GREMLIN Database
YDIR - Putative electron transfer flavoprotein subunit YdiR
UniProt: P77378 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13977
Length: 312 (300)
Sequences: 4064 (2435)
Seq/√Len: 140.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
297_G302_V4.9721.00
288_F294_G3.6711.00
258_L279_I3.4721.00
195_K253_D3.4291.00
199_G260_I3.3141.00
85_L95_A3.1161.00
23_G26_Q2.6581.00
197_V250_L2.6471.00
258_L303_V2.6221.00
51_C165_E2.5871.00
32_Y53_Y2.5701.00
24_A31_V2.5511.00
200_V210_L2.5481.00
219_V307_I2.5101.00
75_L83_L2.4011.00
22_G154_C2.3381.00
45_M162_C2.3221.00
51_C163_P2.1741.00
38_T56_A2.1671.00
157_D160_H2.1521.00
211_K214_H2.1441.00
237_M241_R2.1371.00
11_S17_Y2.1331.00
267_M290_Y2.0951.00
11_S33_A2.0781.00
211_K215_E2.0621.00
226_C237_M2.0551.00
275_V293_Y2.0051.00
215_E307_I2.0041.00
278_A291_A1.9991.00
30_Q51_C1.9801.00
200_V213_V1.9581.00
209_D300_Y1.9371.00
254_L277_V1.9271.00
196_R222_A1.9201.00
258_L299_I1.9131.00
227_S260_I1.8841.00
214_H224_V1.8831.00
216_L307_I1.8771.00
110_A144_I1.8681.00
20_L84_L1.8501.00
204_L213_V1.8091.00
199_G257_T1.7751.00
38_T61_L1.7511.00
213_V258_L1.7451.00
112_A123_E1.7411.00
72_A101_Q1.7401.00
6_S30_Q1.7241.00
68_A101_Q1.7211.00
255_Y266_H1.7151.00
253_D274_K1.7101.00
72_A98_L1.7051.00
123_E132_F1.7001.00
38_T58_N1.6751.00
278_A287_I1.6731.00
216_L303_V1.6701.00
199_G243_I1.6661.00
60_A70_S1.6581.00
190_D193_K1.6571.00
250_L270_G1.6321.00
305_A308_S1.6271.00
32_Y80_P1.6221.00
191_L197_V1.5971.00
197_V225_G1.5711.00
216_L220_L1.5581.00
270_G273_A1.5481.00
198_V216_L1.5331.00
63_R66_N1.5311.00
25_Q50_K1.5271.00
84_L144_I1.5231.00
30_Q50_K1.5181.00
32_Y50_K1.5041.00
64_T93_A1.4721.00
238_E241_R1.4551.00
95_A145_T1.4491.00
72_A76_K1.4431.00
77_D167_V1.4391.00
210_L224_V1.4191.00
214_H218_A1.4181.00
73_A77_D1.4001.00
226_C230_I1.3851.00
57_Q60_A1.3791.00
39_D42_Q1.3641.00
43_A46_P1.3571.00
54_V166_T1.3511.00
114_D123_E1.3421.00
215_E219_V1.3371.00
257_T260_I1.3321.00
219_V310_L1.3151.00
107_V137_I1.3121.00
53_Y165_E1.3121.00
212_M303_V1.3041.00
188_S218_A1.2971.00
7_V24_A1.2911.00
204_L299_I1.2901.00
71_I98_L1.2901.00
10_F94_L1.2871.00
257_T266_H1.2841.00
46_P156_S1.2741.00
20_L86_A1.2681.00
73_A76_K1.2681.00
53_Y167_V1.2661.00
12_D88_T1.2641.00
204_L209_D1.2471.00
295_L302_V1.2441.00
55_L70_S1.2371.00
212_M215_E1.2361.00
45_M160_H1.2321.00
172_P175_E1.2311.00
226_C231_A1.2171.00
225_G243_I1.2161.00
98_L143_I1.2031.00
200_V230_I1.2001.00
192_S248_V1.1981.00
19_E149_G1.1961.00
111_T123_E1.1761.00
67_Y94_L1.1711.00
11_S44_V1.1671.00
199_G250_L1.1660.99
301_K305_A1.1630.99
25_Q31_V1.1630.99
81_A141_L1.1590.99
210_L230_I1.1560.99
111_T132_F1.1560.99
109_D147_A1.1550.99
21_F49_P1.1440.99
305_A309_Q1.1300.99
26_Q112_A1.1280.99
227_S243_I1.1190.99
8_W74_L1.1160.99
6_S32_Y1.1100.99
58_N61_L1.1070.99
110_A146_L1.1050.99
36_Q70_S1.1040.99
13_N40_Q1.1030.99
303_V307_I1.0930.99
288_F296_V1.0900.99
34_I71_I1.0810.99
17_Y33_A1.0680.99
40_Q43_A1.0620.99
126_M131_A1.0590.99
45_M52_L1.0580.99
212_M307_I1.0570.99
299_I304_P1.0540.99
114_D134_Q1.0450.99
74_L167_V1.0450.99
53_Y78_K1.0440.99
43_A156_S1.0440.99
206_A209_D1.0370.99
46_P157_D1.0360.99
71_I94_L1.0280.99
52_L162_C1.0220.99
243_I257_T1.0170.99
68_A98_L1.0110.99
199_G225_G1.0040.98
217_A224_V1.0030.98
10_F71_I1.0000.98
206_A236_W0.9990.98
75_L102_L0.9980.98
231_A242_Y0.9970.98
205_A300_Y0.9910.98
203_G236_W0.9910.98
229_P234_E0.9900.98
115_I118_G0.9900.98
297_G301_K0.9880.98
62_Q67_Y0.9850.98
200_V204_L0.9810.98
171_A174_H0.9730.98
199_G227_S0.9710.98
102_L143_I0.9700.98
251_K272_G0.9620.98
207_Q237_M0.9610.98
76_K79_H0.9590.98
41_A45_M0.9580.98
42_Q46_P0.9550.98
27_W84_L0.9530.98
279_I302_V0.9520.98
47_Y155_T0.9500.98
208_D211_K0.9490.98
107_V110_A0.9470.98
117_D136_K0.9440.98
36_Q67_Y0.9430.98
95_A106_L0.9380.98
45_M157_D0.9290.97
72_A102_L0.9270.97
210_L237_M0.9210.97
225_G241_R0.9150.97
9_V21_F0.9080.97
97_R101_Q0.9050.97
213_V224_V0.9040.97
68_A97_R0.9030.97
218_A221_N0.8990.97
106_L143_I0.8980.97
191_L225_G0.8950.97
148_P249_L0.8940.97
223_E241_R0.8940.97
77_D165_E0.8910.97
32_Y51_C0.8910.97
56_A166_T0.8860.97
209_D212_M0.8840.97
92_K109_D0.8800.97
104_A143_I0.8770.96
200_V237_M0.8750.96
230_I236_W0.8730.96
230_I237_M0.8700.96
256_L279_I0.8670.96
29_Q81_A0.8650.96
87_A109_D0.8520.96
210_L213_V0.8480.96
122_A144_I0.8470.96
42_Q45_M0.8360.95
204_L207_Q0.8360.95
10_F33_A0.8350.95
106_L145_T0.8300.95
212_M304_P0.8240.95
105_A137_I0.8220.95
215_E224_V0.8160.95
191_L248_V0.8090.94
69_E73_A0.8080.94
212_M258_L0.8030.94
178_C181_R0.7990.94
204_L210_L0.7980.94
73_A170_V0.7930.94
8_W78_K0.7920.94
81_A140_P0.7910.94
110_A113_V0.7890.94
62_Q93_A0.7860.94
99_S106_L0.7860.94
35_V40_Q0.7790.93
85_L145_T0.7780.93
270_G290_Y0.7700.93
43_A47_Y0.7680.93
21_F154_C0.7680.93
175_E178_C0.7650.93
25_Q47_Y0.7640.93
33_A49_P0.7610.92
171_A175_E0.7580.92
35_V52_L0.7580.92
113_V122_A0.7570.92
6_S29_Q0.7560.92
123_E134_Q0.7560.92
197_V223_E0.7520.92
9_V84_L0.7510.92
203_G209_D0.7490.92
122_A142_A0.7490.92
203_G207_Q0.7440.92
252_S273_A0.7430.92
53_Y74_L0.7420.91
18_A43_A0.7410.91
232_E242_Y0.7350.91
10_F85_L0.7310.91
46_P158_T0.7310.91
207_Q236_W0.7290.91
87_A91_G0.7250.91
78_K165_E0.7240.90
8_W34_I0.7230.90
39_D43_A0.7220.90
11_S35_V0.7210.90
41_A52_L0.7210.90
204_L212_M0.7180.90
64_T97_R0.7180.90
73_A168_P0.7160.90
45_M164_T0.7160.90
36_Q60_A0.7150.90
125_R147_A0.7100.90
105_A139_S0.7090.90
37_N56_A0.7080.89
204_L300_Y0.7060.89
137_I142_A0.7050.89
78_K167_V0.7040.89
10_F83_L0.7030.89
227_S267_M0.7020.89
75_L141_L0.7010.89
256_L277_V0.6990.89
91_G94_L0.6940.89
19_E153_P0.6940.89
287_I294_G0.6900.88
67_Y90_R0.6880.88
110_A122_A0.6870.88
8_W83_L0.6850.88
23_G151_Q0.6800.88
202_R229_P0.6760.87
76_K102_L0.6750.87
85_L91_G0.6740.87
171_A176_I0.6740.87
41_A162_C0.6710.87
257_T287_I0.6710.87
62_Q94_L0.6670.86
44_V52_L0.6650.86
13_N16_R0.6640.86
200_V226_C0.6580.86
114_D117_D0.6540.85
102_L141_L0.6520.85
203_G212_M0.6510.85
207_Q211_K0.6510.85
47_Y156_S0.6440.85
227_S257_T0.6420.84
118_G136_K0.6420.84
156_S160_H0.6390.84
175_E179_R0.6390.84
176_I179_R0.6370.84
298_D301_K0.6360.84
76_K141_L0.6340.84
250_L273_A0.6330.84
117_D142_A0.6320.83
18_A47_Y0.6300.83
75_L80_P0.6290.83
267_M289_N0.6270.83
50_K160_H0.6260.83
41_A164_T0.6240.83
302_V305_A0.6240.83
275_V292_D0.6230.83
33_A36_Q0.6230.83
9_V20_L0.6210.82
65_E175_E0.6180.82
147_A245_V0.6170.82
210_L245_V0.6150.82
34_I74_L0.6140.82
55_L74_L0.6120.81
33_A44_V0.6110.81
21_F33_A0.6110.81
204_L236_W0.6090.81
68_A72_A0.6090.81
59_D173_R0.6080.81
207_Q214_H0.6070.81
137_I140_P0.6070.81
171_A178_C0.6060.81
174_H178_C0.6060.81
198_V303_V0.6030.80
210_L226_C0.6020.80
31_V49_P0.6020.80
22_G25_Q0.6000.80
40_Q44_V0.5990.80
128_G147_A0.5980.80
18_A153_P0.5980.80
200_V258_L0.5960.80
199_G266_H0.5960.80
216_L219_V0.5940.79
255_Y260_I0.5900.79
267_M270_G0.5890.79
227_S268_V0.5870.79
198_V224_V0.5840.78
69_E170_V0.5840.78
106_L110_A0.5840.78
110_A115_I0.5840.78
115_I136_K0.5830.78
95_A98_L0.5820.78
246_S264_I0.5810.78
24_A84_L0.5790.78
22_G155_T0.5780.78
71_I75_L0.5760.77
13_N17_Y0.5750.77
209_D215_E0.5750.77
57_Q168_P0.5750.77
184_K283_K0.5740.77
85_L98_L0.5720.77
152_E155_T0.5720.77
36_Q55_L0.5690.77
196_R221_N0.5690.77
49_P52_L0.5680.76
157_D161_Q0.5670.76
107_V135_E0.5660.76
182_R185_A0.5660.76
107_V222_A0.5650.76
74_L78_K0.5640.76
62_Q90_R0.5630.76
190_D248_V0.5620.76
82_M113_V0.5610.76
38_T57_Q0.5610.76
203_G299_I0.5600.75
66_N176_I0.5600.75
104_A139_S0.5600.75
204_L303_V0.5580.75
92_K108_N0.5580.75
10_F17_Y0.5550.75
243_I270_G0.5540.75
171_A179_R0.5540.75
239_R243_I0.5540.75
69_E172_P0.5530.75
122_A146_L0.5510.74
160_H163_P0.5510.74
199_G255_Y0.5500.74
206_A300_Y0.5500.74
212_M219_V0.5490.74
45_M49_P0.5480.74
205_A209_D0.5480.74
46_P155_T0.5460.74
293_Y300_Y0.5450.73
276_I290_Y0.5450.73
300_Y304_P0.5450.73
7_V84_L0.5450.73
124_H265_Q0.5430.73
69_E173_R0.5430.73
55_L167_V0.5400.73
18_A156_S0.5400.73
206_A230_I0.5390.73
70_S73_A0.5370.72
99_S143_I0.5360.72
69_E174_H0.5350.72
75_L143_I0.5340.72
172_P176_I0.5330.72
127_Y135_E0.5330.72
60_A170_V0.5310.72
198_V219_V0.5300.71
227_S281_K0.5300.71
228_R242_Y0.5290.71
189_V197_V0.5280.71
51_C78_K0.5270.71
188_S214_H0.5270.71
295_L309_Q0.5260.71
232_E239_R0.5260.71
196_R253_D0.5260.71
224_V241_R0.5250.71
158_T161_Q0.5250.71
189_V223_E0.5250.71
7_V30_Q0.5230.70
214_H222_A0.5230.70
204_L230_I0.5220.70
9_V24_A0.5210.70
220_L256_L0.5210.70
14_P87_A0.5210.70
10_F13_N0.5210.70
219_V222_A0.5200.70
232_E246_S0.5170.70
203_G227_S0.5170.70
27_W115_I0.5160.69
198_V307_I0.5160.69
69_E101_Q0.5150.69
7_V31_V0.5150.69
198_V204_L0.5140.69
105_A133_A0.5140.69
196_R220_L0.5130.69
200_V224_V0.5130.69
283_K286_P0.5120.69
188_S191_L0.5120.69
10_F67_Y0.5100.69
7_V27_W0.5100.69
200_V246_S0.5100.69
97_R100_V0.5100.69
205_A216_L0.5100.69
197_V243_I0.5100.69
250_L290_Y0.5080.68
107_V122_A0.5070.68
278_A288_F0.5070.68
124_H135_E0.5060.68
74_L77_D0.5060.68
286_P289_N0.5060.68
60_A66_N0.5060.68
198_V220_L0.5020.67
214_H241_R0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l2iA 1 0.9936 100 0.055 Contact Map
1efvA 1 0.9679 100 0.076 Contact Map
1o97D 1 0.9551 100 0.077 Contact Map
1efpA 1 0.9487 100 0.09 Contact Map
3ih5A 6 0.5929 100 0.664 Contact Map
3fetA 2 0.5288 99.9 0.727 Contact Map
1efvB 1 0.6474 99.9 0.76 Contact Map
4l2iB 1 0.6987 99.9 0.766 Contact Map
1efpB 1 0.6378 99.9 0.766 Contact Map
1o97C 1 0.6474 99.9 0.769 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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