GREMLIN Database
PHSC - Protein PhsC homolog
UniProt: P77409 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13955
Length: 261 (212)
Sequences: 678 (479)
Seq/√Len: 32.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_V229_I4.2051.00
119_L196_L3.7781.00
80_N125_F3.6701.00
144_G181_Q3.5641.00
74_R257_G3.3311.00
152_Q165_E3.2991.00
92_L96_F3.0581.00
86_L110_V3.0541.00
86_L114_C2.9571.00
36_L40_M2.7381.00
79_S83_L2.5581.00
42_L46_L2.5511.00
251_F255_V2.4340.99
51_R54_G2.3720.99
71_K75_L2.3330.99
35_V104_V2.3210.99
138_Y188_M2.2090.99
145_W151_K2.1860.99
100_G104_V2.1660.99
115_G118_L2.0440.98
60_T144_G1.9920.98
33_A44_L1.9890.98
31_I35_V1.9680.98
119_L200_L1.8810.97
116_F120_A1.7750.95
65_K258_Y1.7450.95
32_I35_V1.7280.95
35_V46_L1.7170.95
148_R151_K1.6970.94
148_R189_Y1.6830.94
43_V49_L1.6490.93
80_N121_C1.6230.93
42_L49_L1.6180.93
115_G227_A1.6050.92
76_W128_I1.5760.92
149_A154_R1.5370.91
243_T247_P1.5170.90
38_V46_L1.5010.89
196_L200_L1.4900.89
44_L50_L1.4820.89
32_I38_V1.4760.89
145_W207_A1.4670.88
186_G233_F1.4540.88
32_I36_L1.4450.88
38_V42_L1.4350.87
44_L51_R1.4330.87
46_L228_F1.4330.87
204_Y209_G1.4150.86
67_Y258_Y1.4080.86
78_W254_M1.4040.86
34_G38_V1.3930.86
47_H50_L1.3730.85
67_Y73_V1.3580.84
195_L226_L1.3320.83
175_K180_Q1.3210.82
108_V112_E1.3100.82
65_K136_H1.3090.82
172_T176_F1.3080.82
205_P208_V1.2950.81
150_A178_P1.2940.81
149_A155_F1.2900.81
241_C246_T1.2810.80
172_T175_K1.2670.80
84_F96_F1.2460.78
41_W235_F1.2380.78
142_R197_L1.2300.78
187_V192_L1.2250.77
180_Q213_P1.2200.77
69_Y176_F1.2040.76
32_I42_L1.2010.76
183_A186_G1.1980.76
40_M44_L1.1960.76
180_Q187_V1.1870.75
123_L127_L1.1750.74
98_M112_E1.1700.74
137_H175_K1.1680.74
149_A185_V1.1610.73
55_V61_D1.1580.73
33_A37_L1.1360.72
37_L46_L1.1110.70
29_W37_L1.1080.70
84_F235_F1.1070.70
83_L117_L1.1000.69
180_Q226_L1.0960.69
52_A56_K1.0920.69
236_G242_T1.0870.68
122_W125_F1.0770.68
115_G140_I1.0740.67
123_L126_V1.0700.67
69_Y76_W1.0690.67
213_P222_T1.0660.67
78_W81_A1.0630.66
182_V235_F1.0560.66
106_S110_V1.0480.65
79_S121_C1.0460.65
156_Y233_F1.0460.65
48_A52_A1.0220.63
35_V39_G1.0190.63
36_L44_L1.0150.63
30_L46_L1.0080.62
126_V196_L0.9980.62
77_H237_H0.9920.61
77_H111_H0.9920.61
111_H237_H0.9920.61
43_V47_H0.9870.61
231_L236_G0.9850.60
154_R166_H0.9830.60
129_N149_A0.9810.60
85_V164_E0.9800.60
113_V222_T0.9800.60
74_R239_Y0.9770.60
183_A234_I0.9710.59
177_N180_Q0.9660.59
38_V41_W0.9600.58
198_T258_Y0.9580.58
122_W164_E0.9420.57
204_Y207_A0.9410.57
77_H199_G0.9390.57
199_G237_H0.9390.57
111_H199_G0.9390.57
88_L234_I0.9370.57
205_P209_G0.9340.56
36_L48_A0.9340.56
55_V248_H0.9320.56
67_Y74_R0.9190.55
35_V40_M0.9170.55
88_L202_C0.9100.54
44_L49_L0.9090.54
41_W85_V0.9080.54
187_V191_L0.8990.53
56_K61_D0.8980.53
199_G257_G0.8970.53
109_A113_V0.8940.53
181_Q185_V0.8860.52
198_T201_L0.8840.52
33_A43_V0.8840.52
232_F235_F0.8820.52
129_N167_P0.8800.52
43_V74_R0.8790.52
183_A240_L0.8720.51
49_L67_Y0.8720.51
47_H51_R0.8660.51
68_L246_T0.8630.50
118_L250_T0.8520.50
106_S109_A0.8270.48
45_G165_E0.8210.47
136_H182_V0.8180.47
94_N108_V0.8140.46
58_S82_L0.8130.46
36_L106_S0.8090.46
118_L192_L0.8070.46
29_W36_L0.8060.46
83_L90_S0.8030.46
195_L230_S0.8010.45
116_F203_L0.7990.45
58_S150_A0.7980.45
68_L259_H0.7950.45
48_A53_R0.7950.45
79_S124_G0.7880.44
105_K227_A0.7850.44
77_H257_G0.7850.44
111_H257_G0.7850.44
237_H257_G0.7850.44
202_C242_T0.7820.44
137_H233_F0.7770.43
98_M217_Y0.7740.43
90_S189_Y0.7720.43
41_W44_L0.7670.43
46_L49_L0.7670.43
180_Q247_P0.7640.42
140_I178_P0.7620.42
129_N173_Q0.7620.42
93_I104_V0.7600.42
223_H237_H0.7550.42
111_H223_H0.7550.42
77_H223_H0.7550.42
50_L53_R0.7550.42
129_N155_F0.7540.42
143_Q227_A0.7520.41
139_R211_V0.7490.41
47_H54_G0.7460.41
93_I107_L0.7440.41
153_T157_L0.7430.41
139_R145_W0.7410.40
177_N240_L0.7390.40
75_L79_S0.7360.40
41_W45_G0.7330.40
66_I198_T0.7330.40
49_L62_H0.7310.40
156_Y177_N0.7300.40
222_T226_L0.7270.39
175_K243_T0.7250.39
66_I153_T0.7250.39
87_L115_G0.7250.39
186_G191_L0.7240.39
33_A36_L0.7240.39
183_A233_F0.7210.39
43_V228_F0.7190.39
37_L235_F0.7110.38
68_L158_F0.7100.38
85_V89_A0.7100.38
92_L243_T0.7070.38
35_V49_L0.7060.38
34_G43_V0.7050.38
70_S73_V0.7020.37
79_S234_I0.7020.37
117_L140_I0.7010.37
69_Y249_E0.7000.37
199_G223_H0.7000.37
188_M258_Y0.6970.37
82_L89_A0.6920.37
189_Y203_L0.6910.37
66_I113_V0.6900.36
154_R164_E0.6900.36
190_G229_I0.6900.36
45_G235_F0.6840.36
31_I90_S0.6810.36
84_F234_I0.6800.36
38_V44_L0.6800.36
29_W220_L0.6780.36
112_E217_Y0.6770.35
30_L233_F0.6770.35
126_V130_A0.6710.35
81_A238_L0.6710.35
58_S143_Q0.6610.34
202_C220_L0.6560.34
154_R179_L0.6540.34
85_V200_L0.6530.34
190_G234_I0.6520.34
40_M120_A0.6510.34
122_W256_D0.6500.33
117_L151_K0.6490.33
228_F235_F0.6490.33
112_E216_R0.6480.33
46_L123_L0.6450.33
182_V197_L0.6420.33
90_S232_F0.6420.33
130_A141_R0.6400.33
221_Q225_A0.6400.33
230_S240_L0.6370.32
150_A157_L0.6280.32
81_A254_M0.6270.32
80_N188_M0.6260.32
149_A238_L0.6240.32
40_M49_L0.6240.32
73_V80_N0.6200.31
34_G53_R0.6160.31
124_G182_V0.6130.31
156_Y240_L0.6120.31
204_Y211_V0.6060.30
50_L148_R0.6050.30
68_L181_Q0.6040.30
228_F232_F0.6030.30
155_F166_H0.6000.30
180_Q184_Y0.5980.30
120_A225_A0.5940.29
34_G44_L0.5930.29
64_E232_F0.5930.29
155_F173_Q0.5930.29
58_S139_R0.5920.29
104_V116_F0.5880.29
234_I243_T0.5880.29
172_T253_S0.5850.29
173_Q254_M0.5840.29
180_Q252_K0.5840.29
46_L61_D0.5820.29
30_L39_G0.5810.29
45_G123_L0.5810.29
158_F164_E0.5800.28
43_V50_L0.5760.28
75_L145_W0.5760.28
44_L48_A0.5750.28
30_L38_V0.5730.28
144_G149_A0.5690.28
226_L235_F0.5680.28
155_F249_E0.5670.28
88_L156_Y0.5670.28
95_H217_Y0.5570.27
73_V128_I0.5560.27
68_L180_Q0.5540.27
214_G258_Y0.5530.27
155_F250_T0.5530.27
45_G49_L0.5490.26
123_L183_A0.5460.26
61_D190_G0.5460.26
127_L145_W0.5450.26
141_R174_S0.5430.26
73_V175_K0.5420.26
127_L192_L0.5420.26
190_G195_L0.5410.26
187_V226_L0.5400.26
86_L225_A0.5390.26
30_L33_A0.5380.26
153_T240_L0.5370.26
39_G42_L0.5370.26
238_L249_E0.5350.26
82_L194_L0.5350.26
94_N227_A0.5340.25
71_K140_I0.5330.25
91_G237_H0.5330.25
91_G111_H0.5330.25
77_H91_G0.5330.25
48_A74_R0.5290.25
39_G198_T0.5230.25
94_N208_V0.5230.25
218_W222_T0.5210.25
120_A238_L0.5190.25
196_L204_Y0.5180.24
236_G239_Y0.5150.24
176_F188_M0.5130.24
67_Y71_K0.5120.24
222_T225_A0.5110.24
95_H137_H0.5100.24
64_E254_M0.5080.24
197_L210_D0.5080.24
38_V45_G0.5030.24
250_T254_M0.5010.23
108_V198_T0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kqfC 3 0.6973 100 0.577 Contact Map
4gd3A 2 0.6015 100 0.597 Contact Map
1pp9C 2 0.682 94.5 0.914 Contact Map
3cx5C 2 0.7126 94.1 0.915 Contact Map
4ogqA 2 0.6935 93.3 0.918 Contact Map
2qjyA 2 0.751 89.7 0.925 Contact Map
4o6yA 2 0.7663 9.8 0.962 Contact Map
2m8rA 1 0.1954 7.7 0.964 Contact Map
4a2nB 1 0.6858 6 0.966 Contact Map
4tllA 1 0.1494 5.2 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0085 seconds.