CITC - ECOLI - GREMLIN Contacts

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CITC - [Citrate [pro-3S]-lyase] ligase

UniProt:	P77390	Sequences: MFGNDIFTRVKRSENKKMAEIAQFLHENDLSVDTTVEVFITVTRDEKLIACGGIAGNIIKCVAISESVRGEGLALTLATELINLAYERHSTHLFIYTKTEYEALFRQCGFSTLTSVPGVMVLMENSATRLKRYAESLKKFRHPGNKIGCIVMNANPFTNGHRYLIQQAAAQCDWLHLFLVKEDSSRFPYEDRLDLVLKGTADIPRLTVHRGSEYIISRATFPCYFIKEQSVINHCYTEIDLKIFRQYLAPALGVTHRFVGTEPFCRVTAQYNQDMRYWLETPTISAPPIELVEIERLRYQEMPISASRVRQLLAKNDLTAIAPLVPAVTLHYLQNLLEHSRQDAAARQKTPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13645
Length:	352 (321)
Sequences:	386 (318)
Seq/√Len:	17.7

ECOLI - CITC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
162_R	202_D	7.460	1.00
148_G	172_C	6.585	1.00
41_T	48_L	5.576	1.00
172_C	258_F	4.403	1.00
59_I	62_V	4.389	1.00
148_G	258_F	4.305	1.00
171_Q	258_F	4.153	1.00
241_L	275_M	3.923	1.00
52_G	81_L	3.842	1.00
39_F	53_G	3.699	1.00
325_V	329_T	3.441	1.00
297_L	304_I	3.354	0.99
176_H	209_H	3.339	0.99
194_D	198_K	3.336	0.99
317_D	320_A	3.305	0.99
321_I	325_V	3.259	0.99
166_Q	203_I	2.856	0.98
180_V	189_Y	2.738	0.98
95_I	123_M	2.694	0.98
200_T	208_V	2.621	0.97
20_E	43_T	2.542	0.96
187_F	333_L	2.531	0.96
188_P	191_D	2.443	0.96
54_I	85_A	2.435	0.95
322_A	330_L	2.384	0.95
327_A	331_H	2.223	0.93
175_L	258_F	2.212	0.92
259_V	291_L	2.140	0.91
152_M	165_I	2.072	0.90
166_Q	202_D	2.068	0.90
335_N	338_E	2.007	0.88
85_A	93_L	2.006	0.88
167_Q	294_I	1.983	0.87
146_K	173_D	1.960	0.87
174_W	207_T	1.941	0.86
42_V	50_A	1.935	0.86
167_Q	171_Q	1.933	0.86
269_A	273_Q	1.923	0.86
147_I	174_W	1.905	0.85
321_I	330_L	1.885	0.85
261_T	295_E	1.864	0.84
308_R	324_L	1.850	0.83
181_K	211_G	1.816	0.82
157_F	199_G	1.812	0.82
148_G	171_Q	1.779	0.81
179_L	196_V	1.764	0.80
264_F	308_R	1.722	0.79
203_I	206_L	1.695	0.77
52_G	59_I	1.685	0.77
193_L	197_L	1.684	0.77
256_H	292_V	1.664	0.76
35_T	55_A	1.650	0.75
264_F	303_P	1.649	0.75
112_T	115_S	1.643	0.75
96_Y	120_M	1.642	0.75
245_R	288_P	1.609	0.74
36_V	113_L	1.593	0.73
116_V	120_M	1.588	0.73
21_I	39_F	1.572	0.72
169_A	205_R	1.539	0.70
157_F	195_L	1.525	0.69
162_R	166_Q	1.523	0.69
165_I	200_T	1.489	0.67
27_E	65_S	1.487	0.67
125_N	176_H	1.486	0.67
33_D	267_V	1.484	0.67
303_P	324_L	1.473	0.67
311_Q	315_K	1.471	0.67
147_I	173_D	1.452	0.65
37_E	90_S	1.450	0.65
256_H	290_E	1.446	0.65
39_F	51_C	1.443	0.65
126_S	209_H	1.432	0.64
84_L	88_R	1.427	0.64
125_N	209_H	1.423	0.64
114_T	242_K	1.417	0.64
191_D	195_L	1.384	0.62
178_F	254_V	1.369	0.61
33_D	61_C	1.349	0.60
193_L	208_V	1.343	0.59
188_P	335_N	1.338	0.59
167_Q	258_F	1.336	0.59
172_C	175_L	1.326	0.58
114_T	239_I	1.306	0.57
88_R	159_N	1.282	0.56
102_E	112_T	1.282	0.56
299_Y	304_I	1.275	0.55
230_S	266_R	1.253	0.54
211_G	215_I	1.250	0.54
21_I	41_T	1.244	0.53
126_S	129_R	1.238	0.53
215_I	264_F	1.226	0.52
188_P	338_E	1.225	0.52
122_L	130_L	1.224	0.52
322_A	327_A	1.220	0.52
126_S	176_H	1.218	0.52
181_K	189_Y	1.210	0.51
302_M	308_R	1.199	0.51
129_R	209_H	1.189	0.50
150_I	154_A	1.187	0.50
259_V	275_M	1.184	0.50
178_F	215_I	1.174	0.49
18_M	22_A	1.152	0.48
54_I	84_L	1.144	0.47
279_L	289_I	1.143	0.47
241_L	291_L	1.143	0.47
130_L	247_Y	1.141	0.47
276_R	293_E	1.129	0.46
51_C	108_C	1.119	0.46
61_C	176_H	1.101	0.45
50_A	96_Y	1.100	0.45
188_P	333_L	1.094	0.44
43_T	48_L	1.090	0.44
330_L	334_Q	1.074	0.43
167_Q	170_A	1.068	0.43
101_Y	104_L	1.061	0.42
102_E	121_V	1.060	0.42
44_R	196_V	1.059	0.42
28_N	63_A	1.059	0.42
233_N	236_Y	1.056	0.42
80_E	275_M	1.054	0.42
149_C	175_L	1.052	0.42
22_A	32_V	1.051	0.42
303_P	308_R	1.042	0.41
223_C	232_I	1.036	0.41
147_I	209_H	1.034	0.41
208_V	226_I	1.031	0.40
179_L	226_I	1.027	0.40
59_I	121_V	1.026	0.40
54_I	88_R	1.005	0.39
180_V	183_D	1.005	0.39
148_G	175_L	1.000	0.39
245_R	287_P	0.997	0.38
303_P	316_N	0.996	0.38
166_Q	216_I	0.996	0.38
102_E	115_S	0.995	0.38
58_I	96_Y	0.991	0.38
121_V	334_Q	0.986	0.38
194_D	197_L	0.984	0.38
79_T	280_E	0.980	0.37
99_T	115_S	0.978	0.37
191_D	332_Y	0.975	0.37
199_G	328_V	0.975	0.37
279_L	291_L	0.972	0.37
20_E	47_K	0.970	0.37
24_F	48_L	0.969	0.37
241_L	274_D	0.968	0.37
312_L	320_A	0.967	0.37
24_F	28_N	0.966	0.37
24_F	265_C	0.959	0.36
242_K	278_W	0.958	0.36
165_I	177_L	0.951	0.36
184_S	218_R	0.951	0.36
33_D	226_I	0.950	0.36
101_Y	123_M	0.946	0.36
181_K	215_I	0.942	0.35
189_Y	196_V	0.939	0.35
157_F	328_V	0.938	0.35
133_Y	137_L	0.934	0.35
22_A	170_A	0.932	0.35
106_R	123_M	0.930	0.35
24_F	55_A	0.928	0.35
92_H	295_E	0.928	0.35
180_V	185_S	0.927	0.34
15_N	273_Q	0.926	0.34
211_G	237_T	0.926	0.34
315_K	320_A	0.925	0.34
249_A	289_I	0.919	0.34
198_K	201_A	0.918	0.34
28_N	69_R	0.917	0.34
67_S	201_A	0.915	0.34
245_R	280_E	0.913	0.34
42_V	77_L	0.910	0.34
195_L	199_G	0.908	0.33
280_E	288_P	0.905	0.33
21_I	307_S	0.905	0.33
179_L	208_V	0.902	0.33
49_I	68_V	0.897	0.33
223_C	236_Y	0.894	0.33
93_L	209_H	0.894	0.33
298_R	301_E	0.891	0.33
215_I	248_L	0.888	0.32
195_L	332_Y	0.883	0.32
199_G	326_P	0.881	0.32
261_T	293_E	0.878	0.32
169_A	203_I	0.864	0.31
129_R	176_H	0.862	0.31
253_G	292_V	0.862	0.31
74_A	104_L	0.859	0.31
50_A	82_I	0.858	0.31
24_F	104_L	0.853	0.31
59_I	86_Y	0.850	0.30
50_A	219_A	0.844	0.30
46_E	331_H	0.842	0.30
60_K	226_I	0.837	0.30
120_M	315_K	0.836	0.30
309_V	329_T	0.830	0.29
114_T	180_V	0.828	0.29
147_I	176_H	0.825	0.29
137_L	252_L	0.823	0.29
52_G	77_L	0.821	0.29
59_I	134_A	0.818	0.29
193_L	210_R	0.814	0.29
99_T	184_S	0.809	0.28
35_T	50_A	0.809	0.28
84_L	87_E	0.808	0.28
276_R	304_I	0.803	0.28
130_L	243_I	0.803	0.28
92_H	130_L	0.797	0.28
193_L	338_E	0.794	0.28
198_K	331_H	0.787	0.27
38_V	88_R	0.785	0.27
228_E	295_E	0.782	0.27
148_G	195_L	0.782	0.27
152_M	206_L	0.781	0.27
94_F	267_V	0.778	0.27
130_L	261_T	0.777	0.27
177_L	208_V	0.776	0.27
27_E	295_E	0.776	0.27
120_M	275_M	0.776	0.27
72_G	79_T	0.775	0.27
177_L	216_I	0.772	0.26
162_R	294_I	0.768	0.26
114_T	159_N	0.767	0.26
123_M	327_A	0.765	0.26
61_C	96_Y	0.761	0.26
95_I	241_L	0.760	0.26
106_R	112_T	0.758	0.26
154_A	184_S	0.758	0.26
56_G	90_S	0.757	0.26
204_P	319_T	0.754	0.26
85_A	90_S	0.753	0.26
195_L	198_K	0.752	0.26
204_P	216_I	0.752	0.26
312_L	325_V	0.752	0.26
194_D	337_L	0.748	0.25
129_R	237_T	0.746	0.25
243_I	273_Q	0.746	0.25
146_K	213_E	0.746	0.25
300_Q	323_P	0.745	0.25
35_T	216_I	0.745	0.25
325_V	330_L	0.739	0.25
89_H	239_I	0.737	0.25
111_S	126_S	0.732	0.25
131_K	198_K	0.732	0.25
157_F	326_P	0.730	0.25
72_G	98_K	0.727	0.24
145_N	173_D	0.726	0.24
120_M	304_I	0.723	0.24
216_I	333_L	0.719	0.24
206_L	294_I	0.716	0.24
76_T	200_T	0.714	0.24
93_L	125_N	0.714	0.24
20_E	293_E	0.711	0.24
123_M	130_L	0.709	0.24
42_V	52_G	0.707	0.24
318_L	330_L	0.705	0.23
29_D	100_E	0.705	0.23
176_H	307_S	0.703	0.23
59_I	78_A	0.701	0.23
171_Q	294_I	0.701	0.23
307_S	324_L	0.700	0.23
216_I	307_S	0.699	0.23
52_G	62_V	0.697	0.23
78_A	194_D	0.693	0.23
181_K	210_R	0.688	0.23
50_A	111_S	0.688	0.23
99_T	241_L	0.685	0.23
163_Y	297_L	0.685	0.23
186_R	227_K	0.683	0.22
24_F	226_I	0.682	0.22
259_V	293_E	0.681	0.22
36_V	61_C	0.680	0.22
191_D	194_D	0.679	0.22
126_S	236_Y	0.678	0.22
58_I	287_P	0.677	0.22
201_A	299_Y	0.675	0.22
234_H	273_Q	0.675	0.22
61_C	333_L	0.674	0.22
241_L	278_W	0.671	0.22
154_A	265_C	0.670	0.22
70_G	182_E	0.668	0.22
74_A	265_C	0.667	0.22
72_G	232_I	0.666	0.22
34_T	332_Y	0.665	0.22
320_A	325_V	0.664	0.22
171_Q	175_L	0.663	0.22
59_I	81_L	0.662	0.22
152_M	175_L	0.660	0.22
177_L	190_E	0.659	0.21
159_N	321_I	0.658	0.21
23_Q	139_K	0.658	0.21
194_D	331_H	0.657	0.21
69_R	293_E	0.656	0.21
43_T	248_L	0.655	0.21
233_N	267_V	0.654	0.21
120_M	211_G	0.653	0.21
37_E	226_I	0.652	0.21
135_E	339_H	0.651	0.21
64_I	77_L	0.650	0.21
54_I	62_V	0.650	0.21
236_Y	241_L	0.650	0.21
56_G	139_K	0.648	0.21
144_G	173_D	0.644	0.21
280_E	291_L	0.644	0.21
53_G	108_C	0.644	0.21
71_E	216_I	0.644	0.21
248_L	328_V	0.643	0.21
32_V	116_V	0.643	0.21
144_G	252_L	0.642	0.21
150_I	165_I	0.639	0.21
154_A	165_I	0.638	0.21
108_C	231_V	0.634	0.20
51_C	75_L	0.632	0.20
177_L	200_T	0.630	0.20
47_K	289_I	0.627	0.20
31_S	234_H	0.626	0.20
183_D	234_H	0.626	0.20
319_T	322_A	0.621	0.20
142_H	248_L	0.619	0.20
149_C	256_H	0.619	0.20
154_A	245_R	0.618	0.20
49_I	215_I	0.617	0.20
33_D	60_K	0.617	0.20
273_Q	289_I	0.617	0.20
99_T	112_T	0.617	0.20
14_E	165_I	0.616	0.20
113_L	191_D	0.615	0.20
53_G	212_S	0.615	0.20
93_L	176_H	0.615	0.20
229_Q	315_K	0.613	0.20
96_Y	116_V	0.612	0.20
321_I	329_T	0.610	0.20
68_V	113_L	0.609	0.19
41_T	236_Y	0.609	0.19
132_R	216_I	0.606	0.19
171_Q	256_H	0.606	0.19
270_Q	274_D	0.605	0.19
29_D	188_P	0.604	0.19
32_V	154_A	0.603	0.19
304_I	321_I	0.602	0.19
182_E	213_E	0.602	0.19
28_N	265_C	0.601	0.19
50_A	77_L	0.601	0.19
57_N	213_E	0.601	0.19
108_C	235_C	0.601	0.19
162_R	323_P	0.600	0.19
154_A	226_I	0.600	0.19
64_I	233_N	0.599	0.19
108_C	122_L	0.598	0.19
43_T	236_Y	0.597	0.19
67_S	294_I	0.596	0.19
33_D	235_C	0.596	0.19
66_E	69_R	0.596	0.19
64_I	205_R	0.595	0.19
234_H	274_D	0.594	0.19
200_T	206_L	0.593	0.19
139_K	327_A	0.593	0.19
47_K	67_S	0.593	0.19
22_A	135_E	0.591	0.19
318_L	325_V	0.590	0.19
23_Q	243_I	0.590	0.19
238_E	264_F	0.590	0.19
306_A	310_R	0.589	0.19
83_N	177_L	0.589	0.19
45_D	86_Y	0.588	0.19
246_Q	288_P	0.587	0.19
49_I	189_Y	0.586	0.19
301_E	304_I	0.586	0.19
36_V	267_V	0.586	0.19
169_A	202_D	0.585	0.19
21_I	53_G	0.583	0.19
61_C	209_H	0.582	0.18
158_T	309_V	0.580	0.18
294_I	298_R	0.580	0.18
33_D	191_D	0.580	0.18
30_L	154_A	0.579	0.18
241_L	276_R	0.577	0.18
42_V	78_A	0.576	0.18
76_T	273_Q	0.576	0.18
321_I	333_L	0.576	0.18
134_A	178_F	0.576	0.18
163_Y	167_Q	0.575	0.18
132_R	165_I	0.575	0.18
82_I	93_L	0.575	0.18
95_I	216_I	0.574	0.18
189_Y	212_S	0.574	0.18
159_N	180_V	0.573	0.18
223_C	239_I	0.573	0.18
21_I	33_D	0.571	0.18
254_V	316_N	0.571	0.18
42_V	81_L	0.571	0.18
182_E	305_S	0.569	0.18
57_N	200_T	0.568	0.18
215_I	254_V	0.568	0.18
130_L	289_I	0.567	0.18
74_A	95_I	0.566	0.18
78_A	88_R	0.565	0.18
292_V	315_K	0.562	0.18
116_V	238_E	0.562	0.18
32_V	69_R	0.562	0.18
21_I	79_T	0.561	0.18
134_A	261_T	0.560	0.18
188_P	288_P	0.558	0.18
55_A	113_L	0.557	0.18
149_C	213_E	0.557	0.18
123_M	189_Y	0.556	0.18
215_I	236_Y	0.555	0.18
166_Q	170_A	0.555	0.18
34_T	49_I	0.553	0.17
183_D	261_T	0.552	0.17
167_Q	174_W	0.552	0.17
193_L	243_I	0.552	0.17
104_L	154_A	0.550	0.17
191_D	337_L	0.548	0.17
130_L	249_A	0.547	0.17
133_Y	249_A	0.543	0.17
93_L	147_I	0.541	0.17
142_H	174_W	0.541	0.17
71_E	201_A	0.540	0.17
40_I	227_K	0.539	0.17
136_S	139_K	0.538	0.17
223_C	265_C	0.538	0.17
183_D	243_I	0.538	0.17
85_A	275_M	0.538	0.17
159_N	206_L	0.537	0.17
204_P	292_V	0.537	0.17
61_C	182_E	0.536	0.17
245_R	250_P	0.536	0.17
21_I	32_V	0.535	0.17
65_S	226_I	0.534	0.17
228_E	301_E	0.533	0.17
227_K	275_M	0.533	0.17
120_M	235_C	0.532	0.17
69_R	73_L	0.532	0.17
79_T	151_V	0.531	0.17
49_I	297_L	0.529	0.17
197_L	201_A	0.528	0.17
58_I	213_E	0.525	0.16
215_I	289_I	0.525	0.16
93_L	126_S	0.524	0.16
68_V	73_L	0.524	0.16
228_E	304_I	0.523	0.16
121_V	180_V	0.523	0.16
48_L	236_Y	0.522	0.16
115_S	314_A	0.521	0.16
26_H	327_A	0.521	0.16
144_G	293_E	0.520	0.16
126_S	226_I	0.520	0.16
93_L	129_R	0.519	0.16
70_G	86_Y	0.518	0.16
23_Q	291_L	0.518	0.16
58_I	210_R	0.518	0.16
201_A	204_P	0.517	0.16
96_Y	130_L	0.517	0.16
96_Y	181_K	0.516	0.16
112_T	121_V	0.516	0.16
300_Q	324_L	0.514	0.16
92_H	196_V	0.513	0.16
178_F	226_I	0.512	0.16
79_T	274_D	0.512	0.16
27_E	67_S	0.511	0.16
111_S	129_R	0.511	0.16
199_G	214_Y	0.509	0.16
104_L	107_Q	0.508	0.16
49_I	141_R	0.507	0.16
43_T	118_G	0.506	0.16
111_S	328_V	0.506	0.16
70_G	77_L	0.505	0.16
44_R	183_D	0.504	0.16
298_R	321_I	0.504	0.16
24_F	248_L	0.504	0.16
183_D	336_L	0.504	0.16
208_V	236_Y	0.503	0.16
99_T	309_V	0.503	0.16
24_F	162_R	0.503	0.16
78_A	311_Q	0.503	0.16
53_G	92_H	0.502	0.16
278_W	286_A	0.502	0.16
39_F	108_C	0.502	0.16
37_E	103_A	0.501	0.16
51_C	212_S	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3gmiA	1	0.6903	100	0.795	Contact Map
2qjoA	3	0.5114	99.8	0.864	Contact Map
4x0eA	1	0.4886	99.8	0.866	Contact Map
2qjtB	2	0.4972	99.8	0.866	Contact Map
1yumA	4	0.5284	99.8	0.871	Contact Map
1ej2A	5	0.4489	99.8	0.872	Contact Map
1k4mA	3	0.5312	99.8	0.873	Contact Map
1f9aA	5	0.446	99.7	0.875	Contact Map
1vlhA	5	0.4432	99.7	0.875	Contact Map
4natA	5	0.4432	99.7	0.875	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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