GREMLIN Database
CITC - [Citrate [pro-3S]-lyase] ligase
UniProt: P77390 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13645
Length: 352 (321)
Sequences: 386 (318)
Seq/√Len: 17.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_R202_D7.4601.00
148_G172_C6.5851.00
41_T48_L5.5761.00
172_C258_F4.4031.00
59_I62_V4.3891.00
148_G258_F4.3051.00
171_Q258_F4.1531.00
241_L275_M3.9231.00
52_G81_L3.8421.00
39_F53_G3.6991.00
325_V329_T3.4411.00
297_L304_I3.3540.99
176_H209_H3.3390.99
194_D198_K3.3360.99
317_D320_A3.3050.99
321_I325_V3.2590.99
166_Q203_I2.8560.98
180_V189_Y2.7380.98
95_I123_M2.6940.98
200_T208_V2.6210.97
20_E43_T2.5420.96
187_F333_L2.5310.96
188_P191_D2.4430.96
54_I85_A2.4350.95
322_A330_L2.3840.95
327_A331_H2.2230.93
175_L258_F2.2120.92
259_V291_L2.1400.91
152_M165_I2.0720.90
166_Q202_D2.0680.90
335_N338_E2.0070.88
85_A93_L2.0060.88
167_Q294_I1.9830.87
146_K173_D1.9600.87
174_W207_T1.9410.86
42_V50_A1.9350.86
167_Q171_Q1.9330.86
269_A273_Q1.9230.86
147_I174_W1.9050.85
321_I330_L1.8850.85
261_T295_E1.8640.84
308_R324_L1.8500.83
181_K211_G1.8160.82
157_F199_G1.8120.82
148_G171_Q1.7790.81
179_L196_V1.7640.80
264_F308_R1.7220.79
203_I206_L1.6950.77
52_G59_I1.6850.77
193_L197_L1.6840.77
256_H292_V1.6640.76
35_T55_A1.6500.75
264_F303_P1.6490.75
112_T115_S1.6430.75
96_Y120_M1.6420.75
245_R288_P1.6090.74
36_V113_L1.5930.73
116_V120_M1.5880.73
21_I39_F1.5720.72
169_A205_R1.5390.70
157_F195_L1.5250.69
162_R166_Q1.5230.69
165_I200_T1.4890.67
27_E65_S1.4870.67
125_N176_H1.4860.67
33_D267_V1.4840.67
303_P324_L1.4730.67
311_Q315_K1.4710.67
147_I173_D1.4520.65
37_E90_S1.4500.65
256_H290_E1.4460.65
39_F51_C1.4430.65
126_S209_H1.4320.64
84_L88_R1.4270.64
125_N209_H1.4230.64
114_T242_K1.4170.64
191_D195_L1.3840.62
178_F254_V1.3690.61
33_D61_C1.3490.60
193_L208_V1.3430.59
188_P335_N1.3380.59
167_Q258_F1.3360.59
172_C175_L1.3260.58
114_T239_I1.3060.57
88_R159_N1.2820.56
102_E112_T1.2820.56
299_Y304_I1.2750.55
230_S266_R1.2530.54
211_G215_I1.2500.54
21_I41_T1.2440.53
126_S129_R1.2380.53
215_I264_F1.2260.52
188_P338_E1.2250.52
122_L130_L1.2240.52
322_A327_A1.2200.52
126_S176_H1.2180.52
181_K189_Y1.2100.51
302_M308_R1.1990.51
129_R209_H1.1890.50
150_I154_A1.1870.50
259_V275_M1.1840.50
178_F215_I1.1740.49
18_M22_A1.1520.48
54_I84_L1.1440.47
279_L289_I1.1430.47
241_L291_L1.1430.47
130_L247_Y1.1410.47
276_R293_E1.1290.46
51_C108_C1.1190.46
61_C176_H1.1010.45
50_A96_Y1.1000.45
188_P333_L1.0940.44
43_T48_L1.0900.44
330_L334_Q1.0740.43
167_Q170_A1.0680.43
101_Y104_L1.0610.42
102_E121_V1.0600.42
44_R196_V1.0590.42
28_N63_A1.0590.42
233_N236_Y1.0560.42
80_E275_M1.0540.42
149_C175_L1.0520.42
22_A32_V1.0510.42
303_P308_R1.0420.41
223_C232_I1.0360.41
147_I209_H1.0340.41
208_V226_I1.0310.40
179_L226_I1.0270.40
59_I121_V1.0260.40
54_I88_R1.0050.39
180_V183_D1.0050.39
148_G175_L1.0000.39
245_R287_P0.9970.38
303_P316_N0.9960.38
166_Q216_I0.9960.38
102_E115_S0.9950.38
58_I96_Y0.9910.38
121_V334_Q0.9860.38
194_D197_L0.9840.38
79_T280_E0.9800.37
99_T115_S0.9780.37
191_D332_Y0.9750.37
199_G328_V0.9750.37
279_L291_L0.9720.37
20_E47_K0.9700.37
24_F48_L0.9690.37
241_L274_D0.9680.37
312_L320_A0.9670.37
24_F28_N0.9660.37
24_F265_C0.9590.36
242_K278_W0.9580.36
165_I177_L0.9510.36
184_S218_R0.9510.36
33_D226_I0.9500.36
101_Y123_M0.9460.36
181_K215_I0.9420.35
189_Y196_V0.9390.35
157_F328_V0.9380.35
133_Y137_L0.9340.35
22_A170_A0.9320.35
106_R123_M0.9300.35
24_F55_A0.9280.35
92_H295_E0.9280.35
180_V185_S0.9270.34
15_N273_Q0.9260.34
211_G237_T0.9260.34
315_K320_A0.9250.34
249_A289_I0.9190.34
198_K201_A0.9180.34
28_N69_R0.9170.34
67_S201_A0.9150.34
245_R280_E0.9130.34
42_V77_L0.9100.34
195_L199_G0.9080.33
280_E288_P0.9050.33
21_I307_S0.9050.33
179_L208_V0.9020.33
49_I68_V0.8970.33
223_C236_Y0.8940.33
93_L209_H0.8940.33
298_R301_E0.8910.33
215_I248_L0.8880.32
195_L332_Y0.8830.32
199_G326_P0.8810.32
261_T293_E0.8780.32
169_A203_I0.8640.31
129_R176_H0.8620.31
253_G292_V0.8620.31
74_A104_L0.8590.31
50_A82_I0.8580.31
24_F104_L0.8530.31
59_I86_Y0.8500.30
50_A219_A0.8440.30
46_E331_H0.8420.30
60_K226_I0.8370.30
120_M315_K0.8360.30
309_V329_T0.8300.29
114_T180_V0.8280.29
147_I176_H0.8250.29
137_L252_L0.8230.29
52_G77_L0.8210.29
59_I134_A0.8180.29
193_L210_R0.8140.29
99_T184_S0.8090.28
35_T50_A0.8090.28
84_L87_E0.8080.28
276_R304_I0.8030.28
130_L243_I0.8030.28
92_H130_L0.7970.28
193_L338_E0.7940.28
198_K331_H0.7870.27
38_V88_R0.7850.27
228_E295_E0.7820.27
148_G195_L0.7820.27
152_M206_L0.7810.27
94_F267_V0.7780.27
130_L261_T0.7770.27
177_L208_V0.7760.27
27_E295_E0.7760.27
120_M275_M0.7760.27
72_G79_T0.7750.27
177_L216_I0.7720.26
162_R294_I0.7680.26
114_T159_N0.7670.26
123_M327_A0.7650.26
61_C96_Y0.7610.26
95_I241_L0.7600.26
106_R112_T0.7580.26
154_A184_S0.7580.26
56_G90_S0.7570.26
204_P319_T0.7540.26
85_A90_S0.7530.26
195_L198_K0.7520.26
204_P216_I0.7520.26
312_L325_V0.7520.26
194_D337_L0.7480.25
129_R237_T0.7460.25
243_I273_Q0.7460.25
146_K213_E0.7460.25
300_Q323_P0.7450.25
35_T216_I0.7450.25
325_V330_L0.7390.25
89_H239_I0.7370.25
111_S126_S0.7320.25
131_K198_K0.7320.25
157_F326_P0.7300.25
72_G98_K0.7270.24
145_N173_D0.7260.24
120_M304_I0.7230.24
216_I333_L0.7190.24
206_L294_I0.7160.24
76_T200_T0.7140.24
93_L125_N0.7140.24
20_E293_E0.7110.24
123_M130_L0.7090.24
42_V52_G0.7070.24
318_L330_L0.7050.23
29_D100_E0.7050.23
176_H307_S0.7030.23
59_I78_A0.7010.23
171_Q294_I0.7010.23
307_S324_L0.7000.23
216_I307_S0.6990.23
52_G62_V0.6970.23
78_A194_D0.6930.23
181_K210_R0.6880.23
50_A111_S0.6880.23
99_T241_L0.6850.23
163_Y297_L0.6850.23
186_R227_K0.6830.22
24_F226_I0.6820.22
259_V293_E0.6810.22
36_V61_C0.6800.22
191_D194_D0.6790.22
126_S236_Y0.6780.22
58_I287_P0.6770.22
201_A299_Y0.6750.22
234_H273_Q0.6750.22
61_C333_L0.6740.22
241_L278_W0.6710.22
154_A265_C0.6700.22
70_G182_E0.6680.22
74_A265_C0.6670.22
72_G232_I0.6660.22
34_T332_Y0.6650.22
320_A325_V0.6640.22
171_Q175_L0.6630.22
59_I81_L0.6620.22
152_M175_L0.6600.22
177_L190_E0.6590.21
159_N321_I0.6580.21
23_Q139_K0.6580.21
194_D331_H0.6570.21
69_R293_E0.6560.21
43_T248_L0.6550.21
233_N267_V0.6540.21
120_M211_G0.6530.21
37_E226_I0.6520.21
135_E339_H0.6510.21
64_I77_L0.6500.21
54_I62_V0.6500.21
236_Y241_L0.6500.21
56_G139_K0.6480.21
144_G173_D0.6440.21
280_E291_L0.6440.21
53_G108_C0.6440.21
71_E216_I0.6440.21
248_L328_V0.6430.21
32_V116_V0.6430.21
144_G252_L0.6420.21
150_I165_I0.6390.21
154_A165_I0.6380.21
108_C231_V0.6340.20
51_C75_L0.6320.20
177_L200_T0.6300.20
47_K289_I0.6270.20
31_S234_H0.6260.20
183_D234_H0.6260.20
319_T322_A0.6210.20
142_H248_L0.6190.20
149_C256_H0.6190.20
154_A245_R0.6180.20
49_I215_I0.6170.20
33_D60_K0.6170.20
273_Q289_I0.6170.20
99_T112_T0.6170.20
14_E165_I0.6160.20
113_L191_D0.6150.20
53_G212_S0.6150.20
93_L176_H0.6150.20
229_Q315_K0.6130.20
96_Y116_V0.6120.20
321_I329_T0.6100.20
68_V113_L0.6090.19
41_T236_Y0.6090.19
132_R216_I0.6060.19
171_Q256_H0.6060.19
270_Q274_D0.6050.19
29_D188_P0.6040.19
32_V154_A0.6030.19
304_I321_I0.6020.19
182_E213_E0.6020.19
28_N265_C0.6010.19
50_A77_L0.6010.19
57_N213_E0.6010.19
108_C235_C0.6010.19
162_R323_P0.6000.19
154_A226_I0.6000.19
64_I233_N0.5990.19
108_C122_L0.5980.19
43_T236_Y0.5970.19
67_S294_I0.5960.19
33_D235_C0.5960.19
66_E69_R0.5960.19
64_I205_R0.5950.19
234_H274_D0.5940.19
200_T206_L0.5930.19
139_K327_A0.5930.19
47_K67_S0.5930.19
22_A135_E0.5910.19
318_L325_V0.5900.19
23_Q243_I0.5900.19
238_E264_F0.5900.19
306_A310_R0.5890.19
83_N177_L0.5890.19
45_D86_Y0.5880.19
246_Q288_P0.5870.19
49_I189_Y0.5860.19
301_E304_I0.5860.19
36_V267_V0.5860.19
169_A202_D0.5850.19
21_I53_G0.5830.19
61_C209_H0.5820.18
158_T309_V0.5800.18
294_I298_R0.5800.18
33_D191_D0.5800.18
30_L154_A0.5790.18
241_L276_R0.5770.18
42_V78_A0.5760.18
76_T273_Q0.5760.18
321_I333_L0.5760.18
134_A178_F0.5760.18
163_Y167_Q0.5750.18
132_R165_I0.5750.18
82_I93_L0.5750.18
95_I216_I0.5740.18
189_Y212_S0.5740.18
159_N180_V0.5730.18
223_C239_I0.5730.18
21_I33_D0.5710.18
254_V316_N0.5710.18
42_V81_L0.5710.18
182_E305_S0.5690.18
57_N200_T0.5680.18
215_I254_V0.5680.18
130_L289_I0.5670.18
74_A95_I0.5660.18
78_A88_R0.5650.18
292_V315_K0.5620.18
116_V238_E0.5620.18
32_V69_R0.5620.18
21_I79_T0.5610.18
134_A261_T0.5600.18
188_P288_P0.5580.18
55_A113_L0.5570.18
149_C213_E0.5570.18
123_M189_Y0.5560.18
215_I236_Y0.5550.18
166_Q170_A0.5550.18
34_T49_I0.5530.17
183_D261_T0.5520.17
167_Q174_W0.5520.17
193_L243_I0.5520.17
104_L154_A0.5500.17
191_D337_L0.5480.17
130_L249_A0.5470.17
133_Y249_A0.5430.17
93_L147_I0.5410.17
142_H174_W0.5410.17
71_E201_A0.5400.17
40_I227_K0.5390.17
136_S139_K0.5380.17
223_C265_C0.5380.17
183_D243_I0.5380.17
85_A275_M0.5380.17
159_N206_L0.5370.17
204_P292_V0.5370.17
61_C182_E0.5360.17
245_R250_P0.5360.17
21_I32_V0.5350.17
65_S226_I0.5340.17
228_E301_E0.5330.17
227_K275_M0.5330.17
120_M235_C0.5320.17
69_R73_L0.5320.17
79_T151_V0.5310.17
49_I297_L0.5290.17
197_L201_A0.5280.17
58_I213_E0.5250.16
215_I289_I0.5250.16
93_L126_S0.5240.16
68_V73_L0.5240.16
228_E304_I0.5230.16
121_V180_V0.5230.16
48_L236_Y0.5220.16
115_S314_A0.5210.16
26_H327_A0.5210.16
144_G293_E0.5200.16
126_S226_I0.5200.16
93_L129_R0.5190.16
70_G86_Y0.5180.16
23_Q291_L0.5180.16
58_I210_R0.5180.16
201_A204_P0.5170.16
96_Y130_L0.5170.16
96_Y181_K0.5160.16
112_T121_V0.5160.16
300_Q324_L0.5140.16
92_H196_V0.5130.16
178_F226_I0.5120.16
79_T274_D0.5120.16
27_E67_S0.5110.16
111_S129_R0.5110.16
199_G214_Y0.5090.16
104_L107_Q0.5080.16
49_I141_R0.5070.16
43_T118_G0.5060.16
111_S328_V0.5060.16
70_G77_L0.5050.16
44_R183_D0.5040.16
298_R321_I0.5040.16
24_F248_L0.5040.16
183_D336_L0.5040.16
208_V236_Y0.5030.16
99_T309_V0.5030.16
24_F162_R0.5030.16
78_A311_Q0.5030.16
53_G92_H0.5020.16
278_W286_A0.5020.16
39_F108_C0.5020.16
37_E103_A0.5010.16
51_C212_S0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gmiA 1 0.6903 100 0.795 Contact Map
2qjoA 3 0.5114 99.8 0.864 Contact Map
4x0eA 1 0.4886 99.8 0.866 Contact Map
2qjtB 2 0.4972 99.8 0.866 Contact Map
1yumA 4 0.5284 99.8 0.871 Contact Map
1ej2A 5 0.4489 99.8 0.872 Contact Map
1k4mA 3 0.5312 99.8 0.873 Contact Map
1f9aA 5 0.446 99.7 0.875 Contact Map
1vlhA 5 0.4432 99.7 0.875 Contact Map
4natA 5 0.4432 99.7 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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