PHSC - ECOLI - GREMLIN Contacts

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PHSC - Protein PhsC homolog

UniProt:	P77409	Sequences: MNPSQHAEQFQSQLANYVPQFTPEFWPVWLIIAGVLLVGMWLVLGLHALLRARGVKKSATDHGEKIYLYSKAVRLWHWSNALLFVLLLASGLINHFAMVGATAVKSLVAVHEVCGFLLLACWLGFVLINAVGDNGHHYRIRRQGWLERAAKQTRFYLFGIMQGEEHPFPATTQSKFNPLQQVAYVGVMYGLLPLLLLTGLLCLYPQAVGDVFPGVRYWLLQTHFALAFISLFFIFGHLYLCTTGRTPHETFKSMVDGYHRH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13955
Length:	261 (212)
Sequences:	678 (479)
Seq/√Len:	32.9

ECOLI - PHSC FDOI FDNI CYBH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
187_V	229_I	4.205	1.00
119_L	196_L	3.778	1.00
80_N	125_F	3.670	1.00
144_G	181_Q	3.564	1.00
74_R	257_G	3.331	1.00
152_Q	165_E	3.299	1.00
92_L	96_F	3.058	1.00
86_L	110_V	3.054	1.00
86_L	114_C	2.957	1.00
36_L	40_M	2.738	1.00
79_S	83_L	2.558	1.00
42_L	46_L	2.551	1.00
251_F	255_V	2.434	0.99
51_R	54_G	2.372	0.99
71_K	75_L	2.333	0.99
35_V	104_V	2.321	0.99
138_Y	188_M	2.209	0.99
145_W	151_K	2.186	0.99
100_G	104_V	2.166	0.99
115_G	118_L	2.044	0.98
60_T	144_G	1.992	0.98
33_A	44_L	1.989	0.98
31_I	35_V	1.968	0.98
119_L	200_L	1.881	0.97
116_F	120_A	1.775	0.95
65_K	258_Y	1.745	0.95
32_I	35_V	1.728	0.95
35_V	46_L	1.717	0.95
148_R	151_K	1.697	0.94
148_R	189_Y	1.683	0.94
43_V	49_L	1.649	0.93
80_N	121_C	1.623	0.93
42_L	49_L	1.618	0.93
115_G	227_A	1.605	0.92
76_W	128_I	1.576	0.92
149_A	154_R	1.537	0.91
243_T	247_P	1.517	0.90
38_V	46_L	1.501	0.89
196_L	200_L	1.490	0.89
44_L	50_L	1.482	0.89
32_I	38_V	1.476	0.89
145_W	207_A	1.467	0.88
186_G	233_F	1.454	0.88
32_I	36_L	1.445	0.88
38_V	42_L	1.435	0.87
44_L	51_R	1.433	0.87
46_L	228_F	1.433	0.87
204_Y	209_G	1.415	0.86
67_Y	258_Y	1.408	0.86
78_W	254_M	1.404	0.86
34_G	38_V	1.393	0.86
47_H	50_L	1.373	0.85
67_Y	73_V	1.358	0.84
195_L	226_L	1.332	0.83
175_K	180_Q	1.321	0.82
108_V	112_E	1.310	0.82
65_K	136_H	1.309	0.82
172_T	176_F	1.308	0.82
205_P	208_V	1.295	0.81
150_A	178_P	1.294	0.81
149_A	155_F	1.290	0.81
241_C	246_T	1.281	0.80
172_T	175_K	1.267	0.80
84_F	96_F	1.246	0.78
41_W	235_F	1.238	0.78
142_R	197_L	1.230	0.78
187_V	192_L	1.225	0.77
180_Q	213_P	1.220	0.77
69_Y	176_F	1.204	0.76
32_I	42_L	1.201	0.76
183_A	186_G	1.198	0.76
40_M	44_L	1.196	0.76
180_Q	187_V	1.187	0.75
123_L	127_L	1.175	0.74
98_M	112_E	1.170	0.74
137_H	175_K	1.168	0.74
149_A	185_V	1.161	0.73
55_V	61_D	1.158	0.73
33_A	37_L	1.136	0.72
37_L	46_L	1.111	0.70
29_W	37_L	1.108	0.70
84_F	235_F	1.107	0.70
83_L	117_L	1.100	0.69
180_Q	226_L	1.096	0.69
52_A	56_K	1.092	0.69
236_G	242_T	1.087	0.68
122_W	125_F	1.077	0.68
115_G	140_I	1.074	0.67
123_L	126_V	1.070	0.67
69_Y	76_W	1.069	0.67
213_P	222_T	1.066	0.67
78_W	81_A	1.063	0.66
182_V	235_F	1.056	0.66
106_S	110_V	1.048	0.65
79_S	121_C	1.046	0.65
156_Y	233_F	1.046	0.65
48_A	52_A	1.022	0.63
35_V	39_G	1.019	0.63
36_L	44_L	1.015	0.63
30_L	46_L	1.008	0.62
126_V	196_L	0.998	0.62
77_H	237_H	0.992	0.61
77_H	111_H	0.992	0.61
111_H	237_H	0.992	0.61
43_V	47_H	0.987	0.61
231_L	236_G	0.985	0.60
154_R	166_H	0.983	0.60
129_N	149_A	0.981	0.60
85_V	164_E	0.980	0.60
113_V	222_T	0.980	0.60
74_R	239_Y	0.977	0.60
183_A	234_I	0.971	0.59
177_N	180_Q	0.966	0.59
38_V	41_W	0.960	0.58
198_T	258_Y	0.958	0.58
122_W	164_E	0.942	0.57
204_Y	207_A	0.941	0.57
77_H	199_G	0.939	0.57
199_G	237_H	0.939	0.57
111_H	199_G	0.939	0.57
88_L	234_I	0.937	0.57
205_P	209_G	0.934	0.56
36_L	48_A	0.934	0.56
55_V	248_H	0.932	0.56
67_Y	74_R	0.919	0.55
35_V	40_M	0.917	0.55
88_L	202_C	0.910	0.54
44_L	49_L	0.909	0.54
41_W	85_V	0.908	0.54
187_V	191_L	0.899	0.53
56_K	61_D	0.898	0.53
199_G	257_G	0.897	0.53
109_A	113_V	0.894	0.53
181_Q	185_V	0.886	0.52
198_T	201_L	0.884	0.52
33_A	43_V	0.884	0.52
232_F	235_F	0.882	0.52
129_N	167_P	0.880	0.52
43_V	74_R	0.879	0.52
183_A	240_L	0.872	0.51
49_L	67_Y	0.872	0.51
47_H	51_R	0.866	0.51
68_L	246_T	0.863	0.50
118_L	250_T	0.852	0.50
106_S	109_A	0.827	0.48
45_G	165_E	0.821	0.47
136_H	182_V	0.818	0.47
94_N	108_V	0.814	0.46
58_S	82_L	0.813	0.46
36_L	106_S	0.809	0.46
118_L	192_L	0.807	0.46
29_W	36_L	0.806	0.46
83_L	90_S	0.803	0.46
195_L	230_S	0.801	0.45
116_F	203_L	0.799	0.45
58_S	150_A	0.798	0.45
68_L	259_H	0.795	0.45
48_A	53_R	0.795	0.45
79_S	124_G	0.788	0.44
105_K	227_A	0.785	0.44
77_H	257_G	0.785	0.44
111_H	257_G	0.785	0.44
237_H	257_G	0.785	0.44
202_C	242_T	0.782	0.44
137_H	233_F	0.777	0.43
98_M	217_Y	0.774	0.43
90_S	189_Y	0.772	0.43
41_W	44_L	0.767	0.43
46_L	49_L	0.767	0.43
180_Q	247_P	0.764	0.42
140_I	178_P	0.762	0.42
129_N	173_Q	0.762	0.42
93_I	104_V	0.760	0.42
223_H	237_H	0.755	0.42
111_H	223_H	0.755	0.42
77_H	223_H	0.755	0.42
50_L	53_R	0.755	0.42
129_N	155_F	0.754	0.42
143_Q	227_A	0.752	0.41
139_R	211_V	0.749	0.41
47_H	54_G	0.746	0.41
93_I	107_L	0.744	0.41
153_T	157_L	0.743	0.41
139_R	145_W	0.741	0.40
177_N	240_L	0.739	0.40
75_L	79_S	0.736	0.40
41_W	45_G	0.733	0.40
66_I	198_T	0.733	0.40
49_L	62_H	0.731	0.40
156_Y	177_N	0.730	0.40
222_T	226_L	0.727	0.39
175_K	243_T	0.725	0.39
66_I	153_T	0.725	0.39
87_L	115_G	0.725	0.39
186_G	191_L	0.724	0.39
33_A	36_L	0.724	0.39
183_A	233_F	0.721	0.39
43_V	228_F	0.719	0.39
37_L	235_F	0.711	0.38
68_L	158_F	0.710	0.38
85_V	89_A	0.710	0.38
92_L	243_T	0.707	0.38
35_V	49_L	0.706	0.38
34_G	43_V	0.705	0.38
70_S	73_V	0.702	0.37
79_S	234_I	0.702	0.37
117_L	140_I	0.701	0.37
69_Y	249_E	0.700	0.37
199_G	223_H	0.700	0.37
188_M	258_Y	0.697	0.37
82_L	89_A	0.692	0.37
189_Y	203_L	0.691	0.37
66_I	113_V	0.690	0.36
154_R	164_E	0.690	0.36
190_G	229_I	0.690	0.36
45_G	235_F	0.684	0.36
31_I	90_S	0.681	0.36
84_F	234_I	0.680	0.36
38_V	44_L	0.680	0.36
29_W	220_L	0.678	0.36
112_E	217_Y	0.677	0.35
30_L	233_F	0.677	0.35
126_V	130_A	0.671	0.35
81_A	238_L	0.671	0.35
58_S	143_Q	0.661	0.34
202_C	220_L	0.656	0.34
154_R	179_L	0.654	0.34
85_V	200_L	0.653	0.34
190_G	234_I	0.652	0.34
40_M	120_A	0.651	0.34
122_W	256_D	0.650	0.33
117_L	151_K	0.649	0.33
228_F	235_F	0.649	0.33
112_E	216_R	0.648	0.33
46_L	123_L	0.645	0.33
182_V	197_L	0.642	0.33
90_S	232_F	0.642	0.33
130_A	141_R	0.640	0.33
221_Q	225_A	0.640	0.33
230_S	240_L	0.637	0.32
150_A	157_L	0.628	0.32
81_A	254_M	0.627	0.32
80_N	188_M	0.626	0.32
149_A	238_L	0.624	0.32
40_M	49_L	0.624	0.32
73_V	80_N	0.620	0.31
34_G	53_R	0.616	0.31
124_G	182_V	0.613	0.31
156_Y	240_L	0.612	0.31
204_Y	211_V	0.606	0.30
50_L	148_R	0.605	0.30
68_L	181_Q	0.604	0.30
228_F	232_F	0.603	0.30
155_F	166_H	0.600	0.30
180_Q	184_Y	0.598	0.30
120_A	225_A	0.594	0.29
34_G	44_L	0.593	0.29
64_E	232_F	0.593	0.29
155_F	173_Q	0.593	0.29
58_S	139_R	0.592	0.29
104_V	116_F	0.588	0.29
234_I	243_T	0.588	0.29
172_T	253_S	0.585	0.29
173_Q	254_M	0.584	0.29
180_Q	252_K	0.584	0.29
46_L	61_D	0.582	0.29
30_L	39_G	0.581	0.29
45_G	123_L	0.581	0.29
158_F	164_E	0.580	0.28
43_V	50_L	0.576	0.28
75_L	145_W	0.576	0.28
44_L	48_A	0.575	0.28
30_L	38_V	0.573	0.28
144_G	149_A	0.569	0.28
226_L	235_F	0.568	0.28
155_F	249_E	0.567	0.28
88_L	156_Y	0.567	0.28
95_H	217_Y	0.557	0.27
73_V	128_I	0.556	0.27
68_L	180_Q	0.554	0.27
214_G	258_Y	0.553	0.27
155_F	250_T	0.553	0.27
45_G	49_L	0.549	0.26
123_L	183_A	0.546	0.26
61_D	190_G	0.546	0.26
127_L	145_W	0.545	0.26
141_R	174_S	0.543	0.26
73_V	175_K	0.542	0.26
127_L	192_L	0.542	0.26
190_G	195_L	0.541	0.26
187_V	226_L	0.540	0.26
86_L	225_A	0.539	0.26
30_L	33_A	0.538	0.26
153_T	240_L	0.537	0.26
39_G	42_L	0.537	0.26
238_L	249_E	0.535	0.26
82_L	194_L	0.535	0.26
94_N	227_A	0.534	0.25
71_K	140_I	0.533	0.25
91_G	237_H	0.533	0.25
91_G	111_H	0.533	0.25
77_H	91_G	0.533	0.25
48_A	74_R	0.529	0.25
39_G	198_T	0.523	0.25
94_N	208_V	0.523	0.25
218_W	222_T	0.521	0.25
120_A	238_L	0.519	0.25
196_L	204_Y	0.518	0.24
236_G	239_Y	0.515	0.24
176_F	188_M	0.513	0.24
67_Y	71_K	0.512	0.24
222_T	225_A	0.511	0.24
95_H	137_H	0.510	0.24
64_E	254_M	0.508	0.24
197_L	210_D	0.508	0.24
38_V	45_G	0.503	0.24
250_T	254_M	0.501	0.23
108_V	198_T	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1kqfC	3	0.6973	100	0.577	Contact Map
4gd3A	2	0.6015	100	0.597	Contact Map
1pp9C	2	0.682	94.5	0.914	Contact Map
3cx5C	2	0.7126	94.1	0.915	Contact Map
4ogqA	2	0.6935	93.3	0.918	Contact Map
2qjyA	2	0.751	89.7	0.925	Contact Map
4o6yA	2	0.7663	9.8	0.962	Contact Map
2m8rA	1	0.1954	7.7	0.964	Contact Map
4a2nB	1	0.6858	6	0.966	Contact Map
4tllA	1	0.1494	5.2	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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