GREMLIN Database
GLXK2 - Glycerate kinase
UniProt: P77364 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13621
Length: 381 (371)
Sequences: 2549 (1922)
Seq/√Len: 99.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_S114_T3.4221.00
67_G71_E3.1571.00
269_I307_G2.8651.00
128_H187_H2.7701.00
29_T367_R2.6051.00
25_A363_F2.6041.00
139_V205_A2.5901.00
234_Q240_N2.4871.00
66_C116_E2.4721.00
77_Y120_H2.4461.00
79_L126_I2.4351.00
273_L278_L2.3831.00
128_H189_E2.3711.00
295_I321_G2.3631.00
279_A314_Q2.3521.00
5_I23_I2.3211.00
143_M153_F2.3181.00
294_R325_V2.2941.00
279_A311_V2.2391.00
151_V176_M2.2081.00
277_N280_Q2.1991.00
27_F370_A2.1981.00
24_K38_C2.1801.00
241_V255_I2.1681.00
71_E103_K2.1571.00
29_T363_F2.1361.00
64_E74_N2.1121.00
62_T74_N2.0861.00
141_G229_Y2.0741.00
215_T218_M2.0691.00
22_A26_G2.0641.00
4_V285_A2.0111.00
37_I281_A1.9851.00
199_V223_E1.9591.00
53_V78_G1.9551.00
24_K28_S1.9411.00
2_K35_N1.9321.00
367_R371_C1.9271.00
20_C38_C1.9151.00
214_A222_L1.8671.00
233_L260_F1.8651.00
161_L167_N1.8631.00
100_A103_K1.8601.00
84_K127_R1.8571.00
23_I366_A1.8391.00
155_D159_Q1.8321.00
191_A271_I1.8261.00
90_M253_M1.8101.00
151_V179_C1.8101.00
61_V124_N1.8091.00
131_L257_A1.8061.00
210_P219_V1.8061.00
21_Q38_C1.7931.00
123_D182_R1.7851.00
76_F92_A1.7731.00
42_A48_T1.7541.00
18_K359_E1.7331.00
50_D60_I1.7291.00
65_V116_E1.7251.00
299_T306_L1.7111.00
64_E72_K1.7011.00
295_I323_A1.6971.00
129_I186_C1.6881.00
127_R185_N1.6881.00
147_Q163_A1.6651.00
56_T81_G1.6461.00
192_C265_I1.6431.00
129_I188_I1.6421.00
155_D170_R1.6401.00
68_P98_L1.6361.00
5_I36_Y1.6321.00
90_M133_I1.6301.00
105_N108_L1.6241.00
133_I190_V1.6111.00
66_C110_S1.5991.00
77_Y124_N1.5891.00
60_I76_F1.5891.00
2_K284_G1.5841.00
205_A219_V1.5831.00
123_D180_D1.5651.00
161_L171_V1.5611.00
14_L358_G1.5581.00
99_V103_K1.5311.00
41_I304_A1.5301.00
153_F171_V1.5241.00
187_H264_D1.5161.00
321_G338_I1.5161.00
39_L281_A1.5051.00
231_R242_C1.5021.00
3_I287_L1.5001.00
67_G73_V1.4991.00
146_A256_A1.4781.00
279_A315_F1.4781.00
166_G225_G1.4681.00
120_H124_N1.4661.00
147_Q153_F1.4661.00
23_I289_I1.4641.00
162_A167_N1.4621.00
282_V317_V1.4591.00
278_L311_V1.4561.00
15_S18_K1.4531.00
14_L359_E1.4521.00
357_S360_T1.4391.00
93_A114_T1.4321.00
322_I366_A1.4301.00
269_I273_L1.4201.00
199_V242_C1.4191.00
19_C362_L1.4171.00
350_P353_E1.4011.00
198_L255_I1.4001.00
313_K339_D1.3981.00
66_C70_G1.3951.00
127_R186_C1.3780.99
152_R175_E1.3770.99
152_R160_A1.3700.99
189_E266_K1.3610.99
288_V308_V1.3430.99
146_A151_V1.3410.99
349_A354_V1.3340.99
274_N311_V1.3300.99
111_S138_T1.3270.99
63_L77_Y1.3250.99
2_K37_I1.3220.99
65_V93_A1.3040.99
7_P23_I1.2990.99
107_L221_E1.2920.99
195_D202_R1.2910.99
247_G258_A1.2900.99
7_P20_C1.2900.99
122_L186_C1.2870.99
31_F34_A1.2800.99
146_A260_F1.2790.99
165_G225_G1.2670.99
122_L182_R1.2650.99
284_G317_V1.2560.99
72_K116_E1.2550.99
143_M161_L1.2500.99
63_L117_L1.2470.99
282_V288_V1.2400.99
7_P16_A1.2390.99
122_L180_D1.2360.99
41_I273_L1.2250.99
233_L255_I1.2240.99
27_F34_A1.2120.99
205_A214_A1.2100.99
280_Q283_Q1.2080.99
202_R301_G1.2020.99
119_R180_D1.2010.99
108_L166_G1.2010.99
12_E97_M1.1950.98
282_V311_V1.1890.98
164_N167_N1.1880.98
165_G222_L1.1870.98
80_T87_V1.1860.98
342_F369_I1.1850.98
190_V265_I1.1830.98
199_V227_Q1.1750.98
169_A221_E1.1580.98
93_A117_L1.1580.98
349_A361_N1.1540.98
257_A263_A1.1460.98
111_S253_M1.1430.98
118_I188_I1.1420.98
206_A220_E1.1410.98
112_F163_A1.1400.98
75_A117_L1.1400.98
107_L218_M1.1390.98
9_S46_E1.1330.98
27_F36_Y1.1270.98
147_Q160_A1.1180.98
346_P361_N1.1100.98
366_A370_A1.1030.97
25_A359_E1.0990.97
49_V92_A1.0980.97
143_M229_Y1.0980.97
52_M275_A1.0920.97
244_M258_A1.0920.97
130_I271_I1.0900.97
309_A338_I1.0860.97
49_V89_E1.0840.97
214_A219_V1.0690.97
323_A326_L1.0680.97
325_V348_L1.0660.97
61_V77_Y1.0610.97
5_I20_C1.0520.97
342_F372_A1.0520.97
14_L19_C1.0450.96
227_Q231_R1.0440.96
112_F116_E1.0410.96
154_L173_S1.0390.96
266_K274_N1.0360.96
112_F148_A1.0350.96
206_A219_V1.0340.96
23_I322_I1.0330.96
50_D54_A1.0280.96
53_V60_I1.0230.96
118_I145_M1.0220.96
119_R123_D1.0140.96
85_T128_H1.0130.96
56_T80_T1.0120.96
90_M111_S1.0040.96
345_L354_V1.0020.95
133_I250_A1.0020.95
353_E357_S0.9940.95
167_N170_R0.9860.95
145_M253_M0.9850.95
273_L311_V0.9840.95
183_L188_I0.9810.95
218_M221_E0.9800.95
143_M147_Q0.9790.95
49_V132_G0.9750.95
342_F365_S0.9740.95
4_V317_V0.9690.95
30_L367_R0.9670.94
239_I262_N0.9630.94
24_K36_Y0.9590.94
306_L310_S0.9580.94
342_F368_N0.9500.94
153_F229_Y0.9490.94
207_V297_S0.9490.94
28_S36_Y0.9480.94
195_D301_G0.9480.94
326_L341_V0.9440.94
169_A225_G0.9420.94
111_S256_A0.9360.93
17_E21_Q0.9320.93
26_G30_L0.9300.93
305_P338_I0.9300.93
12_E104_R0.9300.93
88_I117_L0.9290.93
197_P247_G0.9280.93
156_A172_A0.9220.93
75_A92_A0.9220.93
190_V257_A0.9200.93
205_A223_E0.9170.93
75_A93_A0.9160.93
58_G78_G0.9070.92
39_L276_V0.9060.92
143_M171_V0.9020.92
3_I31_F0.9000.92
322_I369_I0.8960.92
63_L120_H0.8940.92
147_Q164_N0.8820.91
283_Q315_F0.8810.91
106_P109_A0.8800.91
227_Q242_C0.8790.91
27_F289_I0.8760.91
361_N368_N0.8750.91
330_V341_V0.8740.91
62_T76_F0.8700.91
85_T130_I0.8700.91
234_Q242_C0.8660.91
65_V75_A0.8650.90
163_A167_N0.8640.90
13_S358_G0.8600.90
196_N207_V0.8570.90
105_N109_A0.8530.90
4_V284_G0.8530.90
205_A225_G0.8510.90
130_I191_A0.8490.90
49_V76_F0.8470.90
232_V235_Q0.8440.89
69_M99_V0.8410.89
8_D46_E0.8390.89
105_N218_M0.8380.89
359_E363_F0.8340.89
205_A226_L0.8330.89
51_A87_V0.8290.89
295_I341_V0.8280.88
299_T323_A0.8260.88
230_A242_C0.8240.88
4_V282_V0.8220.88
31_F370_A0.8210.88
5_I289_I0.8200.88
90_M145_M0.8190.88
15_S50_D0.8160.88
90_M94_S0.8130.88
294_R327_G0.8110.87
257_A261_L0.8070.87
312_A319_V0.8070.87
17_E54_A0.8050.87
23_I370_A0.8030.87
361_N364_N0.8000.87
288_V312_A0.7970.87
219_V226_L0.7970.87
287_L318_P0.7960.86
306_L333_V0.7960.86
209_G214_A0.7930.86
332_V335_Q0.7910.86
133_I254_G0.7910.86
233_L259_V0.7900.86
107_L166_G0.7880.86
67_G99_V0.7870.86
30_L370_A0.7850.86
51_A54_A0.7850.86
188_I260_F0.7830.86
12_E355_L0.7750.85
7_P19_C0.7750.85
152_R178_E0.7710.85
228_N232_V0.7680.84
118_I129_I0.7620.84
300_A333_V0.7600.84
306_L338_I0.7590.84
143_M164_N0.7590.84
110_S163_A0.7590.84
164_N171_V0.7560.83
297_S332_V0.7550.83
311_V315_F0.7550.83
326_L330_V0.7550.83
121_A126_I0.7540.83
357_S361_N0.7520.83
346_P349_A0.7510.83
81_G84_K0.7500.83
277_N281_A0.7490.83
229_Y233_L0.7490.83
158_G173_S0.7480.83
35_N284_G0.7470.83
176_M179_C0.7470.83
104_R109_A0.7460.83
190_V263_A0.7430.82
22_A359_E0.7390.82
167_N171_V0.7380.82
58_G80_T0.7380.82
347_R357_S0.7370.82
300_A336_Y0.7360.82
295_I299_T0.7360.82
255_I259_V0.7360.82
101_P352_A0.7350.82
86_A121_A0.7330.82
219_V223_E0.7320.81
27_F366_A0.7300.81
69_M109_A0.7290.81
101_P104_R0.7290.81
4_V308_V0.7280.81
49_V53_V0.7260.81
363_F367_R0.7260.81
9_S97_M0.7250.81
269_I304_A0.7240.81
90_M136_S0.7230.81
154_L160_A0.7230.81
136_S250_A0.7210.81
48_T132_G0.7200.80
135_G193_D0.7180.80
68_P73_V0.7160.80
22_A363_F0.7160.80
305_P309_A0.7160.80
112_F147_Q0.7150.80
156_A170_R0.7090.79
306_L336_Y0.7090.79
120_H123_D0.7090.79
206_A223_E0.7080.79
71_E100_A0.7050.79
247_G255_I0.7050.79
23_I362_L0.7020.79
211_Q303_K0.7000.79
155_D161_L0.6990.78
352_A356_A0.6960.78
66_C72_K0.6950.78
287_L373_I0.6940.78
266_K271_I0.6940.78
209_G223_E0.6900.78
329_G332_V0.6890.77
153_F174_I0.6880.77
53_V58_G0.6840.77
20_C23_I0.6830.77
161_L225_G0.6830.77
4_V39_L0.6830.77
351_L355_L0.6830.77
141_G226_L0.6820.77
165_G214_A0.6800.77
232_V236_Q0.6790.76
343_S346_P0.6790.76
297_S327_G0.6760.76
223_E227_Q0.6730.76
225_G228_N0.6680.75
48_T272_V0.6670.75
322_I362_L0.6650.75
179_C183_L0.6620.75
59_N124_N0.6590.74
16_A20_C0.6570.74
334_H368_N0.6570.74
344_I361_N0.6560.74
223_E226_L0.6560.74
171_V229_Y0.6550.74
73_V98_L0.6540.74
145_M257_A0.6540.74
348_L361_N0.6520.73
129_I257_A0.6490.73
176_M237_T0.6480.73
29_T364_N0.6480.73
171_V225_G0.6470.73
118_I183_L0.6460.73
68_P94_S0.6450.73
86_A126_I0.6450.73
166_G169_A0.6400.72
80_T85_T0.6390.72
71_E99_V0.6370.72
330_V334_H0.6340.71
208_F301_G0.6330.71
201_A206_A0.6310.71
106_P218_M0.6300.71
109_A165_G0.6290.71
365_S369_I0.6280.71
106_P139_V0.6240.70
94_S137_A0.6230.70
90_M114_T0.6230.70
321_G326_L0.6200.70
360_T364_N0.6190.70
200_G203_G0.6190.70
15_S19_C0.6170.69
327_G331_E0.6160.69
348_L351_L0.6160.69
282_V315_F0.6160.69
14_L362_L0.6150.69
67_G103_K0.6150.69
138_T253_M0.6140.69
349_A353_E0.6130.69
325_V345_L0.6130.69
169_A228_N0.6110.69
348_L354_V0.6100.68
247_G254_G0.6070.68
333_V341_V0.6070.68
146_A261_L0.6070.68
338_I341_V0.6060.68
346_P364_N0.6060.68
61_V120_H0.6050.68
198_L252_G0.6050.68
37_I284_G0.6050.68
67_G110_S0.6040.68
188_I257_A0.6020.67
16_A40_P0.6000.67
10_F291_G0.5990.67
230_A233_L0.5960.67
173_S236_Q0.5960.67
366_A369_I0.5950.67
233_L241_V0.5940.66
110_S138_T0.5930.66
287_L320_I0.5930.66
365_S368_N0.5920.66
99_V109_A0.5890.66
94_S111_S0.5870.66
141_G233_L0.5860.65
27_F31_F0.5860.65
216_P219_V0.5860.65
241_V259_V0.5850.65
278_L308_V0.5840.65
63_L67_G0.5840.65
205_A222_L0.5830.65
135_G194_V0.5830.65
126_I186_C0.5820.65
212_K303_K0.5820.65
199_V205_A0.5820.65
59_N79_L0.5810.65
221_E224_Q0.5810.65
4_V37_I0.5790.64
189_E264_D0.5790.64
131_L263_A0.5790.64
254_G265_I0.5780.64
133_I265_I0.5760.64
340_A372_A0.5750.64
13_S351_L0.5730.64
207_V210_P0.5720.64
206_A210_P0.5720.64
21_Q24_K0.5710.63
320_I369_I0.5700.63
116_E148_A0.5690.63
228_N231_R0.5680.63
220_E224_Q0.5680.63
231_R235_Q0.5670.63
48_T87_V0.5660.63
36_Y370_A0.5650.63
211_Q298_Q0.5650.63
327_G334_H0.5640.62
21_Q25_A0.5630.62
145_M256_A0.5630.62
141_G168_L0.5630.62
295_I338_I0.5630.62
146_A153_F0.5620.62
208_F211_Q0.5610.62
5_I38_C0.5580.62
289_I370_A0.5580.62
231_R234_Q0.5580.62
114_T117_L0.5550.61
3_I27_F0.5550.61
176_M236_Q0.5530.61
208_F303_K0.5520.61
143_M168_L0.5500.61
225_G229_Y0.5490.60
300_A306_L0.5480.60
26_G366_A0.5470.60
317_V339_D0.5450.60
193_D250_A0.5440.60
49_V60_I0.5440.60
244_M255_I0.5430.60
250_A268_G0.5430.60
49_V88_I0.5420.59
133_I208_F0.5410.59
146_A257_A0.5410.59
143_M225_G0.5400.59
345_L348_L0.5400.59
67_G116_E0.5390.59
292_E303_K0.5390.59
370_A373_I0.5370.59
266_K270_E0.5360.59
9_S298_Q0.5350.58
114_T137_A0.5340.58
109_A214_A0.5330.58
348_L372_A0.5330.58
109_A139_V0.5320.58
183_L186_C0.5320.58
224_Q227_Q0.5290.58
147_Q162_A0.5280.57
11_K46_E0.5280.57
145_M254_G0.5280.57
88_I131_L0.5250.57
62_T75_A0.5250.57
66_C73_V0.5250.57
193_D268_G0.5250.57
322_I365_S0.5250.57
278_L282_V0.5230.57
255_I258_A0.5230.57
116_E119_R0.5220.57
161_L172_A0.5220.57
16_A308_V0.5200.56
288_V317_V0.5200.56
135_G268_G0.5200.56
26_G363_F0.5190.56
344_I362_L0.5190.56
18_K21_Q0.5180.56
151_V175_E0.5180.56
297_S300_A0.5180.56
66_C163_A0.5180.56
320_I372_A0.5180.56
99_V104_R0.5160.56
122_L181_P0.5130.55
344_I365_S0.5120.55
114_T145_M0.5110.55
5_I27_F0.5100.55
181_P185_N0.5100.55
167_N225_G0.5100.55
86_A129_I0.5100.55
189_E271_I0.5090.55
133_I192_C0.5090.55
242_C247_G0.5080.55
39_L278_L0.5070.54
323_A341_V0.5060.54
114_T131_L0.5060.54
143_M163_A0.5050.54
310_S336_Y0.5050.54
345_L349_A0.5040.54
147_Q167_N0.5040.54
68_P137_A0.5020.54
355_L358_G0.5010.54
133_I253_M0.5010.54
270_E311_V0.5000.53
13_S361_N0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cwcA 2 0.979 100 0 Contact Map
1to6A 4 0.9738 100 0.028 Contact Map
2r751 1 0.4698 89.8 0.959 Contact Map
1vimA 4 0.4436 68.3 0.967 Contact Map
3jx9A 2 0.4016 61.4 0.969 Contact Map
2xz9A 2 0.6929 60.7 0.969 Contact Map
1rq2A 2 0.4593 57.4 0.969 Contact Map
4h2dA 1 0.3753 53.3 0.97 Contact Map
1x92A 4 0.4514 51.6 0.97 Contact Map
4hb7A 2 0.5381 48.9 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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