GREMLIN Database
ALLC - Allantoate amidohydrolase
UniProt: P77425 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13623
Length: 411 (398)
Sequences: 4167 (3078)
Seq/√Len: 154.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
241_A315_I4.1401.00
339_T351_V3.7501.00
65_R119_E3.4491.00
47_M64_G3.4391.00
376_S388_T2.9991.00
200_N350_R2.9881.00
78_S100_A2.9461.00
250_V313_M2.9171.00
340_E406_Q2.8941.00
42_Q46_R2.8851.00
344_R402_L2.8311.00
78_S404_L2.8001.00
159_N164_A2.7781.00
220_L245_I2.7301.00
12_T105_D2.6411.00
37_L41_Q2.6341.00
95_F393_L2.6211.00
345_E402_L2.5071.00
44_K62_L2.3221.00
66_L114_P2.2841.00
344_R406_Q2.2151.00
223_E236_R2.2151.00
44_K48_A2.2131.00
8_A102_L2.1481.00
160_S163_D2.1381.00
338_L403_M2.1321.00
66_L108_K2.1241.00
70_E115_L2.1211.00
244_R312_E2.1011.00
50_S101_W2.0651.00
35_E38_E2.0331.00
377_I387_R2.0281.00
208_N351_V2.0231.00
69_T115_L2.0211.00
103_A404_L2.0201.00
104_I120_V2.0051.00
270_R280_K1.9551.00
374_I388_T1.9501.00
248_Q305_D1.9501.00
106_W110_Q1.9371.00
388_T393_L1.9191.00
219_T280_K1.9101.00
380_I383_N1.9091.00
42_Q45_K1.8951.00
260_L298_F1.8791.00
179_P182_D1.8451.00
334_L370_C1.8371.00
331_N368_P1.8321.00
34_P167_A1.8281.00
217_T320_D1.8261.00
116_R184_K1.8161.00
15_W42_Q1.7931.00
11_E15_W1.7711.00
53_E67_N1.7681.00
62_L122_A1.7631.00
34_P38_E1.7621.00
9_I397_V1.7511.00
221_N280_K1.7451.00
339_T343_E1.7191.00
46_R49_A1.7181.00
164_A167_A1.7041.00
268_E282_T1.6951.00
305_D308_A1.6871.00
387_R390_I1.6811.00
308_A312_E1.6761.00
7_Q11_E1.6701.00
106_W401_A1.6661.00
43_F82_I1.6631.00
91_L387_R1.6451.00
75_V117_T1.6341.00
292_A327_P1.6141.00
299_T303_E1.6111.00
245_I306_M1.6011.00
41_Q170_F1.5871.00
9_I98_L1.5851.00
15_W18_S1.5681.00
45_K49_A1.5661.00
244_R313_M1.5651.00
107_L112_G1.5611.00
45_K48_A1.5501.00
220_L283_F1.5461.00
338_L372_I1.5291.00
204_I399_T1.5271.00
225_N230_T1.5271.00
221_N316_G1.5271.00
70_E73_Q1.5271.00
26_G29_R1.5221.00
187_V407_L1.5091.00
376_S392_D1.5041.00
77_L121_V1.5011.00
187_V403_M1.4831.00
300_Q304_N1.4741.00
203_S392_D1.4661.00
47_M101_W1.4631.00
52_L66_L1.4581.00
203_S348_N1.4551.00
78_S103_A1.4511.00
184_K187_V1.4451.00
73_Q116_R1.4411.00
146_N149_D1.4361.00
10_E14_P1.4361.00
337_T406_Q1.4231.00
67_N117_T1.4191.00
181_Q184_K1.4131.00
335_V351_V1.4121.00
43_F64_G1.4081.00
108_K114_P1.4071.00
341_L399_T1.3831.00
44_K54_T1.3771.00
99_A397_V1.3721.00
136_W161_F1.3611.00
107_L114_P1.3601.00
255_R301_Q1.3571.00
106_W398_K1.3571.00
253_A262_L1.3571.00
82_I122_A1.3551.00
239_V267_V1.3551.00
69_T113_A1.3551.00
77_L183_I1.3471.00
303_E307_R1.3431.00
239_V281_T1.3391.00
244_R251_E1.3301.00
304_N308_A1.3301.00
227_A263_T1.3261.00
59_V140_N1.3111.00
248_Q251_E1.3091.00
84_T94_Q1.3071.00
80_S97_A1.3011.00
321_L324_D1.3001.00
402_L406_Q1.2981.00
144_L365_P1.2981.00
360_A369_T1.2971.00
78_S187_V1.2951.00
181_Q187_V1.2881.00
238_T281_T1.2801.00
217_T282_T1.2771.00
199_S234_Y1.2771.00
17_S90_N1.2741.00
52_L104_I1.2741.00
219_T318_D1.2741.00
341_L406_Q1.2741.00
219_T282_T1.2701.00
394_A398_K1.2681.00
221_N318_D1.2581.00
20_G35_E1.2531.00
36_W40_Q1.2511.00
249_S262_L1.2441.00
240_Y250_V1.2441.00
260_L289_H1.2371.00
125_E128_G1.2301.00
310_C317_I1.2251.00
155_D159_N1.2151.00
44_K56_F1.2141.00
12_T102_L1.2141.00
186_F360_A1.2131.00
246_C267_V1.2111.00
242_F246_C1.2091.00
179_P183_I1.2031.00
377_I389_N1.1941.00
130_R155_D1.1931.00
343_E349_Y1.1871.00
240_Y246_C1.1811.00
245_I283_F1.1801.00
12_T46_R1.1791.00
148_D151_R1.1781.00
231_P234_Y1.1721.00
244_R247_H1.1711.00
297_D301_Q1.1691.00
163_D166_K1.1661.00
16_L39_T1.1641.00
74_E116_R1.1551.00
104_I118_V1.1501.00
19_F42_Q1.1371.00
239_V269_P1.1361.00
105_D109_T1.1361.00
196_V231_P1.1361.00
269_P281_T1.1311.00
203_S395_E1.1231.00
14_P18_S1.1191.00
202_Q350_R1.1181.00
10_E390_I1.1131.00
242_F267_V1.1100.99
76_V185_A1.1000.99
101_W120_V1.0980.99
162_V166_K1.0870.99
166_K172_L1.0850.99
104_I108_K1.0800.99
76_V116_R1.0720.99
183_I187_V1.0690.99
43_F47_M1.0690.99
246_C264_F1.0650.99
112_G405_Y1.0620.99
338_L370_C1.0610.99
19_F39_T1.0590.99
147_P151_R1.0570.99
38_E41_Q1.0510.99
63_Y121_V1.0510.99
63_Y77_L1.0450.99
220_L242_F1.0440.99
209_A290_T1.0430.99
292_A326_E1.0410.99
64_G67_N1.0340.99
223_E380_I1.0290.99
171_T174_N1.0240.99
305_D309_I1.0200.99
220_L317_I1.0140.99
66_L104_I0.9920.99
20_G87_N0.9900.99
183_I367_V0.9900.99
389_N392_D0.9880.99
15_W46_R0.9870.99
376_S389_N0.9840.99
34_P164_A0.9820.99
50_S105_D0.9820.99
179_P184_K0.9800.99
374_I396_G0.9790.99
148_D152_N0.9780.99
99_A189_L0.9770.99
103_A401_A0.9760.99
95_F189_L0.9750.99
68_G117_T0.9740.99
41_Q44_K0.9740.99
135_F362_I0.9740.99
37_L168_C0.9720.99
398_K402_L0.9660.99
31_L36_W0.9650.99
154_C160_S0.9610.99
230_T277_V0.9600.99
61_N64_G0.9560.98
61_N137_G0.9550.98
341_L402_L0.9530.98
306_M317_I0.9520.98
342_C399_T0.9480.98
236_R316_G0.9440.98
30_L37_L0.9430.98
347_L395_E0.9430.98
335_V370_C0.9400.98
341_L345_E0.9380.98
86_V273_T0.9350.98
43_F122_A0.9340.98
216_Y299_T0.9280.98
20_G25_G0.9240.98
343_E348_N0.9220.98
397_V401_A0.9200.98
175_A178_T0.9200.98
43_F120_V0.9190.98
340_E344_R0.9170.98
10_E91_L0.9110.98
180_R183_I0.9110.98
256_M297_D0.9030.98
251_E255_R0.9030.98
161_F164_A0.9020.98
206_V338_L0.9010.98
242_F283_F0.9000.98
19_F38_E0.8940.98
330_M369_T0.8930.98
16_L94_Q0.8870.98
183_I186_F0.8780.97
269_P272_N0.8740.97
150_V396_G0.8690.97
65_R75_V0.8670.97
395_E398_K0.8650.97
24_A29_R0.8630.97
336_A340_E0.8570.97
335_V339_T0.8570.97
99_A400_L0.8560.97
363_F367_V0.8540.97
225_N277_V0.8530.97
289_H294_V0.8520.97
183_I189_L0.8520.97
189_L396_G0.8520.97
332_K336_A0.8500.97
30_L33_S0.8490.97
296_R324_D0.8420.97
13_L17_S0.8340.96
151_R162_V0.8280.96
380_I385_A0.8280.96
99_A396_G0.8260.96
292_A296_R0.8240.96
220_L315_I0.8230.96
162_V165_M0.8200.96
345_E398_K0.8150.96
41_Q45_K0.8130.96
82_I94_Q0.8100.96
135_F139_K0.8100.96
391_T395_E0.8090.96
18_S21_A0.8040.96
193_Q196_V0.8040.96
242_F264_F0.8030.96
146_N150_V0.8000.95
66_L107_L0.7990.95
252_K301_Q0.7980.95
218_V285_I0.7940.95
163_D167_A0.7900.95
184_K189_L0.7880.95
16_L98_L0.7870.95
46_R50_S0.7850.95
40_Q62_L0.7830.95
32_Y60_G0.7820.95
130_R362_I0.7820.95
202_Q348_N0.7800.95
260_L294_V0.7800.95
371_M381_S0.7780.95
249_S283_F0.7760.95
74_E184_K0.7750.95
14_P90_N0.7740.95
11_E14_P0.7730.95
149_D153_I0.7730.95
36_W124_A0.7730.95
142_F366_R0.7730.95
67_N72_P0.7720.94
219_T320_D0.7690.94
285_I302_L0.7660.94
193_Q204_I0.7650.94
135_F213_Q0.7640.94
337_T341_L0.7640.94
64_G68_G0.7630.94
198_E202_Q0.7620.94
65_R117_T0.7590.94
85_V123_M0.7580.94
16_L43_F0.7580.94
310_C315_I0.7570.94
270_R282_T0.7540.94
55_R63_Y0.7480.94
142_F363_F0.7470.93
25_G29_R0.7400.93
300_Q303_E0.7400.93
55_R119_E0.7400.93
252_K255_R0.7360.93
32_Y124_A0.7360.93
294_V297_D0.7360.93
54_T62_L0.7360.93
193_Q197_L0.7340.93
47_M54_T0.7310.93
52_L64_G0.7310.93
57_D61_N0.7300.93
206_V335_V0.7290.93
245_I310_C0.7290.93
335_V338_L0.7280.93
218_V319_I0.7240.92
66_L113_A0.7240.92
137_G140_N0.7200.92
262_L287_C0.7180.92
52_L101_W0.7170.92
229_T261_V0.7170.92
252_K298_F0.7160.92
47_M104_I0.7150.92
179_P185_A0.7150.92
187_V190_H0.7140.92
304_N307_R0.7140.92
152_N160_S0.7140.92
187_V400_L0.7130.92
220_L241_A0.7110.92
52_L108_K0.7100.92
388_T392_D0.7090.92
166_K171_T0.7090.92
129_S276_V0.7080.92
139_K145_A0.7070.91
58_E147_P0.7070.91
148_D153_I0.7040.91
123_M186_F0.7040.91
251_E305_D0.7040.91
200_N203_S0.7040.91
196_V200_N0.7030.91
229_T356_A0.7030.91
40_Q124_A0.7020.91
218_V306_M0.7020.91
296_R300_Q0.7010.91
30_L129_S0.6990.91
27_M30_L0.6980.91
182_D185_A0.6960.91
136_W139_K0.6960.91
82_I97_A0.6960.91
50_S108_K0.6950.91
125_E133_Y0.6950.91
287_C298_F0.6940.91
48_A53_E0.6930.91
218_V283_F0.6920.91
346_K349_Y0.6890.90
343_E346_K0.6870.90
107_L113_A0.6870.90
252_K305_D0.6860.90
160_S164_A0.6860.90
266_K284_T0.6850.90
216_Y319_I0.6830.90
24_A384_P0.6830.90
266_K272_N0.6820.90
63_Y141_I0.6820.90
135_F138_S0.6780.90
28_T87_N0.6780.90
247_H250_V0.6760.90
78_S118_V0.6760.90
220_L310_C0.6750.89
43_F97_A0.6740.89
337_T340_E0.6740.89
340_E343_E0.6740.89
159_N167_A0.6740.89
398_K401_A0.6730.89
155_D158_G0.6730.89
179_P187_V0.6730.89
342_C349_Y0.6720.89
145_A150_V0.6700.89
293_A296_R0.6700.89
217_T322_W0.6680.89
123_M363_F0.6680.89
239_V242_F0.6670.89
337_T407_L0.6660.89
79_G359_D0.6640.89
190_H193_Q0.6630.89
243_S247_H0.6620.89
172_L175_A0.6590.88
389_N393_L0.6580.88
224_S238_T0.6580.88
182_D187_V0.6550.88
198_E378_N0.6540.88
102_L106_W0.6530.88
223_E277_V0.6530.88
8_A109_T0.6520.88
182_D189_L0.6510.88
374_I393_L0.6500.88
375_P392_D0.6490.88
17_S27_M0.6480.88
204_I375_P0.6450.87
106_W109_T0.6450.87
214_R299_T0.6440.87
62_L67_N0.6440.87
125_E136_W0.6420.87
152_N351_V0.6400.87
22_D25_G0.6390.87
110_Q401_A0.6380.87
390_I394_A0.6360.87
363_F366_R0.6350.86
140_N150_V0.6350.86
66_L112_G0.6350.86
102_L105_D0.6330.86
37_L56_F0.6290.86
26_G30_L0.6280.86
307_R310_C0.6280.86
28_T31_L0.6270.86
12_T15_W0.6250.86
95_F374_I0.6250.86
147_P150_V0.6240.85
243_S246_C0.6230.85
401_A405_Y0.6210.85
239_V278_P0.6210.85
339_T349_Y0.6190.85
21_A24_A0.6180.85
55_R65_R0.6170.85
43_F101_W0.6160.85
60_G64_G0.6160.85
238_T279_G0.6160.85
309_I313_M0.6160.85
392_D395_E0.6150.85
139_K362_I0.6150.85
41_Q56_F0.6150.85
336_A339_T0.6130.84
125_E227_A0.6130.84
332_K365_P0.6120.84
341_L403_M0.6120.84
46_R101_W0.6110.84
211_V290_T0.6100.84
100_A120_V0.6090.84
239_V243_S0.6090.84
181_Q185_A0.6090.84
201_G204_I0.6080.84
220_L306_M0.6060.84
228_G265_G0.6050.84
62_L65_R0.6030.84
12_T42_Q0.6030.84
223_E378_N0.6010.83
336_A351_V0.5990.83
249_S285_I0.5980.83
147_P156_A0.5960.83
110_Q405_Y0.5920.82
249_S264_F0.5920.82
141_I363_F0.5910.82
56_F62_L0.5900.82
101_W104_I0.5890.82
372_I396_G0.5890.82
68_G73_Q0.5890.82
136_W153_I0.5890.82
195_C199_S0.5880.82
199_S233_G0.5860.82
192_E197_L0.5860.82
336_A343_E0.5850.82
204_I395_E0.5850.82
19_F35_E0.5840.82
16_L82_I0.5840.82
159_N163_D0.5830.81
165_M169_G0.5830.81
111_Y114_P0.5830.81
214_R295_L0.5830.81
203_S375_P0.5810.81
180_R185_A0.5800.81
357_G361_Q0.5790.81
244_R248_Q0.5770.81
245_I317_I0.5760.81
54_T64_G0.5760.81
241_A309_I0.5750.81
231_P355_G0.5740.80
236_R314_D0.5730.80
9_I13_L0.5720.80
59_V147_P0.5710.80
24_A30_L0.5680.80
149_D152_N0.5670.80
291_D294_V0.5670.80
240_Y313_M0.5670.80
216_Y321_L0.5660.79
48_A54_T0.5660.79
69_T72_P0.5660.79
32_Y36_W0.5640.79
146_N151_R0.5620.79
151_R158_G0.5620.79
190_H194_G0.5610.79
155_D353_H0.5580.79
144_L147_P0.5580.79
152_N157_K0.5560.78
27_M94_Q0.5550.78
131_F155_D0.5540.78
187_V404_L0.5540.78
64_G120_V0.5540.78
22_D87_N0.5540.78
153_I354_S0.5520.78
240_Y247_H0.5520.78
290_T353_H0.5510.78
13_L98_L0.5510.78
387_R393_L0.5510.78
151_R171_T0.5510.78
225_N235_R0.5490.77
372_I400_L0.5480.77
396_G400_L0.5480.77
76_V184_K0.5480.77
271_P278_P0.5470.77
84_T90_N0.5450.77
59_V137_G0.5440.77
95_F99_A0.5440.77
227_A265_G0.5440.77
207_V212_G0.5430.77
69_T117_T0.5430.77
194_G197_L0.5430.77
164_A168_C0.5430.77
85_V273_T0.5420.77
24_A27_M0.5420.77
128_G135_F0.5410.76
161_F165_M0.5410.76
204_I347_L0.5390.76
94_Q122_A0.5380.76
136_W150_V0.5360.76
193_Q207_V0.5350.76
152_N162_V0.5350.76
17_S21_A0.5340.75
23_P131_F0.5340.75
81_H92_D0.5340.75
248_Q309_I0.5330.75
239_V246_C0.5310.75
232_M261_V0.5310.75
165_M168_C0.5290.75
196_V234_Y0.5280.75
218_V317_I0.5270.75
151_R157_K0.5260.74
361_Q364_A0.5250.74
297_D300_Q0.5250.74
211_V215_R0.5240.74
146_N156_A0.5200.74
49_A105_D0.5200.74
303_E319_I0.5200.74
33_S36_W0.5200.74
8_A12_T0.5200.74
9_I394_A0.5190.73
181_Q191_I0.5180.73
225_N380_I0.5180.73
61_N121_V0.5180.73
84_T393_L0.5180.73
256_M301_Q0.5160.73
337_T403_M0.5150.73
188_E192_E0.5130.73
24_A28_T0.5120.72
192_E205_G0.5120.72
210_I213_Q0.5120.72
299_T302_L0.5100.72
148_D157_K0.5100.72
333_E337_T0.5100.72
334_L337_T0.5100.72
108_K111_Y0.5090.72
244_R309_I0.5070.72
91_L393_L0.5070.72
53_E65_R0.5060.72
345_E395_E0.5060.72
210_I361_Q0.5050.71
90_N94_Q0.5040.71
55_R140_N0.5030.71
10_E394_A0.5030.71
41_Q48_A0.5020.71
125_E129_S0.5010.71
187_V334_L0.5000.71
17_S20_G0.5000.71
107_L110_Q0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pxdA 2 0.9976 100 0.35 Contact Map
3n5fA 2 0.983 100 0.355 Contact Map
4wjbA 2 0.9927 100 0.355 Contact Map
2v8hA 2 0.9903 100 0.367 Contact Map
4pxeA 2 0.9976 100 0.369 Contact Map
3khxA 1 0.8735 100 0.463 Contact Map
1lfwA 1 0.9538 100 0.471 Contact Map
3gb0A 2 0.8321 100 0.479 Contact Map
3ifeA 2 0.8613 100 0.481 Contact Map
3rzaA 2 0.8273 100 0.481 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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