GREMLIN Database
LSRK - Autoinducer 2 kinase LsrK
UniProt: P77432 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13804
Length: 530 (474)
Sequences: 12491 (8516)
Seq/√Len: 391.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_P215_A4.1171.00
119_E156_H3.7501.00
30_D34_N3.5381.00
26_A69_C3.3111.00
122_E156_H3.2811.00
406_A502_R2.8611.00
197_D200_T2.8601.00
406_A410_Q2.8311.00
138_A204_K2.7971.00
446_P489_T2.7821.00
413_A445_L2.7411.00
41_A68_E2.7101.00
437_Q441_D2.6961.00
351_V392_T2.6951.00
106_I161_I2.6631.00
378_F393_L2.6541.00
196_L221_V2.6391.00
41_A72_Q2.5841.00
39_G72_Q2.5821.00
223_E226_T2.5461.00
28_I73_A2.5441.00
422_S448_N2.5371.00
473_S476_E2.4981.00
472_S476_E2.4681.00
433_K486_R2.4441.00
107_W158_R2.4401.00
202_D215_A2.4181.00
63_W178_M2.4101.00
101_N166_S2.3881.00
60_N178_M2.3841.00
100_N164_Q2.3641.00
197_D204_K2.3501.00
406_A499_Q2.2731.00
340_T343_L2.2571.00
208_L215_A2.2551.00
182_E220_P2.1581.00
17_L66_A2.1411.00
205_P209_D2.0971.00
251_G256_L2.0861.00
176_A250_G2.0861.00
27_V457_A2.0321.00
317_T397_L2.0121.00
12_Y85_A2.0031.00
23_S40_Q1.9751.00
122_E126_L1.9461.00
60_N104_A1.9351.00
491_D494_K1.9351.00
232_S235_A1.9341.00
72_Q76_N1.9191.00
134_E137_R1.9141.00
350_R391_A1.9051.00
277_W314_T1.9011.00
180_S247_V1.8941.00
451_V483_R1.8911.00
389_N392_T1.8901.00
413_A419_H1.8791.00
14_L465_G1.8691.00
51_V54_S1.8651.00
44_R61_K1.8611.00
444_G495_H1.8481.00
343_L346_E1.8421.00
357_G504_K1.8381.00
15_M70_M1.8331.00
425_F436_S1.8191.00
502_R506_Q1.8191.00
184_A222_K1.7951.00
15_M26_A1.7931.00
152_L156_H1.7861.00
19_A24_I1.7781.00
167_T183_L1.7691.00
13_Y36_I1.7651.00
248_V467_G1.7501.00
233_S243_A1.7331.00
321_F397_L1.7301.00
138_A206_A1.7171.00
448_N487_T1.7131.00
13_Y28_I1.7101.00
222_K226_T1.7051.00
134_E138_A1.7051.00
134_E206_A1.6981.00
100_N104_A1.6961.00
354_G357_G1.6911.00
354_G392_T1.6851.00
98_L154_L1.6561.00
103_G177_Y1.6471.00
121_S125_E1.6361.00
441_D494_K1.6331.00
227_L230_V1.6321.00
268_Q422_S1.6311.00
339_D343_L1.6281.00
446_P487_T1.6241.00
97_V171_I1.6091.00
118_R122_E1.6011.00
403_I501_S1.5881.00
441_D491_D1.5781.00
347_M350_R1.5691.00
227_L248_V1.5641.00
507_A511_D1.5591.00
319_R323_D1.5591.00
375_A382_S1.5471.00
358_V378_F1.5451.00
124_K132_E1.5331.00
495_H499_Q1.5241.00
199_T286_P1.5221.00
98_L217_I1.5201.00
410_Q506_Q1.5041.00
347_M391_A1.4951.00
12_Y83_Y1.4931.00
266_P284_A1.4841.00
46_L61_K1.4801.00
160_D163_R1.4551.00
348_A434_L1.4501.00
493_E496_E1.4441.00
133_N137_R1.4371.00
14_L470_I1.4351.00
58_D61_K1.4291.00
410_Q413_A1.4281.00
39_G73_A1.4201.00
39_G69_C1.4161.00
433_K449_I1.4051.00
63_W67_C1.4041.00
176_A228_L1.4001.00
37_A73_A1.3971.00
433_K488_H1.3911.00
74_L81_P1.3821.00
451_V485_E1.3781.00
395_R399_E1.3771.00
17_L70_M1.3721.00
242_K245_T1.3721.00
346_E350_R1.3681.00
31_L470_I1.3571.00
153_W157_H1.3561.00
60_N64_Q1.3561.00
86_A464_A1.3541.00
434_L438_I1.3511.00
180_S229_G1.3491.00
344_L394_F1.3471.00
230_V244_G1.3461.00
422_S446_P1.3301.00
465_G471_F1.3281.00
37_A76_N1.3161.00
174_W178_M1.3081.00
99_Y169_T1.2991.00
273_G439_L1.2981.00
402_A438_I1.2871.00
176_A184_A1.2861.00
214_R217_I1.2701.00
311_S404_V1.2631.00
117_A121_S1.2631.00
269_T420_P1.2621.00
347_M390_K1.2561.00
119_E152_L1.2551.00
93_R252_G1.2491.00
24_I66_A1.2491.00
345_E349_S1.2461.00
187_P201_R1.2441.00
222_K228_L1.2421.00
402_A439_L1.2391.00
402_A442_V1.2381.00
80_A83_Y1.2371.00
28_I79_I1.2321.00
126_L131_F1.2311.00
155_A162_Y1.2301.00
449_I488_H1.2291.00
134_E210_M1.2221.00
208_L218_L1.2211.00
271_V439_L1.2181.00
431_K453_K1.2171.00
126_L210_M1.2031.00
148_I211_A1.1951.00
438_I442_V1.1921.00
462_I481_L1.1911.00
358_V362_F1.1831.00
95_G108_A1.1821.00
496_E500_D1.1791.00
227_L246_P1.1721.00
17_L26_A1.1701.00
346_E349_S1.1651.00
407_C506_Q1.1641.00
64_Q68_E1.1641.00
345_E433_K1.1631.00
135_V143_L1.1621.00
410_Q502_R1.1621.00
267_A421_S1.1611.00
24_I65_L1.1601.00
406_A443_S1.1581.00
356_W385_P1.1581.00
158_R161_I1.1571.00
325_F393_L1.1561.00
251_G463_A1.1551.00
206_A209_D1.1531.00
444_G499_Q1.1521.00
66_A175_L1.1521.00
343_L347_M1.1471.00
484_W487_T1.1431.00
265_R268_Q1.1401.00
137_R288_T1.1391.00
345_E432_G1.1381.00
29_F35_Q1.1291.00
381_L385_P1.1291.00
379_I508_V1.1281.00
313_F317_T1.1251.00
160_D164_Q1.1241.00
436_S488_H1.1181.00
227_L467_G1.1171.00
98_L165_A1.1131.00
59_L97_V1.1031.00
68_E72_Q1.0991.00
120_V143_L1.0981.00
313_F316_L1.0951.00
265_R478_G1.0941.00
184_A228_L1.0911.00
187_P221_V1.0911.00
342_T345_E1.0901.00
12_Y31_L1.0891.00
504_K507_A1.0851.00
358_V397_L1.0751.00
494_K497_L1.0731.00
499_Q503_D1.0711.00
409_L443_S1.0671.00
131_F210_M1.0621.00
98_L151_L1.0611.00
72_Q75_H1.0591.00
29_F461_A1.0581.00
121_S124_K1.0561.00
131_F134_E1.0551.00
107_W161_I1.0541.00
13_Y83_Y1.0541.00
187_P196_L1.0531.00
165_A217_I1.0521.00
268_Q424_V1.0501.00
355_S358_V1.0451.00
347_M394_F1.0341.00
376_P381_L1.0321.00
79_I83_Y1.0311.00
89_A176_A1.0261.00
86_A468_A1.0231.00
62_N171_I1.0151.00
466_V477_T1.0151.00
349_S434_L1.0101.00
119_E157_H1.0101.00
66_A70_M1.0101.00
14_L468_A1.0071.00
401_A429_G1.0061.00
118_R121_S1.0031.00
162_Y165_A1.0031.00
424_V448_N1.0031.00
45_H57_F1.0011.00
403_I442_V0.9941.00
103_G183_L0.9941.00
462_I477_T0.9931.00
265_R475_A0.9921.00
39_G76_N0.9921.00
491_D495_H0.9901.00
43_W65_L0.9881.00
269_T281_V0.9861.00
406_A442_V0.9751.00
14_L86_A0.9741.00
230_V246_P0.9721.00
385_P392_T0.9691.00
86_A248_V0.9681.00
87_V245_T0.9681.00
13_Y79_I0.9631.00
119_E122_E0.9621.00
159_S163_R0.9621.00
85_A468_A0.9601.00
61_K64_Q0.9571.00
148_I194_G0.9551.00
270_A426_A0.9551.00
122_E125_E0.9501.00
161_I164_Q0.9441.00
395_R434_L0.9401.00
115_R153_W0.9401.00
55_M112_V0.9391.00
317_T358_V0.9391.00
49_P52_P0.9371.00
71_R75_H0.9371.00
90_C456_T0.9351.00
208_L213_L0.9351.00
135_V194_G0.9351.00
137_R199_T0.9321.00
98_L168_I0.9291.00
185_V190_A0.9251.00
196_L200_T0.9251.00
74_L84_I0.9251.00
184_A220_P0.9221.00
465_G470_I0.9221.00
265_R421_S0.9211.00
177_Y183_L0.9181.00
15_M84_I0.9171.00
429_G435_W0.9171.00
248_V468_A0.9171.00
151_L168_I0.9151.00
471_F477_T0.9141.00
381_L393_L0.9121.00
444_G497_L0.9091.00
422_S487_T0.9081.00
165_A168_I0.9071.00
104_A178_M0.9051.00
28_I84_I0.9041.00
89_A175_L0.9041.00
26_A73_A0.9041.00
30_D36_I0.9001.00
201_R223_E0.8941.00
187_P300_V0.8931.00
492_P495_H0.8911.00
15_M28_I0.8911.00
154_L161_I0.8881.00
279_Q409_L0.8881.00
284_A304_M0.8861.00
403_I502_R0.8861.00
29_F458_L0.8841.00
96_I168_I0.8821.00
122_E152_L0.8791.00
46_L49_P0.8771.00
291_E414_D0.8741.00
338_I344_L0.8741.00
67_C71_R0.8741.00
476_E480_R0.8721.00
88_S248_V0.8681.00
107_W154_L0.8671.00
181_G232_S0.8661.00
148_I195_L0.8651.00
378_F397_L0.8641.00
41_A69_C0.8631.00
277_W405_S0.8571.00
199_T288_T0.8571.00
235_A239_C0.8571.00
423_L443_S0.8541.00
82_E242_K0.8491.00
202_D220_P0.8491.00
374_A377_S0.8441.00
94_E192_T0.8441.00
99_Y103_G0.8421.00
326_C390_K0.8411.00
120_V149_P0.8391.00
443_S446_P0.8381.00
84_I245_T0.8361.00
187_P223_E0.8351.00
492_P496_E0.8331.00
173_D185_V0.8311.00
222_K249_V0.8301.00
410_Q414_D0.8271.00
169_T183_L0.8251.00
152_L155_A0.8251.00
203_W218_L0.8241.00
500_D503_D0.8221.00
170_M193_T0.8201.00
166_S216_D0.8191.00
19_A175_L0.8181.00
466_V474_M0.8171.00
342_T346_E0.8171.00
430_S453_K0.8091.00
89_A179_L0.8081.00
230_V243_A0.8061.00
257_G426_A0.8061.00
190_A203_W0.8051.00
278_Q310_I0.8021.00
42_E319_R0.8011.00
398_E438_I0.7961.00
348_A395_R0.7951.00
151_L195_L0.7931.00
29_F452_V0.7921.00
233_S244_G0.7921.00
269_T423_L0.7911.00
492_P497_L0.7911.00
85_A470_I0.7861.00
118_R157_H0.7861.00
349_S437_Q0.7851.00
185_V219_S0.7821.00
70_M74_L0.7811.00
106_I164_Q0.7791.00
466_V473_S0.7771.00
61_K65_L0.7761.00
484_W490_P0.7761.00
196_L201_R0.7731.00
38_V454_E0.7711.00
124_K143_L0.7701.00
409_L413_A0.7691.00
261_L426_A0.7671.00
364_D381_L0.7661.00
120_V144_A0.7641.00
411_Q414_D0.7631.00
231_V239_C0.7621.00
41_A65_L0.7621.00
320_W323_D0.7601.00
281_V412_I0.7591.00
35_Q38_V0.7581.00
43_W57_F0.7581.00
507_A510_Q0.7571.00
341_Y344_L0.7571.00
202_D205_P0.7551.00
271_V405_S0.7541.00
496_E501_S0.7521.00
19_A66_A0.7511.00
185_V221_V0.7511.00
121_S373_H0.7501.00
321_F394_F0.7501.00
199_T285_A0.7491.00
448_N484_W0.7491.00
437_Q491_D0.7481.00
309_S408_N0.7471.00
322_R341_Y0.7471.00
319_R341_Y0.7451.00
327_A338_I0.7441.00
365_R368_F0.7431.00
351_V391_A0.7421.00
206_A210_M0.7401.00
425_F449_I0.7391.00
98_L106_I0.7381.00
118_R156_H0.7361.00
398_E432_G0.7361.00
93_R189_N0.7361.00
254_V278_Q0.7351.00
407_C502_R0.7351.00
111_N276_F0.7341.00
16_A88_S0.7341.00
152_L212_G0.7321.00
138_A197_D0.7321.00
209_D215_A0.7311.00
100_N106_I0.7301.00
402_A435_W0.7301.00
271_V277_W0.7281.00
500_D504_K0.7281.00
223_E302_P0.7241.00
425_F439_L0.7231.00
172_S250_G0.7211.00
42_E322_R0.7191.00
406_A506_Q0.7191.00
204_K207_L0.7181.00
60_N174_W0.7151.00
93_R308_E0.7121.00
261_L270_A0.7121.00
241_L244_G0.7121.00
471_F480_R0.7111.00
321_F393_L0.7091.00
87_V231_V0.7061.00
163_R167_T0.7061.00
314_T401_A0.7061.00
430_S436_S0.7051.00
60_N105_P0.7041.00
235_A244_G0.7011.00
223_E300_V0.6991.00
188_S299_H0.6991.00
506_Q510_Q0.6981.00
499_Q502_R0.6981.00
74_L79_I0.6981.00
357_G379_I0.6981.00
135_V207_L0.6971.00
351_V354_G0.6971.00
100_N166_S0.6961.00
283_L307_A0.6951.00
348_A394_F0.6941.00
64_Q67_C0.6931.00
133_N136_Y0.6920.99
349_S433_K0.6900.99
501_S504_K0.6890.99
231_V245_T0.6840.99
24_I43_W0.6830.99
81_P84_I0.6830.99
188_S251_G0.6820.99
356_W359_M0.6810.99
56_E115_R0.6800.99
353_P497_L0.6790.99
358_V396_A0.6790.99
356_W392_T0.6790.99
97_V108_A0.6780.99
231_V241_L0.6770.99
86_A246_P0.6770.99
356_W396_A0.6770.99
197_D202_D0.6770.99
67_C235_A0.6760.99
355_S395_R0.6760.99
27_V35_Q0.6760.99
257_G456_T0.6750.99
68_E71_R0.6740.99
283_L287_V0.6710.99
494_K499_Q0.6690.99
425_F447_V0.6690.99
489_T492_P0.6680.99
176_A180_S0.6660.99
67_C239_C0.6660.99
449_I485_E0.6650.99
423_L445_L0.6650.99
164_Q167_T0.6630.99
345_E434_L0.6630.99
262_G482_V0.6630.99
399_E438_I0.6620.99
475_A478_G0.6610.99
271_V423_L0.6600.99
243_A246_P0.6600.99
103_G166_S0.6590.99
174_W177_Y0.6560.99
101_N164_Q0.6550.99
318_M345_E0.6550.99
21_T110_A0.6540.99
321_F325_F0.6540.99
67_C178_M0.6520.99
366_M369_K0.6500.99
420_P445_L0.6480.99
91_S189_N0.6460.99
263_V270_A0.6460.99
423_L447_V0.6450.99
66_A69_C0.6450.99
109_C115_R0.6440.99
19_A65_L0.6430.99
29_F457_A0.6420.99
70_M73_A0.6370.99
421_S445_L0.6350.99
228_L249_V0.6350.99
227_L468_A0.6340.99
14_L85_A0.6340.99
224_T250_G0.6330.99
70_M239_C0.6310.99
241_L245_T0.6300.99
497_L501_S0.6300.99
503_D506_Q0.6290.99
253_D275_T0.6280.99
67_C70_M0.6280.99
99_Y177_Y0.6270.99
437_Q488_H0.6270.99
263_V268_Q0.6270.99
139_T207_L0.6260.99
31_L85_A0.6260.99
311_S408_N0.6250.99
99_Y167_T0.6250.99
268_Q421_S0.6240.99
183_L232_S0.6240.99
188_S224_T0.6240.99
496_E499_Q0.6230.99
355_S501_S0.6200.99
395_R438_I0.6200.99
230_V233_S0.6200.99
478_G481_L0.6200.99
465_G469_G0.6190.99
209_D214_R0.6180.99
91_S171_I0.6170.99
32_E480_R0.6160.99
146_S192_T0.6150.99
92_M111_N0.6140.99
348_A351_V0.6130.99
286_P295_R0.6130.99
99_Y174_W0.6130.99
446_P490_P0.6120.99
369_K407_C0.6120.99
109_C154_L0.6110.99
143_L194_G0.6100.99
78_G81_P0.6090.99
152_L211_A0.6080.99
239_C245_T0.6060.99
155_A212_G0.6050.99
385_P389_N0.6040.99
444_G492_P0.6030.99
60_N63_W0.6030.99
259_L301_I0.6020.99
141_Q146_S0.6020.99
172_S189_N0.6020.99
277_W439_L0.6010.99
246_P468_A0.6000.99
201_R300_V0.5970.99
477_T481_L0.5970.99
151_L217_I0.5960.99
422_S445_L0.5960.99
152_L162_Y0.5960.99
63_W235_A0.5950.98
433_K437_Q0.5940.98
353_P395_R0.5930.98
59_L108_A0.5920.98
123_L211_A0.5920.98
462_I466_V0.5910.98
452_V458_L0.5900.98
345_E348_A0.5890.98
481_L484_W0.5880.98
182_E222_K0.5870.98
289_D293_N0.5870.98
347_M351_V0.5860.98
162_Y166_S0.5840.98
354_G385_P0.5830.98
369_K506_Q0.5830.98
369_K509_Y0.5830.98
327_A390_K0.5820.98
87_V247_V0.5810.98
280_V306_Q0.5800.98
355_S399_E0.5790.98
235_A241_L0.5780.98
277_W311_S0.5760.98
209_D212_G0.5760.98
117_A144_A0.5730.98
195_L218_L0.5730.98
252_G255_Q0.5720.98
324_A389_N0.5690.98
116_A149_P0.5690.98
96_I147_A0.5690.98
162_Y212_G0.5690.98
35_Q452_V0.5690.98
473_S477_T0.5660.98
258_C280_V0.5650.98
375_A379_I0.5640.98
354_G395_R0.5640.98
115_R157_H0.5630.98
103_G167_T0.5620.98
213_L218_L0.5610.98
471_F481_L0.5600.98
225_G467_G0.5590.98
355_S392_T0.5590.98
14_L471_F0.5580.98
296_V306_Q0.5570.98
316_L319_R0.5570.98
262_G478_G0.5570.98
232_S244_G0.5560.98
474_M478_G0.5550.98
401_A435_W0.5540.98
254_V272_L0.5540.98
123_L149_P0.5530.98
271_V279_Q0.5530.98
38_V76_N0.5530.98
162_Y214_R0.5520.98
319_R322_R0.5520.98
13_Y82_E0.5510.98
193_T203_W0.5510.98
413_A420_P0.5510.98
48_V55_M0.5510.98
499_Q506_Q0.5490.97
273_G425_F0.5490.97
149_P194_G0.5480.97
104_A164_Q0.5480.97
466_V469_G0.5480.97
14_L31_L0.5480.97
135_V211_A0.5470.97
451_V484_W0.5470.97
93_R192_T0.5450.97
34_N451_V0.5450.97
201_R298_P0.5450.97
56_E107_W0.5430.97
98_L107_W0.5430.97
58_D64_Q0.5380.97
345_E398_E0.5380.97
314_T317_T0.5380.97
144_A372_Y0.5380.97
126_L152_L0.5360.97
485_E490_P0.5340.97
34_N483_R0.5340.97
399_E403_I0.5330.97
259_L462_I0.5330.97
466_V471_F0.5330.97
432_G435_W0.5320.97
169_T177_Y0.5320.97
438_I501_S0.5320.97
458_L462_I0.5310.97
318_M344_L0.5310.97
90_C460_C0.5290.97
57_F110_A0.5290.97
268_Q478_G0.5290.97
440_A447_V0.5280.97
272_L426_A0.5280.97
95_G110_A0.5270.97
220_P226_T0.5270.97
207_L211_A0.5270.97
286_P305_V0.5270.97
463_A474_M0.5260.97
21_T111_N0.5250.97
478_G482_V0.5250.97
191_G298_P0.5250.97
344_L432_G0.5230.97
84_I241_L0.5230.97
94_E276_F0.5230.97
457_A460_C0.5230.97
414_D506_Q0.5230.97
430_S449_I0.5220.97
258_C298_P0.5220.97
437_Q440_A0.5210.97
199_T202_D0.5200.97
260_G455_A0.5200.97
341_Y345_E0.5180.96
351_V395_R0.5180.96
281_V420_P0.5170.96
22_G25_R0.5170.96
31_L465_G0.5170.96
12_Y470_I0.5150.96
439_L443_S0.5140.96
59_L171_I0.5140.96
392_T395_R0.5140.96
49_P54_S0.5130.96
187_P224_T0.5120.96
259_L474_M0.5120.96
348_A398_E0.5110.96
156_H212_G0.5100.96
188_S255_Q0.5090.96
357_G403_I0.5090.96
94_E111_N0.5090.96
306_Q310_I0.5090.96
55_M110_A0.5090.96
69_C73_A0.5090.96
224_T251_G0.5080.96
279_Q408_N0.5080.96
403_I406_A0.5080.96
176_A247_V0.5080.96
436_S449_I0.5080.96
96_I154_L0.5060.96
192_T252_G0.5060.96
74_L80_A0.5050.96
338_I343_L0.5050.96
170_M189_N0.5050.96
275_T316_L0.5050.96
444_G494_K0.5040.96
181_G234_Q0.5030.96
344_L434_L0.5030.96
315_G319_R0.5010.96
175_L179_L0.5010.96
54_S109_C0.5000.96
93_R171_I0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ll3A 2 0.9208 100 0.146 Contact Map
3qdkA 2 0.9604 100 0.164 Contact Map
3hz6A 1 0.9113 100 0.169 Contact Map
2itmA 2 0.8887 100 0.17 Contact Map
3ifrA 2 0.9132 100 0.17 Contact Map
3ezwA 3 0.9189 100 0.18 Contact Map
3l0qA 2 0.9377 100 0.18 Contact Map
3wxlA 2 0.9226 100 0.187 Contact Map
3g25A 3 0.917 100 0.191 Contact Map
3h3nX 3 0.9208 100 0.192 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0143 seconds.