GREMLIN Database
EUTE - Ethanolamine utilization protein EutE
UniProt: P77445 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14185
Length: 467 (438)
Sequences: 36342 (21939)
Seq/√Len: 1048.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
279_D374_A5.2771.00
279_D372_R3.3151.00
251_A288_L3.2661.00
282_A372_R3.0341.00
353_T356_H2.8671.00
44_K208_G2.8661.00
15_L27_V2.8411.00
246_E278_V2.8371.00
315_E319_G2.7401.00
255_Q292_Q2.6591.00
170_R173_T2.6051.00
286_M370_V2.5941.00
246_E280_S2.5101.00
68_E99_R2.5011.00
337_I345_T2.4771.00
70_H73_D2.4651.00
398_S404_M2.3831.00
180_V186_E2.3721.00
15_L24_S2.3241.00
44_K210_G2.3201.00
303_Q306_Q2.3051.00
32_V35_S2.2801.00
63_I175_L2.2751.00
71_A92_A2.2021.00
331_G351_E2.1441.00
376_V403_N2.1291.00
322_S338_G2.0871.00
201_Q205_K2.0751.00
387_E435_T2.0601.00
124_A456_R2.0501.00
163_A314_D2.0401.00
312_N321_V2.0311.00
205_K227_H2.0261.00
290_E294_A2.0021.00
406_Q410_A1.9771.00
242_V257_I1.9701.00
59_A184_G1.9481.00
73_D170_R1.9481.00
284_E288_L1.9451.00
333_I350_V1.9321.00
66_A181_A1.8831.00
247_T403_N1.8751.00
37_D202_R1.8681.00
326_V332_K1.8561.00
222_E435_T1.8561.00
276_I382_L1.8561.00
41_A208_G1.8381.00
223_A226_K1.8351.00
349_F358_F1.8121.00
376_V406_Q1.8051.00
412_D434_T1.8051.00
66_A69_K1.8001.00
276_I379_A1.7691.00
278_V373_V1.7631.00
359_A371_V1.7511.00
354_A382_L1.7471.00
123_N453_V1.7331.00
123_N450_R1.7311.00
37_D41_A1.7291.00
66_A174_L1.7181.00
293_H348_L1.7161.00
357_P361_T1.7071.00
77_L170_R1.6971.00
172_I191_T1.6711.00
378_D381_A1.6621.00
290_E333_I1.6581.00
257_I285_L1.6541.00
24_S27_V1.6371.00
282_A286_M1.6191.00
332_K349_F1.6181.00
47_Q51_K1.6161.00
287_R291_G1.6011.00
275_L368_L1.5971.00
61_A99_R1.5971.00
374_A378_D1.5961.00
195_P198_E1.5941.00
262_S293_H1.5861.00
250_L288_L1.5841.00
66_A182_A1.5811.00
331_G350_V1.5751.00
155_S188_L1.5611.00
65_E69_K1.5591.00
37_D206_F1.5551.00
283_D372_R1.5541.00
288_L291_G1.5331.00
323_R357_P1.5181.00
62_A65_E1.5091.00
377_A410_A1.4971.00
68_E95_V1.4911.00
72_R76_E1.4861.00
98_A147_I1.4821.00
254_A288_L1.4821.00
245_D403_N1.4801.00
256_S397_H1.4701.00
276_I373_V1.4701.00
246_E403_N1.4611.00
324_D363_L1.4601.00
76_E80_S1.4461.00
257_I275_L1.4411.00
394_A413_T1.4371.00
52_S410_A1.4351.00
277_V285_L1.4351.00
284_E287_R1.4291.00
292_Q295_V1.4271.00
70_H181_A1.4271.00
13_V27_V1.4261.00
65_E99_R1.4241.00
131_S156_V1.4071.00
104_V107_L1.4051.00
79_V89_D1.4021.00
326_V329_D1.4001.00
282_A350_V1.3991.00
35_S38_D1.3941.00
122_E409_N1.3831.00
318_K322_S1.3831.00
297_L306_Q1.3811.00
225_R438_I1.3701.00
378_D382_L1.3671.00
18_Q21_D1.3651.00
70_H170_R1.3641.00
17_M24_S1.3611.00
321_V365_M1.3561.00
245_D373_V1.3521.00
201_Q227_H1.3401.00
211_L233_I1.3371.00
76_E302_A1.3321.00
98_A143_I1.3311.00
373_V382_L1.3301.00
64_R99_R1.3301.00
172_I189_L1.3281.00
328_R357_P1.3201.00
375_N378_D1.3111.00
110_Q444_E1.3101.00
12_A30_M1.3031.00
47_Q155_S1.3021.00
142_V158_F1.2991.00
291_G294_A1.2911.00
294_A334_A1.2851.00
40_V206_F1.2831.00
283_D287_R1.2781.00
319_G323_R1.2731.00
380_I407_M1.2711.00
315_E318_K1.2691.00
286_M290_E1.2681.00
245_D407_M1.2651.00
64_R68_E1.2591.00
278_V375_N1.2511.00
175_L189_L1.2431.00
318_K338_G1.2431.00
36_L199_T1.2421.00
162_P195_P1.2341.00
243_V379_A1.2331.00
299_A307_P1.2301.00
281_V284_E1.2271.00
74_L170_R1.2261.00
110_Q445_G1.2251.00
278_V281_V1.2231.00
300_E303_Q1.2201.00
355_E360_V1.2181.00
162_P197_I1.2171.00
201_Q223_A1.2151.00
444_E450_R1.2081.00
289_M368_L1.2071.00
187_N190_V1.2051.00
30_M195_P1.2001.00
40_V208_G1.1971.00
33_F202_R1.1961.00
354_A385_K1.1901.00
285_L289_M1.1891.00
297_L308_V1.1851.00
120_L405_N1.1831.00
63_I174_L1.1831.00
41_A45_V1.1821.00
408_A458_C1.1771.00
53_V59_A1.1691.00
123_N455_L1.1691.00
79_V301_Q1.1661.00
62_A66_A1.1651.00
76_E86_R1.1551.00
173_T181_A1.1471.00
40_V209_I1.1461.00
42_A190_V1.1411.00
63_I184_G1.1401.00
286_M333_I1.1401.00
288_L292_Q1.1381.00
220_V223_A1.1371.00
377_A406_Q1.1341.00
291_G295_V1.1331.00
394_A416_F1.1301.00
223_A227_H1.1281.00
360_V385_K1.1281.00
404_M418_K1.1271.00
130_A203_L1.1231.00
146_A189_L1.1221.00
126_W211_L1.1211.00
18_Q300_E1.1181.00
225_R232_L1.1161.00
242_V272_E1.1161.00
330_A349_F1.1131.00
219_A223_A1.1131.00
296_K309_L1.1131.00
341_V344_E1.1121.00
63_I98_A1.1121.00
131_S213_V1.1091.00
360_V387_E1.1061.00
243_V407_M1.1021.00
286_M350_V1.0971.00
239_N273_K1.0951.00
169_Q193_A1.0951.00
26_A166_K1.0871.00
290_E334_A1.0841.00
328_R356_H1.0841.00
20_S301_Q1.0801.00
74_L174_L1.0781.00
137_N268_I1.0751.00
202_R206_F1.0751.00
377_A381_A1.0731.00
70_H174_L1.0671.00
14_L30_M1.0661.00
61_A103_G1.0611.00
249_D399_R1.0601.00
440_T454_R1.0571.00
380_I410_A1.0571.00
243_V383_A1.0541.00
335_A347_L1.0521.00
146_A156_V1.0511.00
376_V407_M1.0511.00
321_V367_V1.0501.00
445_G450_R1.0461.00
130_A209_I1.0441.00
400_N403_N1.0331.00
431_E440_T1.0271.00
46_A155_S1.0211.00
225_R229_N1.0201.00
48_Q381_A1.0171.00
169_Q191_T1.0111.00
126_W231_R1.0061.00
373_V379_A1.0051.00
249_D252_R1.0041.00
445_G455_L0.9961.00
329_D356_H0.9901.00
173_T180_V0.9891.00
122_E458_C0.9861.00
48_Q412_D0.9831.00
433_W454_R0.9831.00
241_P394_A0.9821.00
94_N143_I0.9811.00
324_D357_P0.9801.00
128_V155_S0.9741.00
283_D286_M0.9731.00
260_G272_E0.9611.00
395_A421_P0.9601.00
210_G412_D0.9601.00
261_A273_K0.9591.00
48_Q52_S0.9561.00
326_V349_F0.9551.00
30_M198_E0.9541.00
352_T356_H0.9521.00
73_D76_E0.9511.00
322_S325_W0.9471.00
251_A284_E0.9441.00
44_K48_Q0.9441.00
381_A385_K0.9371.00
336_A347_L0.9361.00
80_S302_A0.9331.00
18_Q80_S0.9321.00
252_R256_S0.9321.00
128_V209_I0.9221.00
250_L254_A0.9191.00
129_V211_L0.9191.00
258_V292_Q0.9181.00
51_K412_D0.9181.00
33_F37_D0.9171.00
69_K181_A0.9151.00
254_A289_M0.9151.00
70_H173_T0.9131.00
245_D376_V0.9121.00
18_Q23_P0.9121.00
119_T428_L0.9021.00
231_R454_R0.9021.00
36_L130_A0.9021.00
82_T164_A0.8991.00
57_Q61_A0.8981.00
321_V363_L0.8971.00
282_A370_V0.8961.00
217_G220_V0.8941.00
371_V382_L0.8931.00
46_A188_L0.8931.00
319_G322_S0.8921.00
282_A351_E0.8891.00
242_V397_H0.8821.00
124_A433_W0.8821.00
124_A409_N0.8801.00
379_A382_L0.8791.00
212_L228_T0.8791.00
66_A70_H0.8781.00
61_A105_E0.8781.00
254_A285_L0.8751.00
58_L62_A0.8741.00
354_A371_V0.8721.00
126_W154_N0.8721.00
94_N139_A0.8721.00
254_A292_Q0.8711.00
253_A257_I0.8691.00
33_F198_E0.8691.00
212_L224_A0.8691.00
396_M407_M0.8681.00
373_V378_D0.8651.00
405_N409_N0.8641.00
225_R228_T0.8601.00
245_D398_S0.8561.00
163_A316_R0.8551.00
330_A356_H0.8541.00
194_N199_T0.8521.00
57_Q105_E0.8501.00
38_D42_A0.8491.00
42_A187_N0.8481.00
222_E226_K0.8481.00
394_A411_I0.8481.00
339_L345_T0.8471.00
221_V236_G0.8451.00
50_L188_L0.8441.00
244_V285_L0.8421.00
380_I384_V0.8421.00
61_A102_P0.8401.00
158_F168_S0.8371.00
52_S409_N0.8371.00
84_M90_K0.8361.00
14_L195_P0.8361.00
34_A38_D0.8321.00
325_W367_V0.8311.00
428_L457_R0.8301.00
126_W454_R0.8281.00
84_M88_E0.8231.00
67_G94_N0.8211.00
60_I151_A0.8211.00
45_V48_Q0.8191.00
169_Q173_T0.8181.00
240_P273_K0.8181.00
148_S448_S0.8181.00
22_T342_P0.8161.00
34_A37_D0.8161.00
62_A182_A0.8141.00
287_R290_E0.8121.00
57_Q102_P0.8121.00
294_A345_T0.8101.00
254_A258_V0.8101.00
197_I201_Q0.8081.00
142_V146_A0.8081.00
31_G35_S0.8051.00
204_F224_A0.8041.00
87_V308_V0.8041.00
204_F227_H0.8011.00
401_I404_M0.8011.00
130_A200_A0.8011.00
152_A453_V0.8001.00
413_T416_F0.7991.00
59_A182_A0.7991.00
38_D41_A0.7981.00
82_T313_I0.7971.00
79_V86_R0.7971.00
31_G39_A0.7971.00
221_V234_A0.7971.00
43_A190_V0.7941.00
184_G189_L0.7921.00
145_N441_P0.7891.00
214_V220_V0.7871.00
253_A285_L0.7861.00
131_S145_N0.7841.00
149_L156_V0.7831.00
75_A79_V0.7831.00
289_M348_L0.7821.00
48_Q51_K0.7781.00
298_T339_L0.7771.00
61_A65_E0.7761.00
324_D361_T0.7751.00
86_R302_A0.7741.00
143_I171_A0.7741.00
241_P383_A0.7731.00
160_P193_A0.7731.00
204_F212_L0.7731.00
25_A80_S0.7701.00
226_K229_N0.7681.00
45_V49_G0.7671.00
296_K308_V0.7651.00
130_A212_L0.7641.00
335_A345_T0.7631.00
293_H334_A0.7611.00
75_A86_R0.7601.00
80_S166_K0.7581.00
114_G119_T0.7531.00
184_G188_L0.7521.00
250_L281_V0.7511.00
299_A303_Q0.7511.00
325_W349_F0.7471.00
316_R319_G0.7471.00
154_N453_V0.7471.00
278_V376_V0.7461.00
139_A167_V0.7451.00
351_E372_R0.7421.00
64_R102_P0.7421.00
36_L202_R0.7401.00
258_V289_M0.7391.00
49_G53_V0.7391.00
17_M22_T0.7391.00
251_A292_Q0.7341.00
218_E435_T0.7341.00
119_T457_R0.7321.00
194_N200_A0.7301.00
68_E71_A0.7301.00
67_G95_V0.7281.00
197_I223_A0.7271.00
290_E293_H0.7251.00
78_A81_E0.7241.00
339_L343_Q0.7241.00
303_Q307_P0.7191.00
18_Q302_A0.7191.00
277_V281_V0.7181.00
142_V168_S0.7141.00
245_D278_V0.7141.00
163_A313_I0.7131.00
158_F189_L0.7121.00
126_W210_G0.7111.00
36_L40_V0.7101.00
68_E92_A0.7101.00
200_A204_F0.7101.00
315_E338_G0.7071.00
50_L59_A0.7071.00
318_K339_L0.7061.00
231_R451_T0.7061.00
375_N381_A0.7061.00
354_A359_A0.7051.00
22_T315_E0.7041.00
228_T232_L0.7011.00
300_E307_P0.7011.00
334_A348_L0.7001.00
352_T359_A0.7001.00
77_L166_K0.7001.00
293_H296_K0.6991.00
275_L285_L0.6991.00
322_S326_V0.6961.00
44_K47_Q0.6941.00
202_R205_K0.6941.00
276_I359_A0.6921.00
376_V380_I0.6911.00
399_R402_E0.6911.00
104_V151_A0.6881.00
74_L139_A0.6861.00
298_T309_L0.6851.00
51_K410_A0.6841.00
317_G320_T0.6841.00
43_A155_S0.6831.00
339_L342_P0.6831.00
332_K335_A0.6831.00
265_N309_L0.6831.00
198_E201_Q0.6831.00
175_L184_G0.6801.00
247_T398_S0.6791.00
244_V253_A0.6771.00
382_L385_K0.6741.00
157_I190_V0.6741.00
142_V171_A0.6731.00
162_P320_T0.6731.00
65_E68_E0.6721.00
257_I289_M0.6711.00
312_N317_G0.6711.00
37_D208_G0.6691.00
73_D173_T0.6681.00
326_V330_A0.6671.00
133_T142_V0.6661.00
349_F352_T0.6651.00
13_V29_E0.6641.00
401_I405_N0.6631.00
51_K125_P0.6631.00
314_D317_G0.6621.00
276_I354_A0.6571.00
450_R453_V0.6571.00
49_G52_S0.6561.00
170_R174_L0.6561.00
72_R86_R0.6551.00
404_M408_A0.6521.00
350_V372_R0.6521.00
29_E193_A0.6501.00
332_K347_L0.6501.00
145_N213_V0.6501.00
258_V296_K0.6481.00
225_R234_A0.6461.00
12_A198_E0.6461.00
42_A186_E0.6441.00
31_G192_V0.6441.00
250_L284_E0.6431.00
320_T323_R0.6421.00
233_I451_T0.6421.00
450_R455_L0.6411.00
247_T399_R0.6401.00
408_A418_K0.6381.00
412_D433_W0.6371.00
363_L367_V0.6371.00
119_T459_V0.6361.00
79_V302_A0.6351.00
48_Q410_A0.6341.00
50_L150_I0.6331.00
146_A158_F0.6321.00
195_P199_T0.6301.00
23_P342_P0.6301.00
289_M370_V0.6291.00
118_L405_N0.6271.00
398_S403_N0.6251.00
41_A44_K0.6251.00
91_F95_V0.6251.00
316_R320_T0.6241.00
28_H165_K0.6241.00
76_E79_V0.6231.00
429_G432_G0.6211.00
39_A192_V0.6201.00
162_P223_A0.6191.00
16_K26_A0.6191.00
252_R255_Q0.6191.00
71_A75_A0.6181.00
252_R399_R0.6161.00
120_L458_C0.6151.00
380_I406_Q0.6151.00
155_S190_V0.6151.00
16_K81_E0.6141.00
84_M137_N0.6121.00
172_I180_V0.6121.00
59_A183_G0.6091.00
396_M404_M0.6051.00
380_I411_I0.6051.00
46_A49_G0.6041.00
67_G98_A0.6041.00
242_V395_A0.6041.00
78_A167_V0.6011.00
33_F205_K0.6011.00
66_A183_G0.6001.00
270_A425_G0.5991.00
51_K124_A0.5981.00
247_T400_N0.5981.00
139_A171_A0.5961.00
402_E405_N0.5961.00
92_A95_V0.5951.00
277_V370_V0.5951.00
277_V282_A0.5951.00
260_G421_P0.5941.00
242_V275_L0.5931.00
352_T358_F0.5921.00
67_G139_A0.5891.00
211_L451_T0.5891.00
25_A166_K0.5881.00
55_M151_A0.5861.00
67_G171_A0.5851.00
129_V154_N0.5821.00
268_I271_D0.5821.00
298_T308_V0.5821.00
140_A144_N0.5821.00
402_E406_Q0.5801.00
78_A90_K0.5771.00
290_E348_L0.5761.00
336_A345_T0.5761.00
416_F456_R0.5751.00
218_E222_E0.5751.00
122_E456_R0.5741.00
340_K343_Q0.5741.00
171_A175_L0.5731.00
354_A381_A0.5731.00
250_L253_A0.5671.00
43_A157_I0.5671.00
415_I424_A0.5661.00
63_I66_A0.5661.00
16_K165_K0.5661.00
275_L370_V0.5661.00
42_A46_A0.5651.00
152_A449_A0.5651.00
328_R355_E0.5641.00
246_E373_V0.5631.00
396_M418_K0.5571.00
261_A368_L0.5561.00
67_G74_L0.5561.00
379_A383_A0.5551.00
128_V210_G0.5531.00
131_S146_A0.5531.00
279_D282_A0.5531.00
59_A63_I0.5521.00
248_A253_A0.5511.00
250_L285_L0.5501.00
44_K128_V0.5491.00
84_M89_D0.5491.00
240_P391_H0.5491.00
376_V410_A0.5481.00
417_V420_G0.5481.00
93_K140_A0.5471.00
272_E395_A0.5461.00
12_A32_V0.5461.00
64_R98_A0.5411.00
28_H166_K0.5411.00
130_A157_I0.5401.00
383_A411_I0.5391.00
359_A382_L0.5391.00
411_I416_F0.5381.00
337_I340_K0.5361.00
129_V156_V0.5351.00
90_K137_N0.5351.00
162_P219_A0.5341.00
130_A204_F0.5331.00
78_A89_D0.5331.00
219_A316_R0.5331.00
254_A281_V0.5321.00
412_D454_R0.5311.00
108_S111_V0.5291.00
438_I454_R0.5281.00
117_G420_G0.5281.00
333_I351_E0.5281.00
264_D268_I0.5281.00
289_M293_H0.5271.00
101_T148_S0.5271.00
150_I189_L0.5251.00
43_A128_V0.5251.00
262_S296_K0.5251.00
39_A190_V0.5241.00
82_T264_D0.5241.00
251_A291_G0.5231.00
330_A352_T0.5221.00
381_A410_A0.5221.00
22_T344_E0.5211.00
91_F139_A0.5211.00
136_T364_M0.5201.00
354_A360_V0.5201.00
30_M162_P0.5181.00
132_V224_A0.5181.00
64_R95_V0.5171.00
150_I184_G0.5171.00
328_R353_T0.5171.00
39_A43_A0.5161.00
62_A183_G0.5161.00
75_A91_F0.5161.00
325_W347_L0.5151.00
332_K336_A0.5151.00
391_H417_V0.5151.00
241_P413_T0.5151.00
407_M411_I0.5141.00
433_W440_T0.5141.00
11_K35_S0.5131.00
129_V213_V0.5131.00
71_A95_V0.5111.00
165_K193_A0.5101.00
16_K25_A0.5101.00
320_T324_D0.5091.00
55_M105_E0.5071.00
287_R294_A0.5071.00
75_A89_D0.5071.00
201_Q204_F0.5061.00
58_L61_A0.5051.00
58_L99_R0.5031.00
326_V337_I0.5021.00
77_L167_V0.5011.00
324_D358_F0.5011.00
232_L438_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o5hA 4 0.9722 100 0.066 Contact Map
4pxlA 4 0.9807 100 0.068 Contact Map
3ek1A 5 0.9743 100 0.068 Contact Map
4yweA 5 0.97 100 0.069 Contact Map
4qf6A 4 0.9722 100 0.071 Contact Map
2o2pA 5 0.97 100 0.072 Contact Map
4lihA 5 0.9657 100 0.072 Contact Map
4pz2A 4 0.9807 100 0.074 Contact Map
4wj9A 4 0.9807 100 0.074 Contact Map
1a4sA 4 0.9786 100 0.075 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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