GREMLIN Database
YPHC - Uncharacterized zinc-type alcohol dehydrogenase-like protein YphC
UniProt: P77360 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13464
Length: 353 (305)
Sequences: 52810 (36427)
Seq/√Len: 2085.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_K150_Y2.9401.00
33_K77_V2.9001.00
331_Q334_D2.8601.00
35_K75_Q2.8121.00
10_P18_R2.6551.00
31_L77_V2.6391.00
177_N201_R2.5241.00
30_V141_L2.4691.00
91_R144_L2.4411.00
87_K90_D2.4101.00
90_D143_L2.3881.00
149_S152_D2.3771.00
327_F338_L2.2881.00
72_P129_G2.2821.00
33_K75_Q2.2551.00
151_E326_R2.2471.00
22_V133_Y2.2231.00
183_L204_G2.2011.00
10_P16_D2.1841.00
235_I238_E2.1821.00
33_K133_Y2.1721.00
173_S176_D2.1601.00
213_A217_Q2.1451.00
178_V194_A2.1131.00
325_H338_L2.0981.00
212_L216_K2.0911.00
8_Y18_R2.0661.00
191_M220_V2.0231.00
26_G29_Q2.0131.00
326_R350_N2.0131.00
72_P94_V2.0091.00
27_I81_Q1.9951.00
85_H138_E1.9931.00
168_L197_R1.9921.00
310_H314_D1.9811.00
27_I82_G1.9421.00
147_A313_T1.9391.00
73_C150_Y1.8721.00
28_N82_G1.8711.00
337_A341_S1.8641.00
91_R150_Y1.8611.00
160_V189_M1.8451.00
328_S331_Q1.8371.00
31_L135_L1.8351.00
77_V133_Y1.8341.00
48_Y340_A1.8261.00
179_L205_V1.7661.00
213_A216_K1.7631.00
179_L244_A1.7541.00
168_L307_K1.7511.00
196_G316_K1.7481.00
206_D212_L1.6911.00
245_D265_A1.6891.00
269_R293_R1.6851.00
338_L343_K1.6831.00
334_D337_A1.6761.00
195_K222_D1.6751.00
203_I244_A1.6721.00
24_T78_A1.6661.00
144_L150_Y1.6551.00
269_R295_I1.6251.00
327_F335_A1.6121.00
144_L153_G1.6111.00
176_D269_R1.6041.00
201_R222_D1.5941.00
334_D338_L1.5911.00
209_P213_A1.5821.00
181_V260_A1.5801.00
214_M217_Q1.5411.00
264_T270_V1.5331.00
80_G83_C1.5151.00
7_A332_A1.5121.00
79_M88_E1.4841.00
86_F143_L1.4821.00
31_L133_Y1.4821.00
264_T292_R1.4811.00
151_E350_N1.4671.00
86_F90_D1.4671.00
130_H336_Y1.4661.00
78_A88_E1.4651.00
5_L19_E1.4641.00
75_Q91_R1.4631.00
230_E235_I1.4561.00
29_Q137_E1.4481.00
34_M72_P1.4441.00
170_G246_V1.4361.00
25_P135_L1.4121.00
28_N137_E1.4011.00
264_T268_G1.4011.00
333_G337_A1.3931.00
25_P31_L1.3881.00
231_G234_Q1.3851.00
247_A264_T1.3771.00
91_R146_D1.3751.00
31_L78_A1.3681.00
29_Q135_L1.3631.00
212_L224_G1.3611.00
247_A260_A1.3611.00
47_I336_Y1.3261.00
209_P226_L1.3241.00
76_I86_F1.3211.00
30_V86_F1.3191.00
5_L132_E1.3181.00
36_S151_E1.3161.00
324_T338_L1.3111.00
5_L330_E1.3091.00
223_H239_L1.3081.00
6_A20_V1.2951.00
75_Q150_Y1.2691.00
310_H313_T1.2671.00
234_Q238_E1.2661.00
191_M204_G1.2631.00
196_G311_D1.2601.00
177_N203_I1.2541.00
190_A248_L1.2481.00
7_A17_L1.2471.00
181_V205_V1.2411.00
164_Y168_L1.2301.00
226_L229_T1.2231.00
201_R223_H1.2211.00
207_M212_L1.2101.00
156_I312_L1.2001.00
35_K91_R1.1941.00
86_F141_L1.1681.00
209_P212_L1.1581.00
229_T235_I1.1571.00
328_S350_N1.1541.00
22_V31_L1.1511.00
34_M134_L1.1471.00
192_M318_W1.1441.00
207_M227_A1.1401.00
172_V199_A1.1391.00
177_N245_D1.1361.00
209_P229_T1.1291.00
28_N138_E1.1271.00
36_S350_N1.1081.00
11_G14_T1.1051.00
136_A141_L1.0911.00
262_Q286_D1.0871.00
235_I239_L1.0811.00
307_K310_H1.0811.00
176_D245_D1.0691.00
32_I74_G1.0671.00
170_G271_V1.0631.00
311_D316_K1.0441.00
165_E304_H1.0431.00
168_L304_H1.0381.00
39_I335_A1.0361.00
77_V88_E1.0341.00
47_I340_A1.0211.00
7_A329_L1.0181.00
231_G235_I1.0161.00
163_A190_A1.0091.00
25_P29_Q1.0081.00
332_A349_I1.0061.00
152_D318_W1.0061.00
32_I92_V0.9981.00
233_P262_Q0.9971.00
36_S150_Y0.9971.00
251_S256_G0.9951.00
216_K224_G0.9921.00
40_C71_E0.9841.00
17_L330_E0.9801.00
306_E310_H0.9801.00
240_T243_G0.9741.00
163_A193_L0.9741.00
204_G220_V0.9721.00
37_S130_H0.9701.00
194_A199_A0.9671.00
8_Y20_V0.9651.00
172_V176_D0.9631.00
35_K73_C0.9541.00
338_L347_V0.9531.00
37_S129_G0.9531.00
183_L206_D0.9531.00
233_P259_L0.9501.00
212_L226_L0.9491.00
166_G273_I0.9481.00
160_V308_C0.9431.00
337_A340_A0.9351.00
83_C138_E0.9321.00
259_L262_Q0.9301.00
164_Y307_K0.9291.00
40_C70_H0.9191.00
44_V339_M0.9181.00
130_H332_A0.9181.00
36_S348_V0.9161.00
191_M202_I0.9091.00
249_D252_G0.9071.00
208_L211_R0.9031.00
10_P14_T0.9031.00
258_L262_Q0.8981.00
20_V127_D0.8911.00
180_V190_A0.8881.00
207_M228_T0.8801.00
66_F127_D0.8791.00
183_L215_A0.8771.00
8_Y67_I0.8761.00
84_R138_E0.8741.00
327_F331_Q0.8741.00
204_G215_A0.8741.00
148_L153_G0.8731.00
236_I244_A0.8721.00
179_L263_S0.8711.00
233_P237_A0.8701.00
181_V247_A0.8701.00
166_G248_L0.8701.00
79_M83_C0.8671.00
188_M214_M0.8671.00
183_L191_M0.8661.00
22_V78_A0.8651.00
307_K311_D0.8631.00
180_V194_A0.8601.00
33_K132_E0.8571.00
93_L309_A0.8461.00
176_D246_V0.8441.00
87_K143_L0.8401.00
72_P134_L0.8391.00
130_H349_I0.8361.00
193_L308_C0.8341.00
38_G71_E0.8241.00
210_E213_A0.8231.00
161_G304_H0.8201.00
22_V77_V0.8171.00
267_W291_Q0.8161.00
28_N80_G0.8091.00
177_N244_A0.8091.00
7_A15_V0.8081.00
24_T31_L0.8061.00
287_L294_I0.8001.00
5_L17_L0.7991.00
303_F307_K0.7961.00
167_I194_A0.7941.00
163_A189_M0.7931.00
39_I339_M0.7891.00
319_P322_A0.7861.00
286_D290_H0.7851.00
79_M87_K0.7841.00
197_R307_K0.7791.00
146_D313_T0.7781.00
6_A67_I0.7751.00
207_M215_A0.7721.00
232_L259_L0.7701.00
142_I306_E0.7691.00
203_I239_L0.7681.00
40_C43_D0.7681.00
94_V136_A0.7621.00
339_M347_V0.7621.00
215_A220_V0.7601.00
178_V199_A0.7591.00
344_C347_V0.7581.00
181_V256_G0.7561.00
303_F306_E0.7511.00
247_A270_V0.7501.00
260_A270_V0.7491.00
193_L311_D0.7471.00
203_I236_I0.7471.00
26_G135_L0.7461.00
224_G227_A0.7441.00
171_E269_R0.7441.00
208_L226_L0.7401.00
231_G259_L0.7401.00
250_C273_I0.7401.00
30_V138_E0.7401.00
287_L296_G0.7331.00
166_G190_A0.7311.00
311_D314_D0.7301.00
172_V246_V0.7281.00
327_F347_V0.7281.00
92_V141_L0.7281.00
42_S70_H0.7271.00
194_A202_I0.7251.00
272_Y294_I0.7241.00
325_H334_D0.7241.00
311_D315_W0.7241.00
17_L329_L0.7241.00
73_C154_A0.7221.00
148_L312_L0.7221.00
168_L193_L0.7211.00
20_V67_I0.7201.00
233_P263_S0.7171.00
25_P78_A0.7161.00
7_A333_G0.7151.00
163_A186_V0.7141.00
93_L144_L0.7091.00
338_L341_S0.7061.00
129_G134_L0.7051.00
171_E295_I0.7001.00
165_E291_Q0.6991.00
28_N81_Q0.6971.00
203_I223_H0.6971.00
234_Q237_A0.6881.00
327_F349_I0.6871.00
309_A313_T0.6741.00
205_V227_A0.6731.00
180_V204_G0.6721.00
203_I225_Y0.6711.00
142_I305_M0.6711.00
244_A247_A0.6711.00
323_I326_R0.6701.00
164_Y308_C0.6681.00
25_P80_G0.6671.00
145_P313_T0.6661.00
164_Y311_D0.6651.00
159_G185_P0.6651.00
216_K223_H0.6641.00
199_A202_I0.6611.00
40_C158_C0.6601.00
199_A246_V0.6571.00
28_N139_K0.6571.00
162_T186_V0.6561.00
90_D146_D0.6541.00
325_H347_V0.6511.00
258_L286_D0.6511.00
163_A167_I0.6491.00
30_V76_I0.6491.00
9_L14_T0.6481.00
246_V271_V0.6481.00
257_R270_V0.6471.00
249_D270_V0.6461.00
216_K222_D0.6461.00
39_I130_H0.6421.00
171_E293_R0.6421.00
214_M218_L0.6411.00
266_D290_H0.6401.00
91_R147_A0.6401.00
73_C144_L0.6401.00
258_L280_E0.6381.00
142_I309_A0.6381.00
40_C159_G0.6351.00
214_M322_A0.6351.00
45_H50_Q0.6321.00
93_L157_S0.6321.00
36_S73_C0.6301.00
254_A258_L0.6291.00
195_K202_I0.6281.00
23_P135_L0.6281.00
192_M218_L0.6281.00
13_S337_A0.6261.00
63_Y66_F0.6251.00
34_M37_S0.6241.00
41_G45_H0.6241.00
70_H158_C0.6231.00
206_D215_A0.6221.00
73_C91_R0.6221.00
12_N337_A0.6221.00
188_M322_A0.6221.00
42_S46_Y0.6211.00
44_V340_A0.6211.00
253_N256_G0.6201.00
164_Y304_H0.6171.00
287_L292_R0.6161.00
169_R293_R0.6151.00
32_I94_V0.6141.00
35_K350_N0.6131.00
236_I263_S0.6121.00
170_G269_R0.6121.00
190_A273_I0.6081.00
191_M218_L0.6061.00
217_Q318_W0.6051.00
94_V141_L0.6031.00
71_E158_C0.6021.00
206_D224_G0.6001.00
36_S326_R0.5981.00
156_I308_C0.5981.00
159_G189_M0.5981.00
246_V269_R0.5971.00
11_G16_D0.5951.00
237_A240_T0.5911.00
336_Y340_A0.5911.00
62_L66_F0.5911.00
169_R304_H0.5881.00
212_L215_A0.5881.00
258_L282_E0.5831.00
305_M309_A0.5831.00
244_A263_S0.5831.00
223_H226_L0.5821.00
338_L344_C0.5811.00
162_T273_I0.5811.00
85_H88_E0.5811.00
155_F348_V0.5801.00
178_V246_V0.5791.00
95_Y142_I0.5771.00
85_H143_L0.5751.00
179_L247_A0.5731.00
46_Y51_H0.5721.00
249_D274_G0.5711.00
195_K220_V0.5691.00
286_D289_H0.5691.00
193_L197_R0.5681.00
32_I141_L0.5681.00
23_P133_Y0.5671.00
155_F319_P0.5661.00
41_G184_G0.5661.00
304_H307_K0.5661.00
237_A243_G0.5641.00
44_V48_Y0.5631.00
232_L236_I0.5601.00
71_E346_K0.5591.00
174_G198_G0.5581.00
191_M215_A0.5571.00
21_A24_T0.5541.00
165_E169_R0.5541.00
84_R87_K0.5541.00
42_S45_H0.5511.00
157_S162_T0.5491.00
40_C346_K0.5481.00
37_S349_I0.5471.00
247_A263_S0.5471.00
256_G260_A0.5431.00
137_E140_D0.5431.00
166_G297_S0.5411.00
79_M90_D0.5411.00
69_G130_H0.5391.00
189_M317_L0.5391.00
271_V297_S0.5391.00
174_G197_R0.5361.00
177_N240_T0.5361.00
23_P29_Q0.5341.00
292_R296_G0.5341.00
73_C153_G0.5331.00
215_A224_G0.5331.00
188_M218_L0.5331.00
22_V135_L0.5331.00
167_I193_L0.5331.00
15_V336_Y0.5311.00
211_R343_K0.5301.00
206_D211_R0.5291.00
149_S326_R0.5291.00
189_M193_L0.5281.00
23_P31_L0.5271.00
324_T345_G0.5231.00
25_P82_G0.5221.00
34_M94_V0.5221.00
312_L319_P0.5201.00
86_F138_E0.5201.00
166_G271_V0.5191.00
94_V129_G0.5191.00
212_L227_A0.5181.00
14_T333_G0.5171.00
39_I349_I0.5171.00
286_D292_R0.5151.00
98_S140_D0.5141.00
280_E284_S0.5131.00
327_F334_D0.5121.00
180_V191_M0.5121.00
289_H298_W0.5111.00
144_L148_L0.5111.00
169_R295_I0.5101.00
67_I128_G0.5091.00
225_Y235_I0.5061.00
325_H331_Q0.5051.00
159_G346_K0.5031.00
191_M195_K0.5031.00
157_S160_V0.5021.00
94_V134_L0.5011.00
164_Y197_R0.5011.00
335_A349_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ukoA 4 0.9745 100 0.162 Contact Map
1cdoA 2 0.9688 100 0.165 Contact Map
4ej6A 1 0.9575 100 0.169 Contact Map
1e3iA 2 0.9632 100 0.169 Contact Map
4ilkA 2 0.949 100 0.17 Contact Map
1f8fA 4 0.9632 100 0.175 Contact Map
2dq4A 4 0.9575 100 0.177 Contact Map
2jhfA 2 0.966 100 0.178 Contact Map
4cpdA 2 0.9518 100 0.178 Contact Map
4oh1A 4 0.9575 100 0.18 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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