GREMLIN Database
YKGG - Uncharacterized protein YkgG
UniProt: P77433 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13584
Length: 231 (205)
Sequences: 2898 (1991)
Seq/√Len: 139.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_A59_L3.4561.00
76_R80_E3.3031.00
54_A225_Y3.1761.00
72_E76_R3.0801.00
143_G199_I2.9241.00
51_I55_S2.8751.00
78_C129_V2.7691.00
143_G201_S2.6791.00
83_D129_V2.6121.00
137_G167_L2.5981.00
129_V164_L2.5331.00
132_V163_S2.4651.00
66_S69_K2.3961.00
50_F137_G2.3871.00
175_R178_Q2.3641.00
81_L222_K2.3081.00
84_Q128_K2.2931.00
50_F225_Y2.2621.00
42_N45_Q2.2581.00
65_T69_K2.2211.00
50_F54_A2.2081.00
161_E221_V2.1861.00
59_L223_A2.0841.00
53_F56_D2.0711.00
134_A137_G1.9771.00
54_A223_A1.9761.00
69_K72_E1.7821.00
162_Y222_K1.7641.00
168_R171_T1.7641.00
128_K161_E1.7361.00
86_V131_V1.7321.00
52_Q55_S1.7261.00
62_C73_A1.7041.00
145_V199_I1.7041.00
75_I102_R1.6831.00
73_A77_L1.6781.00
49_A52_Q1.6731.00
162_Y224_V1.6201.00
166_I228_I1.5981.00
85_S128_K1.5851.00
130_G160_P1.5811.00
134_A171_T1.5761.00
134_A165_F1.5741.00
48_D52_Q1.5621.00
180_A184_H1.5351.00
129_V162_Y1.5211.00
134_A167_L1.5181.00
49_A53_F1.4981.00
169_K227_I1.4951.00
122_S126_Q1.4881.00
59_L225_Y1.4721.00
94_L166_I1.4701.00
47_C172_I1.4651.00
145_V179_L1.4241.00
62_C224_V1.4181.00
46_R174_P1.3891.00
68_A72_E1.3741.00
81_L162_Y1.3721.00
28_A31_N1.3201.00
144_V165_F1.2951.00
87_V127_A1.2841.00
167_L227_I1.2561.00
140_E175_R1.2381.00
45_Q48_D1.2301.00
38_L42_N1.2291.00
89_S152_R1.2271.00
83_D128_K1.2261.00
78_C83_D1.2221.00
51_I63_E1.2161.00
179_L182_K1.2041.00
174_P178_Q1.1991.00
136_Y173_L1.1861.00
31_N35_N1.1851.00
29_P33_Y1.1841.00
74_A226_L1.1791.00
75_I79_K1.1781.00
87_V156_L1.1751.00
144_V223_A1.1710.99
73_A76_R1.1650.99
173_L179_L1.1430.99
204_S208_D1.1390.99
11_V15_L1.1340.99
172_I227_I1.1160.99
38_L46_R1.1110.99
136_Y179_L1.1020.99
164_L226_L1.0920.99
90_G151_E1.0880.99
78_C164_L1.0800.99
206_T209_I1.0780.99
130_G156_L1.0720.99
57_V201_S1.0640.99
60_T224_V1.0590.99
60_T222_K1.0560.99
52_Q56_D1.0440.99
99_I103_L1.0430.99
138_L179_L1.0380.99
9_N13_Q1.0340.99
179_L184_H1.0310.99
47_C51_I1.0210.99
89_S153_G1.0130.99
169_K229_E0.9950.98
208_D220_P0.9920.98
110_V114_P0.9910.98
33_Y36_E0.9760.98
93_R228_I0.9670.98
102_R105_Q0.9660.98
77_L162_Y0.9570.98
204_S210_E0.9520.98
167_L225_Y0.9490.98
15_L19_L0.9370.98
67_E168_R0.9340.97
80_E222_K0.9270.97
85_S126_Q0.9140.97
97_L166_I0.9130.97
85_S123_Q0.9120.97
28_A32_N0.9120.97
202_G219_G0.9110.97
73_A226_L0.9020.97
133_Y168_R0.8970.97
124_A159_L0.8960.97
32_N36_E0.8940.97
42_N46_R0.8870.97
37_R40_Q0.8860.97
101_E104_Q0.8720.96
50_F53_F0.8690.96
15_L20_R0.8680.96
183_L197_I0.8670.96
61_R64_L0.8630.96
109_A113_D0.8600.96
143_G176_V0.8570.96
31_N34_A0.8560.96
95_E100_S0.8520.96
98_G101_E0.8500.96
47_C227_I0.8500.96
64_L229_E0.8480.96
57_V202_G0.8430.95
125_E159_L0.8400.95
112_W116_K0.8370.95
157_S200_I0.8360.95
204_S209_I0.8310.95
114_P118_A0.8290.95
47_C63_E0.8260.95
58_M64_L0.8260.95
154_R157_S0.8250.95
83_D162_Y0.8200.95
89_S156_L0.8150.94
135_E147_F0.8110.94
135_E152_R0.8100.94
39_T46_R0.8090.94
51_I61_R0.8060.94
64_L226_L0.8050.94
133_Y151_E0.8040.94
132_V157_S0.8000.94
70_A228_I0.7990.94
57_V205_S0.7970.94
101_E105_Q0.7910.94
69_K73_A0.7880.93
58_M62_C0.7870.93
73_A224_V0.7850.93
176_V199_I0.7850.93
74_A166_I0.7750.93
93_R167_L0.7690.93
29_P32_N0.7680.93
21_L24_Q0.7670.93
59_L62_C0.7640.92
18_P22_E0.7630.92
205_S220_P0.7620.92
94_L131_V0.7570.92
58_M61_R0.7560.92
92_T95_E0.7460.91
74_A164_L0.7440.91
64_L73_A0.7420.91
44_Q63_E0.7340.91
123_Q126_Q0.7290.91
116_K120_N0.7280.90
89_S132_V0.7270.90
50_F172_I0.7270.90
113_D116_K0.7260.90
155_S158_L0.7240.90
89_S130_G0.7200.90
136_Y182_K0.7160.90
157_S163_S0.7140.90
111_V114_P0.7120.89
179_L199_I0.7110.89
144_V167_L0.7090.89
206_T210_E0.7090.89
30_L33_Y0.7060.89
208_D219_G0.7060.89
173_L182_K0.7050.89
57_V60_T0.7040.89
86_V129_V0.6960.88
68_A71_A0.6940.88
110_V113_D0.6930.88
47_C169_K0.6900.88
70_A97_L0.6850.88
59_L64_L0.6800.87
205_S208_D0.6780.87
70_A74_A0.6780.87
64_L70_A0.6780.87
90_G150_A0.6770.87
43_Q47_C0.6770.87
17_R21_L0.6750.87
138_L173_L0.6720.87
153_G196_C0.6610.86
148_S198_N0.6610.86
32_N35_N0.6610.86
122_S125_E0.6600.86
61_R65_T0.6600.86
140_E177_A0.6600.86
41_L45_Q0.6560.85
75_I78_C0.6550.85
145_V197_I0.6540.85
141_S201_S0.6470.84
92_T96_E0.6460.84
77_L224_V0.6440.84
154_R158_L0.6430.84
127_A160_P0.6380.84
19_L22_E0.6360.83
54_A137_G0.6350.83
30_L34_A0.6350.83
141_S199_I0.6350.83
120_N123_Q0.6320.83
185_Q197_I0.6310.83
135_E149_A0.6310.83
147_F152_R0.6310.83
29_P36_E0.6300.83
43_Q46_R0.6270.83
99_I131_V0.6250.82
88_I95_E0.6240.82
63_E169_K0.6240.82
138_L176_V0.6220.82
205_S221_V0.6200.82
141_S145_V0.6180.82
109_A112_W0.6170.82
209_I219_G0.6160.81
158_L196_C0.6120.81
72_E102_R0.6100.81
28_A33_Y0.6090.81
46_R172_I0.6090.81
204_S221_V0.6070.81
51_I227_I0.6040.80
71_A74_A0.6020.80
201_S205_S0.6010.80
202_G220_P0.5980.80
91_D94_L0.5950.79
117_G120_N0.5940.79
19_L23_P0.5850.78
204_S219_G0.5850.78
135_E151_E0.5850.78
12_A19_L0.5850.78
9_N19_L0.5840.78
204_S207_A0.5830.78
137_G227_I0.5820.78
124_A127_A0.5790.77
76_R79_K0.5760.77
158_L208_D0.5760.77
70_A166_I0.5760.77
200_I204_S0.5740.77
65_T73_A0.5730.77
130_G157_S0.5700.76
49_A139_T0.5690.76
138_L175_R0.5690.76
100_S103_L0.5680.76
83_D164_L0.5670.76
37_R41_L0.5660.76
62_C77_L0.5640.76
179_L183_L0.5620.75
165_F225_Y0.5600.75
55_S60_T0.5580.75
113_D119_E0.5570.75
18_P23_P0.5550.74
67_E71_A0.5540.74
18_P21_L0.5530.74
137_G171_T0.5530.74
96_E101_E0.5490.74
136_Y145_V0.5470.73
148_S153_G0.5470.73
49_A174_P0.5460.73
144_V157_S0.5450.73
202_G207_A0.5430.73
153_G198_N0.5430.73
131_V166_I0.5400.72
119_E122_S0.5400.72
48_D51_I0.5380.72
112_W115_A0.5360.72
50_F223_A0.5360.72
74_A97_L0.5340.72
154_R200_I0.5340.72
176_V180_A0.5330.71
15_L203_P0.5320.71
44_Q48_D0.5310.71
143_G197_I0.5280.71
205_S210_E0.5240.70
77_L80_E0.5210.70
15_L18_P0.5190.69
11_V16_G0.5170.69
48_D55_S0.5160.69
135_E171_T0.5150.69
40_Q46_R0.5140.69
149_A171_T0.5130.69
78_C102_R0.5130.69
206_T219_G0.5120.68
157_S160_P0.5120.68
46_R139_T0.5110.68
71_A228_I0.5070.68
160_P207_A0.5070.68
82_G105_Q0.5040.67
206_T220_P0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2g40A 2 0.7056 100 0.258 Contact Map
3cf4A 2 0.8615 95.5 0.9 Contact Map
1yksA 1 0.3853 53.5 0.941 Contact Map
3brcA 4 0.6061 45.4 0.944 Contact Map
3cl6A 3 0.3377 25.6 0.951 Contact Map
4ct4B 1 0.5541 24.6 0.951 Contact Map
4qbnA 2 0.3377 19.8 0.953 Contact Map
2zj8A 2 0.5152 19.5 0.953 Contact Map
2v6iA 1 0.3203 17.7 0.954 Contact Map
2z83A 1 0.3463 17 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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