GREMLIN Database
YDGJ - Uncharacterized oxidoreductase YdgJ
UniProt: P77376 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13931
Length: 346 (312)
Sequences: 25132 (18487)
Seq/√Len: 1046.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_K83_A3.1161.00
125_R183_D2.8831.00
82_K110_L2.8211.00
78_F106_E2.8051.00
6_R31_E2.7711.00
194_S217_S2.7581.00
132_T135_G2.7291.00
144_E243_S2.6971.00
105_R324_I2.6871.00
40_E44_K2.6381.00
86_E110_L2.6281.00
193_V219_P2.4551.00
72_T80_L2.4371.00
134_K138_A2.4041.00
78_F103_Q2.3921.00
8_G59_L2.3831.00
82_K86_E2.3681.00
82_K106_E2.3481.00
90_H117_V2.3251.00
214_A333_G2.2851.00
85_L116_R2.2851.00
55_E58_H2.1961.00
34_V53_V2.1401.00
76_T80_L2.1371.00
109_A113_S2.0731.00
112_K321_S2.0481.00
135_G139_E2.0341.00
308_D312_G2.0241.00
78_F82_K2.0031.00
51_T62_D1.9921.00
132_T136_L1.9901.00
81_A93_V1.9761.00
85_L111_A1.9381.00
67_L306_I1.9231.00
105_R109_A1.8981.00
105_R328_E1.8851.00
110_L114_L1.8751.00
79_P83_A1.8531.00
39_D42_K1.8481.00
72_T76_T1.8301.00
142_L242_G1.7801.00
86_E114_L1.7731.00
8_G65_I1.7701.00
90_H116_R1.7601.00
24_I69_V1.7251.00
101_L331_E1.7151.00
7_V67_L1.7151.00
68_I84_A1.7101.00
30_Q307_R1.6671.00
81_A107_L1.6651.00
27_T304_A1.6631.00
118_L320_A1.6521.00
65_I89_K1.6461.00
100_T103_Q1.6421.00
54_S58_H1.6351.00
61_N87_A1.6111.00
60_F84_A1.5961.00
199_L337_A1.5811.00
29_G311_N1.5791.00
191_L325_Q1.5751.00
133_L247_Y1.5731.00
134_K187_T1.5701.00
86_E113_S1.5531.00
121_F302_Y1.5491.00
193_V217_S1.5471.00
56_P83_A1.5211.00
108_D324_I1.5151.00
117_V313_D1.5121.00
325_Q328_E1.5101.00
186_I191_L1.4791.00
136_L141_V1.4771.00
99_V103_Q1.4691.00
191_L219_P1.4551.00
108_D320_A1.4471.00
53_V62_D1.4381.00
146_A243_S1.4331.00
78_F107_L1.4321.00
58_H61_N1.4321.00
110_L113_S1.4311.00
57_K61_N1.4241.00
149_E239_I1.4081.00
40_E54_S1.3991.00
98_T107_L1.3981.00
85_L114_L1.3981.00
98_T104_A1.3801.00
43_V52_V1.3711.00
6_R33_A1.3591.00
53_V59_L1.3571.00
83_A86_E1.3521.00
142_L245_G1.3391.00
308_D314_G1.3331.00
6_R66_D1.3221.00
305_A309_A1.3181.00
186_I325_Q1.3131.00
104_A324_I1.3111.00
239_I248_V1.3081.00
83_A87_A1.3011.00
36_S56_P1.3001.00
12_Y35_I1.2911.00
58_H62_D1.2901.00
101_L105_R1.2811.00
101_L328_E1.2811.00
145_V240_V1.2801.00
198_D217_S1.2771.00
192_P218_Y1.2661.00
182_L329_L1.2651.00
70_I80_L1.2551.00
84_A91_V1.2421.00
63_P89_K1.2201.00
56_P80_L1.2081.00
36_S59_L1.2051.00
305_A317_P1.2051.00
88_G114_L1.2021.00
70_I81_A1.1961.00
106_E109_A1.1961.00
59_L65_I1.1941.00
34_V59_L1.1861.00
85_L110_L1.1811.00
186_I218_Y1.1781.00
166_Q169_P1.1641.00
75_D169_P1.1631.00
73_P76_T1.1601.00
41_T44_K1.1581.00
237_R248_V1.1581.00
189_F222_R1.1571.00
108_D321_S1.1511.00
64_N89_K1.1451.00
148_F189_F1.1421.00
319_P322_Q1.1411.00
136_L139_E1.1361.00
26_G300_P1.1341.00
196_T215_I1.1341.00
7_V30_Q1.1341.00
149_E226_H1.1281.00
97_F104_A1.1271.00
109_A112_K1.1271.00
5_I311_N1.1171.00
106_E110_L1.1141.00
304_A308_D1.1081.00
331_E335_E1.1071.00
5_I67_L1.1061.00
186_I322_Q1.1051.00
90_H313_D1.1051.00
47_W50_V1.0961.00
60_F83_A1.0901.00
92_V121_F1.0901.00
130_F187_T1.0881.00
82_K107_L1.0851.00
104_A327_M1.0771.00
142_L247_Y1.0721.00
103_Q106_E1.0681.00
332_L335_E1.0671.00
56_P60_F1.0661.00
307_R311_N1.0651.00
60_F87_A1.0611.00
142_L145_V1.0531.00
92_V302_Y1.0521.00
90_H310_L1.0441.00
20_H69_V1.0371.00
5_I310_L1.0351.00
108_D112_K1.0341.00
34_V65_I1.0301.00
93_V118_L1.0201.00
10_I80_L1.0201.00
335_E338_K1.0141.00
98_T103_Q1.0121.00
62_D65_I1.0111.00
42_K45_A1.0091.00
126_W305_A1.0091.00
305_A314_G1.0061.00
135_G138_A1.0011.00
107_L118_L0.9821.00
43_V54_S0.9821.00
125_R322_Q0.9801.00
102_S105_R0.9771.00
305_A308_D0.9751.00
332_L336_S0.9731.00
131_L317_P0.9681.00
133_L249_K0.9531.00
111_A114_L0.9531.00
81_A91_V0.9491.00
97_F320_A0.9481.00
22_P26_G0.9461.00
192_P216_L0.9451.00
80_L83_A0.9431.00
101_L324_I0.9381.00
145_V189_F0.9371.00
53_V58_H0.9331.00
41_T45_A0.9311.00
17_K46_D0.9281.00
78_F98_T0.9161.00
145_V242_G0.9141.00
123_N298_N0.9131.00
321_S325_Q0.9131.00
300_P304_A0.9131.00
102_S106_E0.9131.00
301_A304_A0.9101.00
119_S306_I0.9101.00
51_T64_N0.9061.00
40_E43_V0.9031.00
97_F118_L0.9031.00
85_L91_V0.9011.00
12_Y37_S0.9001.00
70_I84_A0.8961.00
308_D313_D0.8951.00
148_F240_V0.8841.00
196_T336_S0.8831.00
46_D49_T0.8811.00
309_A312_G0.8791.00
150_S238_Y0.8781.00
197_V333_G0.8781.00
182_L330_I0.8741.00
81_A85_L0.8731.00
93_V97_F0.8661.00
8_G34_V0.8641.00
20_H303_Y0.8621.00
213_H224_I0.8611.00
69_V303_Y0.8591.00
76_T79_P0.8571.00
44_K52_V0.8501.00
62_D89_K0.8491.00
143_G242_G0.8471.00
37_S42_K0.8461.00
111_A118_L0.8451.00
328_E332_L0.8431.00
117_V310_L0.8431.00
334_I338_K0.8421.00
166_Q207_Q0.8421.00
143_G245_G0.8411.00
8_G36_S0.8381.00
167_G338_K0.8371.00
309_A316_N0.8361.00
167_G207_Q0.8361.00
33_A51_T0.8351.00
6_R65_I0.8331.00
192_P219_P0.8321.00
40_E52_V0.8311.00
105_R108_D0.8291.00
192_P329_L0.8271.00
7_V24_I0.8211.00
33_A64_N0.8201.00
239_I246_S0.8181.00
117_V309_A0.8161.00
185_A218_Y0.8141.00
93_V107_L0.8141.00
171_S175_Y0.8121.00
74_N176_D0.8091.00
24_I30_Q0.8091.00
131_L135_G0.8071.00
37_S43_V0.8051.00
111_A116_R0.8051.00
15_A20_H0.8011.00
111_A320_A0.7991.00
16_S22_P0.7991.00
24_I303_Y0.7991.00
149_E224_I0.7911.00
29_G304_A0.7901.00
119_S309_A0.7841.00
99_V170_G0.7831.00
85_L118_L0.7821.00
237_R250_Y0.7811.00
9_L21_A0.7811.00
186_I326_V0.7801.00
16_S71_P0.7791.00
148_F185_A0.7721.00
138_A190_G0.7711.00
67_L90_H0.7701.00
137_L242_G0.7681.00
27_T30_Q0.7661.00
15_A71_P0.7611.00
315_E319_P0.7601.00
33_A65_I0.7571.00
198_D215_I0.7561.00
15_A299_Y0.7561.00
97_F120_V0.7551.00
122_H179_P0.7541.00
10_I56_P0.7521.00
21_A32_L0.7481.00
33_A62_D0.7471.00
104_A108_D0.7461.00
150_S181_L0.7411.00
78_F110_L0.7401.00
306_I310_L0.7401.00
309_A314_G0.7401.00
120_V323_A0.7361.00
8_G68_I0.7351.00
179_P326_V0.7281.00
48_P51_T0.7261.00
173_I227_G0.7261.00
10_I36_S0.7261.00
172_G209_T0.7231.00
59_L62_D0.7221.00
324_I328_E0.7211.00
189_F218_Y0.7181.00
174_W330_I0.7171.00
144_E244_R0.7121.00
12_Y43_V0.7051.00
320_A323_A0.7041.00
327_M331_E0.7031.00
27_T307_R0.7011.00
88_G116_R0.7001.00
82_K85_L0.6991.00
93_V120_V0.6991.00
77_H93_V0.6981.00
10_I72_T0.6981.00
131_L301_A0.6981.00
188_L240_V0.6951.00
200_A217_S0.6941.00
125_R187_T0.6941.00
85_L107_L0.6921.00
137_L240_V0.6911.00
29_G308_D0.6881.00
144_E220_Q0.6841.00
6_R64_N0.6801.00
130_F184_Q0.6801.00
194_S198_D0.6781.00
299_Y302_Y0.6751.00
197_V214_A0.6741.00
191_L328_E0.6731.00
124_R127_D0.6721.00
198_D223_V0.6711.00
7_V307_R0.6701.00
183_D326_V0.6681.00
241_H246_S0.6671.00
122_H183_D0.6671.00
92_V119_S0.6651.00
117_V315_E0.6641.00
209_T334_I0.6631.00
174_W212_F0.6621.00
134_K188_L0.6581.00
17_K45_A0.6581.00
322_Q325_Q0.6571.00
178_A181_L0.6561.00
150_S185_A0.6561.00
29_G307_R0.6551.00
202_L210_D0.6541.00
197_V212_F0.6541.00
79_P106_E0.6531.00
178_A227_G0.6521.00
17_K42_K0.6481.00
81_A118_L0.6451.00
7_V69_V0.6441.00
67_L310_L0.6411.00
176_D229_M0.6401.00
305_A316_N0.6391.00
228_T231_A0.6381.00
123_N299_Y0.6341.00
186_I329_L0.6341.00
53_V63_P0.6291.00
261_N264_R0.6281.00
31_E50_V0.6271.00
89_K116_R0.6251.00
210_D230_L0.6241.00
35_I43_V0.6221.00
183_D187_T0.6191.00
117_V316_N0.6191.00
56_P84_A0.6181.00
182_L333_G0.6141.00
137_L188_L0.6121.00
35_I52_V0.6121.00
119_S305_A0.6111.00
15_A94_D0.6101.00
68_I89_K0.6081.00
214_A225_L0.6081.00
122_H326_V0.6041.00
124_R183_D0.6041.00
258_R261_N0.6011.00
151_H226_H0.5991.00
17_K47_W0.5991.00
86_E106_E0.5981.00
57_K79_P0.5961.00
211_Y228_T0.5951.00
32_L49_T0.5941.00
39_D44_K0.5931.00
147_Y241_H0.5921.00
69_V92_V0.5921.00
326_V330_I0.5901.00
180_H183_D0.5891.00
81_A111_A0.5871.00
95_K176_D0.5841.00
133_L188_L0.5811.00
216_L225_L0.5801.00
196_T217_S0.5791.00
131_L187_T0.5781.00
38_S72_T0.5781.00
203_R210_D0.5771.00
100_T331_E0.5771.00
199_L212_F0.5751.00
147_Y223_V0.5741.00
174_W214_A0.5731.00
79_P82_K0.5721.00
108_D111_A0.5711.00
34_V51_T0.5681.00
308_D311_N0.5681.00
175_Y331_E0.5681.00
48_P52_V0.5671.00
141_V144_E0.5671.00
70_I77_H0.5651.00
330_I334_I0.5651.00
66_D311_N0.5631.00
17_K22_P0.5591.00
30_Q67_L0.5581.00
119_S302_Y0.5571.00
168_G207_Q0.5561.00
14_Y19_F0.5561.00
13_G71_P0.5541.00
151_H237_R0.5541.00
195_M329_L0.5521.00
140_G242_G0.5521.00
94_D121_F0.5491.00
140_G144_E0.5481.00
20_H24_I0.5461.00
36_S53_V0.5451.00
215_I224_I0.5441.00
164_R176_D0.5441.00
258_R262_G0.5431.00
71_P94_D0.5431.00
257_E260_K0.5421.00
13_G16_S0.5411.00
5_I30_Q0.5401.00
215_I223_V0.5401.00
22_P25_A0.5391.00
218_Y222_R0.5381.00
120_V180_H0.5381.00
147_Y211_Y0.5351.00
131_L134_K0.5351.00
170_G208_S0.5331.00
102_S331_E0.5301.00
97_F107_L0.5301.00
5_I307_R0.5301.00
257_E261_N0.5291.00
297_G300_P0.5281.00
117_V306_I0.5271.00
20_H71_P0.5261.00
75_D99_V0.5261.00
128_S301_A0.5261.00
10_I68_I0.5261.00
185_A225_L0.5251.00
10_I70_I0.5251.00
82_K114_L0.5221.00
189_F220_Q0.5211.00
9_L69_V0.5211.00
126_W318_V0.5191.00
290_E293_L0.5181.00
173_I177_L0.5181.00
122_H180_H0.5171.00
95_K180_H0.5171.00
148_F238_Y0.5171.00
9_L32_L0.5151.00
256_E259_L0.5151.00
72_T77_H0.5151.00
21_A25_A0.5141.00
147_Y226_H0.5131.00
163_W166_Q0.5131.00
27_T300_P0.5131.00
216_L329_L0.5121.00
123_N180_H0.5121.00
329_L332_L0.5111.00
134_K190_G0.5101.00
57_K87_A0.5101.00
259_L263_E0.5091.00
251_G254_P0.5091.00
36_S54_S0.5081.00
51_T63_P0.5071.00
104_A323_A0.5071.00
186_I192_P0.5031.00
111_A115_G0.5011.00
147_Y224_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kuxA 2 0.9913 100 0.195 Contact Map
3gdoA 2 0.974 100 0.195 Contact Map
3e82A 2 0.9798 100 0.196 Contact Map
3fhlA 2 0.9624 100 0.204 Contact Map
3dtyA 4 0.9509 100 0.215 Contact Map
1h6dA 8 0.9538 100 0.218 Contact Map
1zh8A 2 0.9017 100 0.219 Contact Map
3v5nA 4 0.9306 100 0.222 Contact Map
3db2A 2 0.9682 100 0.229 Contact Map
2nvwA 3 0.9249 100 0.23 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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