GREMLIN Database
YBEU - Uncharacterized protein YbeU
UniProt: P77427 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13651
Length: 235 (200)
Sequences: 392 (319)
Seq/√Len: 22.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_Y164_A6.7341.00
53_L129_G6.3951.00
49_N52_D5.7481.00
50_R139_E4.5211.00
117_W172_W3.2021.00
14_A203_L3.1911.00
151_A161_Y2.9951.00
50_R54_I2.9570.99
136_T139_E2.7540.99
162_F211_Y2.6860.99
65_H172_W2.5800.99
64_G118_D2.3890.98
48_N52_D2.2860.97
123_G144_Q2.2650.97
53_L125_L2.2640.97
46_G52_D2.2600.97
59_Q64_G2.1960.96
47_I121_R2.0630.94
117_W121_R2.0100.93
118_D121_R1.9900.93
137_E141_L1.9010.91
121_R169_R1.8620.90
140_S216_W1.8240.89
24_K129_G1.7590.88
16_M20_N1.7430.87
8_L152_H1.7190.86
12_L151_A1.6820.85
60_M121_R1.6810.85
64_G117_W1.6650.85
116_A155_Y1.6480.84
126_S147_V1.6160.83
48_N156_H1.5820.81
119_Y151_A1.5390.79
60_M117_W1.5250.79
53_L134_W1.4900.77
45_W60_M1.4790.77
51_D80_S1.4780.77
127_R169_R1.4770.77
157_S216_W1.4660.76
80_S83_E1.4220.74
8_L148_Y1.4220.74
57_I143_L1.4140.73
114_I171_Y1.4030.73
117_W169_R1.4000.73
11_A14_A1.3860.72
73_Y76_W1.3830.72
10_F169_R1.3630.70
43_S130_V1.3530.70
120_V169_R1.3230.68
78_R151_A1.3210.68
44_S121_R1.3110.67
59_Q65_H1.3080.67
124_F128_V1.3000.67
35_G180_N1.2950.66
120_V165_Y1.2910.66
147_V216_W1.2890.66
125_L129_G1.2850.66
127_R141_L1.2840.66
121_R172_W1.2690.65
74_L77_H1.2630.64
63_D66_A1.2430.63
65_H121_R1.2280.62
45_W121_R1.2240.62
206_G210_F1.2080.61
141_L144_Q1.2040.61
149_V152_H1.1920.60
158_W210_F1.1900.60
119_Y133_K1.1810.59
8_L216_W1.1570.58
45_W172_W1.1520.57
88_I159_M1.1390.56
61_T147_V1.1090.54
65_H117_W1.1090.54
209_R212_A1.0820.52
91_G215_P1.0770.52
213_T216_W1.0700.52
56_T59_Q1.0520.50
42_S48_N1.0450.50
27_H141_L1.0340.49
70_A73_Y1.0280.49
123_G214_L1.0240.48
151_A164_A1.0230.48
55_Q138_E1.0170.48
142_W145_S1.0040.47
59_Q63_D0.9970.47
53_L135_L0.9880.46
10_F60_M0.9740.45
9_L123_G0.9740.45
80_S90_G0.9730.45
35_G142_W0.9690.45
27_H140_S0.9630.44
11_A164_A0.9570.44
51_D147_V0.9470.43
62_D81_P0.9360.42
144_Q211_Y0.9300.42
10_F13_S0.9290.42
10_F211_Y0.9250.42
102_V123_G0.9230.42
64_G76_W0.9210.41
71_G74_L0.9160.41
107_M156_H0.9110.41
20_N216_W0.9090.41
49_N134_W0.9050.40
204_A207_S0.9030.40
86_A202_E0.9000.40
203_L209_R0.8940.40
127_R144_Q0.8880.39
58_Y125_L0.8880.39
48_N214_L0.8880.39
133_K160_H0.8770.39
57_I135_L0.8700.38
15_P125_L0.8700.38
46_G121_R0.8690.38
8_L16_M0.8690.38
14_A199_M0.8670.38
39_F51_D0.8660.38
47_I52_D0.8630.38
152_H214_L0.8550.37
197_S201_E0.8540.37
122_M126_S0.8530.37
45_W65_H0.8500.37
94_R201_E0.8430.36
16_M139_E0.8420.36
165_Y172_W0.8420.36
44_S47_I0.8410.36
116_A164_A0.8410.36
80_S166_S0.8400.36
58_Y62_D0.8380.36
130_V135_L0.8360.36
119_Y150_R0.8320.36
169_R196_G0.8320.36
15_P120_V0.8310.36
127_R167_L0.8300.35
60_M122_M0.8280.35
46_G177_C0.8240.35
71_G76_W0.8210.35
162_F200_F0.8170.35
61_T122_M0.8130.34
138_E142_W0.8090.34
13_S203_L0.8070.34
66_A76_W0.8040.34
48_N205_A0.8020.34
122_M175_S0.7970.33
44_S117_W0.7970.33
167_L200_F0.7940.33
172_W216_W0.7920.33
105_T111_E0.7880.33
100_Q125_L0.7840.33
120_V161_Y0.7810.32
164_A198_R0.7770.32
38_E54_I0.7770.32
69_L73_Y0.7760.32
109_C113_G0.7740.32
10_F127_R0.7710.32
22_G124_F0.7680.32
95_G159_M0.7680.32
129_G171_Y0.7650.31
7_Y10_F0.7590.31
45_W215_P0.7550.31
38_E206_G0.7550.31
109_C179_D0.7550.31
28_D207_S0.7520.31
32_M38_E0.7440.30
90_G135_L0.7420.30
21_Q165_Y0.7420.30
135_L138_E0.7370.30
171_Y179_D0.7370.30
125_L170_L0.7340.30
13_S127_R0.7340.30
103_A208_D0.7330.30
89_A115_K0.7290.29
143_L215_P0.7290.29
12_L53_L0.7270.29
120_V127_R0.7260.29
25_P122_M0.7260.29
49_N119_Y0.7250.29
69_L76_W0.7210.29
165_Y216_W0.7180.29
174_S200_F0.7140.29
72_L76_W0.7100.28
90_G206_G0.7100.28
62_D91_G0.7080.28
115_K128_V0.7050.28
115_K154_Y0.7020.28
159_M212_A0.6930.27
56_T117_W0.6920.27
113_G164_A0.6880.27
64_G69_L0.6820.27
39_F43_S0.6820.27
120_V151_A0.6810.27
40_E124_F0.6770.27
58_Y146_R0.6710.26
36_I47_I0.6710.26
145_S151_A0.6690.26
13_S209_R0.6660.26
9_L133_K0.6650.26
134_W201_E0.6630.26
8_L214_L0.6610.26
57_I86_A0.6600.26
57_I178_E0.6600.26
164_A196_G0.6600.26
60_M169_R0.6570.25
20_N117_W0.6530.25
69_L173_Q0.6470.25
80_S170_L0.6410.25
77_H207_S0.6400.25
7_Y52_D0.6390.25
17_E23_C0.6390.25
63_D119_Y0.6380.24
66_A115_K0.6370.24
65_H71_G0.6360.24
42_S89_A0.6360.24
9_L161_Y0.6350.24
31_K37_K0.6280.24
112_G157_S0.6260.24
70_A113_G0.6260.24
22_G86_A0.6250.24
38_E130_V0.6250.24
34_T160_H0.6240.24
43_S198_R0.6230.24
11_A24_K0.6220.24
11_A203_L0.6210.24
140_S144_Q0.6210.24
15_P129_G0.6160.23
125_L172_W0.6130.23
12_L161_Y0.6120.23
25_P141_L0.6120.23
13_S17_E0.6100.23
158_W209_R0.6020.23
50_R198_R0.6000.23
60_M132_N0.5980.22
115_K119_Y0.5980.22
99_T103_A0.5960.22
120_V144_Q0.5910.22
53_L126_S0.5900.22
9_L13_S0.5900.22
8_L113_G0.5890.22
63_D150_R0.5890.22
82_E85_K0.5810.22
98_Y105_T0.5810.22
128_V132_N0.5800.22
57_I126_S0.5780.22
80_S92_S0.5730.21
43_S160_H0.5710.21
136_T140_S0.5710.21
85_K96_L0.5700.21
52_D126_S0.5680.21
118_D165_Y0.5670.21
133_K138_E0.5670.21
42_S197_S0.5670.21
42_S195_A0.5660.21
17_E56_T0.5640.21
17_E22_G0.5640.21
15_P66_A0.5630.21
193_D200_F0.5580.21
66_A199_M0.5580.21
10_F133_K0.5570.21
9_L20_N0.5550.20
109_C165_Y0.5540.20
78_R160_H0.5530.20
54_I129_G0.5530.20
55_Q90_G0.5500.20
42_S119_Y0.5490.20
66_A69_L0.5480.20
43_S58_Y0.5460.20
35_G139_E0.5450.20
54_I138_E0.5430.20
28_D134_W0.5430.20
157_S193_D0.5430.20
102_V139_E0.5420.20
27_H127_R0.5390.20
33_Y123_G0.5390.20
113_G168_G0.5380.20
56_T121_R0.5370.20
121_R139_E0.5350.20
110_G162_F0.5350.20
119_Y161_Y0.5350.20
147_V177_C0.5350.20
80_S203_L0.5340.20
40_E172_W0.5320.19
46_G80_S0.5300.19
160_H207_S0.5290.19
14_A96_L0.5260.19
123_G211_Y0.5240.19
26_A38_E0.5220.19
42_S152_H0.5210.19
85_K114_I0.5210.19
89_A95_G0.5200.19
120_V124_F0.5200.19
163_S197_S0.5190.19
14_A17_E0.5190.19
124_F161_Y0.5190.19
129_G141_L0.5170.19
122_M147_V0.5150.19
66_A142_W0.5110.19
111_E173_Q0.5100.19
211_Y215_P0.5080.18
73_Y161_Y0.5080.18
136_T160_H0.5070.18
8_L217_Q0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q4oA 2 0.6213 16.4 0.952 Contact Map
3a5fA 3 0.6511 13.3 0.954 Contact Map
2yxgA 3 0.6468 11.1 0.956 Contact Map
3cprA 3 0.7021 10.5 0.956 Contact Map
4fhaA 3 0.6723 8.9 0.957 Contact Map
4ly8A 3 0.6638 8.9 0.957 Contact Map
2rfgA 3 0.6468 8.7 0.958 Contact Map
4i7wA 3 0.6468 8.5 0.958 Contact Map
4dppA 3 0.6638 7.9 0.958 Contact Map
4pfmA 2 0.6553 7.7 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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