GREMLIN Database
YQAB - Fructose-1-phosphate phosphatase YqaB
UniProt: P77475 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13530
Length: 188 (181)
Sequences: 25385 (19765)
Seq/√Len: 1469.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_A161_Q3.8811.00
121_A126_R3.0841.00
140_H144_A2.8801.00
150_L154_R2.8341.00
113_S117_E2.6601.00
175_A182_A2.4671.00
7_G157_V2.3981.00
5_Y181_D2.3701.00
166_E171_G2.3231.00
97_K128_Y2.3211.00
104_P130_D2.2961.00
106_A131_A2.2281.00
113_S137_H2.2171.00
150_L153_Q2.1841.00
140_H146_D2.1731.00
33_H74_E2.1431.00
108_G147_T2.1271.00
131_A154_R2.1151.00
10_F105_M2.0871.00
152_A162_C2.0061.00
173_Q177_A1.9951.00
109_T116_A1.9761.00
172_I182_A1.9661.00
8_L103_R1.8911.00
29_E78_A1.8691.00
158_Q161_Q1.8461.00
164_V175_A1.8351.00
98_S102_R1.7781.00
100_H128_Y1.7651.00
39_D42_A1.7371.00
152_A180_M1.7361.00
117_E126_R1.6791.00
163_V183_V1.6261.00
100_H130_D1.6231.00
7_G155_M1.5881.00
9_I108_G1.5871.00
152_A159_P1.5161.00
34_Y74_E1.4831.00
105_M129_F1.4821.00
157_V162_C1.4691.00
106_A155_M1.4581.00
5_Y163_V1.4421.00
9_I151_C1.4411.00
9_I164_V1.4271.00
78_A81_S1.4091.00
15_T165_F1.4041.00
8_L165_F1.3771.00
16_I93_V1.3701.00
169_D173_Q1.3671.00
8_L99_W1.3561.00
53_R56_Q1.3481.00
33_H78_A1.2911.00
29_E33_H1.2881.00
12_M116_A1.2861.00
25_K82_M1.2681.00
133_V154_R1.2601.00
12_M17_L1.2501.00
133_V151_C1.2461.00
145_P149_L1.2261.00
12_M107_V1.2221.00
29_E82_M1.2091.00
98_S101_G1.2041.00
117_E121_A1.1981.00
74_E77_E1.1971.00
70_A74_E1.1781.00
67_D70_A1.1681.00
148_F164_V1.1651.00
89_P125_L1.1531.00
148_F174_A1.1461.00
74_E78_A1.1201.00
176_R182_A1.1101.00
25_K29_E1.1041.00
84_L118_A1.1041.00
7_G162_C1.1021.00
9_I162_C1.1021.00
118_A122_H1.0781.00
146_D150_L1.0781.00
30_V34_Y1.0761.00
151_C155_M1.0751.00
100_H105_M1.0721.00
148_F180_M1.0681.00
7_G104_P1.0671.00
13_D19_T1.0581.00
116_A134_A1.0581.00
52_W56_Q1.0571.00
113_S134_A1.0561.00
124_G127_H1.0531.00
149_L153_Q1.0431.00
28_R32_G1.0381.00
78_A82_M1.0231.00
73_R77_E1.0121.00
42_A45_A1.0121.00
149_L178_A1.0051.00
162_C180_M0.9981.00
164_V180_M0.9931.00
29_E32_G0.9901.00
131_A155_M0.9871.00
107_V129_F0.9871.00
53_R57_A0.9791.00
108_G151_C0.9751.00
96_V129_F0.9721.00
56_Q68_P0.9651.00
25_K28_R0.9651.00
25_K86_S0.9581.00
72_A76_T0.9551.00
12_M111_S0.9541.00
97_K101_G0.9521.00
172_I184_D0.9441.00
57_A60_E0.9421.00
56_Q60_E0.9351.00
118_A121_A0.9311.00
170_F173_Q0.9251.00
77_E81_S0.9201.00
31_L36_L0.9181.00
49_S57_A0.9141.00
9_I155_M0.9131.00
90_L93_V0.9031.00
28_R40_I0.8981.00
146_D149_L0.8971.00
148_F166_E0.8901.00
6_A103_R0.8801.00
7_G106_A0.8761.00
149_L159_P0.8711.00
75_K79_V0.8591.00
109_T134_A0.8581.00
94_D97_K0.8571.00
138_V150_L0.8541.00
113_S136_D0.8541.00
24_R43_M0.8521.00
106_A151_C0.8521.00
40_I44_I0.8481.00
99_W103_R0.8371.00
82_M85_D0.8361.00
17_L123_L0.8351.00
13_D111_S0.8321.00
163_V181_D0.8281.00
133_V150_L0.8251.00
159_P180_M0.8241.00
134_A137_H0.8131.00
174_A178_A0.8101.00
99_W105_M0.8071.00
165_F183_V0.8061.00
24_R28_R0.8061.00
55_A59_I0.7991.00
69_H73_R0.7981.00
157_V161_Q0.7961.00
116_A119_L0.7961.00
12_M119_L0.7931.00
139_K146_D0.7911.00
97_K127_H0.7891.00
9_I180_M0.7881.00
96_V128_Y0.7811.00
117_E132_V0.7801.00
105_M128_Y0.7741.00
120_L126_R0.7731.00
17_L119_L0.7691.00
116_A132_V0.7661.00
21_P88_E0.7651.00
64_A67_D0.7621.00
49_S53_R0.7581.00
38_Y43_M0.7401.00
148_F171_G0.7321.00
5_Y103_R0.7291.00
26_A78_A0.7271.00
104_P157_V0.7261.00
89_P123_L0.7171.00
131_A151_C0.7161.00
13_D109_T0.7141.00
41_Q44_I0.7101.00
94_D98_S0.7031.00
145_P177_A0.7001.00
90_L185_V0.6971.00
82_M86_S0.6941.00
111_S116_A0.6891.00
57_A61_L0.6881.00
6_A104_P0.6871.00
38_Y42_A0.6851.00
114_A118_A0.6841.00
137_H154_R0.6811.00
14_G20_E0.6711.00
24_R40_I0.6701.00
8_L163_V0.6691.00
105_M130_D0.6681.00
22_T87_V0.6661.00
15_T185_V0.6661.00
44_I47_N0.6641.00
17_L87_V0.6631.00
95_V165_F0.6621.00
138_V147_T0.6571.00
5_Y161_Q0.6531.00
80_R114_A0.6531.00
45_A57_A0.6521.00
159_P162_C0.6501.00
9_I106_A0.6481.00
6_A157_V0.6481.00
164_V174_A0.6441.00
50_P53_R0.6411.00
169_D184_D0.6401.00
26_A30_V0.6351.00
30_V74_E0.6321.00
23_H75_K0.6281.00
147_T151_C0.6231.00
110_G141_H0.6221.00
23_H27_W0.6211.00
76_T80_R0.6151.00
93_V96_V0.6141.00
73_R76_T0.6141.00
92_L95_V0.6081.00
100_H127_H0.6051.00
15_T171_G0.6051.00
32_G37_Q0.6041.00
173_Q176_R0.6031.00
34_Y70_A0.6031.00
111_S115_I0.5991.00
95_V98_S0.5991.00
116_A120_L0.5971.00
60_E63_Q0.5971.00
10_F95_V0.5951.00
80_R118_A0.5941.00
181_D184_D0.5941.00
18_D88_E0.5861.00
97_K100_H0.5851.00
42_A61_L0.5791.00
18_D21_P0.5781.00
54_I57_A0.5761.00
108_G164_V0.5761.00
152_A157_V0.5751.00
23_H111_S0.5741.00
84_L122_H0.5741.00
52_W69_H0.5731.00
75_K78_A0.5701.00
18_D90_L0.5701.00
41_Q45_A0.5701.00
66_L70_A0.5691.00
147_T174_A0.5661.00
13_D119_L0.5651.00
148_F175_A0.5601.00
52_W72_A0.5601.00
70_A73_R0.5591.00
63_Q66_L0.5591.00
55_A58_I0.5541.00
152_A178_A0.5541.00
51_T54_I0.5531.00
110_G170_F0.5521.00
133_V147_T0.5521.00
13_D167_D0.5521.00
149_L152_A0.5481.00
170_F174_A0.5471.00
21_P25_K0.5461.00
135_A147_T0.5441.00
164_V171_G0.5421.00
152_A158_Q0.5381.00
121_A127_H0.5351.00
107_V120_L0.5321.00
133_V155_M0.5291.00
8_L105_M0.5291.00
108_G133_V0.5261.00
112_E115_I0.5261.00
22_T25_K0.5231.00
33_H77_E0.5201.00
59_I64_A0.5191.00
77_E80_R0.5181.00
15_T184_D0.5171.00
71_L74_E0.5161.00
174_A177_A0.5151.00
120_L125_L0.5131.00
95_V99_W0.5111.00
5_Y8_L0.5111.00
16_I107_V0.5061.00
28_R38_Y0.5031.00
176_R181_D0.5021.00
111_S166_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uw9A 1 0.9362 100 0.281 Contact Map
3nasA 2 0.9202 100 0.301 Contact Map
3iruA 4 1 100 0.305 Contact Map
3l5kA 1 0.9947 100 0.31 Contact Map
1te2A 2 0.984 100 0.311 Contact Map
3sd7A 1 0.984 100 0.316 Contact Map
3kbbA 1 0.9787 100 0.317 Contact Map
1swvA 2 0.984 100 0.317 Contact Map
3e58A 2 0.984 100 0.322 Contact Map
3s6jA 2 0.9787 100 0.323 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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