SUFS - ECOLI - GREMLIN Contacts

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SUFS - Cysteine desulfurase

UniProt:	P77444	Sequences: MIFSVDKVRADFPVLSREVNGLPLAYLDSAASAQKPSQVIDAEAEFYRHGYAAVHRGIHTLSAQATEKMENVRKRASLFINARSAEELVFVRGTTEGINLVANSWGNSNVRAGDNIIISQMEHHANIVPWQMLCARVGAELRVIPLNPDGTLQLETLPTLFDEKTRLLAITHVSNVLGTENPLAEMITLAHQHGAKVLVDGAQAVMHHPVDVQALDCDFYVFSGHKLYGPTGIGILYVKEALLQEMPPWEGGGSMIATVSLSEGTTWTKAPWRFEAGTPNTGGIIGLGAALEYVSALGLNNIAEYEQNLMHYALSQLESVPDLTLYGPQNRLGVIAFNLGKHHAYDVGSFLDNYGIAVRTGHHCAMPLMAYYNVPAMCRASLAMYNTHEEVDRLVTGLQRIHRLLG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13962
Length:	406 (332)
Sequences:	44445 (29696)
Seq/√Len:	1629.8

ECOLI - SUFS CSDA ISCS SERC DCEA DCEB LTAE
BACSU - SUFS YCBU ISCS2 ISCS1 ISCS PUCG SERC
HALSA - CSD Q9HR11 Q9HMR6 MFNA Q9HHV3
SULSO - Q97WK1 Q97VM5 Q97ZK0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
115_N	142_R	3.733	1.00
316_Q	395_V	3.388	1.00
187_I	197_V	3.369	1.00
312_Y	392_D	3.363	1.00
312_Y	388_H	3.113	1.00
115_N	162_D	3.112	1.00
182_P	185_E	3.111	1.00
158_P	192_Q	2.943	1.00
115_N	140_E	2.932	1.00
211_D	214_A	2.664	1.00
156_T	159_T	2.590	1.00
354_Y	400_R	2.575	1.00
172_H	204_A	2.540	1.00
158_P	189_L	2.501	1.00
187_I	191_H	2.479	1.00
120_Q	145_P	2.378	1.00
115_N	165_T	2.374	1.00
289_A	292_E	2.337	1.00
75_R	292_E	2.288	1.00
201_G	220_Y	2.257	1.00
316_Q	319_S	2.246	1.00
190_A	195_A	2.210	1.00
222_F	235_I	2.190	1.00
320_V	399_Q	2.181	1.00
168_L	190_A	2.164	1.00
316_Q	392_D	2.163	1.00
156_T	160_L	2.151	1.00
312_Y	316_Q	2.133	1.00
280_N	283_G	2.108	1.00
184_A	188_T	2.088	1.00
114_D	166_R	2.029	1.00
354_Y	397_G	2.026	1.00
188_T	192_Q	2.002	1.00
324_T	338_N	1.984	1.00
191_H	218_D	1.959	1.00
311_H	315_S	1.928	1.00
393_R	397_G	1.908	1.00
153_Q	156_T	1.874	1.00
115_N	164_K	1.868	1.00
98_I	125_A	1.841	1.00
167_L	198_L	1.812	1.00
190_A	197_V	1.776	1.00
304_E	308_N	1.768	1.00
380_A	394_L	1.760	1.00
308_N	388_H	1.756	1.00
44_A	48_R	1.750	1.00
145_P	156_T	1.748	1.00
305_Y	309_L	1.745	1.00
350_F	353_N	1.744	1.00
158_P	193_H	1.717	1.00
173_V	332_L	1.714	1.00
92_R	96_E	1.709	1.00
45_E	49_H	1.709	1.00
184_A	214_A	1.697	1.00
81_N	211_D	1.695	1.00
350_F	401_I	1.690	1.00
314_L	335_I	1.686	1.00
154_L	189_L	1.684	1.00
154_L	185_E	1.683	1.00
142_R	160_L	1.665	1.00
185_E	188_T	1.649	1.00
316_Q	399_Q	1.647	1.00
144_I	160_L	1.634	1.00
305_Y	308_N	1.629	1.00
114_D	164_K	1.594	1.00
170_I	197_V	1.579	1.00
324_T	340_G	1.573	1.00
313_A	382_L	1.536	1.00
76_A	235_I	1.534	1.00
161_F	189_L	1.530	1.00
189_L	193_H	1.530	1.00
101_V	219_F	1.527	1.00
319_S	399_Q	1.516	1.00
199_V	217_C	1.499	1.00
78_L	295_S	1.492	1.00
338_N	376_A	1.488	1.00
343_H	346_D	1.481	1.00
155_E	158_P	1.469	1.00
74_K	78_L	1.457	1.00
336_A	377_M	1.453	1.00
155_E	159_T	1.444	1.00
300_N	304_E	1.438	1.00
91_V	97_G	1.435	1.00
217_C	220_Y	1.431	1.00
387_T	390_E	1.427	1.00
170_I	186_M	1.422	1.00
326_Y	338_N	1.416	1.00
307_Q	311_H	1.416	1.00
388_H	392_D	1.408	1.00
87_E	240_E	1.401	1.00
312_Y	391_V	1.401	1.00
158_P	185_E	1.377	1.00
158_P	162_D	1.375	1.00
147_N	151_T	1.366	1.00
118_I	130_W	1.347	1.00
162_D	165_T	1.335	1.00
117_I	165_T	1.329	1.00
157_L	186_M	1.325	1.00
310_M	314_L	1.320	1.00
71_N	75_R	1.313	1.00
117_I	160_L	1.303	1.00
43_E	286_G	1.272	1.00
397_G	400_R	1.272	1.00
75_R	295_S	1.251	1.00
168_L	195_A	1.249	1.00
315_S	318_E	1.234	1.00
250_E	253_G	1.231	1.00
226_K	229_G	1.220	1.00
243_L	246_M	1.213	1.00
105_W	196_K	1.204	1.00
75_R	288_G	1.201	1.00
102_A	130_W	1.197	1.00
140_E	162_D	1.197	1.00
111_R	114_D	1.194	1.00
351_L	358_V	1.190	1.00
142_R	162_D	1.186	1.00
120_Q	143_V	1.185	1.00
350_F	354_Y	1.181	1.00
74_K	77_S	1.177	1.00
298_G	301_N	1.176	1.00
303_A	307_Q	1.174	1.00
113_G	166_R	1.159	1.00
110_V	139_A	1.159	1.00
211_D	215_L	1.144	1.00
209_P	213_Q	1.134	1.00
224_G	287_L	1.134	1.00
191_H	197_V	1.130	1.00
67_E	71_N	1.127	1.00
98_I	198_L	1.122	1.00
392_D	396_T	1.116	1.00
219_F	238_V	1.116	1.00
393_R	396_T	1.108	1.00
389_E	392_D	1.104	1.00
94_T	202_A	1.104	1.00
91_V	100_L	1.101	1.00
250_E	255_M	1.100	1.00
83_R	240_E	1.099	1.00
349_S	353_N	1.098	1.00
97_G	221_V	1.096	1.00
314_L	318_E	1.093	1.00
172_H	183_L	1.093	1.00
346_D	350_F	1.090	1.00
252_G	255_M	1.085	1.00
395_V	399_Q	1.084	1.00
313_A	391_V	1.084	1.00
42_A	289_A	1.083	1.00
183_L	199_V	1.082	1.00
128_V	131_Q	1.077	1.00
147_N	153_Q	1.073	1.00
209_P	212_V	1.072	1.00
154_L	158_P	1.071	1.00
110_V	114_D	1.069	1.00
301_N	304_E	1.067	1.00
75_R	78_L	1.066	1.00
198_L	221_V	1.062	1.00
70_E	74_K	1.061	1.00
316_Q	396_T	1.058	1.00
118_I	143_V	1.056	1.00
42_A	45_E	1.052	1.00
88_L	237_Y	1.049	1.00
247_P	251_G	1.046	1.00
298_G	302_I	1.046	1.00
316_Q	320_V	1.043	1.00
292_E	296_A	1.020	1.00
187_I	216_D	1.017	1.00
83_R	239_K	1.014	1.00
396_T	400_R	1.012	1.00
189_L	192_Q	1.009	1.00
288_G	292_E	1.005	1.00
210_V	214_A	1.005	1.00
249_W	253_G	1.000	1.00
131_Q	135_A	0.999	1.00
279_P	282_G	0.997	1.00
83_R	87_E	0.994	1.00
347_V	401_I	0.989	1.00
72_V	288_G	0.988	1.00
251_G	255_M	0.987	1.00
301_N	305_Y	0.984	1.00
356_I	397_G	0.983	1.00
391_V	395_V	0.976	1.00
315_S	319_S	0.975	1.00
98_I	221_V	0.972	1.00
155_E	185_E	0.968	1.00
127_I	143_V	0.968	1.00
312_Y	315_S	0.964	1.00
149_D	328_P	0.962	1.00
212_V	215_L	0.959	1.00
162_D	193_H	0.956	1.00
289_A	293_Y	0.952	1.00
103_N	251_G	0.951	1.00
230_P	286_G	0.948	1.00
81_N	213_Q	0.945	1.00
77_S	88_L	0.945	1.00
218_D	239_K	0.941	1.00
250_E	254_S	0.941	1.00
309_L	391_V	0.941	1.00
161_F	193_H	0.936	1.00
210_V	213_Q	0.932	1.00
99_N	103_N	0.927	1.00
251_G	254_S	0.921	1.00
177_L	372_Y	0.911	1.00
345_Y	349_S	0.910	1.00
68_K	285_I	0.906	1.00
227_L	287_L	0.905	1.00
308_N	312_Y	0.904	1.00
313_A	394_L	0.903	1.00
358_V	378_C	0.902	1.00
292_E	295_S	0.901	1.00
169_A	198_L	0.901	1.00
161_F	165_T	0.897	1.00
172_H	220_Y	0.896	1.00
269_K	273_R	0.895	1.00
356_I	393_R	0.890	1.00
228_Y	383_A	0.889	1.00
278_T	281_T	0.888	1.00
268_T	272_W	0.882	1.00
161_F	195_A	0.876	1.00
349_S	352_D	0.875	1.00
130_W	141_L	0.875	1.00
348_G	358_V	0.873	1.00
157_L	168_L	0.872	1.00
267_W	271_P	0.868	1.00
144_I	156_T	0.859	1.00
170_I	183_L	0.858	1.00
168_L	186_M	0.858	1.00
249_W	255_M	0.857	1.00
392_D	395_V	0.856	1.00
322_D	340_G	0.856	1.00
271_P	274_F	0.854	1.00
356_I	394_L	0.851	1.00
283_G	286_G	0.850	1.00
80_I	222_F	0.847	1.00
337_F	380_A	0.845	1.00
83_R	241_A	0.842	1.00
117_I	144_I	0.838	1.00
75_R	293_Y	0.835	1.00
132_M	251_G	0.835	1.00
83_R	213_Q	0.834	1.00
269_K	272_W	0.834	1.00
198_L	219_F	0.832	1.00
212_V	216_D	0.832	1.00
205_V	222_F	0.826	1.00
270_A	274_F	0.819	1.00
173_V	204_A	0.819	1.00
190_A	193_H	0.819	1.00
317_L	398_L	0.815	1.00
323_L	328_P	0.814	1.00
171_T	175_N	0.811	1.00
313_A	380_A	0.807	1.00
196_K	219_F	0.804	1.00
118_I	122_E	0.803	1.00
80_I	237_Y	0.801	1.00
348_G	360_T	0.801	1.00
309_L	388_H	0.801	1.00
181_N	186_M	0.801	1.00
288_G	291_L	0.795	1.00
270_A	273_R	0.795	1.00
110_V	113_G	0.794	1.00
68_K	71_N	0.794	1.00
314_L	331_R	0.789	1.00
325_L	328_P	0.788	1.00
105_W	219_F	0.781	1.00
347_V	398_L	0.775	1.00
116_I	130_W	0.775	1.00
157_L	189_L	0.771	1.00
101_V	198_L	0.770	1.00
117_I	142_R	0.770	1.00
212_V	237_Y	0.769	1.00
77_S	82_A	0.768	1.00
330_N	333_G	0.767	1.00
71_N	288_G	0.767	1.00
219_F	242_L	0.766	1.00
249_W	252_G	0.765	1.00
334_V	337_F	0.765	1.00
186_M	197_V	0.765	1.00
302_I	305_Y	0.764	1.00
82_A	237_Y	0.764	1.00
79_F	300_N	0.762	1.00
188_T	191_H	0.758	1.00
87_E	241_A	0.756	1.00
70_E	73_R	0.753	1.00
389_E	393_R	0.752	1.00
267_W	270_A	0.747	1.00
79_F	205_V	0.743	1.00
309_L	382_L	0.741	1.00
196_K	218_D	0.740	1.00
248_P	251_G	0.740	1.00
170_I	181_N	0.736	1.00
185_E	189_L	0.735	1.00
190_A	194_G	0.733	1.00
305_Y	388_H	0.731	1.00
121_M	181_N	0.730	1.00
346_D	349_S	0.728	1.00
290_A	294_V	0.727	1.00
218_D	223_S	0.727	1.00
129_P	133_L	0.726	1.00
118_I	141_L	0.726	1.00
142_R	165_T	0.725	1.00
72_V	90_F	0.723	1.00
69_M	284_I	0.723	1.00
184_A	215_L	0.723	1.00
386_N	391_V	0.721	1.00
94_T	98_I	0.720	1.00
224_G	233_I	0.716	1.00
239_K	242_L	0.716	1.00
154_L	157_L	0.715	1.00
187_I	215_L	0.714	1.00
101_V	105_W	0.711	1.00
283_G	287_L	0.708	1.00
51_Y	54_V	0.701	1.00
285_I	288_G	0.700	1.00
103_N	132_M	0.700	1.00
248_P	255_M	0.699	1.00
72_V	75_R	0.699	1.00
224_G	229_G	0.699	1.00
334_V	338_N	0.699	1.00
161_F	168_L	0.696	1.00
191_H	216_D	0.696	1.00
312_Y	395_V	0.696	1.00
126_N	169_A	0.693	1.00
320_V	395_V	0.691	1.00
335_I	338_N	0.689	1.00
331_R	335_I	0.687	1.00
318_E	328_P	0.686	1.00
218_D	221_V	0.685	1.00
310_M	335_I	0.684	1.00
43_E	47_Y	0.682	1.00
209_P	215_L	0.681	1.00
140_E	164_K	0.679	1.00
320_V	323_L	0.679	1.00
331_R	334_V	0.678	1.00
196_K	242_L	0.677	1.00
242_L	245_E	0.676	1.00
367_P	371_Y	0.676	1.00
386_N	390_E	0.674	1.00
172_H	215_L	0.672	1.00
317_L	337_F	0.672	1.00
313_A	395_V	0.671	1.00
247_P	250_E	0.671	1.00
267_W	272_W	0.668	1.00
302_I	384_M	0.668	1.00
382_L	391_V	0.666	1.00
145_P	160_L	0.665	1.00
87_E	239_K	0.664	1.00
71_N	74_K	0.664	1.00
180_E	208_H	0.664	1.00
105_W	109_N	0.662	1.00
281_T	284_I	0.659	1.00
116_I	167_L	0.659	1.00
249_W	254_S	0.657	1.00
333_G	336_A	0.656	1.00
75_R	297_L	0.656	1.00
221_V	224_G	0.655	1.00
209_P	214_A	0.654	1.00
159_T	163_E	0.654	1.00
276_A	279_P	0.649	1.00
102_A	167_L	0.647	1.00
133_L	139_A	0.647	1.00
358_V	380_A	0.646	1.00
273_R	276_A	0.646	1.00
397_G	401_I	0.645	1.00
82_A	87_E	0.645	1.00
167_L	196_K	0.644	1.00
220_Y	223_S	0.643	1.00
88_L	235_I	0.642	1.00
201_G	204_A	0.641	1.00
290_A	295_S	0.640	1.00
109_N	112_A	0.640	1.00
127_I	131_Q	0.637	1.00
224_G	227_L	0.637	1.00
324_T	327_G	0.637	1.00
160_L	163_E	0.636	1.00
71_N	292_E	0.634	1.00
58_I	62_S	0.632	1.00
287_L	291_L	0.631	1.00
313_A	335_I	0.628	1.00
270_A	275_E	0.625	1.00
209_P	300_N	0.623	1.00
76_A	291_L	0.623	1.00
218_D	224_G	0.623	1.00
313_A	317_L	0.621	1.00
95_T	99_N	0.621	1.00
394_L	397_G	0.619	1.00
151_T	330_N	0.618	1.00
271_P	275_E	0.618	1.00
308_N	311_H	0.617	1.00
302_I	306_E	0.615	1.00
304_E	307_Q	0.615	1.00
325_L	338_N	0.615	1.00
314_L	325_L	0.614	1.00
342_H	346_D	0.614	1.00
210_V	215_L	0.613	1.00
279_P	284_I	0.613	1.00
344_A	360_T	0.612	1.00
269_K	274_F	0.610	1.00
238_V	243_L	0.610	1.00
248_P	252_G	0.609	1.00
309_L	313_A	0.609	1.00
272_W	275_E	0.606	1.00
394_L	398_L	0.606	1.00
76_A	90_F	0.604	1.00
98_I	169_A	0.603	1.00
58_I	63_A	0.601	1.00
79_F	291_L	0.601	1.00
102_A	169_A	0.600	1.00
189_L	195_A	0.599	1.00
172_H	199_V	0.598	1.00
124_H	128_V	0.597	1.00
45_E	48_R	0.596	1.00
240_E	244_Q	0.594	1.00
313_A	316_Q	0.594	1.00
326_Y	377_M	0.593	1.00
248_P	254_S	0.590	1.00
286_G	290_A	0.588	1.00
267_W	273_R	0.587	1.00
396_T	399_Q	0.586	1.00
80_I	212_V	0.585	1.00
311_H	314_L	0.582	1.00
120_Q	146_L	0.581	1.00
154_L	182_P	0.580	1.00
96_E	99_N	0.580	1.00
335_I	339_L	0.580	1.00
187_I	190_A	0.579	1.00
163_E	193_H	0.578	1.00
240_E	243_L	0.578	1.00
115_N	163_E	0.575	1.00
204_A	220_Y	0.573	1.00
268_T	273_R	0.571	1.00
268_T	271_P	0.571	1.00
92_R	95_T	0.570	1.00
60_T	64_Q	0.568	1.00
229_G	233_I	0.562	1.00
187_I	217_C	0.562	1.00
94_T	221_V	0.562	1.00
201_G	205_V	0.562	1.00
390_E	397_G	0.561	1.00
64_Q	67_E	0.561	1.00
147_N	156_T	0.559	1.00
213_Q	216_D	0.557	1.00
347_V	378_C	0.556	1.00
183_L	187_I	0.556	1.00
235_I	239_K	0.554	1.00
294_V	297_L	0.553	1.00
157_L	161_F	0.552	1.00
326_Y	336_A	0.551	1.00
220_Y	224_G	0.549	1.00
191_H	195_A	0.546	1.00
323_L	339_L	0.546	1.00
99_N	132_M	0.545	1.00
170_I	199_V	0.544	1.00
235_I	238_V	0.544	1.00
131_Q	143_V	0.543	1.00
47_Y	282_G	0.543	1.00
353_N	361_G	0.541	1.00
57_G	62_S	0.541	1.00
172_H	210_V	0.540	1.00
348_G	359_R	0.538	1.00
300_N	303_A	0.537	1.00
73_R	90_F	0.537	1.00
306_E	333_G	0.534	1.00
158_P	188_T	0.533	1.00
205_V	227_L	0.532	1.00
197_V	217_C	0.531	1.00
367_P	372_Y	0.530	1.00
385_Y	390_E	0.529	1.00
66_T	70_E	0.524	1.00
188_T	216_D	0.523	1.00
57_G	60_T	0.523	1.00
151_T	181_N	0.522	1.00
69_M	90_F	0.522	1.00
130_W	169_A	0.521	1.00
267_W	275_E	0.519	1.00
367_P	370_A	0.518	1.00
72_V	292_E	0.518	1.00
111_R	166_R	0.517	1.00
247_P	253_G	0.516	1.00
228_Y	384_M	0.516	1.00
183_L	197_V	0.516	1.00
158_P	161_F	0.515	1.00
121_M	179_T	0.515	1.00
248_P	253_G	0.514	1.00
98_I	102_A	0.512	1.00
382_L	386_N	0.512	1.00
226_K	379_R	0.512	1.00
294_V	298_G	0.511	1.00
388_H	391_V	0.510	1.00
233_I	283_G	0.508	1.00
95_T	98_I	0.507	1.00
187_I	199_V	0.506	1.00
281_T	285_I	0.506	1.00
132_M	136_R	0.506	1.00
78_L	81_N	0.503	1.00
268_T	274_F	0.502	1.00
212_V	217_C	0.501	1.00
75_R	79_F	0.500	1.00
144_I	157_L	0.500	1.00
60_T	63_A	0.500	1.00
291_L	295_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1kmjA	2	0.9975	100	0.293	Contact Map
4w91A	2	0.9951	100	0.321	Contact Map
4q75A	2	0.9951	100	0.326	Contact Map
1t3iA	2	0.9901	100	0.328	Contact Map
4lw2A	2	0.9828	100	0.329	Contact Map
3e9kA	2	0.9532	100	0.34	Contact Map
3caiA	2	0.9261	100	0.362	Contact Map
1eluA	2	0.9138	100	0.371	Contact Map
4isyA	2	0.8793	100	0.387	Contact Map
3a9zA	2	0.8892	100	0.388	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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