GREMLIN Database
GLSA1 - Glutaminase 1
UniProt: P77454 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13247
Length: 310 (300)
Sequences: 1593 (1069)
Seq/√Len: 61.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_S199_L6.0801.00
145_Q223_K4.7921.00
149_E204_E4.3301.00
166_F173_W4.2691.00
40_L60_Y4.2031.00
217_V224_R3.4101.00
71_C208_L3.3831.00
46_V206_A3.3611.00
165_N193_T3.3321.00
79_D138_R3.2821.00
209_G267_L3.0161.00
42_A202_T2.9881.00
17_Q298_S2.8161.00
8_Q12_D2.7681.00
13_Q302_Q2.7071.00
256_L268_A2.5641.00
41_A295_M2.5531.00
25_Q28_D2.4911.00
54_S58_S2.4511.00
89_I123_T2.4281.00
253_R297_A2.3311.00
246_R284_D2.2901.00
67_I265_G2.2531.00
16_T19_H2.1441.00
61_R204_E2.1401.00
36_V40_L2.0541.00
47_T51_N2.0371.00
258_G268_A2.0201.00
27_A30_I1.9971.00
84_A87_D1.9661.00
162_Q190_D1.9651.00
137_Q141_H1.9411.00
32_F35_N1.9261.00
12_D55_A1.8921.00
46_V52_V1.8741.00
278_A292_G1.8701.00
44_A203_I1.8671.00
59_D203_I1.8551.00
64_L68_S1.8541.00
239_M251_A1.8521.00
140_L198_T1.8311.00
29_Y262_V1.8271.00
171_I175_L1.8031.00
15_Y41_A1.7981.00
162_Q193_T1.7700.99
72_T139_I1.7690.99
218_N221_T1.7490.99
32_F160_S1.7430.99
43_V295_M1.7120.99
78_E227_Q1.7020.99
32_F156_E1.7000.99
68_S195_Q1.6950.99
280_S291_R1.6820.99
94_T116_V1.6360.99
162_Q165_N1.6350.99
121_I193_T1.6240.99
61_R201_N1.6130.99
43_V55_A1.6110.99
15_Y55_A1.5980.99
52_V203_I1.5920.99
268_A296_V1.5900.99
85_V126_L1.5670.99
155_D194_R1.5540.99
78_E230_N1.5480.99
155_D159_Q1.5140.98
44_A54_S1.5030.98
18_F298_S1.5020.98
67_I70_V1.4870.98
166_F176_Y1.4840.98
124_T191_V1.4760.98
40_L57_D1.4470.98
294_K297_A1.4450.98
218_N225_V1.4290.98
54_S59_D1.4270.98
30_I33_L1.4210.98
74_A211_T1.4020.97
36_V263_G1.3980.97
207_T218_N1.3840.97
243_L258_G1.3820.97
270_V274_M1.3810.97
171_I174_L1.3810.97
298_S302_Q1.3800.97
44_A202_T1.3610.97
139_I195_Q1.3500.97
37_P40_L1.3420.97
143_Q151_V1.3400.96
59_D201_N1.3320.96
35_N156_E1.3130.96
227_Q230_N1.2940.96
102_I106_L1.2900.96
27_A262_V1.2890.96
129_A183_C1.2690.95
142_I146_L1.2680.95
121_I165_N1.2530.95
63_A157_V1.2460.95
209_G275_G1.2440.95
73_L86_Q1.2430.95
40_L279_F1.2410.95
122_A175_L1.2350.94
129_A134_Q1.2290.94
65_E161_E1.2280.94
189_C193_T1.2110.94
159_Q163_T1.2030.94
31_P160_S1.2010.94
212_L234_I1.2000.94
92_D245_G1.1900.93
54_S203_I1.1850.93
72_T143_Q1.1730.93
27_A33_L1.1710.93
26_N38_G1.1670.93
122_A180_Y1.1630.92
31_P164_T1.1590.92
72_T124_T1.1550.92
10_A302_Q1.1520.92
184_D187_E1.1470.92
205_L277_A1.1420.92
93_P241_E1.1330.91
210_A219_P1.1260.91
48_C214_A1.1250.91
52_V206_A1.1220.91
294_K298_S1.1210.91
30_I161_E1.1080.90
61_R181_L1.0990.90
121_I188_A1.0910.90
21_L294_K1.0830.89
274_M305_Y1.0790.89
167_H177_S1.0680.89
211_T218_N1.0680.89
169_R186_M1.0650.89
29_Y33_L1.0600.88
144_Q149_E1.0550.88
121_I189_C1.0510.88
72_T195_Q1.0500.88
266_I289_S1.0490.88
139_I191_V1.0360.87
12_D16_T1.0350.87
131_N134_Q1.0290.87
132_V191_V1.0250.87
256_L269_V1.0230.87
88_K182_Y1.0170.86
43_V299_V1.0170.86
79_D128_N1.0140.86
47_T53_Y1.0130.86
129_A135_R1.0090.86
15_Y19_H1.0080.86
249_D253_R1.0060.86
72_T127_I1.0040.86
132_V135_R0.9910.85
39_Q282_P0.9890.85
48_C210_A0.9840.84
30_I160_S0.9800.84
207_T211_T0.9770.84
158_N162_Q0.9770.84
14_A295_M0.9760.84
208_L212_L0.9710.84
144_Q147_A0.9630.83
88_K180_Y0.9620.83
44_A52_V0.9540.82
67_I205_L0.9530.82
52_V207_T0.9460.82
136_W153_L0.9270.81
104_L111_P0.9210.80
38_G282_P0.9160.80
68_S72_T0.9150.80
269_V275_G0.9110.79
48_C213_A0.9060.79
93_P111_P0.9050.79
282_P291_R0.9010.79
14_A298_S0.9000.79
211_T225_V0.8890.78
258_G284_D0.8880.78
131_N135_R0.8830.77
74_A212_L0.8830.77
100_S103_A0.8830.77
233_Y252_Y0.8790.77
183_C188_A0.8760.77
147_A151_V0.8750.77
181_L188_A0.8670.76
64_L263_G0.8650.76
86_Q233_Y0.8650.76
144_Q151_V0.8620.76
169_R173_W0.8610.75
140_L144_Q0.8590.75
10_A303_L0.8500.75
76_A80_V0.8490.74
94_T112_L0.8480.74
187_E190_D0.8470.74
66_S69_K0.8430.74
45_I276_I0.8420.74
109_G112_L0.8400.74
93_P245_G0.8330.73
130_E134_Q0.8330.73
15_Y295_M0.8310.73
21_L282_P0.8270.73
266_I278_A0.8270.73
111_P161_E0.8240.72
27_A161_E0.8210.72
124_T195_Q0.8180.72
147_A208_L0.8140.71
102_I175_L0.8120.71
47_T212_L0.8090.71
170_A173_W0.8060.71
96_L103_A0.8030.70
82_P229_D0.8010.70
93_P104_L0.7990.70
42_A58_S0.7930.69
11_V247_S0.7920.69
236_A306_N0.7850.69
104_L112_L0.7850.69
137_Q140_L0.7840.68
249_D265_G0.7840.68
224_R228_A0.7800.68
117_N168_N0.7790.68
229_D301_K0.7770.68
27_A164_T0.7740.67
14_A18_F0.7730.67
243_L284_D0.7690.67
152_A199_L0.7690.67
216_G219_P0.7670.67
127_I139_I0.7650.67
30_I34_A0.7640.66
29_Y160_S0.7620.66
122_A125_S0.7620.66
26_N34_A0.7620.66
105_E109_G0.7610.66
66_S244_Y0.7600.66
77_L89_I0.7580.66
116_V241_E0.7530.65
92_D241_E0.7530.65
143_Q198_T0.7510.65
61_R150_Q0.7480.65
69_K244_Y0.7480.65
61_R149_E0.7480.65
270_V273_V0.7450.64
161_E262_V0.7440.64
63_A158_N0.7440.64
12_D23_G0.7430.64
33_L160_S0.7370.64
221_T237_E0.7360.64
251_A270_V0.7350.63
43_V278_A0.7330.63
46_V50_G0.7310.63
141_H145_Q0.7290.63
57_D279_F0.7190.62
162_Q189_C0.7150.61
246_R293_Q0.7140.61
239_M308_F0.7120.61
146_L226_L0.7110.61
153_L194_R0.7090.61
33_L63_A0.7050.60
157_V160_S0.7040.60
271_P280_S0.7030.60
65_E197_S0.7020.60
80_V126_L0.7020.60
92_D95_G0.7000.60
101_V171_I0.6970.59
38_G280_S0.6940.59
230_N234_I0.6930.59
22_N282_P0.6880.58
175_L181_L0.6880.58
74_A226_L0.6870.58
169_R189_C0.6870.58
41_A291_R0.6790.57
124_T139_I0.6790.57
11_V15_Y0.6770.57
14_A17_Q0.6750.57
71_C212_L0.6700.56
30_I262_V0.6690.56
262_V287_G0.6670.56
63_A279_F0.6640.56
32_F157_V0.6640.56
8_Q53_Y0.6640.56
164_T169_R0.6620.55
99_N116_V0.6610.55
166_F186_M0.6610.55
154_S157_V0.6600.55
74_A146_L0.6590.55
94_T103_A0.6570.55
139_I171_I0.6570.55
167_H178_A0.6560.55
141_H150_Q0.6560.55
46_V207_T0.6550.55
148_G210_A0.6530.54
158_N197_S0.6510.54
19_H57_D0.6470.54
48_C215_G0.6470.54
159_Q162_Q0.6470.54
203_I207_T0.6470.54
226_L231_V0.6450.54
89_I111_P0.6420.53
140_L150_Q0.6400.53
77_L230_N0.6380.53
84_A134_Q0.6380.53
76_A254_V0.6370.53
240_M251_A0.6360.52
108_G234_I0.6360.52
133_E194_R0.6350.52
235_L269_V0.6310.52
295_M299_V0.6310.52
214_A219_P0.6280.52
117_N259_K0.6240.51
129_A138_R0.6230.51
115_L243_L0.6220.51
161_E197_S0.6220.51
250_W254_V0.6210.51
284_D288_N0.6200.51
184_D231_V0.6200.51
93_P251_A0.6200.51
95_G248_G0.6200.51
61_R199_L0.6180.50
290_V293_Q0.6140.50
244_Y259_K0.6100.50
11_V55_A0.6090.49
123_T126_L0.6080.49
26_N282_P0.6080.49
254_V300_A0.6050.49
17_Q302_Q0.6050.49
174_L250_W0.6040.49
30_I65_E0.6040.49
15_Y291_R0.6040.49
9_Q16_T0.6030.49
181_L195_Q0.6020.49
210_A213_A0.6020.49
140_L285_E0.6010.49
136_W194_R0.6000.48
93_P116_V0.5990.48
209_G274_M0.5990.48
217_V221_T0.5980.48
172_A181_L0.5980.48
158_N190_D0.5970.48
27_A160_S0.5930.48
48_C207_T0.5930.48
113_S241_E0.5930.48
217_V220_L0.5900.47
134_Q138_R0.5880.47
196_C262_V0.5860.47
106_L174_L0.5830.46
46_V210_A0.5830.46
158_N194_R0.5830.46
70_V115_L0.5820.46
18_F294_K0.5810.46
246_R249_D0.5810.46
216_G225_V0.5800.46
76_A191_V0.5790.46
75_L127_I0.5790.46
174_L247_S0.5790.46
158_N297_A0.5790.46
282_P290_V0.5770.46
239_M307_V0.5770.46
71_C143_Q0.5760.46
37_P222_H0.5760.46
26_N193_T0.5740.45
66_S117_N0.5720.45
65_E262_V0.5710.45
35_N203_I0.5710.45
117_N196_C0.5690.45
70_V238_M0.5690.45
74_A230_N0.5680.45
36_V200_L0.5680.45
113_S198_T0.5670.45
25_Q130_E0.5660.45
151_V200_L0.5660.45
267_L277_A0.5640.44
211_T221_T0.5630.44
151_V234_I0.5620.44
259_K262_V0.5610.44
241_E296_V0.5600.44
13_Q229_D0.5580.44
127_I206_A0.5580.44
42_A61_R0.5570.44
23_G282_P0.5570.44
216_G221_T0.5560.43
103_A112_L0.5550.43
70_V267_L0.5550.43
95_G245_G0.5540.43
74_A234_I0.5540.43
210_A214_A0.5540.43
136_W165_N0.5520.43
51_N121_I0.5520.43
32_F163_T0.5510.43
91_A252_Y0.5490.43
65_E167_H0.5490.43
30_I98_F0.5480.43
43_V201_N0.5460.42
236_A239_M0.5460.42
45_I270_V0.5440.42
26_N185_A0.5440.42
69_K117_N0.5420.42
65_E92_D0.5410.42
75_L142_I0.5410.42
154_S267_L0.5410.42
139_I147_A0.5390.42
226_L230_N0.5390.42
25_Q163_T0.5380.41
128_N181_L0.5370.41
230_N233_Y0.5350.41
236_A252_Y0.5340.41
46_V213_A0.5340.41
98_F244_Y0.5330.41
144_Q152_A0.5330.41
63_A115_L0.5320.41
93_P240_M0.5320.41
171_I231_V0.5320.41
137_Q150_Q0.5320.41
11_V96_L0.5300.41
278_A296_V0.5300.41
10_A14_A0.5300.41
80_V128_N0.5290.40
214_A301_K0.5290.40
66_S168_N0.5280.40
121_I162_Q0.5270.40
13_Q20_S0.5260.40
45_I274_M0.5250.40
237_E245_G0.5250.40
266_I292_G0.5240.40
144_Q150_Q0.5240.40
297_A301_K0.5220.40
13_Q16_T0.5190.39
16_T20_S0.5180.39
86_Q263_G0.5180.39
233_Y263_G0.5180.39
256_L300_A0.5170.39
98_F196_C0.5170.39
19_H291_R0.5160.39
74_A193_T0.5160.39
21_L291_R0.5150.39
77_L305_Y0.5150.39
244_Y262_V0.5140.39
96_L240_M0.5140.39
173_W275_G0.5120.39
251_A308_F0.5110.38
85_V123_T0.5100.38
126_L219_P0.5100.38
65_E113_S0.5090.38
8_Q59_D0.5080.38
205_L265_G0.5080.38
29_Y161_E0.5080.38
289_S292_G0.5070.38
209_G231_V0.5060.38
168_N244_Y0.5050.38
58_S61_R0.5040.38
70_V151_V0.5030.38
12_D39_Q0.5030.38
152_A155_D0.5030.38
209_G288_N0.5030.38
145_Q225_V0.5010.37
73_L234_I0.5010.37
13_Q17_Q0.5010.37
88_K122_A0.5010.37
104_L199_L0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u60A 4 0.9968 100 -0.005 Contact Map
2pbyA 3 0.9355 100 0.012 Contact Map
4bqmA 3 0.9806 100 0.017 Contact Map
3uo9A 3 0.9935 100 0.019 Contact Map
1mkiA 3 0.9452 100 0.03 Contact Map
3agdA 2 0.9903 100 0.054 Contact Map
1ghpA 1 0.7516 98.6 0.915 Contact Map
4m3kA 1 0.7677 98.4 0.919 Contact Map
2wuqA 2 0.8161 98.3 0.921 Contact Map
4ua6A 1 0.7677 98.1 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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