GREMLIN Database
PAAG - 1,2-epoxyphenylacetyl-CoA isomerase
UniProt: P77467 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13741
Length: 262 (246)
Sequences: 30270 (19558)
Seq/√Len: 1246.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_K169_Q3.1591.00
126_A181_I2.9341.00
183_Q193_T2.9051.00
104_C121_G2.8481.00
128_R186_D2.7671.00
193_T196_Q2.6531.00
15_T195_Q2.6531.00
40_K94_R2.4531.00
43_E99_P2.3621.00
168_N200_H2.1911.00
129_S187_D2.1721.00
174_Q177_E2.1401.00
15_T54_T2.1101.00
9_V14_M2.1081.00
24_L58_R2.0391.00
6_L19_N2.0341.00
36_A94_R2.0251.00
171_S174_Q2.0201.00
12_G49_R2.0121.00
17_T56_A2.0021.00
223_T226_T1.9921.00
159_R178_W1.9521.00
162_G168_N1.9501.00
105_A194_A1.9471.00
24_L59_G1.9401.00
249_S253_A1.9341.00
164_A212_I1.9301.00
138_K204_Q1.9071.00
17_T54_T1.9021.00
19_N56_A1.8891.00
105_A191_A1.8591.00
7_S14_M1.8561.00
9_V45_D1.8541.00
30_E34_Q1.7991.00
41_Q45_D1.7791.00
111_A133_V1.7621.00
14_M48_I1.7451.00
195_Q199_R1.7161.00
128_R173_E1.7041.00
125_I185_V1.7031.00
161_M217_N1.6931.00
14_M42_V1.6721.00
157_R161_M1.6661.00
189_T192_D1.6521.00
174_Q178_W1.6021.00
246_E255_R1.6001.00
185_V193_T1.5981.00
51_L98_L1.5631.00
125_I197_L1.5581.00
162_G182_W1.5451.00
173_E177_E1.5371.00
33_A87_F1.5251.00
126_A132_F1.5171.00
10_E195_Q1.5141.00
93_R97_K1.5001.00
189_T193_T1.4981.00
43_E94_R1.4921.00
42_V51_L1.4891.00
162_G183_Q1.4801.00
16_L38_C1.4741.00
128_R187_D1.4671.00
106_V118_A1.4661.00
161_M165_L1.4351.00
36_A40_K1.4351.00
127_A187_D1.4181.00
6_L56_A1.4121.00
124_V158_A1.4121.00
93_R225_D1.3831.00
211_L237_L1.3811.00
118_A124_V1.3681.00
107_N127_A1.3511.00
11_K199_R1.3501.00
176_H184_V1.3451.00
124_V154_V1.3421.00
122_D213_K1.3391.00
50_C198_A1.3251.00
115_A134_M1.3151.00
39_L98_L1.3141.00
107_N129_S1.3141.00
7_S42_V1.3121.00
10_E15_T1.3081.00
59_G109_V1.3041.00
163_L170_L1.3011.00
15_T191_A1.2911.00
159_R162_G1.2871.00
106_V110_A1.2811.00
36_A90_P1.2751.00
95_L102_V1.2741.00
54_T191_A1.2721.00
43_E98_L1.2721.00
109_V131_K1.2711.00
20_R23_R1.2621.00
10_E199_R1.2591.00
161_M216_I1.2541.00
158_A182_W1.2541.00
96_A150_L1.2491.00
222_N226_T1.2231.00
133_V169_Q1.2211.00
34_Q38_C1.2191.00
168_N174_Q1.2161.00
218_S230_L1.1921.00
29_D68_D1.1771.00
191_A195_Q1.1761.00
159_R174_Q1.1731.00
28_N31_M1.1561.00
8_H17_T1.1481.00
9_V47_T1.1471.00
192_D196_Q1.1381.00
29_D33_A1.1311.00
54_T107_N1.1281.00
244_Y248_V1.1181.00
170_L178_W1.1171.00
18_L31_M1.1171.00
58_R107_N1.1161.00
38_C41_Q1.1061.00
214_Q218_S1.1061.00
97_K225_D1.1031.00
204_Q209_L1.0991.00
190_L194_A1.0891.00
8_H15_T1.0801.00
23_R67_N1.0801.00
6_L17_T1.0681.00
186_D189_T1.0631.00
54_T105_A1.0621.00
207_F243_D1.0611.00
34_Q37_E1.0601.00
127_A190_L1.0601.00
137_S167_G1.0541.00
102_V121_G1.0521.00
116_T147_G1.0421.00
155_A159_R1.0341.00
191_A194_A1.0311.00
222_N230_L1.0261.00
51_L102_V1.0211.00
172_A184_V1.0201.00
51_L100_K1.0151.00
173_E176_H1.0121.00
154_V158_A1.0081.00
18_L61_C1.0071.00
9_V41_Q1.0031.00
157_R220_E1.0011.00
123_I197_L0.9851.00
156_G159_R0.9851.00
245_R249_S0.9841.00
99_P210_G0.9821.00
37_E41_Q0.9801.00
211_L214_Q0.9771.00
13_V50_C0.9671.00
52_L194_A0.9621.00
198_A202_A0.9601.00
214_Q234_Y0.9501.00
61_C114_G0.9481.00
206_T210_G0.9411.00
211_L234_Y0.9361.00
88_Y145_C0.9301.00
105_A190_L0.9291.00
115_A132_F0.9261.00
131_K171_S0.9221.00
36_A87_F0.9201.00
111_A169_Q0.9051.00
82_M86_R0.9001.00
48_I100_K0.8971.00
142_I238_A0.8891.00
230_L233_D0.8861.00
176_H183_Q0.8841.00
29_D87_F0.8801.00
20_R65_D0.8791.00
226_T229_D0.8771.00
24_L62_A0.8701.00
193_T197_L0.8611.00
128_R184_V0.8601.00
9_V48_I0.8551.00
176_H181_I0.8521.00
230_L234_Y0.8521.00
163_L178_W0.8471.00
194_A198_A0.8471.00
32_H91_L0.8401.00
137_S212_I0.8351.00
127_A188_E0.8321.00
16_L51_L0.8321.00
15_T52_L0.8311.00
107_N190_L0.8251.00
164_A216_I0.8181.00
183_Q197_L0.8151.00
149_W227_Q0.8131.00
106_V132_F0.8121.00
39_L95_L0.8121.00
200_H204_Q0.8091.00
162_G166_L0.8041.00
67_N252_L0.8011.00
40_K44_R0.8011.00
192_D195_Q0.7971.00
138_K169_Q0.7931.00
43_E100_K0.7901.00
196_Q200_H0.7881.00
53_L121_G0.7871.00
234_Y237_L0.7861.00
195_Q198_A0.7831.00
211_L238_A0.7811.00
33_A37_E0.7731.00
40_K90_P0.7711.00
155_A163_L0.7711.00
242_A245_R0.7701.00
123_I182_W0.7621.00
36_A91_L0.7621.00
86_R232_R0.7611.00
27_F31_M0.7511.00
57_G107_N0.7511.00
175_A180_M0.7491.00
106_V124_V0.7431.00
92_V120_G0.7421.00
157_R217_N0.7411.00
107_N187_D0.7401.00
125_I183_Q0.7381.00
149_W152_P0.7341.00
172_A181_I0.7301.00
119_L180_M0.7261.00
156_G160_A0.7261.00
151_L155_A0.7241.00
148_T231_E0.7231.00
7_S38_C0.7181.00
218_S222_N0.7171.00
46_D100_K0.7131.00
99_P214_Q0.7081.00
224_L228_L0.7071.00
98_L102_V0.7071.00
20_R28_N0.7061.00
215_A234_Y0.7051.00
201_L209_L0.7041.00
86_R90_P0.7011.00
24_L109_V0.7001.00
42_V48_I0.7001.00
205_P243_D0.7001.00
199_R203_T0.6981.00
197_L200_H0.6961.00
70_N249_S0.6961.00
166_L197_L0.6891.00
30_E33_A0.6891.00
28_N68_D0.6871.00
103_I198_A0.6861.00
132_F181_I0.6861.00
31_M34_Q0.6851.00
196_Q199_R0.6841.00
49_R206_T0.6821.00
229_D233_D0.6801.00
207_F241_S0.6781.00
52_L105_A0.6761.00
59_G107_N0.6751.00
40_K43_E0.6741.00
82_M233_D0.6741.00
50_C202_A0.6721.00
159_R176_H0.6681.00
45_D48_I0.6671.00
106_V130_A0.6671.00
38_C42_V0.6671.00
248_V252_L0.6641.00
246_E250_A0.6611.00
142_I215_A0.6551.00
13_V52_L0.6541.00
83_S87_F0.6531.00
13_V195_Q0.6511.00
12_G47_T0.6481.00
90_P94_R0.6481.00
232_R236_R0.6451.00
109_V169_Q0.6441.00
170_L175_A0.6401.00
7_S41_Q0.6401.00
50_C103_I0.6391.00
53_L102_V0.6391.00
49_R202_A0.6381.00
242_A246_E0.6361.00
215_A230_L0.6361.00
20_R26_S0.6361.00
111_A135_A0.6281.00
181_I184_V0.6261.00
52_L195_Q0.6261.00
82_M236_R0.6251.00
173_E184_V0.6241.00
90_P93_R0.6221.00
249_S252_L0.6181.00
23_R65_D0.6171.00
126_A130_A0.6161.00
207_F238_A0.6151.00
185_V190_L0.6151.00
104_C124_V0.6141.00
13_V198_A0.6111.00
149_W153_R0.6101.00
80_L83_S0.6091.00
116_T136_F0.6081.00
37_E40_K0.6071.00
73_P80_L0.6051.00
148_T227_Q0.6011.00
45_D100_K0.5981.00
162_G174_Q0.5951.00
212_I215_A0.5921.00
155_A160_A0.5911.00
233_D237_L0.5911.00
134_M147_G0.5871.00
225_D229_D0.5871.00
118_A121_G0.5851.00
7_S16_L0.5811.00
125_I190_L0.5811.00
104_C118_A0.5801.00
165_L209_L0.5791.00
246_E249_S0.5791.00
133_V167_G0.5781.00
157_R216_I0.5771.00
166_L201_L0.5761.00
129_S172_A0.5761.00
39_L102_V0.5751.00
189_T196_Q0.5751.00
206_T209_L0.5751.00
200_H203_T0.5741.00
125_I194_A0.5741.00
70_N252_L0.5721.00
166_L200_H0.5721.00
143_P212_I0.5711.00
159_R177_E0.5701.00
16_L53_L0.5691.00
35_L91_L0.5671.00
64_Q69_R0.5651.00
9_V12_G0.5631.00
154_V182_W0.5631.00
125_I193_T0.5621.00
141_L244_Y0.5621.00
32_H36_A0.5601.00
229_D232_R0.5601.00
134_M164_A0.5591.00
115_A180_M0.5581.00
16_L42_V0.5531.00
98_L101_P0.5491.00
39_L94_R0.5461.00
124_V181_I0.5451.00
123_I201_L0.5401.00
214_Q230_L0.5401.00
107_N191_A0.5391.00
87_F90_P0.5381.00
96_A217_N0.5381.00
247_G250_A0.5361.00
155_A178_W0.5351.00
66_L139_L0.5301.00
89_N93_R0.5301.00
115_A119_L0.5261.00
162_G197_L0.5251.00
134_M151_L0.5241.00
137_S204_Q0.5241.00
153_R223_T0.5231.00
112_G135_A0.5231.00
153_R220_E0.5221.00
30_E68_D0.5211.00
27_F113_A0.5201.00
222_N227_Q0.5191.00
136_F144_D0.5151.00
171_S177_E0.5151.00
102_V122_D0.5141.00
96_A224_L0.5141.00
13_V202_A0.5131.00
33_A36_A0.5131.00
17_T191_A0.5111.00
70_N248_V0.5091.00
116_T134_M0.5071.00
136_F143_P0.5071.00
168_N183_Q0.5061.00
172_A176_H0.5061.00
137_S209_L0.5041.00
175_A181_I0.5031.00
152_P219_A0.5031.00
42_V100_K0.5011.00
48_I51_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3g64A 6 1 100 0.065 Contact Map
4jfcA 3 0.9809 100 0.068 Contact Map
4mi2A 3 0.9924 100 0.069 Contact Map
2ej5A 3 0.958 100 0.07 Contact Map
3qxzA 3 0.9809 100 0.07 Contact Map
1nzyA 4 1 100 0.071 Contact Map
4lk5A 3 0.9504 100 0.071 Contact Map
3sllA 6 0.9847 100 0.071 Contact Map
2fbmA 3 0.9542 100 0.072 Contact Map
3peaA 3 0.9809 100 0.073 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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