GREMLIN Database
YBCL - UPF0098 protein YbcL
UniProt: P77368 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13628
Length: 183 (151)
Sequences: 2574 (1765)
Seq/√Len: 143.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_K169_N4.9981.00
60_V67_F3.8471.00
46_C129_C3.3091.00
120_F126_G2.8461.00
71_V141_F2.7411.00
38_S99_V2.7341.00
69_V143_V2.6431.00
22_F174_A2.5101.00
34_Q179_V2.4841.00
89_N152_P2.3741.00
27_N54_S2.2971.00
28_E99_V2.2731.00
28_E54_S2.2211.00
30_K33_E2.0281.00
140_Q177_T1.9061.00
29_I178_P1.8771.00
142_K175_E1.8371.00
68_A162_V1.8261.00
67_F92_A1.7761.00
35_L128_A1.7381.00
24_V143_V1.7021.00
38_S49_G1.6841.00
50_N127_G1.6831.00
146_L166_L1.5821.00
88_V116_G1.5811.00
60_V95_T1.5651.00
116_G162_V1.5631.00
52_S97_L1.5241.00
54_S96_Y1.4931.00
56_T96_Y1.4771.00
136_P181_E1.4661.00
135_K181_E1.4461.00
110_P113_A1.4451.00
87_V113_A1.4121.00
89_N150_K1.4001.00
68_A166_L1.3881.00
26_S176_I1.3861.00
75_D138_H1.3821.00
90_I94_V1.3751.00
24_V174_A1.3471.00
142_K173_T1.3371.00
57_W97_L1.3061.00
162_V166_L1.2981.00
66_S148_T1.2971.00
88_V162_V1.2861.00
35_L178_P1.2741.00
73_D84_H1.2741.00
29_I36_T1.2591.00
83_W159_G1.2161.00
34_Q181_E1.2111.00
66_S89_N1.1891.00
158_S161_L1.1821.00
100_D103_R1.1731.00
24_V55_L1.1541.00
125_F128_A1.1530.99
86_T162_V1.1460.99
23_Q58_S1.1440.99
148_T169_N1.1440.99
86_T116_G1.1420.99
82_W120_F1.1390.99
165_M168_A1.1330.99
166_L170_K1.1320.99
38_S51_T1.1300.99
27_N56_T1.1250.99
144_W166_L1.1100.99
89_N114_V1.0970.99
66_S150_K1.0900.99
26_S55_L1.0900.99
61_P64_T1.0760.99
115_Q124_G1.0640.99
88_V157_S1.0600.99
102_G115_Q1.0530.99
140_Q175_E1.0280.99
98_P101_A1.0110.99
67_F143_V1.0090.99
51_T99_V1.0090.99
68_A146_L1.0090.99
109_L113_A0.9940.98
22_F172_A0.9920.98
52_S85_W0.9910.98
26_S29_I0.9770.98
61_P145_A0.9730.98
60_V64_T0.9720.98
151_I166_L0.9630.98
72_Y80_S0.9620.98
144_W170_K0.9580.98
72_Y83_W0.9540.98
88_V114_V0.9490.98
84_H130_P0.9470.98
53_P141_F0.9360.98
22_F60_V0.9330.98
60_V63_G0.9300.98
89_N151_I0.9250.98
63_G171_I0.9240.98
24_V176_I0.9150.97
67_F95_T0.9100.97
138_H177_T0.9050.97
143_V174_A0.8980.97
61_P67_F0.8970.97
71_V125_F0.8970.97
31_T177_T0.8900.97
57_W67_F0.8840.97
64_T171_I0.8830.97
72_Y142_K0.8810.97
29_I33_E0.8780.97
25_T56_T0.8710.97
64_T67_F0.8700.97
157_S162_V0.8690.96
84_H137_H0.8470.96
50_N120_F0.8460.96
85_W115_Q0.8420.96
117_R156_N0.8370.96
74_P140_Q0.8360.96
73_D137_H0.8100.95
130_P137_H0.8050.95
34_Q136_P0.8000.94
157_S161_L0.7970.94
64_T145_A0.7950.94
52_S101_A0.7900.94
34_Q37_T0.7890.94
80_S160_A0.7860.94
32_G177_T0.7830.94
29_I176_I0.7760.94
85_W102_G0.7750.93
147_K170_K0.7640.93
58_S95_T0.7630.93
161_L165_M0.7510.92
79_G163_G0.7480.92
73_D130_P0.7450.92
63_G172_A0.7410.92
82_W126_G0.7340.91
50_N126_G0.7330.91
154_D157_S0.7250.91
51_T100_D0.7230.91
86_T159_G0.7220.91
37_T47_E0.7150.90
55_L141_F0.7030.90
32_G179_V0.7000.89
33_E179_V0.6980.89
87_V115_Q0.6960.89
123_A156_N0.6960.89
89_N148_T0.6950.89
118_N126_G0.6950.89
70_T166_L0.6930.89
45_G48_G0.6930.89
76_A79_G0.6920.89
25_T58_S0.6900.89
72_Y159_G0.6890.89
170_K173_T0.6730.88
100_D108_K0.6720.87
76_A82_W0.6650.87
55_L176_I0.6630.87
132_K136_P0.6570.86
48_G129_C0.6570.86
46_C126_G0.6570.86
161_L164_Y0.6560.86
59_G67_F0.6560.86
50_N122_Y0.6390.85
167_N173_T0.6330.84
159_G163_G0.6310.84
116_G159_G0.6280.84
166_L169_N0.6270.84
145_A171_I0.6260.84
118_N122_Y0.6190.83
59_G95_T0.6160.83
33_E178_P0.6140.82
82_W161_L0.6100.82
136_P179_V0.6100.82
122_Y126_G0.6070.82
76_A81_G0.6070.82
87_V90_I0.6050.81
55_L69_V0.6020.81
153_V162_V0.6000.81
117_R121_G0.5970.81
47_E180_Y0.5930.80
117_R123_A0.5920.80
21_A59_G0.5910.80
35_L141_F0.5900.80
82_W164_Y0.5900.80
72_Y163_G0.5890.80
142_K163_G0.5810.79
61_P172_A0.5700.77
130_P133_G0.5680.77
44_F47_E0.5610.76
69_V90_I0.5590.76
68_A116_G0.5560.76
72_Y140_Q0.5540.75
38_S44_F0.5540.75
115_Q123_A0.5470.75
72_Y81_G0.5440.74
84_H127_G0.5440.74
52_S100_D0.5430.74
75_D84_H0.5430.74
56_T95_T0.5380.73
153_V157_S0.5380.73
76_A119_D0.5380.73
75_D137_H0.5370.73
76_A80_S0.5370.73
84_H131_P0.5360.73
31_T175_E0.5360.73
57_W96_Y0.5360.73
83_W119_D0.5340.73
146_L170_K0.5340.73
57_W172_A0.5340.73
60_V172_A0.5340.73
147_K171_I0.5340.73
97_L101_A0.5280.72
37_T49_G0.5270.72
87_V102_G0.5260.72
66_S169_N0.5250.72
73_D76_A0.5230.71
146_L171_I0.5220.71
67_F145_A0.5220.71
87_V109_L0.5190.71
57_W143_V0.5160.70
45_G180_Y0.5150.70
103_R109_L0.5140.70
123_A155_S0.5120.70
82_W118_N0.5080.69
82_W119_D0.5050.69
168_A171_I0.5050.69
76_A137_H0.5040.68
77_P138_H0.5040.68
103_R115_Q0.5040.68
22_F59_G0.5000.68
68_A144_W0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fuxA 2 0.8962 100 0.184 Contact Map
4begA 4 0.9617 100 0.206 Contact Map
1fjjA 2 0.8689 100 0.209 Contact Map
3n08A 2 0.8142 100 0.235 Contact Map
2evvA 2 0.8415 100 0.297 Contact Map
1wpxB 1 0.8689 100 0.545 Contact Map
2jyzA 1 0.8142 99.9 0.579 Contact Map
1vw41 1 0.847 99.9 0.585 Contact Map
2gzqA 1 0.8525 99.9 0.586 Contact Map
3axyA 1 0.8033 99.9 0.597 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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