GREMLIN Database
WZXC - Lipopolysaccharide biosynthesis protein WzxC
UniProt: P77377 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13576
Length: 492 (451)
Sequences: 17345 (14928)
Seq/√Len: 702.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_D281_K4.9391.00
140_E143_K3.3171.00
207_A211_R3.2661.00
98_L101_L3.2111.00
324_I328_Q3.0671.00
352_R355_I3.0111.00
45_T247_N2.9071.00
416_L420_L2.8621.00
354_D358_K2.8111.00
305_M328_Q2.7781.00
139_L274_K2.7021.00
309_N313_P2.4111.00
363_K394_N2.3231.00
308_S324_I2.3181.00
239_G242_V2.2831.00
329_L381_I2.2431.00
336_L392_I2.2161.00
230_S246_Y2.1841.00
308_S328_Q2.1651.00
326_V380_A2.1451.00
417_S420_L2.1401.00
370_A386_G2.1271.00
218_A357_F2.1251.00
245_G322_S2.1061.00
431_V459_A2.1041.00
284_V288_K2.0761.00
275_I281_K2.0661.00
112_A116_K2.0611.00
230_S371_I2.0541.00
96_F116_K2.0541.00
359_F397_L2.0221.00
234_L238_L2.0021.00
303_G307_V2.0001.00
13_W142_N1.9951.00
329_L388_L1.9711.00
428_T432_S1.9451.00
168_L171_T1.9391.00
238_L242_V1.9261.00
37_D40_Q1.9141.00
310_N313_P1.9071.00
69_R212_F1.8821.00
279_T283_R1.8501.00
203_L207_A1.8361.00
303_G453_I1.8171.00
307_V310_N1.8151.00
34_R317_G1.8091.00
233_V375_G1.7881.00
374_G386_G1.7791.00
46_V235_A1.7631.00
378_A385_L1.7401.00
375_G383_V1.7301.00
100_D112_A1.7151.00
309_N324_I1.7101.00
297_N338_S1.6961.00
325_P381_I1.6791.00
286_F346_L1.6781.00
222_I361_V1.6701.00
238_L380_A1.6681.00
76_E80_L1.6651.00
74_H78_T1.6601.00
142_N146_M1.6551.00
233_V371_I1.6541.00
373_I376_Q1.6541.00
302_L429_L1.6531.00
366_L393_I1.6411.00
432_S456_G1.6311.00
281_K284_V1.6241.00
396_I400_F1.6151.00
301_L335_L1.6141.00
428_T456_G1.6091.00
371_I375_G1.6071.00
44_L48_L1.6061.00
99_S116_K1.5981.00
336_L395_T1.5951.00
427_P463_M1.5841.00
134_L138_E1.5711.00
382_G386_G1.5661.00
326_V384_T1.5621.00
283_R287_Y1.5581.00
318_E321_N1.5561.00
379_G382_G1.5561.00
312_V323_I1.5551.00
139_L271_A1.5501.00
329_L385_L1.5301.00
75_L79_T1.5301.00
457_V461_V1.5291.00
230_S387_F1.5291.00
325_P328_Q1.5221.00
304_L331_C1.5201.00
309_N328_Q1.5171.00
312_V327_L1.5151.00
281_K285_N1.5111.00
298_F425_S1.5101.00
329_L384_T1.5071.00
155_G179_N1.5001.00
372_V376_Q1.4981.00
140_E194_I1.4951.00
234_L383_V1.4861.00
412_R416_L1.4861.00
253_A330_L1.4841.00
73_S76_E1.4821.00
333_V388_L1.4771.00
424_L463_M1.4681.00
272_F282_L1.4551.00
369_P373_I1.4501.00
374_G378_A1.4501.00
47_S118_L1.4451.00
167_P171_T1.4441.00
282_L346_L1.4431.00
287_Y291_S1.4401.00
373_I377_M1.4301.00
429_L433_Y1.4301.00
386_G390_V1.4241.00
242_V380_A1.4241.00
33_A248_L1.4161.00
215_W357_F1.4101.00
20_I149_T1.4101.00
171_T175_G1.4081.00
95_V119_S1.4051.00
307_V311_F1.4021.00
269_F273_A1.3931.00
358_K362_F1.3911.00
114_L173_I1.3881.00
367_F371_I1.3751.00
352_R406_V1.3711.00
234_L243_A1.3611.00
249_A323_I1.3521.00
158_C175_G1.3371.00
70_K73_S1.3361.00
202_S205_S1.3361.00
322_S325_P1.3231.00
275_I285_N1.3211.00
19_V23_G1.3141.00
359_F401_V1.3121.00
160_V164_H1.3121.00
229_L368_I1.3111.00
65_S212_F1.3101.00
268_L289_L1.3031.00
233_V372_V1.3021.00
303_G428_T1.2981.00
279_T350_K1.2941.00
154_A182_V1.2901.00
29_M251_N1.2821.00
434_A437_I1.2701.00
228_N231_T1.2691.00
280_E284_V1.2681.00
249_A326_V1.2671.00
381_I384_T1.2571.00
30_T34_R1.2561.00
65_S69_R1.2511.00
38_N245_G1.2501.00
28_Q156_F1.2491.00
26_L30_T1.2421.00
239_G243_A1.2411.00
72_I75_L1.2371.00
131_F188_G1.2311.00
434_A438_V1.2261.00
147_I186_L1.2241.00
233_V237_I1.2231.00
286_F343_I1.2131.00
436_G452_Q1.2121.00
147_I187_F1.2111.00
333_V384_T1.2061.00
123_V126_P1.2051.00
312_V324_I1.2031.00
374_G377_M1.2011.00
359_F398_S1.1971.00
45_T244_G1.1961.00
403_I406_V1.1961.00
17_A145_G1.1941.00
40_Q43_L1.1921.00
78_T82_W1.1911.00
222_I364_T1.1891.00
378_A382_G1.1881.00
96_F100_D1.1791.00
157_T161_V1.1781.00
304_L327_L1.1751.00
59_D63_A1.1721.00
366_L370_A1.1701.00
77_L134_L1.1701.00
245_G323_I1.1671.00
294_G298_F1.1661.00
332_V388_L1.1661.00
317_G320_W1.1621.00
21_I152_V1.1611.00
215_W354_D1.1591.00
248_L316_F1.1581.00
371_I374_G1.1561.00
367_F387_F1.1511.00
371_I387_F1.1471.00
222_I357_F1.1441.00
424_L428_T1.1441.00
188_G192_R1.1441.00
425_S429_L1.1431.00
326_V381_I1.1411.00
272_F349_A1.1371.00
100_D104_D1.1351.00
214_A218_A1.1321.00
124_V181_A1.1311.00
343_I399_Y1.1311.00
33_A316_F1.1301.00
82_W86_G1.1241.00
212_F353_V1.1241.00
38_N319_K1.1221.00
433_Y437_I1.1201.00
219_D356_S1.1191.00
185_L189_Y1.1181.00
52_A56_T1.1151.00
367_F390_V1.1151.00
175_G179_N1.1101.00
370_A374_G1.1061.00
23_G27_V1.1011.00
241_G245_G1.1011.00
41_F45_T1.1011.00
301_L305_M1.1001.00
430_V434_A1.0981.00
14_S267_V1.0921.00
120_L177_L1.0861.00
75_L202_S1.0831.00
86_G90_V1.0791.00
141_F267_V1.0761.00
44_L172_A1.0731.00
271_A274_K1.0711.00
321_N324_I1.0631.00
158_C162_S1.0591.00
365_F369_P1.0591.00
310_N436_G1.0591.00
280_E283_R1.0581.00
225_L364_T1.0571.00
143_K190_F1.0551.00
234_L246_Y1.0531.00
308_S327_L1.0521.00
358_K361_V1.0521.00
100_D116_K1.0481.00
361_V365_F1.0481.00
208_P351_A1.0451.00
450_A454_A1.0431.00
69_R208_P1.0421.00
237_I375_G1.0411.00
67_I133_A1.0391.00
83_L206_V1.0381.00
210_L213_G1.0321.00
101_L104_D1.0301.00
174_L178_V1.0281.00
38_N244_G1.0271.00
400_F404_K1.0241.00
448_L452_Q1.0211.00
120_L123_V1.0181.00
6_K9_S1.0171.00
226_N367_F1.0071.00
343_I398_S1.0041.00
339_V395_T1.0001.00
24_L156_F0.9941.00
249_A330_L0.9931.00
89_I93_V0.9891.00
176_Y180_S0.9881.00
230_S367_F0.9841.00
124_V184_T0.9811.00
103_G111_L0.9811.00
433_Y436_G0.9801.00
311_F315_V0.9801.00
43_L240_A0.9781.00
11_A267_V0.9771.00
92_C95_V0.9761.00
113_P116_K0.9741.00
32_L172_A0.9721.00
453_I457_V0.9701.00
170_M173_I0.9701.00
385_L389_L0.9691.00
29_M316_F0.9691.00
68_Q351_A0.9681.00
31_V35_I0.9651.00
234_L380_A0.9651.00
305_M308_S0.9651.00
313_P321_N0.9641.00
159_T175_G0.9631.00
306_V429_L0.9631.00
282_L350_K0.9621.00
94_A98_L0.9591.00
37_D320_W0.9581.00
189_Y193_K0.9571.00
158_C178_V0.9551.00
79_T83_L0.9521.00
18_T22_I0.9481.00
35_I164_H0.9471.00
99_S112_A0.9461.00
46_V243_A0.9461.00
310_N452_Q0.9441.00
161_V164_H0.9431.00
92_C96_F0.9431.00
397_L400_F0.9391.00
65_S213_G0.9371.00
328_Q332_V0.9371.00
330_L384_T0.9371.00
205_S208_P0.9351.00
186_L190_F0.9311.00
65_S209_N0.9301.00
299_P460_F0.9281.00
355_I401_V0.9251.00
35_I163_A0.9231.00
275_I278_D0.9231.00
333_V336_L0.9211.00
244_G248_L0.9201.00
135_M191_G0.9151.00
312_V316_F0.9141.00
116_K120_L0.9131.00
314_L449_L0.9121.00
271_A275_I0.9111.00
37_D319_K0.9101.00
388_L391_Q0.9091.00
348_M356_S0.9071.00
253_A334_G0.9051.00
79_T206_V0.8981.00
11_A264_I0.8961.00
323_I326_V0.8911.00
47_S114_L0.8901.00
249_A327_L0.8901.00
425_S428_T0.8851.00
267_V270_P0.8841.00
307_V452_Q0.8831.00
80_L209_N0.8781.00
113_P170_M0.8771.00
86_G89_I0.8761.00
24_L28_Q0.8741.00
30_T316_F0.8711.00
393_I397_L0.8701.00
14_S145_G0.8671.00
204_A207_A0.8641.00
305_M332_V0.8631.00
321_N325_P0.8631.00
319_K322_S0.8611.00
302_L425_S0.8601.00
81_Y84_N0.8601.00
347_L401_V0.8501.00
215_W353_V0.8491.00
210_L214_A0.8491.00
314_L446_G0.8471.00
15_A263_I0.8461.00
107_N110_D0.8461.00
67_I137_K0.8451.00
179_N183_R0.8421.00
10_G139_L0.8401.00
246_Y330_L0.8401.00
244_G247_N0.8381.00
435_L455_T0.8381.00
49_V231_T0.8371.00
250_Y254_V0.8361.00
77_L80_L0.8351.00
251_N255_V0.8341.00
101_L105_V0.8341.00
99_S103_G0.8331.00
368_I372_V0.8301.00
11_A15_A0.8291.00
97_L101_L0.8291.00
385_L388_L0.8291.00
30_T33_A0.8271.00
357_F361_V0.8261.00
305_M309_N0.8211.00
415_I419_W0.8211.00
162_S167_P0.8191.00
370_A389_L0.8181.00
8_I12_K0.8181.00
293_V338_S0.8161.00
97_L100_D0.8161.00
247_N251_N0.8101.00
9_S142_N0.8091.00
174_L177_L0.8091.00
13_W17_A0.8081.00
103_G112_A0.8081.00
333_V387_F0.8081.00
36_I40_Q0.8061.00
119_S123_V0.8021.00
216_L353_V0.8021.00
211_R214_A0.8021.00
68_Q353_V0.7991.00
81_Y131_F0.7971.00
165_F168_L0.7951.00
355_I358_K0.7931.00
397_L401_V0.7911.00
221_I225_L0.7891.00
232_L236_R0.7881.00
12_K16_I0.7881.00
7_T11_A0.7881.00
48_L52_A0.7861.00
88_G92_C0.7861.00
237_I376_Q0.7861.00
235_A243_A0.7851.00
121_A180_S0.7831.00
70_K74_H0.7801.00
222_I360_N0.7801.00
79_T82_W0.7771.00
437_I441_G0.7761.00
85_V89_I0.7731.00
177_L180_S0.7711.00
381_I385_L0.7701.00
83_L87_L0.7691.00
345_S349_A0.7681.00
75_L78_T0.7671.00
248_L251_N0.7661.00
100_D103_G0.7651.00
453_I456_G0.7611.00
371_I383_V0.7611.00
302_L306_V0.7591.00
117_T177_L0.7591.00
269_F345_S0.7581.00
248_L320_W0.7571.00
291_S295_I0.7541.00
151_A155_G0.7531.00
128_G184_T0.7531.00
66_I80_L0.7521.00
90_V94_A0.7511.00
362_F397_L0.7491.00
84_N88_G0.7491.00
230_S250_Y0.7481.00
260_L263_I0.7481.00
356_S360_N0.7461.00
417_S421_P0.7461.00
30_T315_V0.7431.00
29_M33_A0.7431.00
124_V177_L0.7421.00
299_P425_S0.7381.00
237_I372_V0.7381.00
155_G159_T0.7371.00
269_F349_A0.7371.00
251_N254_V0.7361.00
305_M331_C0.7361.00
224_Y228_N0.7361.00
332_V336_L0.7351.00
343_I395_T0.7341.00
370_A373_I0.7321.00
32_L159_T0.7321.00
44_L169_A0.7311.00
73_S138_E0.7301.00
377_M381_I0.7251.00
270_P274_K0.7251.00
347_L356_S0.7231.00
132_R136_Q0.7191.00
303_G456_G0.7191.00
113_P117_T0.7181.00
231_T243_A0.7171.00
228_N254_V0.7171.00
333_V391_Q0.7151.00
38_N320_W0.7151.00
155_G175_G0.7141.00
93_V97_L0.7121.00
80_L84_N0.7111.00
345_S348_M0.7101.00
285_N289_L0.7081.00
31_V164_H0.7061.00
288_K291_S0.7041.00
332_V335_L0.7031.00
359_F363_K0.7011.00
116_K119_S0.7011.00
231_T247_N0.7001.00
211_R215_W0.6991.00
143_K146_M0.6981.00
419_W423_Y0.6951.00
96_F99_S0.6951.00
289_L342_P0.6931.00
452_Q456_G0.6921.00
42_G244_G0.6911.00
127_H184_T0.6901.00
138_E194_I0.6891.00
41_F244_G0.6861.00
38_N241_G0.6861.00
52_A55_D0.6851.00
16_I20_I0.6841.00
459_A463_M0.6811.00
39_H240_A0.6811.00
72_I205_S0.6771.00
435_L438_V0.6751.00
151_A183_R0.6751.00
82_W85_V0.6751.00
300_A303_G0.6751.00
187_F190_F0.6741.00
61_G213_G0.6721.00
376_Q383_V0.6691.00
264_I268_L0.6691.00
99_S102_I0.6681.00
41_F248_L0.6671.00
8_I11_A0.6671.00
216_L348_M0.6661.00
10_G267_V0.6651.00
31_V160_V0.6621.00
177_L181_A0.6621.00
299_P302_L0.6571.00
246_Y250_Y0.6571.00
90_V93_V0.6561.00
405_P408_G0.6541.00
62_I80_L0.6521.00
15_A19_V0.6511.00
261_N265_T0.6511.00
20_I24_L0.6501.00
55_D59_D0.6501.00
71_E75_L0.6461.00
403_I407_L0.6451.00
206_V210_L0.6451.00
198_G201_F0.6451.00
421_P425_S0.6451.00
285_N288_K0.6441.00
156_F160_V0.6421.00
295_I299_P0.6421.00
432_S436_G0.6401.00
366_L369_P0.6401.00
228_N232_L0.6401.00
161_V165_F0.6391.00
125_I180_S0.6381.00
226_N364_T0.6361.00
136_Q144_I0.6361.00
293_V342_P0.6361.00
340_G395_T0.6351.00
392_I396_I0.6341.00
153_L157_T0.6331.00
32_L41_F0.6331.00
308_S331_C0.6321.00
427_P430_V0.6321.00
17_A149_T0.6311.00
229_L233_V0.6311.00
88_G126_P0.6301.00
253_A256_P0.6301.00
135_M143_K0.6291.00
132_R148_E0.6291.00
219_D360_N0.6291.00
212_F216_L0.6291.00
158_C161_V0.6261.00
95_V99_S0.6251.00
420_L424_L0.6251.00
211_R354_D0.6241.00
400_F405_P0.6241.00
117_T173_I0.6241.00
310_N448_L0.6241.00
252_V316_F0.6191.00
275_I282_L0.6191.00
384_T388_L0.6191.00
36_I169_A0.6181.00
78_T81_Y0.6181.00
51_I122_F0.6181.00
209_N213_G0.6141.00
327_L331_C0.6141.00
344_G356_S0.6131.00
20_I153_L0.6131.00
423_Y426_L0.6131.00
313_P317_G0.6111.00
388_L392_I0.6091.00
183_R187_F0.6091.00
437_I440_K0.6071.00
103_G115_I0.6051.00
231_T250_Y0.6051.00
73_S77_L0.6051.00
238_L379_G0.6041.00
313_P324_I0.6041.00
117_T174_L0.6021.00
362_F365_F0.6021.00
117_T170_M0.5991.00
51_I55_D0.5981.00
147_I183_R0.5971.00
353_V356_S0.5971.00
361_V364_T0.5941.00
21_I25_G0.5921.00
147_I151_A0.5911.00
76_E79_T0.5911.00
371_I386_G0.5911.00
263_I266_R0.5901.00
446_G450_A0.5891.00
39_H43_L0.5881.00
33_A320_W0.5881.00
98_L102_I0.5851.00
436_G448_L0.5851.00
299_P428_T0.5841.00
133_A137_K0.5841.00
251_N316_F0.5831.00
431_V455_T0.5821.00
271_A285_N0.5821.00
61_G68_Q0.5811.00
14_S141_F0.5791.00
25_G29_M0.5791.00
83_L88_G0.5781.00
44_L173_I0.5781.00
267_V271_A0.5771.00
219_D223_N0.5741.00
146_M150_S0.5711.00
248_L323_I0.5701.00
63_A133_A0.5691.00
436_G440_K0.5671.00
229_L367_F0.5661.00
391_Q395_T0.5651.00
92_C123_V0.5641.00
366_L390_V0.5641.00
141_F145_G0.5641.00
387_F390_V0.5631.00
46_V49_V0.5631.00
184_T188_G0.5621.00
302_L305_M0.5601.00
432_S452_Q0.5591.00
336_L388_L0.5581.00
46_V231_T0.5581.00
115_I119_S0.5571.00
53_L224_Y0.5541.00
201_F206_V0.5541.00
268_L272_F0.5541.00
69_R209_N0.5531.00
117_T121_A0.5531.00
131_F191_G0.5531.00
291_S417_S0.5511.00
29_M41_F0.5501.00
167_P170_M0.5491.00
408_G411_Y0.5471.00
355_I359_F0.5461.00
172_A176_Y0.5451.00
276_Q279_T0.5441.00
374_G382_G0.5441.00
190_F194_I0.5441.00
73_S79_T0.5441.00
14_S18_T0.5431.00
78_T198_G0.5421.00
421_P424_L0.5411.00
68_Q349_A0.5411.00
230_S233_V0.5401.00
301_L331_C0.5391.00
298_F302_L0.5391.00
151_A179_N0.5381.00
121_A125_I0.5381.00
159_T163_A0.5371.00
369_P376_Q0.5371.00
50_I54_A0.5361.00
152_V156_F0.5361.00
416_L419_W0.5351.00
391_Q394_N0.5351.00
360_N364_T0.5341.00
170_M174_L0.5341.00
223_N227_T0.5321.00
189_Y192_R0.5301.00
104_D107_N0.5291.00
71_E74_H0.5281.00
307_V453_I0.5281.00
262_P266_R0.5281.00
79_T202_S0.5261.00
131_F187_F0.5261.00
242_V245_G0.5251.00
238_L375_G0.5241.00
313_P318_E0.5241.00
171_T174_L0.5231.00
418_L421_P0.5231.00
73_S80_L0.5221.00
337_R341_N0.5201.00
73_S88_G0.5201.00
344_G348_M0.5201.00
124_V128_G0.5201.00
337_R391_Q0.5191.00
200_H203_L0.5191.00
155_G158_C0.5181.00
363_K390_V0.5171.00
40_Q169_A0.5151.00
12_K19_V0.5141.00
452_Q455_T0.5141.00
92_C119_S0.5130.99
426_L430_V0.5130.99
82_W199_L0.5120.99
219_D357_F0.5120.99
346_L350_K0.5100.99
150_S154_A0.5100.99
299_P303_G0.5090.99
32_L36_I0.5090.99
76_E84_N0.5090.99
20_I23_G0.5080.99
80_L88_G0.5080.99
456_G460_F0.5070.99
220_S224_Y0.5060.99
346_L403_I0.5060.99
297_N331_C0.5050.99
226_N229_L0.5030.99
284_V287_Y0.5020.99
424_L460_F0.5010.99
422_F426_L0.5010.99
358_K401_V0.5010.99
449_L452_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.8333 100 0.418 Contact Map
4humA 1 0.8455 100 0.428 Contact Map
3w4tA 1 0.8171 100 0.431 Contact Map
3mktA 1 0.8415 100 0.441 Contact Map
2cfqA 1 0.8028 72.2 0.935 Contact Map
3wdoA 1 0.7988 70.2 0.936 Contact Map
1pw4A 1 0.4228 35 0.949 Contact Map
4xnjA 1 0.4106 23.1 0.953 Contact Map
4pypA 1 0.8049 20.2 0.954 Contact Map
3dinC 1 0.5711 18.7 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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