GREMLIN Database
ALAC - Glutamate-pyruvate aminotransferase AlaC
UniProt: P77434 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14198
Length: 412 (352)
Sequences: 42382 (29010)
Seq/√Len: 1546.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_C63_Q3.0921.00
165_I202_R3.0581.00
104_T110_G2.9551.00
305_R380_R2.9141.00
124_T145_Q2.9061.00
354_A392_A2.8331.00
123_D173_K2.8181.00
304_K308_D2.8051.00
190_L194_E2.7871.00
320_M333_K2.6221.00
385_Q389_G2.5981.00
309_V384_R2.5961.00
82_A290_E2.5211.00
52_P56_E2.4611.00
119_L144_A2.3951.00
88_Q94_E2.3271.00
258_G263_V2.2751.00
78_R286_I2.2531.00
112_A116_L2.1491.00
194_E198_A2.1191.00
253_I285_A2.0951.00
313_G387_I2.0801.00
342_G345_E2.0631.00
189_E192_F2.0381.00
385_Q388_R2.0291.00
89_D293_Q2.0061.00
81_R85_R1.9691.00
56_E60_T1.9461.00
162_E195_K1.9151.00
139_A144_A1.9101.00
152_V192_F1.8971.00
204_D235_V1.8801.00
85_R290_E1.8651.00
312_K316_E1.8531.00
313_G316_E1.8321.00
41_F386_A1.8041.00
165_I195_K1.7831.00
200_A207_V1.7621.00
81_R97_P1.7611.00
124_T147_R1.7541.00
163_R167_E1.7471.00
313_G388_R1.7371.00
114_L237_V1.7371.00
174_M208_V1.7291.00
311_V315_H1.7151.00
315_H321_V1.7141.00
308_D312_K1.7121.00
84_S97_P1.7071.00
348_K352_N1.7031.00
379_N382_R1.6761.00
208_V239_F1.6581.00
212_A241_T1.6381.00
309_V313_G1.6341.00
160_E163_R1.6281.00
124_T169_Y1.6201.00
77_P81_R1.6121.00
124_T172_P1.6091.00
309_V380_R1.5881.00
107_S239_F1.5811.00
114_L208_V1.5771.00
313_G317_A1.5751.00
60_T287_A1.5751.00
310_L330_V1.5751.00
313_G391_K1.5731.00
100_E260_K1.5711.00
195_K198_A1.5691.00
124_T171_K1.5631.00
95_I257_V1.5631.00
358_V372_V1.5541.00
125_V139_A1.5481.00
129_N148_S1.5421.00
158_F192_F1.5341.00
87_Y257_V1.5091.00
349_K393_M1.5081.00
380_R384_R1.4991.00
343_S362_I1.4901.00
198_A202_R1.4901.00
311_V323_M1.4901.00
163_R166_R1.4881.00
83_I255_F1.4601.00
55_V59_C1.4571.00
191_E194_E1.4561.00
115_M139_A1.4471.00
256_M266_L1.4461.00
78_R290_E1.4401.00
136_I140_V1.4331.00
82_A85_R1.4201.00
98_E260_K1.3941.00
278_F281_L1.3921.00
165_I203_Y1.3871.00
354_A389_G1.3861.00
161_L199_L1.3831.00
311_V330_V1.3791.00
200_A205_V1.3751.00
168_S199_L1.3691.00
331_W361_G1.3681.00
316_E391_K1.3491.00
129_N150_P1.3481.00
297_R301_E1.3431.00
242_L285_A1.3351.00
169_Y172_P1.3331.00
345_E349_K1.3301.00
102_I263_V1.3291.00
237_V258_G1.3161.00
302_Q380_R1.3101.00
56_E59_C1.3101.00
302_Q305_R1.3041.00
199_L203_Y1.3001.00
310_L387_I1.3001.00
161_L195_K1.3001.00
150_P163_R1.2931.00
83_I103_V1.2911.00
388_R392_A1.2891.00
311_V321_V1.2861.00
82_A286_I1.2741.00
190_L224_P1.2671.00
384_R388_R1.2571.00
85_R89_D1.2491.00
345_E348_K1.2491.00
58_L284_A1.2491.00
297_R300_A1.2441.00
115_M176_I1.2421.00
57_K287_A1.2381.00
74_R267_A1.2341.00
76_I283_V1.2331.00
301_E304_K1.2261.00
198_A201_K1.2131.00
199_L205_V1.2101.00
126_L172_P1.2061.00
83_I101_A1.1981.00
58_L62_A1.1931.00
192_F195_K1.1881.00
333_K371_H1.1821.00
350_L390_I1.1761.00
87_Y255_F1.1731.00
74_R80_R1.1731.00
55_V63_Q1.1731.00
347_A358_V1.1721.00
332_A374_F1.1721.00
109_E270_K1.1711.00
36_E355_K1.1691.00
342_G369_D1.1611.00
307_R311_V1.1581.00
115_M119_L1.1551.00
190_L229_V1.1511.00
317_A391_K1.1441.00
265_A268_R1.1431.00
127_V146_V1.1421.00
270_K274_D1.1361.00
126_L149_V1.1321.00
240_F255_F1.1311.00
286_I290_E1.1251.00
80_R84_S1.1251.00
335_P370_T1.1241.00
382_R385_Q1.1111.00
301_E305_R1.1111.00
119_L125_V1.1101.00
105_I109_E1.1041.00
116_L142_A1.1021.00
165_I169_Y1.1011.00
191_E195_K1.0971.00
333_K370_T1.0961.00
117_A269_I1.0901.00
78_R283_V1.0871.00
165_I199_L1.0871.00
152_V160_E1.0831.00
378_E382_R1.0831.00
139_A146_V1.0781.00
287_A290_E1.0771.00
96_D100_E1.0741.00
237_V256_M1.0691.00
315_H323_M1.0671.00
197_V232_A1.0661.00
175_M205_V1.0661.00
53_H291_G1.0651.00
234_D259_N1.0651.00
136_I148_S1.0641.00
78_R81_R1.0631.00
343_S370_T1.0581.00
264_S268_R1.0561.00
190_L228_Q1.0551.00
118_T174_M1.0541.00
120_D123_D1.0461.00
96_D260_K1.0451.00
302_Q306_R1.0421.00
77_P97_P1.0381.00
84_S101_A1.0351.00
121_H143_G1.0341.00
313_G384_R1.0331.00
86_W293_Q1.0281.00
52_P55_V1.0251.00
55_V62_A1.0191.00
293_Q297_R1.0191.00
219_D325_K1.0181.00
307_R376_L1.0161.00
100_E263_V1.0161.00
77_P80_R1.0141.00
207_V226_I1.0091.00
57_K60_T1.0071.00
346_F372_V1.0001.00
197_V207_V0.9981.00
113_H270_K0.9961.00
312_K384_R0.9961.00
152_V155_V0.9911.00
344_L362_I0.9861.00
206_L237_V0.9841.00
317_A388_R0.9811.00
194_E229_V0.9801.00
349_K352_N0.9801.00
79_L103_V0.9741.00
84_S96_D0.9741.00
110_G239_F0.9701.00
118_T206_L0.9671.00
356_V390_I0.9671.00
201_K234_D0.9601.00
149_V167_E0.9571.00
201_K233_R0.9561.00
131_S178_G0.9561.00
125_V174_M0.9431.00
350_L358_V0.9431.00
110_G256_M0.9411.00
117_A266_L0.9351.00
101_A257_V0.9351.00
306_R309_V0.9321.00
162_E166_R0.9321.00
310_L383_I0.9311.00
206_L235_V0.9301.00
381_D384_R0.9271.00
197_V236_A0.9261.00
135_H176_I0.9211.00
102_I266_L0.9181.00
168_S205_V0.9171.00
194_E232_A0.9121.00
312_K315_H0.9111.00
308_D323_M0.9091.00
239_F256_M0.9091.00
225_S228_Q0.9071.00
226_I236_A0.9051.00
100_E233_R0.9041.00
190_L222_K0.9011.00
309_V312_K0.9001.00
37_D355_K0.8991.00
57_K61_V0.8971.00
217_V220_G0.8961.00
105_I278_F0.8941.00
48_G302_Q0.8941.00
349_K354_A0.8911.00
374_F386_A0.8881.00
287_A291_G0.8861.00
319_W334_I0.8861.00
56_E63_Q0.8861.00
294_Q298_D0.8831.00
93_V227_M0.8831.00
86_W215_D0.8821.00
319_W332_A0.8801.00
114_L266_L0.8751.00
46_P303_Y0.8751.00
140_V146_V0.8701.00
159_N192_F0.8701.00
298_D301_E0.8681.00
206_L262_L0.8671.00
169_Y203_Y0.8671.00
307_R324_P0.8651.00
310_L313_G0.8581.00
213_Y329_Y0.8581.00
172_P205_V0.8561.00
231_G234_D0.8561.00
227_M238_E0.8561.00
317_A387_I0.8551.00
107_S241_T0.8531.00
126_L167_E0.8531.00
161_L196_V0.8481.00
107_S212_A0.8481.00
217_V223_A0.8471.00
162_E165_I0.8441.00
108_K134_I0.8361.00
361_G364_F0.8341.00
263_V267_A0.8311.00
76_I286_I0.8291.00
115_M174_M0.8261.00
344_L348_K0.8181.00
258_G266_L0.8181.00
310_L376_L0.8161.00
168_S172_P0.8141.00
298_D302_Q0.8101.00
309_V387_I0.8081.00
383_I386_A0.8071.00
152_V163_R0.8061.00
126_L175_M0.8041.00
358_V374_F0.8041.00
295_C298_D0.8021.00
60_T63_Q0.7981.00
211_L238_E0.7931.00
53_H287_A0.7921.00
86_W91_Y0.7901.00
119_L174_M0.7891.00
283_V286_I0.7891.00
79_L83_I0.7831.00
260_K264_S0.7821.00
201_K235_V0.7811.00
125_V144_A0.7811.00
86_W246_Y0.7781.00
270_K277_T0.7771.00
60_T65_P0.7751.00
119_L123_D0.7711.00
41_F383_I0.7701.00
215_D245_S0.7691.00
237_V262_L0.7691.00
53_H56_E0.7681.00
126_L164_A0.7661.00
108_K132_Y0.7651.00
334_I372_V0.7621.00
354_A393_M0.7621.00
305_R308_D0.7611.00
128_P149_V0.7611.00
37_D382_R0.7601.00
218_Y304_K0.7591.00
109_E274_D0.7571.00
356_V389_G0.7551.00
85_R88_Q0.7551.00
106_G252_R0.7541.00
201_K231_G0.7531.00
253_I277_T0.7521.00
320_M335_P0.7511.00
242_L255_F0.7461.00
161_L192_F0.7431.00
164_A175_M0.7391.00
35_G355_K0.7361.00
232_A236_A0.7321.00
219_D307_R0.7291.00
124_T173_K0.7281.00
102_I256_M0.7281.00
347_A360_P0.7261.00
127_V139_A0.7251.00
161_L165_I0.7251.00
151_L181_S0.7241.00
164_A199_L0.7221.00
343_S360_P0.7211.00
49_A55_V0.7171.00
346_F393_M0.7141.00
211_L225_S0.7131.00
318_G335_P0.7131.00
128_P181_S0.7121.00
67_T283_V0.7111.00
104_T256_M0.7091.00
306_R380_R0.7081.00
37_D385_Q0.7061.00
295_C299_I0.7051.00
341_M345_E0.7041.00
308_D311_V0.7041.00
76_I282_Q0.7021.00
40_D45_N0.7011.00
176_I208_V0.7001.00
253_I281_L0.6991.00
128_P159_N0.6961.00
61_V284_A0.6961.00
201_K232_A0.6951.00
232_A235_V0.6941.00
122_G145_Q0.6941.00
109_E113_H0.6941.00
153_E320_M0.6931.00
344_L360_P0.6931.00
75_G80_R0.6921.00
58_L280_P0.6891.00
147_R169_Y0.6891.00
299_I303_Y0.6811.00
361_G371_H0.6801.00
84_S95_I0.6751.00
51_P54_I0.6751.00
155_V158_F0.6721.00
294_Q297_R0.6711.00
80_R97_P0.6661.00
175_M200_A0.6661.00
182_N213_Y0.6651.00
309_V383_I0.6621.00
82_A289_L0.6611.00
160_E192_F0.6601.00
153_E333_K0.6591.00
181_S184_T0.6591.00
347_A372_V0.6581.00
168_S203_Y0.6561.00
341_M346_F0.6541.00
114_L239_F0.6521.00
233_R236_A0.6501.00
246_Y293_Q0.6471.00
224_P228_Q0.6471.00
310_L374_F0.6471.00
113_H266_L0.6471.00
91_Y214_A0.6451.00
154_G192_F0.6441.00
113_H269_I0.6421.00
305_R309_V0.6391.00
135_H139_A0.6381.00
147_R172_P0.6371.00
50_T295_C0.6341.00
356_V386_A0.6341.00
59_C62_A0.6331.00
112_A142_A0.6311.00
172_P175_M0.6311.00
57_K284_A0.6291.00
137_Y140_V0.6291.00
103_V253_I0.6291.00
296_V300_A0.6261.00
332_A371_H0.6261.00
216_I300_A0.6251.00
177_L193_F0.6241.00
207_V232_A0.6241.00
111_L138_G0.6221.00
388_R391_K0.6211.00
123_D171_K0.6211.00
187_C326_A0.6211.00
155_V163_R0.6171.00
219_D304_K0.6171.00
147_R167_E0.6171.00
44_G213_Y0.6171.00
50_T54_I0.6151.00
261_T264_S0.6131.00
343_S347_A0.6121.00
115_M144_A0.6121.00
218_Y307_R0.6101.00
226_I229_V0.6091.00
108_K275_Y0.6071.00
179_F211_L0.6061.00
225_S238_E0.6061.00
245_S296_V0.6061.00
86_W214_A0.6051.00
149_V163_R0.6031.00
234_D261_T0.6021.00
47_D306_R0.6011.00
316_E384_R0.5991.00
53_H295_C0.5981.00
258_G262_L0.5971.00
346_F350_L0.5951.00
342_G346_F0.5921.00
159_N164_A0.5921.00
103_V282_Q0.5901.00
218_Y326_A0.5881.00
112_A138_G0.5871.00
200_A204_D0.5861.00
115_M142_A0.5861.00
314_L332_A0.5851.00
351_L357_C0.5851.00
87_Y238_E0.5841.00
50_T53_H0.5831.00
307_R323_M0.5821.00
127_V136_I0.5821.00
331_W371_H0.5791.00
158_F189_E0.5781.00
209_H238_E0.5761.00
341_M349_K0.5761.00
54_I288_A0.5741.00
127_V148_S0.5741.00
35_G38_I0.5721.00
389_G392_A0.5701.00
120_D173_K0.5701.00
39_I385_Q0.5691.00
105_I277_T0.5681.00
116_L269_I0.5681.00
54_I248_M0.5661.00
218_Y376_L0.5651.00
102_I258_G0.5641.00
333_K336_E0.5631.00
150_P160_E0.5631.00
300_A304_K0.5631.00
114_L174_M0.5631.00
385_Q392_A0.5611.00
53_H294_Q0.5611.00
129_N365_G0.5591.00
350_L393_M0.5531.00
188_V192_F0.5511.00
267_A270_K0.5501.00
180_P326_A0.5491.00
320_M336_E0.5481.00
155_V192_F0.5481.00
71_S76_I0.5471.00
102_I267_A0.5471.00
119_L173_K0.5461.00
186_Q325_K0.5461.00
89_D290_E0.5451.00
154_G189_E0.5451.00
50_T55_V0.5451.00
95_I227_M0.5441.00
42_S357_C0.5431.00
242_L289_L0.5421.00
331_W373_R0.5411.00
224_P229_V0.5401.00
81_R290_E0.5371.00
152_V158_F0.5361.00
315_H320_M0.5351.00
284_A287_A0.5351.00
129_N367_Y0.5341.00
279_T283_V0.5311.00
321_V330_V0.5311.00
188_V193_F0.5311.00
95_I100_E0.5291.00
283_V287_A0.5271.00
100_E258_G0.5261.00
88_Q92_D0.5261.00
223_A226_I0.5251.00
112_A273_H0.5251.00
293_Q296_V0.5241.00
193_F226_I0.5221.00
193_F209_H0.5211.00
179_F187_C0.5211.00
115_M138_G0.5211.00
224_P227_M0.5201.00
243_S252_R0.5191.00
150_P167_E0.5181.00
166_R169_Y0.5161.00
343_S372_V0.5151.00
319_W394_F0.5151.00
140_V145_Q0.5131.00
71_S276_G0.5131.00
347_A351_L0.5131.00
79_L285_A0.5121.00
44_G329_Y0.5111.00
72_T77_P0.5101.00
81_R84_S0.5091.00
197_V229_V0.5091.00
304_K307_R0.5051.00
264_S267_A0.5051.00
125_V176_I0.5041.00
218_Y324_P0.5021.00
200_A203_Y0.5021.00
164_A196_V0.5011.00
313_G383_I0.5001.00
303_Y328_M0.5001.00
282_Q286_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x5dA 3 0.9223 100 0.295 Contact Map
3dydA 2 0.8981 100 0.31 Contact Map
1yizA 2 0.9345 100 0.315 Contact Map
3e2yA 2 0.9223 100 0.317 Contact Map
1j32A 2 0.9345 100 0.32 Contact Map
2o1bA 2 0.9102 100 0.321 Contact Map
3piuA 2 0.915 100 0.324 Contact Map
3h14A 2 0.8932 100 0.324 Contact Map
1xi9A 4 0.9369 100 0.324 Contact Map
3b46A 2 0.9442 100 0.325 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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