PGMB - ECOLI - GREMLIN Contacts

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PGMB - Beta-phosphoglucomutase

UniProt:	P77366	Sequences: MKLQGVIFDLDGVITDTAHLHFQAWQQIAAEIGISIDAQFNESLKGISRDESLRRILQHGGKEGDFNSQERAQLAYRKNLLYVHSLRELTVNAVLPGIRSLLADLRAQQISVGLASVSLNAPTILAALELREFFTFCADASQLKNSKPDPEIFLAACAGLGVPPQACIGIEDAQAGIDAINASGMRSVGIGAGLTGAQLLLPSTESLTWPRLSAFWQNV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13918
Length:	219 (196)
Sequences:	27803 (21733)
Seq/√Len:	1552.3

ECOLI - PGMB YNIC YFBT GPH YJJG YIEH YIGB YRFG YQAB YIHX
BACSU - PGMB YHCW PPAX YSAA YFNB
HALSA - Q9HQE2 Q9HSS2 Q9HP74 Q9HMC4
SULSO - Q97ZU6 Q7LXL6 Q7LX46 Q97WT6 Q97X58 Q97YZ1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
4_Q	166_A	4.318	1.00
126_A	131_R	2.955	1.00
155_A	159_G	2.916	1.00
145_N	149_D	2.789	1.00
171_E	176_G	2.575	1.00
5_G	162_V	2.532	1.00
180_I	187_S	2.486	1.00
103_A	133_F	2.476	1.00
3_L	186_R	2.408	1.00
99_R	103_A	2.378	1.00
113_G	136_F	2.300	1.00
111_S	135_T	2.271	1.00
155_A	158_A	2.263	1.00
115_A	152_I	2.223	1.00
120_N	142_Q	2.217	1.00
157_C	167_C	2.144	1.00
31_E	77_R	2.126	1.00
8_F	112_V	2.106	1.00
145_N	151_E	2.076	1.00
202_P	206_S	2.049	1.00
136_F	159_G	2.022	1.00
177_I	187_S	1.953	1.00
181_N	198_Q	1.942	1.00
178_D	182_A	1.913	1.00
27_Q	81_L	1.882	1.00
104_D	108_Q	1.875	1.00
163_P	166_A	1.872	1.00
116_S	121_A	1.794	1.00
6_V	110_I	1.790	1.00
169_G	180_I	1.760	1.00
157_C	185_M	1.714	1.00
106_R	133_F	1.700	1.00
106_R	135_T	1.688	1.00
168_I	188_V	1.685	1.00
7_I	169_G	1.661	1.00
122_P	131_R	1.658	1.00
186_R	198_Q	1.639	1.00
5_G	160_L	1.584	1.00
162_V	167_C	1.563	1.00
112_V	134_F	1.544	1.00
7_I	156_A	1.542	1.00
98_I	204_T	1.540	1.00
7_I	115_A	1.538	1.00
37_D	40_F	1.512	1.00
157_C	164_P	1.499	1.00
113_G	160_L	1.437	1.00
32_I	77_R	1.434	1.00
191_G	202_P	1.421	1.00
95_L	192_A	1.421	1.00
6_V	170_I	1.420	1.00
6_V	105_L	1.410	1.00
31_E	81_L	1.408	1.00
13_V	170_I	1.324	1.00
51_E	54_R	1.320	1.00
81_L	84_H	1.306	1.00
10_L	15_T	1.304	1.00
14_I	98_I	1.277	1.00
104_D	107_A	1.272	1.00
174_Q	178_D	1.265	1.00
27_Q	31_E	1.251	1.00
188_V	201_L	1.242	1.00
10_L	114_L	1.238	1.00
27_Q	85_S	1.228	1.00
122_P	126_A	1.217	1.00
97_G	100_S	1.210	1.00
191_G	200_L	1.197	1.00
153_F	179_A	1.195	1.00
138_A	159_G	1.194	1.00
10_L	121_A	1.175	1.00
153_F	169_G	1.172	1.00
101_L	204_T	1.170	1.00
11_D	17_T	1.166	1.00
70_E	73_Q	1.163	1.00
150_P	154_L	1.159	1.00
77_R	80_L	1.152	1.00
94_V	130_L	1.143	1.00
81_L	85_S	1.131	1.00
23_Q	89_L	1.123	1.00
7_I	167_C	1.120	1.00
167_C	185_M	1.117	1.00
121_A	139_D	1.111	1.00
188_V	199_L	1.091	1.00
138_A	156_A	1.089	1.00
203_S	206_S	1.087	1.00
85_S	88_E	1.085	1.00
28_I	32_I	1.081	1.00
5_G	111_S	1.072	1.00
153_F	185_M	1.071	1.00
77_R	81_L	1.058	1.00
23_Q	85_S	1.058	1.00
73_Q	77_R	1.052	1.00
120_N	139_D	1.049	1.00
5_G	167_C	1.042	1.00
10_L	118_S	1.029	1.00
115_A	156_A	1.026	1.00
23_Q	27_Q	1.023	1.00
3_L	168_I	1.023	1.00
100_S	205_E	1.022	1.00
151_E	155_A	1.015	1.00
50_D	54_R	1.015	1.00
106_R	112_V	1.011	1.00
114_L	134_F	1.011	1.00
103_A	107_A	1.000	1.00
136_F	160_L	0.996	1.00
181_N	187_S	0.992	1.00
129_E	132_E	0.984	1.00
47_I	51_E	0.982	1.00
154_L	158_A	0.982	1.00
27_Q	30_A	0.970	1.00
102_L	134_F	0.967	1.00
26_Q	30_A	0.966	1.00
123_T	127_A	0.961	1.00
169_G	185_M	0.950	1.00
156_A	160_L	0.949	1.00
153_F	171_E	0.947	1.00
11_D	118_S	0.943	1.00
87_R	123_T	0.943	1.00
123_T	126_A	0.942	1.00
154_L	183_S	0.941	1.00
23_Q	26_Q	0.933	1.00
99_R	133_F	0.932	1.00
54_R	58_Q	0.931	1.00
80_L	84_H	0.924	1.00
120_N	141_S	0.909	1.00
76_Y	80_L	0.907	1.00
186_R	199_L	0.906	1.00
26_Q	38_A	0.901	1.00
100_S	103_A	0.900	1.00
103_A	132_E	0.889	1.00
72_A	76_Y	0.886	1.00
95_L	190_I	0.881	1.00
121_A	124_I	0.879	1.00
7_I	160_L	0.873	1.00
175_A	178_D	0.872	1.00
5_G	113_G	0.868	1.00
51_E	55_R	0.865	1.00
94_V	99_R	0.864	1.00
143_L	155_A	0.861	1.00
55_R	58_Q	0.861	1.00
144_K	151_E	0.859	1.00
151_E	154_L	0.857	1.00
54_R	71_R	0.849	1.00
105_L	110_I	0.848	1.00
170_I	188_V	0.840	1.00
97_G	203_S	0.835	1.00
138_A	155_A	0.830	1.00
39_Q	43_S	0.823	1.00
11_D	116_S	0.811	1.00
181_N	196_G	0.810	1.00
116_S	139_D	0.808	1.00
29_A	34_I	0.799	1.00
95_L	98_I	0.798	1.00
154_L	164_P	0.797	1.00
58_Q	61_G	0.796	1.00
102_L	133_F	0.794	1.00
179_A	183_S	0.794	1.00
113_G	156_A	0.792	1.00
105_L	112_V	0.784	1.00
47_I	55_R	0.782	1.00
168_I	186_R	0.779	1.00
164_P	185_M	0.774	1.00
4_Q	110_I	0.774	1.00
10_L	124_I	0.771	1.00
7_I	185_M	0.769	1.00
49_R	52_S	0.766	1.00
177_I	197_A	0.765	1.00
139_D	142_Q	0.760	1.00
22_F	26_Q	0.751	1.00
112_V	133_F	0.750	1.00
162_V	166_A	0.742	1.00
48_S	51_E	0.741	1.00
20_L	92_N	0.739	1.00
6_V	168_I	0.737	1.00
153_F	176_G	0.737	1.00
177_I	189_G	0.734	1.00
11_D	172_D	0.734	1.00
49_R	53_L	0.731	1.00
85_S	89_L	0.726	1.00
189_G	200_L	0.724	1.00
82_Y	86_L	0.721	1.00
152_I	156_A	0.717	1.00
15_T	128_L	0.711	1.00
12_G	18_A	0.708	1.00
117_V	146_S	0.705	1.00
40_F	43_S	0.700	1.00
75_A	79_N	0.697	1.00
15_T	124_I	0.696	1.00
21_H	78_K	0.695	1.00
125_L	131_R	0.692	1.00
99_R	132_E	0.689	1.00
7_I	113_G	0.687	1.00
22_F	41_N	0.682	1.00
112_V	135_T	0.681	1.00
50_D	72_A	0.679	1.00
4_Q	111_S	0.679	1.00
201_L	204_T	0.676	1.00
122_P	137_C	0.675	1.00
3_L	110_I	0.675	1.00
121_A	137_C	0.673	1.00
142_Q	159_G	0.671	1.00
19_H	93_A	0.669	1.00
53_L	57_L	0.668	1.00
24_A	28_I	0.668	1.00
136_F	156_A	0.668	1.00
4_Q	162_V	0.666	1.00
178_D	181_N	0.666	1.00
13_V	190_I	0.665	1.00
99_R	129_E	0.660	1.00
21_H	25_W	0.651	1.00
150_P	182_A	0.649	1.00
101_L	170_I	0.649	1.00
143_L	152_I	0.649	1.00
192_A	204_T	0.648	1.00
97_G	101_L	0.647	1.00
39_Q	42_E	0.645	1.00
152_I	179_A	0.641	1.00
169_G	176_G	0.641	1.00
16_D	93_A	0.640	1.00
15_T	92_N	0.639	1.00
3_L	166_A	0.636	1.00
55_R	59_H	0.635	1.00
100_S	104_D	0.635	1.00
97_G	205_E	0.635	1.00
94_V	128_L	0.632	1.00
78_K	82_Y	0.630	1.00
111_S	162_V	0.628	1.00
115_A	169_G	0.623	1.00
201_L	207_L	0.617	1.00
48_S	52_S	0.615	1.00
118_S	121_A	0.615	1.00
24_A	81_L	0.614	1.00
57_L	62_K	0.610	1.00
42_E	45_K	0.609	1.00
169_G	179_A	0.608	1.00
134_F	137_C	0.604	1.00
21_H	118_S	0.603	1.00
30_A	35_S	0.602	1.00
87_R	127_A	0.601	1.00
164_P	167_C	0.600	1.00
13_V	176_G	0.596	1.00
115_A	138_A	0.592	1.00
22_F	38_A	0.590	1.00
140_A	152_I	0.585	1.00
73_Q	76_Y	0.584	1.00
157_C	162_V	0.581	1.00
17_T	118_S	0.580	1.00
138_A	152_I	0.576	1.00
170_I	207_L	0.568	1.00
8_F	101_L	0.563	1.00
32_I	73_Q	0.563	1.00
38_A	42_E	0.562	1.00
16_D	19_H	0.561	1.00
187_S	198_Q	0.561	1.00
7_I	153_F	0.561	1.00
106_R	132_E	0.560	1.00
41_N	45_K	0.558	1.00
98_I	101_L	0.558	1.00
28_I	77_R	0.557	1.00
84_H	88_E	0.554	1.00
97_G	192_A	0.554	1.00
74_L	77_R	0.552	1.00
188_V	207_L	0.550	1.00
11_D	124_I	0.549	1.00
118_S	171_E	0.548	1.00
117_V	175_A	0.545	1.00
103_A	106_R	0.544	1.00
84_H	87_R	0.539	1.00
153_F	180_I	0.538	1.00
57_L	60_G	0.536	1.00
21_H	82_Y	0.535	1.00
52_S	57_L	0.533	1.00
98_I	102_L	0.527	1.00
19_H	23_Q	0.526	1.00
71_R	75_A	0.524	1.00
57_L	61_G	0.524	1.00
36_I	41_N	0.521	1.00
43_S	55_R	0.520	1.00
79_N	83_V	0.520	1.00
126_A	132_E	0.518	1.00
50_D	75_A	0.518	1.00
190_I	204_T	0.518	1.00
83_V	87_R	0.515	1.00
101_L	104_D	0.513	1.00
175_A	179_A	0.513	1.00
47_I	52_S	0.512	1.00
96_P	205_E	0.512	1.00
154_L	157_C	0.511	1.00
40_F	44_L	0.511	1.00
28_I	74_L	0.510	1.00
101_L	105_L	0.507	1.00
76_Y	79_N	0.505	1.00
157_C	183_S	0.505	1.00
40_F	59_H	0.503	1.00
80_L	83_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3nasA	2	0.9498	100	0.274	Contact Map
4uw9A	1	0.9543	100	0.277	Contact Map
4g9bA	2	1	100	0.289	Contact Map
2wf7A	1	0.9817	100	0.303	Contact Map
4gibA	1	0.9909	100	0.309	Contact Map
3iruA	4	0.9863	100	0.313	Contact Map
1swvA	2	0.9726	100	0.318	Contact Map
1te2A	2	0.9498	100	0.328	Contact Map
3l5kA	1	0.9543	100	0.332	Contact Map
3qxgA	3	0.9543	100	0.332	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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