CUSS - ECOLI - GREMLIN Contacts

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CUSS - Sensor kinase CusS

UniProt:	P77485	Sequences: MVSKPFQRPFSLATRLTFFISLATIAAFFAFAWIMIHSVKVHFAEQDINDLKEISATLERVLNHPDETQARRLMTLEDIVSGYSNVLISLADSQGKTVYHSPGAPDIREFTRDAIPDKDAQGGEVYLLSGPTMMMPGHGHGHMEHSNWRMINLPVGPLVDGKPIYTLYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELRFVGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVITLPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13642
Length:	480 (438)
Sequences:	52368 (45118)
Seq/√Len:	2155.8

ECOLI - CUSS BARA GLRK YEDV TORS CREC BAES PHOQ QSEC CPXA ENVZ RSTB RCSC RCSD ATOS ZRAS DCUS ARCB EVGS NARX DPIB NARQ BASS KDPD PHOR YPDA NTRB UHPB
BACSU - YCLK YKOH YYCG CSSS RESE YVRG PHOR KIND DCTS YVCQ YRKQ MALK CITS KINB YESM KINE YXDK YCBM BCES KINA GLNK KINC YBDK LYTS LIAS COMP YWPD DEGS NATK
HALSA - Q9HQ15 Q9HQG5 Q9HQ16 Q9HQE9 Q9HRE4 O51970 Q9HR10 Q9HRG1 Q9HNM2 BAT Q9HNA6 Q9HQB9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
413_E	473_R	4.063	1.00
414_N	418_P	3.922	1.00
453_K	457_V	3.706	1.00
336_L	371_G	3.701	1.00
407_L	477_T	3.678	1.00
284_T	304_N	3.634	1.00
464_A	475_V	3.558	1.00
411_I	473_R	3.165	1.00
400_R	411_I	3.008	1.00
404_V	409_Q	3.003	1.00
424_L	467_S	3.001	1.00
409_Q	477_T	2.834	1.00
411_I	475_V	2.815	1.00
371_G	459_H	2.809	1.00
361_R	398_V	2.796	1.00
420_A	423_H	2.738	1.00
402_Q	409_Q	2.738	1.00
409_Q	475_V	2.733	1.00
288_L	305_L	2.699	1.00
391_T	415_P	2.678	1.00
398_V	413_E	2.654	1.00
335_M	370_A	2.638	1.00
465_V	474_F	2.593	1.00
288_L	302_Y	2.570	1.00
452_V	463_V	2.567	1.00
281_I	309_T	2.565	1.00
396_T	415_P	2.556	1.00
379_A	456_V	2.538	1.00
361_R	396_T	2.509	1.00
400_R	413_E	2.464	1.00
402_Q	411_I	2.459	1.00
466_T	475_V	2.452	1.00
456_V	461_G	2.434	1.00
466_T	473_R	2.419	1.00
424_L	465_V	2.391	1.00
428_F	463_V	2.338	1.00
419_I	427_L	2.334	1.00
337_N	340_D	2.319	1.00
335_M	368_Q	2.294	1.00
467_S	472_T	2.268	1.00
423_H	426_R	2.243	1.00
344_K	377_R	2.243	1.00
281_I	308_L	2.228	1.00
239_I	242_E	2.200	1.00
334_K	373_P	2.175	1.00
462_T	477_T	2.155	1.00
294_Q	297_L	2.133	1.00
456_V	476_I	2.076	1.00
349_F	381_S	2.064	1.00
359_E	396_T	2.007	1.00
421_P	424_L	1.970	1.00
379_A	455_I	1.956	1.00
379_A	452_V	1.936	1.00
312_A	316_S	1.903	1.00
333_K	370_A	1.889	1.00
281_I	312_A	1.883	1.00
371_G	376_L	1.858	1.00
426_R	429_D	1.835	1.00
419_I	423_H	1.825	1.00
455_I	459_H	1.823	1.00
353_A	388_L	1.814	1.00
464_A	477_T	1.810	1.00
285_E	305_L	1.798	1.00
264_N	268_D	1.797	1.00
426_R	432_Y	1.795	1.00
252_I	255_I	1.795	1.00
423_H	432_Y	1.762	1.00
260_T	264_N	1.749	1.00
385_S	389_R	1.732	1.00
92_D	96_K	1.730	1.00
251_M	255_I	1.724	1.00
380_L	410_V	1.720	1.00
238_P	242_E	1.699	1.00
457_V	462_T	1.699	1.00
241_L	245_V	1.697	1.00
410_V	476_I	1.682	1.00
293_S	297_L	1.679	1.00
33_W	37_H	1.668	1.00
283_Q	300_V	1.658	1.00
372_D	375_M	1.654	1.00
284_T	305_L	1.650	1.00
391_T	395_E	1.618	1.00
256_E	259_F	1.615	1.00
404_V	477_T	1.604	1.00
288_L	298_E	1.596	1.00
287_A	301_L	1.589	1.00
248_F	251_M	1.577	1.00
419_I	472_T	1.568	1.00
339_A	401_C	1.568	1.00
245_V	249_N	1.558	1.00
423_H	434_V	1.549	1.00
339_A	343_G	1.533	1.00
395_E	415_P	1.525	1.00
398_V	415_P	1.523	1.00
280_L	308_L	1.522	1.00
414_N	471_G	1.520	1.00
262_Q	266_S	1.517	1.00
305_L	309_T	1.503	1.00
222_N	227_D	1.501	1.00
249_N	252_I	1.449	1.00
429_D	432_Y	1.448	1.00
217_S	221_Q	1.443	1.00
379_A	476_I	1.440	1.00
382_N	452_V	1.439	1.00
344_K	373_P	1.435	1.00
348_F	377_R	1.432	1.00
428_F	465_V	1.421	1.00
375_M	378_R	1.420	1.00
456_V	463_V	1.415	1.00
293_S	296_E	1.396	1.00
280_L	304_N	1.394	1.00
424_L	428_F	1.392	1.00
467_S	470_R	1.388	1.00
281_I	305_L	1.387	1.00
337_N	366_K	1.385	1.00
279_N	307_E	1.379	1.00
390_Y	433_R	1.361	1.00
373_P	377_R	1.350	1.00
185_N	189_M	1.349	1.00
337_N	368_Q	1.339	1.00
350_E	354_E	1.316	1.00
287_A	297_L	1.316	1.00
290_Q	297_L	1.315	1.00
214_R	217_S	1.305	1.00
352_L	355_D	1.297	1.00
252_I	256_E	1.290	1.00
279_N	283_Q	1.288	1.00
407_L	462_T	1.273	1.00
375_M	458_A	1.268	1.00
454_S	457_V	1.267	1.00
202_V	206_V	1.267	1.00
217_S	243_Q	1.263	1.00
220_I	223_I	1.258	1.00
259_F	262_Q	1.255	1.00
236_T	242_E	1.246	1.00
433_R	442_G	1.241	1.00
268_D	430_R	1.234	1.00
427_L	465_V	1.231	1.00
346_F	362_F	1.229	1.00
375_M	455_I	1.229	1.00
341_E	345_V	1.228	1.00
272_E	378_R	1.219	1.00
302_Y	306_E	1.217	1.00
257_D	261_R	1.215	1.00
331_P	372_D	1.214	1.00
428_F	474_F	1.206	1.00
465_V	472_T	1.205	1.00
284_T	308_L	1.204	1.00
283_Q	303_S	1.194	1.00
461_G	478_L	1.189	1.00
391_T	397_I	1.169	1.00
363_V	400_R	1.165	1.00
223_I	252_I	1.164	1.00
313_K	374_L	1.160	1.00
265_F	269_I	1.159	1.00
241_L	244_L	1.155	1.00
343_G	362_F	1.144	1.00
216_V	220_I	1.144	1.00
342_V	401_C	1.127	1.00
73_L	77_E	1.122	1.00
333_K	459_H	1.114	1.00
404_V	407_L	1.113	1.00
419_I	424_L	1.106	1.00
284_T	288_L	1.105	1.00
294_Q	298_E	1.104	1.00
367_C	408_V	1.095	1.00
247_S	250_H	1.094	1.00
284_T	301_L	1.093	1.00
217_S	220_I	1.092	1.00
206_V	210_H	1.088	1.00
382_N	385_S	1.087	1.00
345_V	349_F	1.082	1.00
413_E	468_D	1.079	1.00
282_T	286_I	1.075	1.00
428_F	453_K	1.074	1.00
231_R	253_E	1.072	1.00
319_L	322_A	1.071	1.00
376_L	459_H	1.068	1.00
242_E	245_V	1.067	1.00
259_F	263_S	1.063	1.00
345_V	381_S	1.063	1.00
227_D	230_V	1.061	1.00
91_A	97_T	1.050	1.00
173_I	177_L	1.050	1.00
250_H	254_R	1.048	1.00
316_S	320_F	1.046	1.00
279_N	282_T	1.044	1.00
222_N	230_V	1.040	1.00
55_S	59_E	1.037	1.00
419_I	465_V	1.036	1.00
339_A	366_K	1.031	1.00
387_A	397_I	1.031	1.00
89_S	97_T	1.029	1.00
181_N	185_N	1.026	1.00
414_N	472_T	1.025	1.00
340_D	344_K	1.024	1.00
207_H	211_A	1.024	1.00
307_E	310_R	1.023	1.00
299_D	303_S	1.021	1.00
383_L	474_F	1.020	1.00
187_L	191_A	1.015	1.00
15_R	239_I	1.008	1.00
245_V	248_F	1.007	1.00
430_R	454_S	1.005	1.00
345_V	377_R	0.997	1.00
34_I	38_S	0.995	1.00
238_P	241_L	0.992	1.00
256_E	260_T	0.990	1.00
392_P	395_E	0.986	1.00
380_L	412_V	0.984	1.00
274_R	316_S	0.984	1.00
303_S	307_E	0.983	1.00
258_V	262_Q	0.983	1.00
383_L	463_V	0.981	1.00
89_S	168_Y	0.979	1.00
349_F	384_L	0.979	1.00
298_E	302_Y	0.978	1.00
421_P	467_S	0.976	1.00
380_L	384_L	0.975	1.00
126_Y	129_S	0.969	1.00
336_L	341_E	0.964	1.00
338_L	410_V	0.964	1.00
59_E	63_N	0.963	1.00
40_K	44_A	0.961	1.00
272_E	382_N	0.960	1.00
346_F	350_E	0.959	1.00
348_F	381_S	0.959	1.00
345_V	384_L	0.958	1.00
317_D	375_M	0.957	1.00
264_N	430_R	0.957	1.00
186_K	189_M	0.955	1.00
48_I	52_K	0.954	1.00
377_R	381_S	0.953	1.00
281_I	285_E	0.950	1.00
52_K	56_A	0.950	1.00
381_S	385_S	0.947	1.00
32_A	36_I	0.938	1.00
313_K	317_D	0.936	1.00
44_A	48_I	0.929	1.00
251_M	254_R	0.928	1.00
427_L	474_F	0.925	1.00
331_P	375_M	0.922	1.00
308_L	312_A	0.921	1.00
384_L	399_V	0.921	1.00
87_L	170_A	0.920	1.00
260_T	263_S	0.919	1.00
199_V	203_L	0.917	1.00
419_I	425_P	0.916	1.00
77_E	81_S	0.914	1.00
390_Y	417_T	0.911	1.00
220_I	224_T	0.906	1.00
13_A	207_H	0.904	1.00
383_L	452_V	0.895	1.00
341_E	371_G	0.894	1.00
271_H	382_N	0.889	1.00
54_I	57_T	0.885	1.00
233_D	249_N	0.885	1.00
306_E	344_K	0.882	1.00
212_P	217_S	0.881	1.00
447_I	451_I	0.881	1.00
242_E	246_L	0.880	1.00
184_M	188_I	0.877	1.00
154_P	166_T	0.871	1.00
200_F	204_L	0.870	1.00
342_V	380_L	0.869	1.00
162_K	165_Y	0.869	1.00
248_F	252_I	0.868	1.00
223_I	251_M	0.868	1.00
176_H	180_I	0.867	1.00
452_V	456_V	0.865	1.00
66_D	70_A	0.864	1.00
337_N	367_C	0.862	1.00
304_N	308_L	0.861	1.00
152_N	166_T	0.861	1.00
343_G	347_D	0.858	1.00
219_Q	232_L	0.858	1.00
295_K	298_E	0.857	1.00
209_G	212_P	0.854	1.00
51_L	55_S	0.852	1.00
220_I	248_F	0.850	1.00
456_V	478_L	0.848	1.00
352_L	385_S	0.848	1.00
187_L	190_T	0.846	1.00
204_L	208_K	0.846	1.00
143_M	146_S	0.844	1.00
234_P	246_L	0.843	1.00
379_A	459_H	0.830	1.00
367_C	403_T	0.830	1.00
73_L	76_L	0.828	1.00
378_R	455_I	0.828	1.00
246_L	249_N	0.826	1.00
417_T	442_G	0.826	1.00
55_S	58_L	0.826	1.00
203_L	207_H	0.821	1.00
291_S	297_L	0.820	1.00
231_R	249_N	0.818	1.00
76_L	80_V	0.818	1.00
363_V	398_V	0.817	1.00
274_R	312_A	0.816	1.00
418_P	472_T	0.814	1.00
101_S	104_A	0.814	1.00
212_P	216_V	0.813	1.00
349_F	385_S	0.812	1.00
275_T	279_N	0.811	1.00
103_G	106_D	0.810	1.00
220_I	247_S	0.810	1.00
454_S	458_A	0.809	1.00
333_K	371_G	0.806	1.00
342_V	399_V	0.806	1.00
272_E	276_P	0.804	1.00
383_L	476_I	0.804	1.00
353_A	397_I	0.800	1.00
217_S	247_S	0.799	1.00
273_I	311_M	0.797	1.00
97_T	100_H	0.796	1.00
180_I	184_M	0.796	1.00
331_P	458_A	0.791	1.00
291_S	294_Q	0.790	1.00
36_I	184_M	0.787	1.00
419_I	467_S	0.786	1.00
278_T	282_T	0.786	1.00
87_L	100_H	0.786	1.00
302_Y	305_L	0.780	1.00
257_D	260_T	0.778	1.00
86_V	89_S	0.773	1.00
244_L	248_F	0.773	1.00
347_D	350_E	0.772	1.00
48_I	149_R	0.771	1.00
420_A	434_V	0.771	1.00
161_G	164_I	0.770	1.00
433_R	444_G	0.770	1.00
320_F	378_R	0.769	1.00
102_P	105_P	0.768	1.00
219_Q	230_V	0.766	1.00
47_D	50_D	0.765	1.00
156_G	163_P	0.762	1.00
333_K	460_K	0.761	1.00
384_L	397_I	0.760	1.00
374_L	377_R	0.759	1.00
283_Q	304_N	0.759	1.00
297_L	300_V	0.758	1.00
338_L	408_V	0.758	1.00
208_K	211_A	0.758	1.00
102_P	106_D	0.757	1.00
246_L	250_H	0.756	1.00
461_G	476_I	0.755	1.00
309_T	312_A	0.755	1.00
277_I	315_V	0.753	1.00
299_D	302_Y	0.752	1.00
188_I	192_S	0.751	1.00
339_A	364_G	0.749	1.00
218_R	222_N	0.749	1.00
321_L	450_A	0.748	1.00
332_E	372_D	0.747	1.00
37_H	40_K	0.747	1.00
150_M	170_A	0.745	1.00
221_Q	243_Q	0.745	1.00
399_V	412_V	0.744	1.00
279_N	303_S	0.743	1.00
50_D	53_E	0.743	1.00
343_G	346_F	0.742	1.00
401_C	408_V	0.741	1.00
182_D	186_K	0.741	1.00
346_F	360_L	0.737	1.00
45_E	48_I	0.732	1.00
453_K	462_T	0.730	1.00
358_V	362_F	0.729	1.00
364_G	401_C	0.726	1.00
243_Q	247_S	0.725	1.00
177_L	180_I	0.724	1.00
206_V	209_G	0.722	1.00
44_A	47_D	0.721	1.00
247_S	251_M	0.720	1.00
78_D	82_G	0.720	1.00
354_E	357_G	0.718	1.00
389_R	442_G	0.718	1.00
91_A	168_Y	0.717	1.00
92_D	95_G	0.717	1.00
424_L	466_T	0.716	1.00
303_S	306_E	0.716	1.00
359_E	362_F	0.715	1.00
320_F	375_M	0.715	1.00
414_N	417_T	0.714	1.00
401_C	410_V	0.714	1.00
214_R	218_R	0.713	1.00
231_R	252_I	0.713	1.00
181_N	184_M	0.712	1.00
67_E	70_A	0.712	1.00
286_I	290_Q	0.712	1.00
310_R	377_R	0.711	1.00
72_R	77_E	0.710	1.00
166_T	170_A	0.710	1.00
288_L	301_L	0.709	1.00
421_P	425_P	0.709	1.00
421_P	468_D	0.707	1.00
74_M	78_D	0.705	1.00
238_P	245_V	0.704	1.00
387_A	412_V	0.702	1.00
411_I	466_T	0.702	1.00
23_A	27_A	0.702	1.00
224_T	250_H	0.701	1.00
349_F	388_L	0.699	1.00
37_H	41_V	0.698	1.00
464_A	476_I	0.697	1.00
213_I	216_V	0.696	1.00
234_P	239_I	0.695	1.00
213_I	217_S	0.694	1.00
403_T	408_V	0.692	1.00
100_H	104_A	0.692	1.00
351_A	355_D	0.690	1.00
424_L	474_F	0.689	1.00
148_W	152_N	0.689	1.00
92_D	98_V	0.688	1.00
61_V	64_H	0.688	1.00
391_T	394_G	0.688	1.00
49_N	52_K	0.686	1.00
244_L	247_S	0.686	1.00
198_I	202_V	0.686	1.00
366_K	369_V	0.685	1.00
100_H	103_G	0.685	1.00
296_E	300_V	0.685	1.00
283_Q	307_E	0.685	1.00
43_F	46_Q	0.685	1.00
219_Q	222_N	0.684	1.00
74_M	77_E	0.683	1.00
271_H	275_T	0.683	1.00
269_I	318_M	0.681	1.00
352_L	356_R	0.680	1.00
69_Q	73_L	0.680	1.00
345_V	348_F	0.680	1.00
383_L	456_V	0.679	1.00
78_D	81_S	0.677	1.00
29_F	33_W	0.677	1.00
358_V	388_L	0.677	1.00
266_S	269_I	0.675	1.00
141_G	144_E	0.669	1.00
147_N	154_P	0.669	1.00
186_K	190_T	0.668	1.00
46_Q	50_D	0.667	1.00
185_N	188_I	0.666	1.00
261_R	264_N	0.666	1.00
451_I	455_I	0.666	1.00
272_E	451_I	0.665	1.00
336_L	370_A	0.665	1.00
319_L	323_Q	0.662	1.00
208_K	212_P	0.662	1.00
375_M	459_H	0.661	1.00
375_M	379_A	0.661	1.00
263_S	325_D	0.660	1.00
79_I	82_G	0.658	1.00
249_N	253_E	0.658	1.00
351_A	354_E	0.657	1.00
336_L	373_P	0.654	1.00
329_L	375_M	0.653	1.00
317_D	378_R	0.652	1.00
152_N	168_Y	0.652	1.00
73_L	79_I	0.651	1.00
358_V	391_T	0.650	1.00
363_V	402_Q	0.650	1.00
139_G	143_M	0.649	1.00
100_H	105_P	0.648	1.00
150_M	153_L	0.646	1.00
353_A	356_R	0.646	1.00
300_V	304_N	0.646	1.00
427_L	450_A	0.644	1.00
79_I	83_Y	0.644	1.00
148_W	170_A	0.644	1.00
234_P	245_V	0.644	1.00
140_H	143_M	0.642	1.00
286_I	300_V	0.641	1.00
211_A	215_S	0.640	1.00
272_E	314_M	0.640	1.00
177_L	181_N	0.639	1.00
239_I	243_Q	0.639	1.00
357_G	394_G	0.639	1.00
258_V	261_R	0.639	1.00
367_C	370_A	0.638	1.00
409_Q	464_A	0.638	1.00
243_Q	246_L	0.638	1.00
42_H	46_Q	0.635	1.00
338_L	369_V	0.634	1.00
254_R	257_D	0.633	1.00
220_I	244_L	0.633	1.00
311_M	315_V	0.632	1.00
58_L	61_V	0.632	1.00
140_H	144_E	0.631	1.00
290_Q	300_V	0.631	1.00
353_A	360_L	0.631	1.00
53_E	56_A	0.628	1.00
50_D	54_I	0.628	1.00
71_R	74_M	0.627	1.00
182_D	185_N	0.625	1.00
378_R	381_S	0.625	1.00
60_R	64_H	0.625	1.00
147_N	150_M	0.625	1.00
418_P	471_G	0.624	1.00
180_I	183_L	0.623	1.00
353_A	358_V	0.622	1.00
265_F	272_E	0.621	1.00
232_L	245_V	0.617	1.00
86_V	171_L	0.616	1.00
305_L	308_L	0.615	1.00
339_A	367_C	0.613	1.00
367_C	401_C	0.612	1.00
66_D	69_Q	0.610	1.00
143_M	148_W	0.610	1.00
56_A	59_E	0.608	1.00
70_A	74_M	0.607	1.00
423_H	436_P	0.607	1.00
164_I	168_Y	0.607	1.00
340_D	373_P	0.606	1.00
357_G	393_T	0.606	1.00
344_K	348_F	0.605	1.00
165_Y	169_I	0.604	1.00
216_V	219_Q	0.603	1.00
307_E	348_F	0.601	1.00
215_S	218_R	0.599	1.00
146_S	150_M	0.599	1.00
397_I	412_V	0.599	1.00
41_V	45_E	0.598	1.00
341_E	377_R	0.598	1.00
230_V	233_D	0.596	1.00
413_E	469_A	0.595	1.00
433_R	443_E	0.595	1.00
232_L	249_N	0.593	1.00
450_A	454_S	0.591	1.00
403_T	407_L	0.591	1.00
347_D	351_A	0.591	1.00
51_L	54_I	0.591	1.00
60_R	63_N	0.589	1.00
141_G	145_H	0.587	1.00
41_V	44_A	0.586	1.00
398_V	401_C	0.586	1.00
215_S	219_Q	0.586	1.00
149_R	152_N	0.585	1.00
255_I	258_V	0.583	1.00
142_H	146_S	0.582	1.00
235_Q	238_P	0.581	1.00
228_L	231_R	0.580	1.00
125_V	128_L	0.580	1.00
143_M	147_N	0.578	1.00
463_V	474_F	0.578	1.00
341_E	376_L	0.578	1.00
161_G	165_Y	0.578	1.00
336_L	376_L	0.578	1.00
301_L	305_L	0.578	1.00
49_N	53_E	0.578	1.00
47_D	51_L	0.577	1.00
36_I	40_K	0.577	1.00
376_L	380_L	0.576	1.00
278_T	281_I	0.575	1.00
275_T	282_T	0.575	1.00
287_A	300_V	0.573	1.00
154_P	163_P	0.572	1.00
331_P	459_H	0.571	1.00
419_I	474_F	0.571	1.00
33_W	36_I	0.570	1.00
312_A	315_V	0.568	1.00
34_I	37_H	0.568	1.00
356_R	388_L	0.564	1.00
58_L	62_L	0.563	1.00
471_G	474_F	0.563	1.00
38_S	42_H	0.562	1.00
72_R	75_T	0.562	1.00
184_M	187_L	0.561	1.00
452_V	455_I	0.560	1.00
213_I	244_L	0.559	1.00
253_E	257_D	0.559	1.00
38_S	41_V	0.559	1.00
138_H	141_G	0.559	1.00
240_E	243_Q	0.558	1.00
321_L	454_S	0.557	1.00
285_E	289_S	0.555	1.00
75_T	79_I	0.555	1.00
221_Q	247_S	0.554	1.00
30_A	34_I	0.553	1.00
62_L	65_P	0.553	1.00
318_M	431_F	0.551	1.00
424_L	472_T	0.551	1.00
236_T	239_I	0.550	1.00
173_I	176_H	0.550	1.00
280_L	284_T	0.549	1.00
321_L	430_R	0.548	1.00
238_P	244_L	0.548	1.00
97_T	101_S	0.548	1.00
210_H	214_R	0.548	1.00
273_I	276_P	0.546	1.00
176_H	179_Y	0.546	1.00
268_D	272_E	0.545	1.00
207_H	210_H	0.545	1.00
272_E	275_T	0.545	1.00
346_F	399_V	0.544	1.00
266_S	270_A	0.544	1.00
46_Q	49_N	0.543	1.00
389_R	444_G	0.542	1.00
175_F	178_H	0.542	1.00
40_K	43_F	0.541	1.00
428_F	431_F	0.541	1.00
13_A	214_R	0.541	1.00
77_E	80_V	0.539	1.00
233_D	236_T	0.537	1.00
230_V	234_P	0.537	1.00
201_I	205_A	0.536	1.00
57_T	61_V	0.535	1.00
21_S	24_T	0.533	1.00
56_A	60_R	0.533	1.00
234_P	238_P	0.532	1.00
48_I	51_L	0.532	1.00
19_F	23_A	0.531	1.00
216_V	248_F	0.531	1.00
55_S	169_I	0.529	1.00
280_L	307_E	0.528	1.00
104_A	108_R	0.527	1.00
283_Q	308_L	0.527	1.00
61_V	65_P	0.526	1.00
216_V	221_Q	0.526	1.00
218_R	221_Q	0.526	1.00
392_P	415_P	0.526	1.00
139_G	142_H	0.525	1.00
346_F	349_F	0.523	1.00
270_A	276_P	0.521	1.00
244_L	249_N	0.519	1.00
290_Q	293_S	0.518	1.00
192_S	196_I	0.517	1.00
309_T	313_K	0.517	1.00
417_T	472_T	0.517	1.00
213_I	241_L	0.517	1.00
311_M	319_L	0.516	1.00
71_R	75_T	0.516	1.00
224_T	254_R	0.516	1.00
383_L	412_V	0.515	1.00
142_H	145_H	0.514	1.00
325_D	430_R	0.514	1.00
216_V	245_V	0.514	1.00
456_V	462_T	0.513	1.00
273_I	315_V	0.513	1.00
107_I	110_F	0.512	1.00
14_T	18_F	0.512	1.00
144_E	148_W	0.512	1.00
290_Q	296_E	0.511	1.00
427_L	432_Y	0.510	1.00
369_V	408_V	0.510	1.00
144_E	147_N	0.509	1.00
276_P	311_M	0.508	1.00
226_K	229_D	0.508	1.00
70_A	73_L	0.506	1.00
22_L	25_I	0.506	1.00
285_E	288_L	0.505	1.00
220_I	251_M	0.505	1.00
431_F	450_A	0.504	1.00
156_G	161_G	0.504	1.00
254_R	258_V	0.504	1.00
389_R	443_E	0.504	1.00
317_D	374_L	0.503	1.00
138_H	142_H	0.502	1.00
348_F	352_L	0.501	1.00
245_V	251_M	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.5625	100	0.35	Contact Map
4bixA	2	0.4646	100	0.4	Contact Map
4ctiA	2	0.475	100	0.427	Contact Map
3a0rA	2	0.6771	100	0.454	Contact Map
4q20A	2	0.4708	100	0.459	Contact Map
4gczA	2	0.7375	100	0.469	Contact Map
4mpcA	2	0.6083	100	0.48	Contact Map
3jz3A	2	0.3292	100	0.483	Contact Map
2c2aA	2	0.4771	100	0.485	Contact Map
3d36A	2	0.4542	100	0.488	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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