_A1.0711.00
376_L459_H1.0681.00
242_E245_V1.0671.00
259_F263_S1.0631.00
345_V381_S1.0631.00
227_D230_V1.0611.00
91_A97_T1.0501.00
173_I177_L1.0501.00
250_H254_R1.0481.00
316_S320_F1.0461.00
279_N282_T1.0441.00
222_N230_V1.0401.00
55_S59_E1.0371.00
419_I465_V1.0361.00
339_A366_K1.0311.00
387_A397_I1.0311.00
89_S97_T1.0291.00
181_N185_N1.0261.00
414_N472_T1.0251.00
340_D344_K1.0241.00
207_H211_A1.0241.00
307_E310_R1.0231.00
299_D303_S1.0211.00
383_L474_F1.0201.00
187_L191_A1.0151.00
15_R239_I1.0081.00
245_V248_F1.0071.00
430_R454_S1.0051.00
345_V377_R0.9971.00
34_I38_S0.9951.00
238_P241_L0.9921.00
256_E260_T0.9901.00
392_P395_E0.9861.00
380_L412_V0.9841.00
274_R316_S0.9841.00
303_S307_E0.9831.00
258_V262_Q0.9831.00
383_L463_V0.9811.00
89_S168_Y0.9791.00
349_F384_L0.9791.00
298_E302_Y0.9781.00
421_P467_S0.9761.00
380_L384_L0.9751.00
126_Y129_S0.9691.00
336_L341_E0.9641.00
338_L410_V0.9641.00
59_E63_N0.9631.00
40_K44_A0.9611.00
272_E382_N0.9601.00
346_F350_E0.9591.00
348_F381_S0.9591.00
345_V384_L0.9581.00
317_D375_M0.9571.00
264_N430_R0.9571.00
186_K189_M0.9551.00
48_I52_K0.9541.00
377_R381_S0.9531.00
281_I285_E0.9501.00
52_K56_A0.9501.00
381_S385_S0.9471.00
32_A36_I0.9381.00
313_K317_D0.9361.00
44_A48_I0.9291.00
251_M254_R0.9281.00
427_L474_F0.9251.00
331_P375_M0.9221.00
308_L312_A0.9211.00
384_L399_V0.9211.00
87_L170_A0.9201.00
260_T263_S0.9191.00
199_V203_L0.9171.00
419_I425_P0.9161.00
77_E81_S0.9141.00
390_Y417_T0.9111.00
220_I224_T0.9061.00
13_A207_H0.9041.00
383_L452_V0.8951.00
341_E371_G0.8941.00
271_H382_N0.8891.00
54_I57_T0.8851.00
233_D249_N0.8851.00
306_E344_K0.8821.00
212_P217_S0.8811.00
447_I451_I0.8811.00
242_E246_L0.8801.00
184_M188_I0.8771.00
154_P166_T0.8711.00
200_F204_L0.8701.00
342_V380_L0.8691.00
162_K165_Y0.8691.00
248_F252_I0.8681.00
223_I251_M0.8681.00
176_H180_I0.8671.00
452_V456_V0.8651.00
66_D70_A0.8641.00
337_N367_C0.8621.00
304_N308_L0.8611.00
152_N166_T0.8611.00
343_G347_D0.8581.00
219_Q232_L0.8581.00
295_K298_E0.8571.00
209_G212_P0.8541.00
51_L55_S0.8521.00
220_I248_F0.8501.00
456_V478_L0.8481.00
352_L385_S0.8481.00
187_L190_T0.8461.00
204_L208_K0.8461.00
143_M146_S0.8441.00
234_P246_L0.8431.00
379_A459_H0.8301.00
367_C403_T0.8301.00
73_L76_L0.8281.00
378_R455_I0.8281.00
246_L249_N0.8261.00
417_T442_G0.8261.00
55_S58_L0.8261.00
203_L207_H0.8211.00
291_S297_L0.8201.00
231_R249_N0.8181.00
76_L80_V0.8181.00
363_V398_V0.8171.00
274_R312_A0.8161.00
418_P472_T0.8141.00
101_S104_A0.8141.00
212_P216_V0.8131.00
349_F385_S0.8121.00
275_T279_N0.8111.00
103_G106_D0.8101.00
220_I247_S0.8101.00
454_S458_A0.8091.00
333_K371_G0.8061.00
342_V399_V0.8061.00
272_E276_P0.8041.00
383_L476_I0.8041.00
353_A397_I0.8001.00
217_S247_S0.7991.00
273_I311_M0.7971.00
97_T100_H0.7961.00
180_I184_M0.7961.00
331_P458_A0.7911.00
291_S294_Q0.7901.00
36_I184_M0.7871.00
419_I467_S0.7861.00
278_T282_T0.7861.00
87_L100_H0.7861.00
302_Y305_L0.7801.00
257_D260_T0.7781.00
86_V89_S0.7731.00
244_L248_F0.7731.00
347_D350_E0.7721.00
48_I149_R0.7711.00
420_A434_V0.7711.00
161_G164_I0.7701.00
433_R444_G0.7701.00
320_F378_R0.7691.00
102_P105_P0.7681.00
219_Q230_V0.7661.00
47_D50_D0.7651.00
156_G163_P0.7621.00
333_K460_K0.7611.00
384_L397_I0.7601.00
374_L377_R0.7591.00
283_Q304_N0.7591.00
297_L300_V0.7581.00
338_L408_V0.7581.00
208_K211_A0.7581.00
102_P106_D0.7571.00
246_L250_H0.7561.00
461_G476_I0.7551.00
309_T312_A0.7551.00
277_I315_V0.7531.00
299_D302_Y0.7521.00
188_I192_S0.7511.00
339_A364_G0.7491.00
218_R222_N0.7491.00
321_L450_A0.7481.00
332_E372_D0.7471.00
37_H40_K0.7471.00
150_M170_A0.7451.00
221_Q243_Q0.7451.00
399_V412_V0.7441.00
279_N303_S0.7431.00
50_D53_E0.7431.00
343_G346_F0.7421.00
401_C408_V0.7411.00
182_D186_K0.7411.00
346_F360_L0.7371.00
45_E48_I0.7321.00
453_K462_T0.7301.00
358_V362_F0.7291.00
364_G401_C0.7261.00
243_Q247_S0.7251.00
177_L180_I0.7241.00
206_V209_G0.7221.00
44_A47_D0.7211.00
247_S251_M0.7201.00
78_D82_G0.7201.00
354_E357_G0.7181.00
389_R442_G0.7181.00
91_A168_Y0.7171.00
92_D95_G0.7171.00
424_L466_T0.7161.00
303_S306_E0.7161.00
359_E362_F0.7151.00
320_F375_M0.7151.00
414_N417_T0.7141.00
401_C410_V0.7141.00
214_R218_R0.7131.00
231_R252_I0.7131.00
181_N184_M0.7121.00
67_E70_A0.7121.00
286_I290_Q0.7121.00
310_R377_R0.7111.00
72_R77_E0.7101.00
166_T170_A0.7101.00
288_L301_L0.7091.00
421_P425_P0.7091.00
421_P468_D0.7071.00
74_M78_D0.7051.00
238_P245_V0.7041.00
387_A412_V0.7021.00
411_I466_T0.7021.00
23_A27_A0.7021.00
224_T250_H0.7011.00
349_F388_L0.6991.00
37_H41_V0.6981.00
464_A476_I0.6971.00
213_I216_V0.6961.00
234_P239_I0.6951.00
213_I217_S0.6941.00
403_T408_V0.6921.00
100_H104_A0.6921.00
351_A355_D0.6901.00
424_L474_F0.6891.00
148_W152_N0.6891.00
92_D98_V0.6881.00
61_V64_H0.6881.00
391_T394_G0.6881.00
49_N52_K0.6861.00
244_L247_S0.6861.00
198_I202_V0.6861.00
366_K369_V0.6851.00
100_H103_G0.6851.00
296_E300_V0.6851.00
283_Q307_E0.6851.00
43_F46_Q0.6851.00
219_Q222_N0.6841.00
74_M77_E0.6831.00
271_H275_T0.6831.00
269_I318_M0.6811.00
352_L356_R0.6801.00
69_Q73_L0.6801.00
345_V348_F0.6801.00
383_L456_V0.6791.00
78_D81_S0.6771.00
29_F33_W0.6771.00
358_V388_L0.6771.00
266_S269_I0.6751.00
141_G144_E0.6691.00
147_N154_P0.6691.00
186_K190_T0.6681.00
46_Q50_D0.6671.00
185_N188_I0.6661.00
261_R264_N0.6661.00
451_I455_I0.6661.00
272_E451_I0.6651.00
336_L370_A0.6651.00
319_L323_Q0.6621.00
208_K212_P0.6621.00
375_M459_H0.6611.00
375_M379_A0.6611.00
263_S325_D0.6601.00
79_I82_G0.6581.00
249_N253_E0.6581.00
351_A354_E0.6571.00
336_L373_P0.6541.00
329_L375_M0.6531.00
317_D378_R0.6521.00
152_N168_Y0.6521.00
73_L79_I0.6511.00
358_V391_T0.6501.00
363_V402_Q0.6501.00
139_G143_M0.6491.00
100_H105_P0.6481.00
150_M153_L0.6461.00
353_A356_R0.6461.00
300_V304_N0.6461.00
427_L450_A0.6441.00
79_I83_Y0.6441.00
148_W170_A0.6441.00
234_P245_V0.6441.00
140_H143_M0.6421.00
286_I300_V0.6411.00
211_A215_S0.6401.00
272_E314_M0.6401.00
177_L181_N0.6391.00
239_I243_Q0.6391.00
357_G394_G0.6391.00
258_V261_R0.6391.00
367_C370_A0.6381.00
409_Q464_A0.6381.00
243_Q246_L0.6381.00
42_H46_Q0.6351.00
338_L369_V0.6341.00
254_R257_D0.6331.00
220_I244_L0.6331.00
311_M315_V0.6321.00
58_L61_V0.6321.00
140_H144_E0.6311.00
290_Q300_V0.6311.00
353_A360_L0.6311.00
53_E56_A0.6281.00
50_D54_I0.6281.00
71_R74_M0.6271.00
182_D185_N0.6251.00
378_R381_S0.6251.00
60_R64_H0.6251.00
147_N150_M0.6251.00
418_P471_G0.6241.00
180_I183_L0.6231.00
353_A358_V0.6221.00
265_F272_E0.6211.00
232_L245_V0.6171.00
86_V171_L0.6161.00
305_L308_L0.6151.00
339_A367_C0.6131.00
367_C401_C0.6121.00
66_D69_Q0.6101.00
143_M148_W0.6101.00
56_A59_E0.6081.00
70_A74_M0.6071.00
423_H436_P0.6071.00
164_I168_Y0.6071.00
340_D373_P0.6061.00
357_G393_T0.6061.00
344_K348_F0.6051.00
165_Y169_I0.6041.00
216_V219_Q0.6031.00
307_E348_F0.6011.00
215_S218_R0.5991.00
146_S150_M0.5991.00
397_I412_V0.5991.00
41_V45_E0.5981.00
341_E377_R0.5981.00
230_V233_D0.5961.00
413_E469_A0.5951.00
433_R443_E0.5951.00
232_L249_N0.5931.00
450_A454_S0.5911.00
403_T407_L0.5911.00
347_D351_A0.5911.00
51_L54_I0.5911.00
60_R63_N0.5891.00
141_G145_H0.5871.00
41_V44_A0.5861.00
398_V401_C0.5861.00
215_S219_Q0.5861.00
149_R152_N0.5851.00
255_I258_V0.5831.00
142_H146_S0.5821.00
235_Q238_P0.5811.00
228_L231_R0.5801.00
125_V128_L0.5801.00
143_M147_N0.5781.00
463_V474_F0.5781.00
341_E376_L0.5781.00
161_G165_Y0.5781.00
336_L376_L0.5781.00
301_L305_L0.5781.00
49_N53_E0.5781.00
47_D51_L0.5771.00
36_I40_K0.5771.00
376_L380_L0.5761.00
278_T281_I0.5751.00
275_T282_T0.5751.00
287_A300_V0.5731.00
154_P163_P0.5721.00
331_P459_H0.5711.00
419_I474_F0.5711.00
33_W36_I0.5701.00
312_A315_V0.5681.00
34_I37_H0.5681.00
356_R388_L0.5641.00
58_L62_L0.5631.00
471_G474_F0.5631.00
38_S42_H0.5621.00
72_R75_T0.5621.00
184_M187_L0.5611.00
452_V455_I0.5601.00
213_I244_L0.5591.00
253_E257_D0.5591.00
38_S41_V0.5591.00
138_H141_G0.5591.00
240_E243_Q0.5581.00
321_L454_S0.5571.00
285_E289_S0.5551.00
75_T79_I0.5551.00
221_Q247_S0.5541.00
30_A34_I0.5531.00
62_L65_P0.5531.00
318_M431_F0.5511.00
424_L472_T0.5511.00
236_T239_I0.5501.00
173_I176_H0.5501.00
280_L284_T0.5491.00
321_L430_R0.5481.00
238_P244_L0.5481.00
97_T101_S0.5481.00
210_H214_R0.5481.00
273_I276_P0.5461.00
176_H179_Y0.5461.00
268_D272_E0.5451.00
207_H210_H0.5451.00
272_E275_T0.5451.00
346_F399_V0.5441.00
266_S270_A0.5441.00
46_Q49_N0.5431.00
389_R444_G0.5421.00
175_F178_H0.5421.00
40_K43_F0.5411.00
428_F431_F0.5411.00
13_A214_R0.5411.00
77_E80_V0.5391.00
233_D236_T0.5371.00
230_V234_P0.5371.00
201_I205_A0.5361.00
57_T61_V0.5351.00
21_S24_T0.5331.00
56_A60_R0.5331.00
234_P238_P0.5321.00
48_I51_L0.5321.00
19_F23_A0.5311.00
216_V248_F0.5311.00
55_S169_I0.5291.00
280_L307_E0.5281.00
104_A108_R0.5271.00
283_Q308_L0.5271.00
61_V65_P0.5261.00
216_V221_Q0.5261.00
218_R221_Q0.5261.00
392_P415_P0.5261.00
139_G142_H0.5251.00
346_F349_F0.5231.00
270_A276_P0.5211.00
244_L249_N0.5191.00
290_Q293_S0.5181.00
192_S196_I0.5171.00
309_T313_K0.5171.00
417_T472_T0.5171.00
213_I241_L0.5171.00
311_M319_L0.5161.00
71_R75_T0.5161.00
224_T254_R0.5161.00
383_L412_V0.5151.00
142_H145_H0.5141.00
325_D430_R0.5141.00
216_V245_V0.5141.00
456_V462_T0.5131.00
273_I315_V0.5131.00
107_I110_F0.5121.00
14_T18_F0.5121.00
144_E148_W0.5121.00
290_Q296_E0.5111.00
427_L432_Y0.5101.00
369_V408_V0.5101.00
144_E147_N0.5091.00
276_P311_M0.5081.00
226_K229_D0.5081.00
70_A73_L0.5061.00
22_L25_I0.5061.00
285_E288_L0.5051.00
220_I251_M0.5051.00
431_F450_A0.5041.00
156_G161_G0.5041.00
254_R258_V0.5041.00
389_R443_E0.5041.00
317_D374_L0.5031.00
138_H142_H0.5021.00
348_F352_L0.5011.00
245_V251_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.5625 100 0.35 Contact Map
4bixA 2 0.4646 100 0.4 Contact Map
4ctiA 2 0.475 100 0.427 Contact Map
3a0rA 2 0.6771 100 0.454 Contact Map
4q20A 2 0.4708 100 0.459 Contact Map
4gczA 2 0.7375 100 0.469 Contact Map
4mpcA 2 0.6083 100 0.48 Contact Map
3jz3A 2 0.3292 100 0.483 Contact Map
2c2aA 2 0.4771 100 0.485 Contact Map
3d36A 2 0.4542 100 0.488 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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