GREMLIN Database
SUFS - Cysteine desulfurase
UniProt: P77444 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13962
Length: 406 (332)
Sequences: 44445 (29696)
Seq/√Len: 1629.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_N142_R3.7331.00
316_Q395_V3.3881.00
187_I197_V3.3691.00
312_Y392_D3.3631.00
312_Y388_H3.1131.00
115_N162_D3.1121.00
182_P185_E3.1111.00
158_P192_Q2.9431.00
115_N140_E2.9321.00
211_D214_A2.6641.00
156_T159_T2.5901.00
354_Y400_R2.5751.00
172_H204_A2.5401.00
158_P189_L2.5011.00
187_I191_H2.4791.00
120_Q145_P2.3781.00
115_N165_T2.3741.00
289_A292_E2.3371.00
75_R292_E2.2881.00
201_G220_Y2.2571.00
316_Q319_S2.2461.00
190_A195_A2.2101.00
222_F235_I2.1901.00
320_V399_Q2.1811.00
168_L190_A2.1641.00
316_Q392_D2.1631.00
156_T160_L2.1511.00
312_Y316_Q2.1331.00
280_N283_G2.1081.00
184_A188_T2.0881.00
114_D166_R2.0291.00
354_Y397_G2.0261.00
188_T192_Q2.0021.00
324_T338_N1.9841.00
191_H218_D1.9591.00
311_H315_S1.9281.00
393_R397_G1.9081.00
153_Q156_T1.8741.00
115_N164_K1.8681.00
98_I125_A1.8411.00
167_L198_L1.8121.00
190_A197_V1.7761.00
304_E308_N1.7681.00
380_A394_L1.7601.00
308_N388_H1.7561.00
44_A48_R1.7501.00
145_P156_T1.7481.00
305_Y309_L1.7451.00
350_F353_N1.7441.00
158_P193_H1.7171.00
173_V332_L1.7141.00
92_R96_E1.7091.00
45_E49_H1.7091.00
184_A214_A1.6971.00
81_N211_D1.6951.00
350_F401_I1.6901.00
314_L335_I1.6861.00
154_L189_L1.6841.00
154_L185_E1.6831.00
142_R160_L1.6651.00
185_E188_T1.6491.00
316_Q399_Q1.6471.00
144_I160_L1.6341.00
305_Y308_N1.6291.00
114_D164_K1.5941.00
170_I197_V1.5791.00
324_T340_G1.5731.00
313_A382_L1.5361.00
76_A235_I1.5341.00
161_F189_L1.5301.00
189_L193_H1.5301.00
101_V219_F1.5271.00
319_S399_Q1.5161.00
199_V217_C1.4991.00
78_L295_S1.4921.00
338_N376_A1.4881.00
343_H346_D1.4811.00
155_E158_P1.4691.00
74_K78_L1.4571.00
336_A377_M1.4531.00
155_E159_T1.4441.00
300_N304_E1.4381.00
91_V97_G1.4351.00
217_C220_Y1.4311.00
387_T390_E1.4271.00
170_I186_M1.4221.00
326_Y338_N1.4161.00
307_Q311_H1.4161.00
388_H392_D1.4081.00
87_E240_E1.4011.00
312_Y391_V1.4011.00
158_P185_E1.3771.00
158_P162_D1.3751.00
147_N151_T1.3661.00
118_I130_W1.3471.00
162_D165_T1.3351.00
117_I165_T1.3291.00
157_L186_M1.3251.00
310_M314_L1.3201.00
71_N75_R1.3131.00
117_I160_L1.3031.00
43_E286_G1.2721.00
397_G400_R1.2721.00
75_R295_S1.2511.00
168_L195_A1.2491.00
315_S318_E1.2341.00
250_E253_G1.2311.00
226_K229_G1.2201.00
243_L246_M1.2131.00
105_W196_K1.2041.00
75_R288_G1.2011.00
102_A130_W1.1971.00
140_E162_D1.1971.00
111_R114_D1.1941.00
351_L358_V1.1901.00
142_R162_D1.1861.00
120_Q143_V1.1851.00
350_F354_Y1.1811.00
74_K77_S1.1771.00
298_G301_N1.1761.00
303_A307_Q1.1741.00
113_G166_R1.1591.00
110_V139_A1.1591.00
211_D215_L1.1441.00
209_P213_Q1.1341.00
224_G287_L1.1341.00
191_H197_V1.1301.00
67_E71_N1.1271.00
98_I198_L1.1221.00
392_D396_T1.1161.00
219_F238_V1.1161.00
393_R396_T1.1081.00
389_E392_D1.1041.00
94_T202_A1.1041.00
91_V100_L1.1011.00
250_E255_M1.1001.00
83_R240_E1.0991.00
349_S353_N1.0981.00
97_G221_V1.0961.00
314_L318_E1.0931.00
172_H183_L1.0931.00
346_D350_F1.0901.00
252_G255_M1.0851.00
395_V399_Q1.0841.00
313_A391_V1.0841.00
42_A289_A1.0831.00
183_L199_V1.0821.00
128_V131_Q1.0771.00
147_N153_Q1.0731.00
209_P212_V1.0721.00
154_L158_P1.0711.00
110_V114_D1.0691.00
301_N304_E1.0671.00
75_R78_L1.0661.00
198_L221_V1.0621.00
70_E74_K1.0611.00
316_Q396_T1.0581.00
118_I143_V1.0561.00
42_A45_E1.0521.00
88_L237_Y1.0491.00
247_P251_G1.0461.00
298_G302_I1.0461.00
316_Q320_V1.0431.00
292_E296_A1.0201.00
187_I216_D1.0171.00
83_R239_K1.0141.00
396_T400_R1.0121.00
189_L192_Q1.0091.00
288_G292_E1.0051.00
210_V214_A1.0051.00
249_W253_G1.0001.00
131_Q135_A0.9991.00
279_P282_G0.9971.00
83_R87_E0.9941.00
347_V401_I0.9891.00
72_V288_G0.9881.00
251_G255_M0.9871.00
301_N305_Y0.9841.00
356_I397_G0.9831.00
391_V395_V0.9761.00
315_S319_S0.9751.00
98_I221_V0.9721.00
155_E185_E0.9681.00
127_I143_V0.9681.00
312_Y315_S0.9641.00
149_D328_P0.9621.00
212_V215_L0.9591.00
162_D193_H0.9561.00
289_A293_Y0.9521.00
103_N251_G0.9511.00
230_P286_G0.9481.00
81_N213_Q0.9451.00
77_S88_L0.9451.00
218_D239_K0.9411.00
250_E254_S0.9411.00
309_L391_V0.9411.00
161_F193_H0.9361.00
210_V213_Q0.9321.00
99_N103_N0.9271.00
251_G254_S0.9211.00
177_L372_Y0.9111.00
345_Y349_S0.9101.00
68_K285_I0.9061.00
227_L287_L0.9051.00
308_N312_Y0.9041.00
313_A394_L0.9031.00
358_V378_C0.9021.00
292_E295_S0.9011.00
169_A198_L0.9011.00
161_F165_T0.8971.00
172_H220_Y0.8961.00
269_K273_R0.8951.00
356_I393_R0.8901.00
228_Y383_A0.8891.00
278_T281_T0.8881.00
268_T272_W0.8821.00
161_F195_A0.8761.00
349_S352_D0.8751.00
130_W141_L0.8751.00
348_G358_V0.8731.00
157_L168_L0.8721.00
267_W271_P0.8681.00
144_I156_T0.8591.00
170_I183_L0.8581.00
168_L186_M0.8581.00
249_W255_M0.8571.00
392_D395_V0.8561.00
322_D340_G0.8561.00
271_P274_F0.8541.00
356_I394_L0.8511.00
283_G286_G0.8501.00
80_I222_F0.8471.00
337_F380_A0.8451.00
83_R241_A0.8421.00
117_I144_I0.8381.00
75_R293_Y0.8351.00
132_M251_G0.8351.00
83_R213_Q0.8341.00
269_K272_W0.8341.00
198_L219_F0.8321.00
212_V216_D0.8321.00
205_V222_F0.8261.00
270_A274_F0.8191.00
173_V204_A0.8191.00
190_A193_H0.8191.00
317_L398_L0.8151.00
323_L328_P0.8141.00
171_T175_N0.8111.00
313_A380_A0.8071.00
196_K219_F0.8041.00
118_I122_E0.8031.00
80_I237_Y0.8011.00
348_G360_T0.8011.00
309_L388_H0.8011.00
181_N186_M0.8011.00
288_G291_L0.7951.00
270_A273_R0.7951.00
110_V113_G0.7941.00
68_K71_N0.7941.00
314_L331_R0.7891.00
325_L328_P0.7881.00
105_W219_F0.7811.00
347_V398_L0.7751.00
116_I130_W0.7751.00
157_L189_L0.7711.00
101_V198_L0.7701.00
117_I142_R0.7701.00
212_V237_Y0.7691.00
77_S82_A0.7681.00
330_N333_G0.7671.00
71_N288_G0.7671.00
219_F242_L0.7661.00
249_W252_G0.7651.00
334_V337_F0.7651.00
186_M197_V0.7651.00
302_I305_Y0.7641.00
82_A237_Y0.7641.00
79_F300_N0.7621.00
188_T191_H0.7581.00
87_E241_A0.7561.00
70_E73_R0.7531.00
389_E393_R0.7521.00
267_W270_A0.7471.00
79_F205_V0.7431.00
309_L382_L0.7411.00
196_K218_D0.7401.00
248_P251_G0.7401.00
170_I181_N0.7361.00
185_E189_L0.7351.00
190_A194_G0.7331.00
305_Y388_H0.7311.00
121_M181_N0.7301.00
346_D349_S0.7281.00
290_A294_V0.7271.00
218_D223_S0.7271.00
129_P133_L0.7261.00
118_I141_L0.7261.00
142_R165_T0.7251.00
72_V90_F0.7231.00
69_M284_I0.7231.00
184_A215_L0.7231.00
386_N391_V0.7211.00
94_T98_I0.7201.00
224_G233_I0.7161.00
239_K242_L0.7161.00
154_L157_L0.7151.00
187_I215_L0.7141.00
101_V105_W0.7111.00
283_G287_L0.7081.00
51_Y54_V0.7011.00
285_I288_G0.7001.00
103_N132_M0.7001.00
248_P255_M0.6991.00
72_V75_R0.6991.00
224_G229_G0.6991.00
334_V338_N0.6991.00
161_F168_L0.6961.00
191_H216_D0.6961.00
312_Y395_V0.6961.00
126_N169_A0.6931.00
320_V395_V0.6911.00
335_I338_N0.6891.00
331_R335_I0.6871.00
318_E328_P0.6861.00
218_D221_V0.6851.00
310_M335_I0.6841.00
43_E47_Y0.6821.00
209_P215_L0.6811.00
140_E164_K0.6791.00
320_V323_L0.6791.00
331_R334_V0.6781.00
196_K242_L0.6771.00
242_L245_E0.6761.00
367_P371_Y0.6761.00
386_N390_E0.6741.00
172_H215_L0.6721.00
317_L337_F0.6721.00
313_A395_V0.6711.00
247_P250_E0.6711.00
267_W272_W0.6681.00
302_I384_M0.6681.00
382_L391_V0.6661.00
145_P160_L0.6651.00
87_E239_K0.6641.00
71_N74_K0.6641.00
180_E208_H0.6641.00
105_W109_N0.6621.00
281_T284_I0.6591.00
116_I167_L0.6591.00
249_W254_S0.6571.00
333_G336_A0.6561.00
75_R297_L0.6561.00
221_V224_G0.6551.00
209_P214_A0.6541.00
159_T163_E0.6541.00
276_A279_P0.6491.00
102_A167_L0.6471.00
133_L139_A0.6471.00
358_V380_A0.6461.00
273_R276_A0.6461.00
397_G401_I0.6451.00
82_A87_E0.6451.00
167_L196_K0.6441.00
220_Y223_S0.6431.00
88_L235_I0.6421.00
201_G204_A0.6411.00
290_A295_S0.6401.00
109_N112_A0.6401.00
127_I131_Q0.6371.00
224_G227_L0.6371.00
324_T327_G0.6371.00
160_L163_E0.6361.00
71_N292_E0.6341.00
58_I62_S0.6321.00
287_L291_L0.6311.00
313_A335_I0.6281.00
270_A275_E0.6251.00
209_P300_N0.6231.00
76_A291_L0.6231.00
218_D224_G0.6231.00
313_A317_L0.6211.00
95_T99_N0.6211.00
394_L397_G0.6191.00
151_T330_N0.6181.00
271_P275_E0.6181.00
308_N311_H0.6171.00
302_I306_E0.6151.00
304_E307_Q0.6151.00
325_L338_N0.6151.00
314_L325_L0.6141.00
342_H346_D0.6141.00
210_V215_L0.6131.00
279_P284_I0.6131.00
344_A360_T0.6121.00
269_K274_F0.6101.00
238_V243_L0.6101.00
248_P252_G0.6091.00
309_L313_A0.6091.00
272_W275_E0.6061.00
394_L398_L0.6061.00
76_A90_F0.6041.00
98_I169_A0.6031.00
58_I63_A0.6011.00
79_F291_L0.6011.00
102_A169_A0.6001.00
189_L195_A0.5991.00
172_H199_V0.5981.00
124_H128_V0.5971.00
45_E48_R0.5961.00
240_E244_Q0.5941.00
313_A316_Q0.5941.00
326_Y377_M0.5931.00
248_P254_S0.5901.00
286_G290_A0.5881.00
267_W273_R0.5871.00
396_T399_Q0.5861.00
80_I212_V0.5851.00
311_H314_L0.5821.00
120_Q146_L0.5811.00
154_L182_P0.5801.00
96_E99_N0.5801.00
335_I339_L0.5801.00
187_I190_A0.5791.00
163_E193_H0.5781.00
240_E243_L0.5781.00
115_N163_E0.5751.00
204_A220_Y0.5731.00
268_T273_R0.5711.00
268_T271_P0.5711.00
92_R95_T0.5701.00
60_T64_Q0.5681.00
229_G233_I0.5621.00
187_I217_C0.5621.00
94_T221_V0.5621.00
201_G205_V0.5621.00
390_E397_G0.5611.00
64_Q67_E0.5611.00
147_N156_T0.5591.00
213_Q216_D0.5571.00
347_V378_C0.5561.00
183_L187_I0.5561.00
235_I239_K0.5541.00
294_V297_L0.5531.00
157_L161_F0.5521.00
326_Y336_A0.5511.00
220_Y224_G0.5491.00
191_H195_A0.5461.00
323_L339_L0.5461.00
99_N132_M0.5451.00
170_I199_V0.5441.00
235_I238_V0.5441.00
131_Q143_V0.5431.00
47_Y282_G0.5431.00
353_N361_G0.5411.00
57_G62_S0.5411.00
172_H210_V0.5401.00
348_G359_R0.5381.00
300_N303_A0.5371.00
73_R90_F0.5371.00
306_E333_G0.5341.00
158_P188_T0.5331.00
205_V227_L0.5321.00
197_V217_C0.5311.00
367_P372_Y0.5301.00
385_Y390_E0.5291.00
66_T70_E0.5241.00
188_T216_D0.5231.00
57_G60_T0.5231.00
151_T181_N0.5221.00
69_M90_F0.5221.00
130_W169_A0.5211.00
267_W275_E0.5191.00
367_P370_A0.5181.00
72_V292_E0.5181.00
111_R166_R0.5171.00
247_P253_G0.5161.00
228_Y384_M0.5161.00
183_L197_V0.5161.00
158_P161_F0.5151.00
121_M179_T0.5151.00
248_P253_G0.5141.00
98_I102_A0.5121.00
382_L386_N0.5121.00
226_K379_R0.5121.00
294_V298_G0.5111.00
388_H391_V0.5101.00
233_I283_G0.5081.00
95_T98_I0.5071.00
187_I199_V0.5061.00
281_T285_I0.5061.00
132_M136_R0.5061.00
78_L81_N0.5031.00
268_T274_F0.5021.00
212_V217_C0.5011.00
75_R79_F0.5001.00
144_I157_L0.5001.00
60_T63_A0.5001.00
291_L295_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kmjA 2 0.9975 100 0.293 Contact Map
4w91A 2 0.9951 100 0.321 Contact Map
4q75A 2 0.9951 100 0.326 Contact Map
1t3iA 2 0.9901 100 0.328 Contact Map
4lw2A 2 0.9828 100 0.329 Contact Map
3e9kA 2 0.9532 100 0.34 Contact Map
3caiA 2 0.9261 100 0.362 Contact Map
1eluA 2 0.9138 100 0.371 Contact Map
4isyA 2 0.8793 100 0.387 Contact Map
3a9zA 2 0.8892 100 0.388 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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