GREMLIN Database
YLAB - Putative cyclic-di-GMP phosphodiesterase YlaB
UniProt: P77473 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14237
Length: 516 (425)
Sequences: 19337 (15294)
Seq/√Len: 741.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
302_A508_F4.1191.00
294_L494_G3.8941.00
94_E98_I3.6841.00
335_T366_V3.3591.00
446_K450_D3.2491.00
500_S503_L3.1531.00
340_R382_H3.1301.00
336_L375_L3.1271.00
377_R415_A3.0511.00
413_R440_D2.9881.00
267_R320_S2.9521.00
288_Y345_D2.8981.00
285_C309_P2.8341.00
166_P169_S2.8281.00
391_A441_I2.6941.00
293_S296_N2.6681.00
480_S484_E2.5151.00
466_K492_H2.5141.00
347_G351_R2.5001.00
485_W489_H2.4641.00
274_R310_Q2.4031.00
350_L389_Q2.3711.00
310_Q314_S2.2921.00
110_H183_V2.2441.00
325_A334_L2.2121.00
483_E499_Y2.1741.00
477_I494_G2.1661.00
345_D505_K2.0841.00
420_Y441_I2.0791.00
306_A338_I2.0211.00
268_I327_Q2.0201.00
341_S344_E1.9951.00
337_L341_S1.9861.00
345_D349_W1.9541.00
105_C109_E1.9331.00
459_P467_T1.9271.00
131_W224_I1.9181.00
483_E494_G1.9151.00
129_R228_T1.9041.00
343_F379_M1.9031.00
479_T482_Q1.8901.00
379_M383_Y1.8881.00
114_P232_T1.8861.00
277_D281_N1.8471.00
231_S234_M1.8441.00
282_R341_S1.8431.00
310_Q313_G1.8371.00
131_W200_Q1.8361.00
341_S345_D1.8271.00
287_H504_P1.8251.00
85_V89_Y1.8021.00
286_V338_I1.7941.00
409_I419_I1.7931.00
309_P315_W1.7751.00
292_V499_Y1.7671.00
285_C315_W1.7401.00
291_I493_Y1.7321.00
362_L372_I1.6951.00
357_H418_E1.6721.00
346_M385_V1.6711.00
386_N389_Q1.6711.00
340_R383_Y1.6701.00
109_E113_P1.6431.00
291_I441_I1.6361.00
283_D310_Q1.6321.00
441_I473_V1.6151.00
349_W505_K1.6141.00
480_S498_L1.6061.00
142_R150_A1.5981.00
504_P507_D1.5971.00
152_Y155_M1.5891.00
459_P489_H1.5861.00
246_W255_L1.5861.00
284_I306_A1.5801.00
418_E440_D1.5761.00
113_P175_A1.5741.00
391_A420_Y1.5671.00
340_R379_M1.5661.00
136_N223_N1.5651.00
483_E487_R1.5571.00
462_I489_H1.5541.00
380_I417_H1.5441.00
442_L465_A1.5431.00
471_K492_H1.5411.00
421_L439_V1.5371.00
497_W502_A1.5201.00
291_I391_A1.5171.00
287_H315_W1.5141.00
453_E481_K1.5111.00
459_P463_E1.5061.00
462_I491_V1.5051.00
286_V337_L1.5031.00
156_I159_A1.5011.00
156_I211_G1.4981.00
249_L255_L1.4981.00
362_L392_L1.4931.00
483_E498_L1.4771.00
291_I301_G1.4771.00
137_D251_L1.4511.00
99_D176_I1.4231.00
81_E85_V1.4211.00
350_L386_N1.4171.00
471_K493_Y1.4151.00
113_P116_T1.3851.00
453_E485_W1.3741.00
357_H391_A1.3721.00
352_Q509_L1.3661.00
152_Y214_Y1.3631.00
503_L511_W1.3621.00
300_V493_Y1.3491.00
446_K476_G1.3421.00
81_E86_S1.3411.00
159_A162_I1.3381.00
435_Q451_A1.3351.00
212_I217_L1.3331.00
129_R196_I1.3281.00
85_V88_S1.3201.00
306_A337_L1.3191.00
474_A491_V1.3021.00
306_A334_L1.2981.00
226_I256_L1.2881.00
245_I248_P1.2801.00
299_I511_W1.2781.00
177_I183_V1.2751.00
378_D382_H1.2721.00
452_L485_W1.2721.00
283_D308_W1.2671.00
377_R411_R1.2611.00
274_R313_G1.2551.00
91_Y95_V1.2511.00
507_D510_R1.2481.00
277_D283_D1.2341.00
441_I471_K1.2311.00
313_G320_S1.2211.00
349_W509_L1.2171.00
110_H175_A1.2121.00
439_V470_L1.2111.00
165_I174_A1.2101.00
364_S397_R1.2071.00
344_E383_Y1.2071.00
153_V220_P1.2041.00
115_D232_T1.2041.00
465_A472_M1.2031.00
192_A195_I1.2021.00
94_E103_P1.1991.00
86_S89_Y1.1981.00
197_T256_L1.1971.00
342_V358_I1.1931.00
93_Q97_Y1.1911.00
267_R313_G1.1901.00
406_A410_S1.1891.00
157_D207_I1.1841.00
346_M358_I1.1741.00
484_E487_R1.1741.00
348_D352_Q1.1601.00
156_I160_S1.1581.00
494_G499_Y1.1571.00
238_G262_L1.1551.00
186_T199_L1.1541.00
380_I387_P1.1531.00
375_L379_M1.1501.00
201_K205_E1.1501.00
332_E369_S1.1441.00
406_A436_D1.1401.00
484_E488_Q1.1361.00
291_I359_S1.1341.00
284_I337_L1.1311.00
452_L458_T1.1301.00
133_T222_M1.1291.00
410_S414_E1.1291.00
135_H157_D1.1281.00
311_T314_S1.1191.00
376_L412_Y1.1171.00
286_V342_V1.1161.00
293_S298_K1.1091.00
246_W253_I1.1011.00
294_L483_E1.1011.00
355_Q389_Q1.1011.00
196_I200_Q1.1001.00
197_T201_K1.0971.00
271_P324_L1.0971.00
207_I222_M1.0921.00
98_I109_E1.0891.00
200_Q226_I1.0891.00
500_S511_W1.0881.00
234_M238_G1.0861.00
391_A418_E1.0801.00
345_D348_D1.0791.00
373_P377_R1.0771.00
245_I255_L1.0751.00
206_H209_N1.0741.00
152_Y156_I1.0721.00
359_S391_A1.0681.00
104_Q158_P1.0671.00
132_L183_V1.0601.00
319_D446_K1.0551.00
132_L243_V1.0511.00
140_I272_H1.0501.00
340_R344_E1.0461.00
402_P437_L1.0441.00
460_H467_T1.0441.00
84_R87_Y1.0431.00
318_P321_F1.0401.00
293_S300_V1.0331.00
229_W235_L1.0311.00
82_M85_V1.0241.00
137_D140_I1.0241.00
291_I357_H1.0221.00
227_I238_G1.0211.00
134_S247_L1.0171.00
453_E479_T1.0161.00
297_G487_R1.0151.00
377_R381_N1.0151.00
310_Q316_L1.0141.00
245_I249_L1.0141.00
376_L392_L1.0111.00
275_L325_A1.0101.00
292_V511_W1.0091.00
301_G357_H1.0081.00
91_Y94_E1.0061.00
347_G350_L1.0041.00
441_I493_Y1.0021.00
346_M350_L1.0001.00
204_G254_G1.0001.00
212_I215_D0.9941.00
347_G383_Y0.9921.00
480_S483_E0.9921.00
285_C504_P0.9891.00
160_S211_G0.9861.00
453_E482_Q0.9781.00
392_L417_H0.9771.00
142_R179_N0.9751.00
117_F187_S0.9691.00
270_S274_R0.9671.00
344_E348_D0.9661.00
343_F390_I0.9631.00
373_P408_I0.9591.00
208_E252_V0.9591.00
303_E361_N0.9591.00
109_E112_S0.9581.00
117_F128_Y0.9561.00
207_I211_G0.9561.00
328_T332_E0.9481.00
401_D404_T0.9461.00
503_L507_D0.9451.00
342_V360_I0.9441.00
97_Y112_S0.9431.00
274_R312_D0.9421.00
286_V306_A0.9421.00
293_S492_H0.9411.00
326_Q331_S0.9391.00
82_M86_S0.9391.00
204_G224_I0.9381.00
87_Y91_Y0.9381.00
135_H222_M0.9381.00
374_Q411_R0.9331.00
283_D311_T0.9321.00
400_A433_Y0.9301.00
128_Y229_W0.9301.00
505_K509_L0.9291.00
291_I473_V0.9281.00
330_L333_P0.9281.00
97_Y108_L0.9281.00
463_E467_T0.9281.00
137_D272_H0.9251.00
113_P117_F0.9251.00
136_N251_L0.9241.00
339_I379_M0.9221.00
89_Y93_Q0.9181.00
333_P336_L0.9171.00
115_D119_E0.9161.00
313_G316_L0.9161.00
221_E252_V0.9151.00
161_F174_A0.9151.00
280_E333_P0.9141.00
322_I331_S0.9131.00
165_I169_S0.9121.00
473_V493_Y0.9091.00
477_I486_L0.9061.00
272_H276_Q0.9061.00
230_A238_G0.9051.00
373_P411_R0.9041.00
345_D509_L0.9031.00
411_R414_E0.9021.00
404_T408_I0.9001.00
142_R151_H0.9001.00
134_S180_A0.8971.00
148_G233_K0.8951.00
111_E233_K0.8941.00
295_A492_H0.8941.00
304_A358_I0.8901.00
485_W488_Q0.8851.00
357_H389_Q0.8821.00
278_A284_I0.8801.00
155_M159_A0.8751.00
149_T152_Y0.8731.00
462_I472_M0.8701.00
241_R261_V0.8691.00
408_I411_R0.8641.00
128_Y185_I0.8641.00
347_G384_Q0.8631.00
197_T254_G0.8611.00
282_R340_R0.8591.00
450_D482_Q0.8591.00
165_I184_V0.8551.00
100_N108_L0.8551.00
153_V211_G0.8541.00
302_A356_Q0.8531.00
462_I466_K0.8531.00
131_W186_T0.8521.00
371_K375_L0.8511.00
225_S239_W0.8501.00
379_M382_H0.8501.00
275_L284_I0.8471.00
200_Q254_G0.8451.00
217_L277_D0.8421.00
372_I376_L0.8391.00
339_I376_L0.8351.00
149_T216_I0.8351.00
213_I218_P0.8321.00
234_M237_K0.8281.00
343_F385_V0.8271.00
369_S375_L0.8261.00
164_V206_H0.8251.00
393_E443_K0.8231.00
258_A261_V0.8211.00
406_A438_D0.8201.00
160_S210_N0.8201.00
277_D280_E0.8181.00
262_L266_R0.8161.00
164_V202_T0.8141.00
282_R337_L0.8121.00
199_L202_T0.8111.00
374_Q378_D0.8081.00
486_L491_V0.8071.00
418_E471_K0.8061.00
328_T331_S0.8031.00
466_K472_M0.8011.00
395_T423_D0.8011.00
228_T256_L0.8011.00
205_E208_E0.8001.00
110_H114_P0.7991.00
276_Q330_L0.7981.00
133_T184_V0.7971.00
286_V304_A0.7971.00
295_A487_R0.7951.00
278_A283_D0.7941.00
158_P174_A0.7931.00
259_M263_R0.7921.00
83_R86_S0.7921.00
292_V299_I0.7871.00
200_Q204_G0.7861.00
407_P411_R0.7861.00
350_L353_H0.7851.00
245_I264_I0.7851.00
325_A331_S0.7841.00
223_N251_L0.7831.00
111_E115_D0.7811.00
90_R93_Q0.7801.00
435_Q457_V0.7791.00
449_V474_A0.7781.00
250_G253_I0.7781.00
147_M240_H0.7781.00
112_S116_T0.7771.00
114_P185_I0.7741.00
423_D475_E0.7711.00
474_A486_L0.7701.00
201_K204_G0.7691.00
166_P202_T0.7681.00
343_F383_Y0.7671.00
138_L154_V0.7671.00
332_E366_V0.7661.00
257_A262_L0.7651.00
139_G143_Y0.7651.00
227_I235_L0.7641.00
193_Q197_T0.7631.00
225_S242_Q0.7621.00
306_A321_F0.7611.00
385_V390_I0.7611.00
88_S91_Y0.7601.00
336_L379_M0.7551.00
97_Y109_E0.7541.00
276_Q333_P0.7531.00
226_I254_G0.7511.00
410_S438_D0.7501.00
200_Q224_I0.7491.00
375_L378_D0.7471.00
191_I195_I0.7451.00
336_L340_R0.7441.00
196_I228_T0.7401.00
325_A329_G0.7401.00
380_I383_Y0.7391.00
348_D505_K0.7371.00
240_H244_F0.7371.00
390_I417_H0.7351.00
163_D206_H0.7341.00
134_S244_F0.7341.00
288_Y302_A0.7331.00
141_I150_A0.7331.00
92_I95_V0.7321.00
109_E175_A0.7321.00
451_A454_Y0.7321.00
309_P314_S0.7281.00
249_L253_I0.7281.00
279_I337_L0.7261.00
132_L177_I0.7241.00
449_V452_L0.7231.00
272_H324_L0.7211.00
97_Y105_C0.7211.00
288_Y304_A0.7201.00
424_F461_I0.7201.00
98_I105_C0.7191.00
179_N244_F0.7191.00
350_L355_Q0.7181.00
88_S92_I0.7181.00
131_W184_V0.7161.00
272_H328_T0.7101.00
304_A342_V0.7071.00
101_N155_M0.7021.00
138_L142_R0.7011.00
348_D351_R0.7001.00
133_T224_I0.6981.00
463_E466_K0.6961.00
367_L408_I0.6951.00
136_N221_E0.6951.00
370_E404_T0.6951.00
227_I239_W0.6951.00
407_P410_S0.6941.00
139_G244_F0.6941.00
472_M492_H0.6941.00
290_P500_S0.6931.00
402_P405_S0.6921.00
134_S142_R0.6921.00
94_E97_Y0.6911.00
288_Y505_K0.6901.00
118_P229_W0.6891.00
181_H240_H0.6891.00
157_D161_F0.6861.00
367_L398_E0.6861.00
164_V203_P0.6851.00
157_D211_G0.6851.00
183_V236_Q0.6831.00
193_Q256_L0.6811.00
145_V218_P0.6801.00
409_I438_D0.6781.00
270_S312_D0.6761.00
81_E89_Y0.6741.00
292_V297_G0.6741.00
132_L239_W0.6731.00
145_V216_I0.6731.00
331_S365_P0.6721.00
477_I483_E0.6721.00
260_F263_R0.6701.00
138_L150_A0.6701.00
137_D327_Q0.6701.00
285_C506_E0.6691.00
421_L433_Y0.6681.00
349_W508_F0.6671.00
149_T213_I0.6671.00
275_L278_A0.6671.00
194_G197_T0.6651.00
478_E497_W0.6631.00
257_A261_V0.6621.00
287_H309_P0.6611.00
110_H185_I0.6601.00
348_D509_L0.6601.00
319_D323_P0.6591.00
86_S90_R0.6591.00
395_T475_E0.6571.00
178_G181_H0.6561.00
508_F511_W0.6551.00
149_T218_P0.6551.00
290_P503_L0.6511.00
184_V203_P0.6511.00
497_W501_K0.6501.00
111_E232_T0.6491.00
297_G480_S0.6491.00
238_G257_A0.6481.00
297_G483_E0.6461.00
404_T407_P0.6451.00
426_T448_F0.6431.00
166_P199_L0.6411.00
462_I486_L0.6401.00
198_R202_T0.6401.00
84_R88_S0.6401.00
126_D188_S0.6401.00
376_L379_M0.6381.00
356_Q389_Q0.6361.00
360_I390_I0.6361.00
121_G229_W0.6361.00
402_P406_A0.6351.00
195_I198_R0.6341.00
346_M355_Q0.6331.00
180_A247_L0.6321.00
373_P415_A0.6311.00
275_L330_L0.6291.00
392_L419_I0.6261.00
317_S320_S0.6251.00
83_R87_Y0.6251.00
449_V458_T0.6221.00
271_P274_R0.6201.00
336_L378_D0.6201.00
346_M389_Q0.6191.00
302_A358_I0.6181.00
361_N422_D0.6161.00
358_I385_V0.6151.00
346_M390_I0.6131.00
339_I360_I0.6131.00
131_W226_I0.6131.00
162_I174_A0.6121.00
374_Q377_R0.6121.00
376_L417_H0.6101.00
128_Y235_L0.6071.00
107_S111_E0.6071.00
219_L276_Q0.6071.00
294_L487_R0.6061.00
230_A235_L0.6061.00
361_N443_K0.6051.00
433_Y436_D0.6041.00
503_L508_F0.6041.00
204_G222_M0.6021.00
141_I153_V0.6021.00
275_L334_L0.5971.00
486_L494_G0.5971.00
260_F264_I0.5971.00
186_T196_I0.5971.00
290_P299_I0.5961.00
336_L369_S0.5951.00
426_T447_S0.5931.00
385_V389_Q0.5931.00
303_E443_K0.5921.00
340_R375_L0.5921.00
89_Y92_I0.5921.00
263_R267_R0.5901.00
451_A455_K0.5891.00
444_I491_V0.5861.00
346_M383_Y0.5851.00
270_S313_G0.5841.00
457_V461_I0.5821.00
419_I440_D0.5811.00
359_S441_I0.5811.00
159_A163_D0.5811.00
442_L470_L0.5811.00
204_G252_V0.5801.00
111_E236_Q0.5791.00
335_T338_I0.5781.00
211_G220_P0.5761.00
418_E441_I0.5761.00
126_D187_S0.5751.00
113_P185_I0.5741.00
136_N252_V0.5731.00
364_S398_E0.5731.00
316_L323_P0.5711.00
309_P313_G0.5691.00
287_H502_A0.5691.00
303_E422_D0.5681.00
81_E84_R0.5651.00
116_T187_S0.5651.00
380_I385_V0.5631.00
305_L361_N0.5621.00
148_G237_K0.5621.00
396_E425_G0.5611.00
101_N151_H0.5591.00
145_V149_T0.5591.00
464_M468_L0.5561.00
336_L366_V0.5561.00
88_S95_V0.5551.00
301_G359_S0.5531.00
108_L111_E0.5521.00
196_I226_I0.5511.00
371_K374_Q0.5491.00
461_I465_A0.5471.00
499_Y502_A0.5471.00
362_L366_V0.5461.00
147_M150_A0.5451.00
465_A470_L0.5451.00
121_G128_Y0.5441.00
274_R308_W0.5441.00
105_C175_A0.5431.00
284_I308_W0.5421.00
199_L203_P0.5421.00
107_S151_H0.5421.00
265_L269_Q0.5411.00
205_E209_N0.5351.00
139_G142_R0.5351.00
301_G356_Q0.5351.00
279_I334_L0.5351.00
143_Y244_F0.5321.00
174_A184_V0.5311.00
334_L338_I0.5311.00
204_G208_E0.5311.00
342_V346_M0.5271.00
403_K407_P0.5271.00
100_N103_P0.5261.00
339_I362_L0.5261.00
458_T474_A0.5251.00
506_E509_L0.5241.00
457_V464_M0.5241.00
274_R277_D0.5231.00
400_A405_S0.5231.00
121_G124_S0.5221.00
201_K254_G0.5221.00
413_R419_I0.5221.00
408_I412_Y0.5211.00
326_Q363_E0.5201.00
266_R270_S0.5201.00
223_N246_W0.5191.00
411_R415_A0.5191.00
332_E336_L0.5181.00
339_I343_F0.5181.00
366_V372_I0.5181.00
117_F185_I0.5161.00
347_G385_V0.5151.00
403_K436_D0.5141.00
339_I375_L0.5141.00
444_I461_I0.5131.00
114_P128_Y0.5131.00
271_P308_W0.5131.00
433_Y437_L0.5111.00
326_Q397_R0.5101.00
147_M244_F0.5101.00
142_R247_L0.5081.00
481_K484_E0.5081.00
164_V199_L0.5081.00
118_P128_Y0.5061.00
361_N497_W0.5061.00
412_Y417_H0.5051.00
134_S138_L0.5051.00
378_D381_N0.5051.00
263_R266_R0.5041.00
148_G214_Y0.5041.00
188_S191_I0.5021.00
148_G152_Y0.5021.00
402_P436_D0.5011.00
372_I375_L0.5011.00
443_K495_Q0.5011.00
365_P368_T0.5011.00
142_R154_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rnhA 2 0.7907 100 0.18 Contact Map
4j40A 2 0.4787 100 0.191 Contact Map
3pjxA 1 0.7965 100 0.206 Contact Map
3gfzA 2 0.7248 100 0.329 Contact Map
4hjfA 1 0.4884 100 0.37 Contact Map
4hu4A 1 0.4612 100 0.446 Contact Map
2r6oA 2 0.4826 100 0.45 Contact Map
4kieA 1 0.4942 100 0.453 Contact Map
4rniA 2 0.4806 100 0.455 Contact Map
3sy8A 6 0.7364 100 0.465 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0125 seconds.