ALAC - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

ALAC - Glutamate-pyruvate aminotransferase AlaC

UniProt:	P77434	Sequences: MADTRPERRFTRIDRLPPYVFNITAELKMAARRRGEDIIDFSMGNPDGATPPHIVEKLCTVAQRPDTHGYSTSRGIPRLRRAISRWYQDRYDVEIDPESEAIVTIGSKEGLAHLMLATLDHGDTVLVPNPSYPIHIYGAVIAGAQVRSVPLVEGVDFFNELERAIRESYPKPKMMILGFPSNPTAQCVELEFFEKVVALAKRYDVLVVHDLAYADIVYDGWKAPSIMQVPGARDVAVEFFTLSKSYNMAGWRIGFMVGNKTLVSALARIKSYHDYGTFTPLQVAAIAALEGDQQCVRDIAEQYKRRRDVLVKGLHEAGWMVEMPKASMYVWAKIPEPYAAMGSLEFAKKLLNEAKVCVSPGIGFGDYGDTHVRFALIENRDRIRQAIRGIKAMFRADGLLPASSKHIHENAE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14198
Length:	412 (352)
Sequences:	42382 (29010)
Seq/√Len:	1546.2

ECOLI - ALAC YBDL ALAA MALY YJIR YDCR AVTA HIS8
BACSU - MTNE AAT2 AAT1 YUGH PATA YDFD YISV CBL YHDI AAT3 YDEF YDEL YCXD GABR HIS8
HALSA - Q9HRM6 Q9HQK2 Q9HRX4 Q9HQW2 HIS8 Q9HPL0
SULSO - AAT Y104 Q97YX5 Q97TY7 HIS8 Q97ZX4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
59_C	63_Q	3.092	1.00
165_I	202_R	3.058	1.00
104_T	110_G	2.955	1.00
305_R	380_R	2.914	1.00
124_T	145_Q	2.906	1.00
354_A	392_A	2.833	1.00
123_D	173_K	2.818	1.00
304_K	308_D	2.805	1.00
190_L	194_E	2.787	1.00
320_M	333_K	2.622	1.00
385_Q	389_G	2.598	1.00
309_V	384_R	2.596	1.00
82_A	290_E	2.521	1.00
52_P	56_E	2.461	1.00
119_L	144_A	2.395	1.00
88_Q	94_E	2.327	1.00
258_G	263_V	2.275	1.00
78_R	286_I	2.253	1.00
112_A	116_L	2.149	1.00
194_E	198_A	2.119	1.00
253_I	285_A	2.095	1.00
313_G	387_I	2.080	1.00
342_G	345_E	2.063	1.00
189_E	192_F	2.038	1.00
385_Q	388_R	2.029	1.00
89_D	293_Q	2.006	1.00
81_R	85_R	1.969	1.00
56_E	60_T	1.946	1.00
162_E	195_K	1.915	1.00
139_A	144_A	1.910	1.00
152_V	192_F	1.897	1.00
204_D	235_V	1.880	1.00
85_R	290_E	1.865	1.00
312_K	316_E	1.853	1.00
313_G	316_E	1.832	1.00
41_F	386_A	1.804	1.00
165_I	195_K	1.783	1.00
200_A	207_V	1.762	1.00
81_R	97_P	1.761	1.00
124_T	147_R	1.754	1.00
163_R	167_E	1.747	1.00
313_G	388_R	1.737	1.00
114_L	237_V	1.737	1.00
174_M	208_V	1.729	1.00
311_V	315_H	1.715	1.00
315_H	321_V	1.714	1.00
308_D	312_K	1.712	1.00
84_S	97_P	1.707	1.00
348_K	352_N	1.703	1.00
379_N	382_R	1.676	1.00
208_V	239_F	1.658	1.00
212_A	241_T	1.638	1.00
309_V	313_G	1.634	1.00
160_E	163_R	1.628	1.00
124_T	169_Y	1.620	1.00
77_P	81_R	1.612	1.00
124_T	172_P	1.609	1.00
309_V	380_R	1.588	1.00
107_S	239_F	1.581	1.00
114_L	208_V	1.577	1.00
313_G	317_A	1.575	1.00
60_T	287_A	1.575	1.00
310_L	330_V	1.575	1.00
313_G	391_K	1.573	1.00
100_E	260_K	1.571	1.00
195_K	198_A	1.569	1.00
124_T	171_K	1.563	1.00
95_I	257_V	1.563	1.00
358_V	372_V	1.554	1.00
125_V	139_A	1.548	1.00
129_N	148_S	1.542	1.00
158_F	192_F	1.534	1.00
87_Y	257_V	1.509	1.00
349_K	393_M	1.508	1.00
380_R	384_R	1.499	1.00
343_S	362_I	1.490	1.00
198_A	202_R	1.490	1.00
311_V	323_M	1.490	1.00
163_R	166_R	1.488	1.00
83_I	255_F	1.460	1.00
55_V	59_C	1.457	1.00
191_E	194_E	1.456	1.00
115_M	139_A	1.447	1.00
256_M	266_L	1.446	1.00
78_R	290_E	1.440	1.00
136_I	140_V	1.433	1.00
82_A	85_R	1.420	1.00
98_E	260_K	1.394	1.00
278_F	281_L	1.392	1.00
165_I	203_Y	1.387	1.00
354_A	389_G	1.386	1.00
161_L	199_L	1.383	1.00
311_V	330_V	1.379	1.00
200_A	205_V	1.375	1.00
168_S	199_L	1.369	1.00
331_W	361_G	1.368	1.00
316_E	391_K	1.349	1.00
129_N	150_P	1.348	1.00
297_R	301_E	1.343	1.00
242_L	285_A	1.335	1.00
169_Y	172_P	1.333	1.00
345_E	349_K	1.330	1.00
102_I	263_V	1.329	1.00
237_V	258_G	1.316	1.00
302_Q	380_R	1.310	1.00
56_E	59_C	1.310	1.00
302_Q	305_R	1.304	1.00
199_L	203_Y	1.300	1.00
310_L	387_I	1.300	1.00
161_L	195_K	1.300	1.00
150_P	163_R	1.293	1.00
83_I	103_V	1.291	1.00
388_R	392_A	1.289	1.00
311_V	321_V	1.286	1.00
82_A	286_I	1.274	1.00
190_L	224_P	1.267	1.00
384_R	388_R	1.257	1.00
85_R	89_D	1.249	1.00
345_E	348_K	1.249	1.00
58_L	284_A	1.249	1.00
297_R	300_A	1.244	1.00
115_M	176_I	1.242	1.00
57_K	287_A	1.238	1.00
74_R	267_A	1.234	1.00
76_I	283_V	1.233	1.00
301_E	304_K	1.226	1.00
198_A	201_K	1.213	1.00
199_L	205_V	1.210	1.00
126_L	172_P	1.206	1.00
83_I	101_A	1.198	1.00
58_L	62_A	1.193	1.00
192_F	195_K	1.188	1.00
333_K	371_H	1.182	1.00
350_L	390_I	1.176	1.00
87_Y	255_F	1.173	1.00
74_R	80_R	1.173	1.00
55_V	63_Q	1.173	1.00
347_A	358_V	1.172	1.00
332_A	374_F	1.172	1.00
109_E	270_K	1.171	1.00
36_E	355_K	1.169	1.00
342_G	369_D	1.161	1.00
307_R	311_V	1.158	1.00
115_M	119_L	1.155	1.00
190_L	229_V	1.151	1.00
317_A	391_K	1.144	1.00
265_A	268_R	1.143	1.00
127_V	146_V	1.142	1.00
270_K	274_D	1.136	1.00
126_L	149_V	1.132	1.00
240_F	255_F	1.131	1.00
286_I	290_E	1.125	1.00
80_R	84_S	1.125	1.00
335_P	370_T	1.124	1.00
382_R	385_Q	1.111	1.00
301_E	305_R	1.111	1.00
119_L	125_V	1.110	1.00
105_I	109_E	1.104	1.00
116_L	142_A	1.102	1.00
165_I	169_Y	1.101	1.00
191_E	195_K	1.097	1.00
333_K	370_T	1.096	1.00
117_A	269_I	1.090	1.00
78_R	283_V	1.087	1.00
165_I	199_L	1.087	1.00
152_V	160_E	1.083	1.00
378_E	382_R	1.083	1.00
139_A	146_V	1.078	1.00
287_A	290_E	1.077	1.00
96_D	100_E	1.074	1.00
237_V	256_M	1.069	1.00
315_H	323_M	1.067	1.00
197_V	232_A	1.066	1.00
175_M	205_V	1.066	1.00
53_H	291_G	1.065	1.00
234_D	259_N	1.065	1.00
136_I	148_S	1.064	1.00
78_R	81_R	1.063	1.00
343_S	370_T	1.058	1.00
264_S	268_R	1.056	1.00
190_L	228_Q	1.055	1.00
118_T	174_M	1.054	1.00
120_D	123_D	1.046	1.00
96_D	260_K	1.045	1.00
302_Q	306_R	1.042	1.00
77_P	97_P	1.038	1.00
84_S	101_A	1.035	1.00
121_H	143_G	1.034	1.00
313_G	384_R	1.033	1.00
86_W	293_Q	1.028	1.00
52_P	55_V	1.025	1.00
55_V	62_A	1.019	1.00
293_Q	297_R	1.019	1.00
219_D	325_K	1.018	1.00
307_R	376_L	1.016	1.00
100_E	263_V	1.016	1.00
77_P	80_R	1.014	1.00
207_V	226_I	1.009	1.00
57_K	60_T	1.007	1.00
346_F	372_V	1.000	1.00
197_V	207_V	0.998	1.00
113_H	270_K	0.996	1.00
312_K	384_R	0.996	1.00
152_V	155_V	0.991	1.00
344_L	362_I	0.986	1.00
206_L	237_V	0.984	1.00
317_A	388_R	0.981	1.00
194_E	229_V	0.980	1.00
349_K	352_N	0.980	1.00
79_L	103_V	0.974	1.00
84_S	96_D	0.974	1.00
110_G	239_F	0.970	1.00
118_T	206_L	0.967	1.00
356_V	390_I	0.967	1.00
201_K	234_D	0.960	1.00
149_V	167_E	0.957	1.00
201_K	233_R	0.956	1.00
131_S	178_G	0.956	1.00
125_V	174_M	0.943	1.00
350_L	358_V	0.943	1.00
110_G	256_M	0.941	1.00
117_A	266_L	0.935	1.00
101_A	257_V	0.935	1.00
306_R	309_V	0.932	1.00
162_E	166_R	0.932	1.00
310_L	383_I	0.931	1.00
206_L	235_V	0.930	1.00
381_D	384_R	0.927	1.00
197_V	236_A	0.926	1.00
135_H	176_I	0.921	1.00
102_I	266_L	0.918	1.00
168_S	205_V	0.917	1.00
194_E	232_A	0.912	1.00
312_K	315_H	0.911	1.00
308_D	323_M	0.909	1.00
239_F	256_M	0.909	1.00
225_S	228_Q	0.907	1.00
226_I	236_A	0.905	1.00
100_E	233_R	0.904	1.00
190_L	222_K	0.901	1.00
309_V	312_K	0.900	1.00
37_D	355_K	0.899	1.00
57_K	61_V	0.897	1.00
217_V	220_G	0.896	1.00
105_I	278_F	0.894	1.00
48_G	302_Q	0.894	1.00
349_K	354_A	0.891	1.00
374_F	386_A	0.888	1.00
287_A	291_G	0.886	1.00
319_W	334_I	0.886	1.00
56_E	63_Q	0.886	1.00
294_Q	298_D	0.883	1.00
93_V	227_M	0.883	1.00
86_W	215_D	0.882	1.00
319_W	332_A	0.880	1.00
114_L	266_L	0.875	1.00
46_P	303_Y	0.875	1.00
140_V	146_V	0.870	1.00
159_N	192_F	0.870	1.00
298_D	301_E	0.868	1.00
206_L	262_L	0.867	1.00
169_Y	203_Y	0.867	1.00
307_R	324_P	0.865	1.00
310_L	313_G	0.858	1.00
213_Y	329_Y	0.858	1.00
172_P	205_V	0.856	1.00
231_G	234_D	0.856	1.00
227_M	238_E	0.856	1.00
317_A	387_I	0.855	1.00
107_S	241_T	0.853	1.00
126_L	167_E	0.853	1.00
161_L	196_V	0.848	1.00
107_S	212_A	0.848	1.00
217_V	223_A	0.847	1.00
162_E	165_I	0.844	1.00
108_K	134_I	0.836	1.00
361_G	364_F	0.834	1.00
263_V	267_A	0.831	1.00
76_I	286_I	0.829	1.00
115_M	174_M	0.826	1.00
344_L	348_K	0.818	1.00
258_G	266_L	0.818	1.00
310_L	376_L	0.816	1.00
168_S	172_P	0.814	1.00
298_D	302_Q	0.810	1.00
309_V	387_I	0.808	1.00
383_I	386_A	0.807	1.00
152_V	163_R	0.806	1.00
126_L	175_M	0.804	1.00
358_V	374_F	0.804	1.00
295_C	298_D	0.802	1.00
60_T	63_Q	0.798	1.00
211_L	238_E	0.793	1.00
53_H	287_A	0.792	1.00
86_W	91_Y	0.790	1.00
119_L	174_M	0.789	1.00
283_V	286_I	0.789	1.00
79_L	83_I	0.783	1.00
260_K	264_S	0.782	1.00
201_K	235_V	0.781	1.00
125_V	144_A	0.781	1.00
86_W	246_Y	0.778	1.00
270_K	277_T	0.777	1.00
60_T	65_P	0.775	1.00
119_L	123_D	0.771	1.00
41_F	383_I	0.770	1.00
215_D	245_S	0.769	1.00
237_V	262_L	0.769	1.00
53_H	56_E	0.768	1.00
126_L	164_A	0.766	1.00
108_K	132_Y	0.765	1.00
334_I	372_V	0.762	1.00
354_A	393_M	0.762	1.00
305_R	308_D	0.761	1.00
128_P	149_V	0.761	1.00
37_D	382_R	0.760	1.00
218_Y	304_K	0.759	1.00
109_E	274_D	0.757	1.00
356_V	389_G	0.755	1.00
85_R	88_Q	0.755	1.00
106_G	252_R	0.754	1.00
201_K	231_G	0.753	1.00
253_I	277_T	0.752	1.00
320_M	335_P	0.751	1.00
242_L	255_F	0.746	1.00
161_L	192_F	0.743	1.00
164_A	175_M	0.739	1.00
35_G	355_K	0.736	1.00
232_A	236_A	0.732	1.00
219_D	307_R	0.729	1.00
124_T	173_K	0.728	1.00
102_I	256_M	0.728	1.00
347_A	360_P	0.726	1.00
127_V	139_A	0.725	1.00
161_L	165_I	0.725	1.00
151_L	181_S	0.724	1.00
164_A	199_L	0.722	1.00
343_S	360_P	0.721	1.00
49_A	55_V	0.717	1.00
346_F	393_M	0.714	1.00
211_L	225_S	0.713	1.00
318_G	335_P	0.713	1.00
128_P	181_S	0.712	1.00
67_T	283_V	0.711	1.00
104_T	256_M	0.709	1.00
306_R	380_R	0.708	1.00
37_D	385_Q	0.706	1.00
295_C	299_I	0.705	1.00
341_M	345_E	0.704	1.00
308_D	311_V	0.704	1.00
76_I	282_Q	0.702	1.00
40_D	45_N	0.701	1.00
176_I	208_V	0.700	1.00
253_I	281_L	0.699	1.00
128_P	159_N	0.696	1.00
61_V	284_A	0.696	1.00
201_K	232_A	0.695	1.00
232_A	235_V	0.694	1.00
122_G	145_Q	0.694	1.00
109_E	113_H	0.694	1.00
153_E	320_M	0.693	1.00
344_L	360_P	0.693	1.00
75_G	80_R	0.692	1.00
58_L	280_P	0.689	1.00
147_R	169_Y	0.689	1.00
299_I	303_Y	0.681	1.00
361_G	371_H	0.680	1.00
84_S	95_I	0.675	1.00
51_P	54_I	0.675	1.00
155_V	158_F	0.672	1.00
294_Q	297_R	0.671	1.00
80_R	97_P	0.666	1.00
175_M	200_A	0.666	1.00
182_N	213_Y	0.665	1.00
309_V	383_I	0.662	1.00
82_A	289_L	0.661	1.00
160_E	192_F	0.660	1.00
153_E	333_K	0.659	1.00
181_S	184_T	0.659	1.00
347_A	372_V	0.658	1.00
168_S	203_Y	0.656	1.00
341_M	346_F	0.654	1.00
114_L	239_F	0.652	1.00
233_R	236_A	0.650	1.00
246_Y	293_Q	0.647	1.00
224_P	228_Q	0.647	1.00
310_L	374_F	0.647	1.00
113_H	266_L	0.647	1.00
91_Y	214_A	0.645	1.00
154_G	192_F	0.644	1.00
113_H	269_I	0.642	1.00
305_R	309_V	0.639	1.00
135_H	139_A	0.638	1.00
147_R	172_P	0.637	1.00
50_T	295_C	0.634	1.00
356_V	386_A	0.634	1.00
59_C	62_A	0.633	1.00
112_A	142_A	0.631	1.00
172_P	175_M	0.631	1.00
57_K	284_A	0.629	1.00
137_Y	140_V	0.629	1.00
103_V	253_I	0.629	1.00
296_V	300_A	0.626	1.00
332_A	371_H	0.626	1.00
216_I	300_A	0.625	1.00
177_L	193_F	0.624	1.00
207_V	232_A	0.624	1.00
111_L	138_G	0.622	1.00
388_R	391_K	0.621	1.00
123_D	171_K	0.621	1.00
187_C	326_A	0.621	1.00
155_V	163_R	0.617	1.00
219_D	304_K	0.617	1.00
147_R	167_E	0.617	1.00
44_G	213_Y	0.617	1.00
50_T	54_I	0.615	1.00
261_T	264_S	0.613	1.00
343_S	347_A	0.612	1.00
115_M	144_A	0.612	1.00
218_Y	307_R	0.610	1.00
226_I	229_V	0.609	1.00
108_K	275_Y	0.607	1.00
179_F	211_L	0.606	1.00
225_S	238_E	0.606	1.00
245_S	296_V	0.606	1.00
86_W	214_A	0.605	1.00
149_V	163_R	0.603	1.00
234_D	261_T	0.602	1.00
47_D	306_R	0.601	1.00
316_E	384_R	0.599	1.00
53_H	295_C	0.598	1.00
258_G	262_L	0.597	1.00
346_F	350_L	0.595	1.00
342_G	346_F	0.592	1.00
159_N	164_A	0.592	1.00
103_V	282_Q	0.590	1.00
218_Y	326_A	0.588	1.00
112_A	138_G	0.587	1.00
200_A	204_D	0.586	1.00
115_M	142_A	0.586	1.00
314_L	332_A	0.585	1.00
351_L	357_C	0.585	1.00
87_Y	238_E	0.584	1.00
50_T	53_H	0.583	1.00
307_R	323_M	0.582	1.00
127_V	136_I	0.582	1.00
331_W	371_H	0.579	1.00
158_F	189_E	0.578	1.00
209_H	238_E	0.576	1.00
341_M	349_K	0.576	1.00
54_I	288_A	0.574	1.00
127_V	148_S	0.574	1.00
35_G	38_I	0.572	1.00
389_G	392_A	0.570	1.00
120_D	173_K	0.570	1.00
39_I	385_Q	0.569	1.00
105_I	277_T	0.568	1.00
116_L	269_I	0.568	1.00
54_I	248_M	0.566	1.00
218_Y	376_L	0.565	1.00
102_I	258_G	0.564	1.00
333_K	336_E	0.563	1.00
150_P	160_E	0.563	1.00
300_A	304_K	0.563	1.00
114_L	174_M	0.563	1.00
385_Q	392_A	0.561	1.00
53_H	294_Q	0.561	1.00
129_N	365_G	0.559	1.00
350_L	393_M	0.553	1.00
188_V	192_F	0.551	1.00
267_A	270_K	0.550	1.00
180_P	326_A	0.549	1.00
320_M	336_E	0.548	1.00
155_V	192_F	0.548	1.00
71_S	76_I	0.547	1.00
102_I	267_A	0.547	1.00
119_L	173_K	0.546	1.00
186_Q	325_K	0.546	1.00
89_D	290_E	0.545	1.00
154_G	189_E	0.545	1.00
50_T	55_V	0.545	1.00
95_I	227_M	0.544	1.00
42_S	357_C	0.543	1.00
242_L	289_L	0.542	1.00
331_W	373_R	0.541	1.00
224_P	229_V	0.540	1.00
81_R	290_E	0.537	1.00
152_V	158_F	0.536	1.00
315_H	320_M	0.535	1.00
284_A	287_A	0.535	1.00
129_N	367_Y	0.534	1.00
279_T	283_V	0.531	1.00
321_V	330_V	0.531	1.00
188_V	193_F	0.531	1.00
95_I	100_E	0.529	1.00
283_V	287_A	0.527	1.00
100_E	258_G	0.526	1.00
88_Q	92_D	0.526	1.00
223_A	226_I	0.525	1.00
112_A	273_H	0.525	1.00
293_Q	296_V	0.524	1.00
193_F	226_I	0.522	1.00
193_F	209_H	0.521	1.00
179_F	187_C	0.521	1.00
115_M	138_G	0.521	1.00
224_P	227_M	0.520	1.00
243_S	252_R	0.519	1.00
150_P	167_E	0.518	1.00
166_R	169_Y	0.516	1.00
343_S	372_V	0.515	1.00
319_W	394_F	0.515	1.00
140_V	145_Q	0.513	1.00
71_S	276_G	0.513	1.00
347_A	351_L	0.513	1.00
79_L	285_A	0.512	1.00
44_G	329_Y	0.511	1.00
72_T	77_P	0.510	1.00
81_R	84_S	0.509	1.00
197_V	229_V	0.509	1.00
304_K	307_R	0.505	1.00
264_S	267_A	0.505	1.00
125_V	176_I	0.504	1.00
218_Y	324_P	0.502	1.00
200_A	203_Y	0.502	1.00
164_A	196_V	0.501	1.00
313_G	383_I	0.500	1.00
303_Y	328_M	0.500	1.00
282_Q	286_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2x5dA	3	0.9223	100	0.295	Contact Map
3dydA	2	0.8981	100	0.31	Contact Map
1yizA	2	0.9345	100	0.315	Contact Map
3e2yA	2	0.9223	100	0.317	Contact Map
1j32A	2	0.9345	100	0.32	Contact Map
2o1bA	2	0.9102	100	0.321	Contact Map
3piuA	2	0.915	100	0.324	Contact Map
3h14A	2	0.8932	100	0.324	Contact Map
1xi9A	4	0.9369	100	0.324	Contact Map
3b46A	2	0.9442	100	0.325	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0113 seconds.