GREMLIN Database
WCAA - Putative colanic acid biosynthesis glycosyl transferase WcaA
UniProt: P77414 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13569
Length: 279 (228)
Sequences: 31938 (27672)
Seq/√Len: 1832.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_R94_D3.2611.00
164_A168_K3.1991.00
17_Q47_W2.5971.00
67_N79_Q2.5391.00
105_V200_E2.4791.00
183_D187_R2.4571.00
79_Q83_L2.3981.00
41_D66_H2.2631.00
8_S86_G2.2621.00
99_T204_I2.2591.00
82_M171_L2.2171.00
13_T48_E2.1791.00
88_Y110_K2.1751.00
36_E63_T2.1261.00
71_S75_A2.1221.00
31_D104_S2.0901.00
67_N71_S2.0871.00
40_V80_A2.0791.00
116_H196_W2.0541.00
11_M37_M2.0341.00
22_R206_H1.9941.00
10_Y80_A1.9781.00
21_I25_K1.9041.00
22_R97_E1.8571.00
15_N45_T1.8351.00
109_H196_W1.8161.00
7_I107_L1.8021.00
75_A174_T1.7961.00
65_I83_L1.7921.00
98_W102_R1.7871.00
8_S36_E1.7791.00
124_Y204_I1.7541.00
90_T161_F1.7441.00
77_R93_D1.7411.00
109_H198_V1.7371.00
106_F161_F1.7291.00
166_R193_G1.7061.00
117_A163_W1.6721.00
49_Q66_H1.6661.00
52_Q55_T1.6621.00
97_E204_I1.6611.00
11_M23_A1.6601.00
101_N105_V1.6501.00
67_N75_A1.6301.00
102_R106_F1.5991.00
90_T103_L1.5721.00
6_L87_E1.5671.00
41_D44_S1.5341.00
79_Q82_M1.5281.00
90_T102_R1.5251.00
32_Y107_L1.5221.00
92_I98_W1.5201.00
73_A77_R1.5161.00
25_K29_R1.5101.00
65_I79_Q1.4761.00
63_T83_L1.4671.00
74_C180_Q1.4601.00
13_T39_I1.4571.00
14_W70_N1.4561.00
47_W50_L1.4541.00
88_Y161_F1.4481.00
49_Q64_Y1.4051.00
51_Q55_T1.4041.00
7_I103_L1.3991.00
6_L34_N1.3941.00
118_F195_P1.3891.00
173_D183_D1.3651.00
36_E86_G1.3591.00
110_K161_F1.3581.00
104_S108_A1.3521.00
13_T16_R1.3511.00
77_R91_G1.3501.00
89_I164_A1.3301.00
169_E191_E1.3251.00
105_V108_A1.3251.00
117_A193_G1.3181.00
39_I52_Q1.3101.00
32_Y35_W1.3071.00
53_Y57_L1.2991.00
165_W169_E1.2891.00
21_I54_V1.2891.00
49_Q53_Y1.2721.00
50_L54_V1.2691.00
160_V185_F1.2631.00
24_I37_M1.2591.00
87_E163_W1.2561.00
166_R188_M1.2551.00
50_L53_Y1.2461.00
26_S98_W1.2391.00
97_E206_H1.2361.00
67_N76_V1.2351.00
106_F121_A1.2301.00
16_R19_L1.2271.00
81_I167_F1.2261.00
73_A180_Q1.2161.00
8_S84_A1.2071.00
40_V76_V1.2011.00
84_A164_A1.2001.00
81_I91_G1.1821.00
110_K119_L1.1811.00
90_T98_W1.1731.00
53_Y56_A1.1661.00
23_A92_I1.1641.00
42_D70_N1.1581.00
169_E193_G1.1531.00
107_L111_Q1.1521.00
36_E85_Q1.1391.00
53_Y66_H1.1361.00
15_N44_S1.1351.00
13_T94_D1.1311.00
122_N197_K1.1291.00
165_W168_K1.1221.00
126_C204_I1.1101.00
73_A212_M1.1031.00
7_I161_F1.0841.00
124_Y201_A1.0821.00
101_N104_S1.0801.00
29_R100_P1.0611.00
37_M62_I1.0521.00
109_H112_Q1.0521.00
123_D158_N1.0501.00
105_V198_V1.0441.00
108_A112_Q1.0371.00
27_V92_I1.0081.00
102_R121_A1.0061.00
8_S38_I1.0051.00
54_V57_L1.0031.00
167_F184_I0.9931.00
163_W166_R0.9871.00
28_L59_D0.9871.00
12_P76_V0.9821.00
75_A79_Q0.9771.00
25_K28_L0.9751.00
6_L85_Q0.9751.00
115_T194_E0.9591.00
208_N211_E0.9551.00
21_I55_T0.9541.00
31_D101_N0.9521.00
81_I89_I0.9491.00
6_L86_G0.9391.00
106_F119_L0.9341.00
97_E126_C0.9231.00
88_Y107_L0.9161.00
42_D76_V0.9151.00
26_S97_E0.9131.00
63_T85_Q0.9051.00
41_D49_Q0.9021.00
99_T124_Y0.9001.00
118_F188_M0.8991.00
42_D67_N0.8991.00
170_C191_E0.8991.00
102_R202_T0.8961.00
109_H119_L0.8921.00
105_V109_H0.8791.00
77_R180_Q0.8751.00
42_D72_G0.8741.00
117_A194_E0.8701.00
13_T20_A0.8641.00
9_I27_V0.8621.00
225_F229_R0.8591.00
25_K55_T0.8471.00
28_L61_R0.8471.00
28_L62_I0.8441.00
9_I90_T0.8421.00
166_R170_C0.8341.00
71_S76_V0.8241.00
52_Q56_A0.8211.00
35_W103_L0.8191.00
74_C78_N0.8151.00
19_L206_H0.8071.00
117_A166_R0.8051.00
106_F110_K0.8001.00
126_C130_V0.7981.00
24_I39_I0.7981.00
226_H230_K0.7951.00
27_V37_M0.7951.00
43_C67_N0.7931.00
73_A157_G0.7911.00
127_Q131_Y0.7761.00
78_N171_L0.7751.00
157_G172_F0.7701.00
7_I90_T0.7651.00
158_N203_Q0.7641.00
162_T185_F0.7621.00
121_A202_T0.7601.00
6_L111_Q0.7591.00
73_A93_D0.7571.00
40_V79_Q0.7571.00
67_N70_N0.7561.00
51_Q54_V0.7561.00
5_P87_E0.7551.00
27_V98_W0.7551.00
23_A26_S0.7541.00
52_Q64_Y0.7531.00
222_S226_H0.7531.00
99_T102_R0.7511.00
16_R208_N0.7481.00
11_M27_V0.7481.00
31_D100_P0.7461.00
73_A76_V0.7441.00
91_G172_F0.7431.00
17_Q53_Y0.7391.00
50_L55_T0.7381.00
9_I103_L0.7321.00
32_Y104_S0.7311.00
42_D71_S0.7301.00
25_K57_L0.7291.00
166_R169_E0.7281.00
58_N61_R0.7261.00
71_S79_Q0.7201.00
5_P111_Q0.7171.00
146_S149_L0.7151.00
24_I55_T0.7141.00
122_N199_E0.7141.00
125_V207_I0.7141.00
120_Y197_K0.7141.00
81_I84_A0.7101.00
184_I188_M0.7091.00
32_Y103_L0.7021.00
110_K116_H0.7001.00
76_V79_Q0.6941.00
157_G160_V0.6901.00
59_D62_I0.6901.00
21_I51_Q0.6871.00
223_G226_H0.6871.00
20_A94_D0.6861.00
43_C70_N0.6821.00
38_I80_A0.6821.00
12_P94_D0.6801.00
90_T159_Q0.6791.00
17_Q46_S0.6771.00
9_I35_W0.6771.00
54_V58_N0.6751.00
170_C188_M0.6701.00
99_T202_T0.6681.00
51_Q66_H0.6681.00
22_R25_K0.6671.00
17_Q21_I0.6661.00
40_V67_N0.6631.00
17_Q51_Q0.6571.00
47_W52_Q0.6561.00
12_P77_R0.6551.00
38_I63_T0.6511.00
126_C206_H0.6471.00
28_L55_T0.6421.00
23_A95_D0.6371.00
167_F171_L0.6361.00
109_H116_H0.6311.00
98_W103_L0.6301.00
81_I171_L0.6301.00
108_A111_Q0.6281.00
105_V202_T0.6281.00
5_P32_Y0.6281.00
19_L208_N0.6261.00
24_I28_L0.6251.00
87_E165_W0.6241.00
162_T184_I0.6231.00
12_P42_D0.6201.00
121_A159_Q0.6121.00
78_N172_F0.6111.00
96_D205_L0.6101.00
23_A27_V0.6101.00
110_K163_W0.6061.00
222_S225_F0.6061.00
84_A89_I0.6021.00
38_I83_L0.6021.00
173_D187_R0.6021.00
168_K171_L0.6011.00
137_L140_Y0.5941.00
173_D230_K0.5921.00
21_I56_A0.5861.00
13_T50_L0.5831.00
107_L161_F0.5831.00
171_L184_I0.5831.00
63_T66_H0.5801.00
189_V195_P0.5801.00
162_T167_F0.5791.00
226_H229_R0.5781.00
17_Q20_A0.5761.00
179_A182_Y0.5751.00
158_N205_L0.5731.00
14_W42_D0.5731.00
13_T41_D0.5691.00
6_L35_W0.5681.00
30_Q104_S0.5671.00
78_N82_M0.5661.00
88_Y163_W0.5651.00
190_V234_K0.5651.00
120_Y155_I0.5591.00
6_L107_L0.5581.00
39_I62_I0.5561.00
38_I84_A0.5551.00
28_L37_M0.5541.00
10_Y84_A0.5541.00
120_Y160_V0.5541.00
87_E111_Q0.5531.00
207_I214_I0.5531.00
78_N174_T0.5491.00
201_A204_I0.5491.00
188_M193_G0.5491.00
117_A192_Y0.5471.00
198_V201_A0.5461.00
182_Y186_L0.5451.00
131_Y134_P0.5431.00
211_E214_I0.5431.00
27_V30_Q0.5391.00
159_Q203_Q0.5381.00
93_D180_Q0.5351.00
122_N201_A0.5351.00
25_K58_N0.5331.00
21_I58_N0.5321.00
130_V133_Q0.5311.00
55_T58_N0.5291.00
136_S140_Y0.5291.00
166_R192_Y0.5281.00
114_V196_W0.5271.00
136_S139_L0.5261.00
52_Q57_L0.5251.00
14_W43_C0.5251.00
98_W203_Q0.5241.00
173_D176_L0.5231.00
11_M39_I0.5201.00
17_Q50_L0.5191.00
92_I203_Q0.5191.00
225_F228_Y0.5171.00
183_D230_K0.5161.00
127_Q130_V0.5151.00
144_P149_L0.5131.00
107_L110_K0.5111.00
231_H234_K0.5091.00
140_Y145_Y0.5091.00
30_Q103_L0.5071.00
224_Y228_Y0.5061.00
224_Y227_F0.5061.00
10_Y40_V0.5031.00
96_D203_Q0.5031.00
144_P147_R0.5021.00
116_H194_E0.5021.00
6_L32_Y0.5011.00
228_Y231_H0.5011.00
23_A94_D0.5011.00
23_A96_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bcvA 2 0.6416 100 0.267 Contact Map
2d7iA 1 0.9964 100 0.27 Contact Map
1xhbA 1 0.9642 100 0.281 Contact Map
2z86A 2 0.9104 100 0.282 Contact Map
1qg8A 1 0.7885 100 0.284 Contact Map
5ajoA 1 0.9857 100 0.289 Contact Map
3l7iA 4 0 100 0.292 Contact Map
4fixA 3 0.9857 100 0.36 Contact Map
3ckjA 2 0.9462 100 0.389 Contact Map
4p02A 1 0.9534 100 0.42 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0095 seconds.