GREMLIN Database
PGMB - Beta-phosphoglucomutase
UniProt: P77366 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13918
Length: 219 (196)
Sequences: 27803 (21733)
Seq/√Len: 1552.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_Q166_A4.3181.00
126_A131_R2.9551.00
155_A159_G2.9161.00
145_N149_D2.7891.00
171_E176_G2.5751.00
5_G162_V2.5321.00
180_I187_S2.4861.00
103_A133_F2.4761.00
3_L186_R2.4081.00
99_R103_A2.3781.00
113_G136_F2.3001.00
111_S135_T2.2711.00
155_A158_A2.2631.00
115_A152_I2.2231.00
120_N142_Q2.2171.00
157_C167_C2.1441.00
31_E77_R2.1261.00
8_F112_V2.1061.00
145_N151_E2.0761.00
202_P206_S2.0491.00
136_F159_G2.0221.00
177_I187_S1.9531.00
181_N198_Q1.9421.00
178_D182_A1.9131.00
27_Q81_L1.8821.00
104_D108_Q1.8751.00
163_P166_A1.8721.00
116_S121_A1.7941.00
6_V110_I1.7901.00
169_G180_I1.7601.00
157_C185_M1.7141.00
106_R133_F1.7001.00
106_R135_T1.6881.00
168_I188_V1.6851.00
7_I169_G1.6611.00
122_P131_R1.6581.00
186_R198_Q1.6391.00
5_G160_L1.5841.00
162_V167_C1.5631.00
112_V134_F1.5441.00
7_I156_A1.5421.00
98_I204_T1.5401.00
7_I115_A1.5381.00
37_D40_F1.5121.00
157_C164_P1.4991.00
113_G160_L1.4371.00
32_I77_R1.4341.00
191_G202_P1.4211.00
95_L192_A1.4211.00
6_V170_I1.4201.00
6_V105_L1.4101.00
31_E81_L1.4081.00
13_V170_I1.3241.00
51_E54_R1.3201.00
81_L84_H1.3061.00
10_L15_T1.3041.00
14_I98_I1.2771.00
104_D107_A1.2721.00
174_Q178_D1.2651.00
27_Q31_E1.2511.00
188_V201_L1.2421.00
10_L114_L1.2381.00
27_Q85_S1.2281.00
122_P126_A1.2171.00
97_G100_S1.2101.00
191_G200_L1.1971.00
153_F179_A1.1951.00
138_A159_G1.1941.00
10_L121_A1.1751.00
153_F169_G1.1721.00
101_L204_T1.1701.00
11_D17_T1.1661.00
70_E73_Q1.1631.00
150_P154_L1.1591.00
77_R80_L1.1521.00
94_V130_L1.1431.00
81_L85_S1.1311.00
23_Q89_L1.1231.00
7_I167_C1.1201.00
167_C185_M1.1171.00
121_A139_D1.1111.00
188_V199_L1.0911.00
138_A156_A1.0891.00
203_S206_S1.0871.00
85_S88_E1.0851.00
28_I32_I1.0811.00
5_G111_S1.0721.00
153_F185_M1.0711.00
77_R81_L1.0581.00
23_Q85_S1.0581.00
73_Q77_R1.0521.00
120_N139_D1.0491.00
5_G167_C1.0421.00
10_L118_S1.0291.00
115_A156_A1.0261.00
23_Q27_Q1.0231.00
3_L168_I1.0231.00
100_S205_E1.0221.00
151_E155_A1.0151.00
50_D54_R1.0151.00
106_R112_V1.0111.00
114_L134_F1.0111.00
103_A107_A1.0001.00
136_F160_L0.9961.00
181_N187_S0.9921.00
129_E132_E0.9841.00
47_I51_E0.9821.00
154_L158_A0.9821.00
27_Q30_A0.9701.00
102_L134_F0.9671.00
26_Q30_A0.9661.00
123_T127_A0.9611.00
169_G185_M0.9501.00
156_A160_L0.9491.00
153_F171_E0.9471.00
11_D118_S0.9431.00
87_R123_T0.9431.00
123_T126_A0.9421.00
154_L183_S0.9411.00
23_Q26_Q0.9331.00
99_R133_F0.9321.00
54_R58_Q0.9311.00
80_L84_H0.9241.00
120_N141_S0.9091.00
76_Y80_L0.9071.00
186_R199_L0.9061.00
26_Q38_A0.9011.00
100_S103_A0.9001.00
103_A132_E0.8891.00
72_A76_Y0.8861.00
95_L190_I0.8811.00
121_A124_I0.8791.00
7_I160_L0.8731.00
175_A178_D0.8721.00
5_G113_G0.8681.00
51_E55_R0.8651.00
94_V99_R0.8641.00
143_L155_A0.8611.00
55_R58_Q0.8611.00
144_K151_E0.8591.00
151_E154_L0.8571.00
54_R71_R0.8491.00
105_L110_I0.8481.00
170_I188_V0.8401.00
97_G203_S0.8351.00
138_A155_A0.8301.00
39_Q43_S0.8231.00
11_D116_S0.8111.00
181_N196_G0.8101.00
116_S139_D0.8081.00
29_A34_I0.7991.00
95_L98_I0.7981.00
154_L164_P0.7971.00
58_Q61_G0.7961.00
102_L133_F0.7941.00
179_A183_S0.7941.00
113_G156_A0.7921.00
105_L112_V0.7841.00
47_I55_R0.7821.00
168_I186_R0.7791.00
164_P185_M0.7741.00
4_Q110_I0.7741.00
10_L124_I0.7711.00
7_I185_M0.7691.00
49_R52_S0.7661.00
177_I197_A0.7651.00
139_D142_Q0.7601.00
22_F26_Q0.7511.00
112_V133_F0.7501.00
162_V166_A0.7421.00
48_S51_E0.7411.00
20_L92_N0.7391.00
6_V168_I0.7371.00
153_F176_G0.7371.00
177_I189_G0.7341.00
11_D172_D0.7341.00
49_R53_L0.7311.00
85_S89_L0.7261.00
189_G200_L0.7241.00
82_Y86_L0.7211.00
152_I156_A0.7171.00
15_T128_L0.7111.00
12_G18_A0.7081.00
117_V146_S0.7051.00
40_F43_S0.7001.00
75_A79_N0.6971.00
15_T124_I0.6961.00
21_H78_K0.6951.00
125_L131_R0.6921.00
99_R132_E0.6891.00
7_I113_G0.6871.00
22_F41_N0.6821.00
112_V135_T0.6811.00
50_D72_A0.6791.00
4_Q111_S0.6791.00
201_L204_T0.6761.00
122_P137_C0.6751.00
3_L110_I0.6751.00
121_A137_C0.6731.00
142_Q159_G0.6711.00
19_H93_A0.6691.00
53_L57_L0.6681.00
24_A28_I0.6681.00
136_F156_A0.6681.00
4_Q162_V0.6661.00
178_D181_N0.6661.00
13_V190_I0.6651.00
99_R129_E0.6601.00
21_H25_W0.6511.00
150_P182_A0.6491.00
101_L170_I0.6491.00
143_L152_I0.6491.00
192_A204_T0.6481.00
97_G101_L0.6471.00
39_Q42_E0.6451.00
152_I179_A0.6411.00
169_G176_G0.6411.00
16_D93_A0.6401.00
15_T92_N0.6391.00
3_L166_A0.6361.00
55_R59_H0.6351.00
100_S104_D0.6351.00
97_G205_E0.6351.00
94_V128_L0.6321.00
78_K82_Y0.6301.00
111_S162_V0.6281.00
115_A169_G0.6231.00
201_L207_L0.6171.00
48_S52_S0.6151.00
118_S121_A0.6151.00
24_A81_L0.6141.00
57_L62_K0.6101.00
42_E45_K0.6091.00
169_G179_A0.6081.00
134_F137_C0.6041.00
21_H118_S0.6031.00
30_A35_S0.6021.00
87_R127_A0.6011.00
164_P167_C0.6001.00
13_V176_G0.5961.00
115_A138_A0.5921.00
22_F38_A0.5901.00
140_A152_I0.5851.00
73_Q76_Y0.5841.00
157_C162_V0.5811.00
17_T118_S0.5801.00
138_A152_I0.5761.00
170_I207_L0.5681.00
8_F101_L0.5631.00
32_I73_Q0.5631.00
38_A42_E0.5621.00
16_D19_H0.5611.00
187_S198_Q0.5611.00
7_I153_F0.5611.00
106_R132_E0.5601.00
41_N45_K0.5581.00
98_I101_L0.5581.00
28_I77_R0.5571.00
84_H88_E0.5541.00
97_G192_A0.5541.00
74_L77_R0.5521.00
188_V207_L0.5501.00
11_D124_I0.5491.00
118_S171_E0.5481.00
117_V175_A0.5451.00
103_A106_R0.5441.00
84_H87_R0.5391.00
153_F180_I0.5381.00
57_L60_G0.5361.00
21_H82_Y0.5351.00
52_S57_L0.5331.00
98_I102_L0.5271.00
19_H23_Q0.5261.00
71_R75_A0.5241.00
57_L61_G0.5241.00
36_I41_N0.5211.00
43_S55_R0.5201.00
79_N83_V0.5201.00
126_A132_E0.5181.00
50_D75_A0.5181.00
190_I204_T0.5181.00
83_V87_R0.5151.00
101_L104_D0.5131.00
175_A179_A0.5131.00
47_I52_S0.5121.00
96_P205_E0.5121.00
154_L157_C0.5111.00
40_F44_L0.5111.00
28_I74_L0.5101.00
101_L105_L0.5071.00
76_Y79_N0.5051.00
157_C183_S0.5051.00
40_F59_H0.5031.00
80_L83_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nasA 2 0.9498 100 0.274 Contact Map
4uw9A 1 0.9543 100 0.277 Contact Map
4g9bA 2 1 100 0.289 Contact Map
2wf7A 1 0.9817 100 0.303 Contact Map
4gibA 1 0.9909 100 0.309 Contact Map
3iruA 4 0.9863 100 0.313 Contact Map
1swvA 2 0.9726 100 0.318 Contact Map
1te2A 2 0.9498 100 0.328 Contact Map
3l5kA 1 0.9543 100 0.332 Contact Map
3qxgA 3 0.9543 100 0.332 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0086 seconds.