ABGA - ECOLI - GREMLIN Contacts

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ABGA - p-aminobenzoyl-glutamate hydrolase subunit A

UniProt:	P77357	Sequences: MESLNQFVNSLAPKLSHWRRDFHHYAESGWVEFRTATLVAEELHQLGYSLALGREVVNESSRMGLPDEFTLQREFERARQQGALAQWIAAFEGGFTGIVATLDTGRPGPVMAFRVDMDALDLSEEQDVSHRPYRDGFASCNAGMMHACGHDGHTAIGLGLAHTLKQFESGLHGVIKLIFQPAEEGTRGARAMVDAGVVDDVDYFTAVHIGTGVPAGTVVCGSDNFMATTKFDAHFTGTAAHAGAKPEDGHNALLAAAQATLALHAIAPHSEGASRVNVGVMQAGSGRNVVPASALLKVETRGASDVINQYVFDRAQQAIQGAATMYGVGVETRLMGAATASSPSPQWVAWLQSQAAQVAGVNQAIERVEAPAGSEDATLMMARVQQHQGQASYVVFGTQLAAGHHNEKFDFDEQVLAIAVETLARTALNFPWTRGI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13352
Length:	436 (361)
Sequences:	27628 (19546)
Seq/√Len:	1028.8

ECOLI - ABGA YGEY DAPE PEPT ARGE ABGB ALLC PEPD
BACSU - YTNL YODQ DAPEL YXEP YHAA FAPD PEPT AMHX YQJE PEPVL ALLC
HALSA - Q9HS25
SULSO - Q97Y12 CBPX1 CBPX2 Q97ZB7 Q97V97 LYSK Q97VB6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
101_T	176_K	3.299	1.00
234_H	293_S	3.121	1.00
234_H	295_L	2.819	1.00
75_F	79_R	2.810	1.00
56_V	73_R	2.796	1.00
103_D	174_V	2.676	1.00
255_A	328_V	2.626	1.00
144_M	410_D	2.518	1.00
240_A	249_G	2.513	1.00
232_D	295_L	2.469	1.00
357_Q	429_N	2.458	1.00
316_Q	320_Q	2.445	1.00
236_T	329_G	2.435	1.00
357_Q	425_R	2.431	1.00
110_V	174_V	2.421	1.00
353_S	429_N	2.398	1.00
312_F	316_Q	2.393	1.00
235_F	259_A	2.369	1.00
236_T	293_S	2.364	1.00
77_R	80_Q	2.304	1.00
234_H	331_E	2.247	1.00
163_T	424_A	2.238	1.00
232_D	297_K	2.228	1.00
256_A	281_M	2.196	1.00
236_T	331_E	2.156	1.00
110_V	176_K	2.149	1.00
256_A	294_A	2.134	1.00
232_D	333_R	2.127	1.00
73_R	77_R	2.124	1.00
313_D	317_Q	2.119	1.00
282_Q	295_L	2.113	1.00
101_T	174_V	2.091	1.00
112_A	201_V	2.074	1.00
78_A	100_A	2.065	1.00
256_A	296_L	2.057	1.00
47_G	417_A	2.019	1.00
280_V	297_K	1.977	1.00
352_Q	356_A	1.961	1.00
81_Q	162_H	1.935	1.00
354_Q	429_N	1.888	1.00
60_S	73_R	1.865	1.00
358_V	425_R	1.860	1.00
68_E	72_Q	1.854	1.00
163_T	167_F	1.846	1.00
190_R	194_D	1.838	1.00
49_S	162_H	1.827	1.00
258_Q	261_L	1.826	1.00
257_A	260_T	1.821	1.00
129_S	408_K	1.806	1.00
76_E	80_Q	1.773	1.00
351_L	426_T	1.770	1.00
259_A	319_I	1.755	1.00
320_Q	324_T	1.742	1.00
234_H	333_R	1.683	1.00
72_Q	76_E	1.665	1.00
69_F	72_Q	1.663	1.00
50_L	420_V	1.629	1.00
257_A	261_L	1.624	1.00
77_R	81_Q	1.619	1.00
53_G	77_R	1.614	1.00
83_A	102_L	1.598	1.00
309_Q	313_D	1.596	1.00
75_F	87_W	1.580	1.00
425_R	428_L	1.572	1.00
381_M	386_Q	1.563	1.00
356_A	362_N	1.562	1.00
314_R	317_Q	1.562	1.00
56_V	69_F	1.561	1.00
73_R	76_E	1.554	1.00
250_H	255_A	1.549	1.00
252_A	294_A	1.543	1.00
55_E	59_E	1.538	1.00
75_F	98_I	1.531	1.00
254_L	264_H	1.525	1.00
239_A	292_A	1.518	1.00
162_H	166_Q	1.513	1.00
349_A	352_Q	1.511	1.00
258_Q	326_Y	1.508	1.00
68_E	96_T	1.500	1.00
52_L	56_V	1.497	1.00
50_L	159_G	1.496	1.00
56_V	60_S	1.495	1.00
307_I	310_Y	1.492	1.00
112_A	178_I	1.492	1.00
56_V	59_E	1.482	1.00
74_E	117_M	1.476	1.00
245_K	248_D	1.476	1.00
106_R	172_H	1.475	1.00
191_A	195_A	1.460	1.00
156_I	419_A	1.458	1.00
71_L	117_M	1.458	1.00
191_A	194_D	1.452	1.00
350_W	429_N	1.451	1.00
112_A	204_F	1.442	1.00
262_A	321_G	1.425	1.00
84_L	103_D	1.422	1.00
77_R	162_H	1.420	1.00
109_P	202_D	1.416	1.00
425_R	429_N	1.403	1.00
238_T	250_H	1.394	1.00
283_A	294_A	1.392	1.00
310_Y	314_R	1.390	1.00
48_Y	52_L	1.384	1.00
229_T	308_N	1.376	1.00
76_E	79_R	1.374	1.00
262_A	318_A	1.371	1.00
196_G	199_D	1.368	1.00
392_S	395_V	1.366	1.00
418_I	421_E	1.362	1.00
235_F	256_A	1.353	1.00
231_F	298_V	1.350	1.00
59_E	140_C	1.336	1.00
270_S	314_R	1.328	1.00
258_Q	325_M	1.327	1.00
52_L	55_E	1.323	1.00
312_F	334_L	1.307	1.00
323_A	330_V	1.307	1.00
51_A	55_E	1.302	1.00
152_G	411_F	1.301	1.00
313_D	316_Q	1.298	1.00
55_E	413_E	1.294	1.00
355_A	422_T	1.293	1.00
79_R	85_A	1.287	1.00
102_L	165_K	1.285	1.00
354_Q	425_R	1.280	1.00
274_S	311_V	1.274	1.00
358_V	421_E	1.272	1.00
317_Q	321_G	1.265	1.00
113_F	427_A	1.263	1.00
233_A	296_L	1.262	1.00
104_T	174_V	1.260	1.00
417_A	421_E	1.259	1.00
105_G	172_H	1.233	1.00
414_Q	418_I	1.211	1.00
62_R	70_T	1.207	1.00
49_S	52_L	1.206	1.00
319_I	330_V	1.203	1.00
250_H	328_V	1.202	1.00
203_Y	430_F	1.196	1.00
75_F	85_A	1.196	1.00
353_S	357_Q	1.193	1.00
165_K	168_E	1.191	1.00
143_G	414_Q	1.190	1.00
58_N	147_A	1.190	1.00
235_F	255_A	1.190	1.00
125_E	408_K	1.187	1.00
86_Q	101_T	1.184	1.00
253_L	281_M	1.174	1.00
53_G	73_R	1.171	1.00
350_W	354_Q	1.166	1.00
352_Q	368_V	1.163	1.00
113_F	157_G	1.140	1.00
152_G	209_I	1.139	1.00
317_Q	320_Q	1.122	1.00
64_G	185_G	1.120	1.00
310_Y	313_D	1.119	1.00
349_A	353_S	1.118	1.00
72_Q	75_F	1.115	1.00
47_G	414_Q	1.113	1.00
211_T	404_H	1.112	1.00
50_L	155_A	1.112	1.00
53_G	159_G	1.110	1.00
140_C	413_E	1.106	1.00
47_G	51_A	1.104	1.00
316_Q	332_T	1.098	1.00
127_D	138_A	1.082	1.00
207_V	423_L	1.079	1.00
59_E	137_F	1.078	1.00
345_P	349_A	1.070	1.00
353_S	356_A	1.069	1.00
108_G	173_G	1.068	1.00
69_F	73_R	1.064	1.00
260_T	296_L	1.061	1.00
266_I	314_R	1.056	1.00
161_A	177_L	1.056	1.00
354_Q	358_V	1.055	1.00
74_E	154_T	1.053	1.00
110_V	202_D	1.048	1.00
261_L	265_A	1.048	1.00
167_F	428_L	1.044	1.00
412_D	415_V	1.044	1.00
57_V	70_T	1.041	1.00
60_S	69_F	1.039	1.00
263_L	315_A	1.037	1.00
139_S	142_A	1.036	1.00
167_F	424_A	1.035	1.00
56_V	77_R	1.033	1.00
83_A	100_A	1.032	1.00
278_V	298_V	1.029	1.00
304_S	307_I	1.028	1.00
286_G	289_V	1.016	1.00
109_P	173_G	1.011	1.00
58_N	150_H	1.010	1.00
262_A	265_A	1.008	1.00
231_F	312_F	1.005	1.00
124_E	127_D	1.001	1.00
312_F	336_G	0.997	1.00
49_S	53_G	0.992	1.00
318_A	322_A	0.990	1.00
421_E	425_R	0.981	1.00
254_L	260_T	0.979	1.00
232_D	335_M	0.978	1.00
65_L	182_A	0.972	1.00
206_A	388_Q	0.970	1.00
318_A	321_G	0.970	1.00
260_T	278_V	0.966	1.00
253_L	283_A	0.966	1.00
314_R	318_A	0.965	1.00
258_Q	262_A	0.956	1.00
81_Q	165_K	0.955	1.00
190_R	379_L	0.954	1.00
258_Q	265_A	0.953	1.00
140_C	143_G	0.950	1.00
144_M	412_D	0.950	1.00
199_D	383_R	0.948	1.00
71_L	98_I	0.947	1.00
50_L	416_L	0.944	1.00
262_A	322_A	0.941	1.00
57_V	73_R	0.941	1.00
160_L	423_L	0.939	1.00
97_G	181_P	0.937	1.00
203_Y	347_W	0.934	1.00
84_L	101_T	0.934	1.00
232_D	287_R	0.934	1.00
424_A	428_L	0.930	1.00
356_A	361_V	0.928	1.00
420_V	424_A	0.927	1.00
160_L	424_A	0.926	1.00
55_E	140_C	0.923	1.00
321_G	324_T	0.922	1.00
354_Q	357_Q	0.922	1.00
102_L	171_L	0.922	1.00
71_L	75_F	0.917	1.00
176_K	201_V	0.917	1.00
163_T	421_E	0.914	1.00
117_M	179_F	0.910	1.00
287_R	297_K	0.906	1.00
281_M	294_A	0.904	1.00
214_P	217_T	0.904	1.00
338_A	341_S	0.904	1.00
205_T	430_F	0.901	1.00
157_G	177_L	0.897	1.00
321_G	325_M	0.890	1.00
159_G	162_H	0.890	1.00
260_T	281_M	0.889	1.00
320_Q	323_A	0.888	1.00
129_S	141_N	0.888	1.00
350_W	353_S	0.888	1.00
322_A	325_M	0.886	1.00
236_T	292_A	0.884	1.00
348_V	387_H	0.881	1.00
233_A	259_A	0.881	1.00
354_Q	426_T	0.879	1.00
161_A	165_K	0.870	1.00
256_A	260_T	0.866	1.00
55_E	138_A	0.859	1.00
282_Q	285_S	0.858	1.00
49_S	77_R	0.854	1.00
143_G	412_D	0.854	1.00
391_A	394_V	0.852	1.00
204_F	384_V	0.849	1.00
411_F	416_L	0.849	1.00
99_V	176_K	0.845	1.00
348_V	352_Q	0.845	1.00
258_Q	264_H	0.843	1.00
233_A	319_I	0.840	1.00
415_V	418_I	0.836	1.00
254_L	265_A	0.835	1.00
346_Q	349_A	0.835	1.00
115_V	154_T	0.834	1.00
111_M	203_Y	0.830	1.00
53_G	162_H	0.823	1.00
152_G	416_L	0.823	1.00
278_V	296_L	0.822	1.00
254_L	257_A	0.821	1.00
344_S	347_W	0.821	1.00
317_Q	324_T	0.818	1.00
222_S	349_A	0.815	1.00
163_T	420_V	0.812	1.00
167_F	170_G	0.810	1.00
83_A	165_K	0.810	1.00
351_L	387_H	0.809	1.00
56_V	76_E	0.806	1.00
322_A	326_Y	0.805	1.00
350_W	426_T	0.805	1.00
205_T	426_T	0.803	1.00
346_Q	350_W	0.800	1.00
309_Q	312_F	0.799	1.00
63_M	66_P	0.799	1.00
162_H	165_K	0.799	1.00
65_L	185_G	0.796	1.00
402_A	408_K	0.793	1.00
117_M	154_T	0.793	1.00
119_A	133_Y	0.793	1.00
78_A	158_L	0.793	1.00
305_D	309_Q	0.789	1.00
403_G	406_N	0.786	1.00
392_S	396_F	0.777	1.00
85_A	100_A	0.776	1.00
83_A	161_A	0.773	1.00
70_T	117_M	0.769	1.00
63_M	121_D	0.769	1.00
222_S	345_P	0.768	1.00
141_N	144_M	0.764	1.00
416_L	420_V	0.762	1.00
302_G	308_N	0.761	1.00
253_L	294_A	0.760	1.00
156_I	160_L	0.757	1.00
238_T	406_N	0.757	1.00
159_G	420_V	0.756	1.00
102_L	161_A	0.752	1.00
229_T	312_F	0.752	1.00
53_G	155_A	0.749	1.00
81_Q	158_L	0.746	1.00
271_E	274_S	0.746	1.00
113_F	160_L	0.744	1.00
255_A	326_Y	0.740	1.00
74_E	179_F	0.739	1.00
156_I	420_V	0.734	1.00
393_Y	411_F	0.734	1.00
163_T	166_Q	0.734	1.00
72_Q	87_W	0.733	1.00
414_Q	417_A	0.733	1.00
105_G	170_G	0.732	1.00
261_L	264_H	0.730	1.00
379_L	383_R	0.729	1.00
173_G	202_D	0.729	1.00
379_L	382_A	0.729	1.00
252_A	291_P	0.728	1.00
263_L	276_V	0.727	1.00
71_L	96_T	0.725	1.00
80_Q	162_H	0.724	1.00
79_R	87_W	0.723	1.00
51_A	140_C	0.722	1.00
395_V	400_L	0.721	1.00
359_A	422_T	0.721	1.00
351_L	422_T	0.720	1.00
160_L	420_V	0.720	1.00
235_F	296_L	0.713	1.00
221_G	370_A	0.712	1.00
323_A	328_V	0.708	1.00
137_F	140_C	0.708	1.00
206_A	377_A	0.707	1.00
77_R	158_L	0.706	1.00
305_D	382_A	0.705	1.00
276_V	300_T	0.705	1.00
231_F	315_A	0.703	1.00
53_G	56_V	0.702	1.00
176_K	200_D	0.699	1.00
306_V	310_Y	0.696	1.00
336_G	341_S	0.695	1.00
259_A	296_L	0.694	1.00
57_V	154_T	0.692	1.00
300_T	311_V	0.691	1.00
54_R	145_M	0.690	1.00
350_W	430_F	0.690	1.00
282_Q	297_K	0.689	1.00
240_A	290_V	0.689	1.00
250_H	327_G	0.686	1.00
59_E	138_A	0.683	1.00
102_L	177_L	0.682	1.00
124_E	128_V	0.682	1.00
119_A	148_C	0.681	1.00
402_A	406_N	0.679	1.00
395_V	401_A	0.677	1.00
205_T	347_W	0.673	1.00
53_G	57_V	0.671	1.00
309_Q	336_G	0.669	1.00
393_Y	396_F	0.668	1.00
74_E	158_L	0.666	1.00
230_K	287_R	0.665	1.00
157_G	207_V	0.665	1.00
267_A	276_V	0.664	1.00
355_A	358_V	0.661	1.00
189_A	193_V	0.658	1.00
155_A	159_G	0.658	1.00
385_Q	388_Q	0.651	1.00
53_G	158_L	0.649	1.00
63_M	144_M	0.648	1.00
154_T	179_F	0.647	1.00
308_N	312_F	0.646	1.00
78_A	83_A	0.646	1.00
111_M	427_A	0.644	1.00
74_E	98_I	0.643	1.00
79_R	84_L	0.643	1.00
55_E	58_N	0.640	1.00
280_V	295_L	0.639	1.00
141_N	146_H	0.638	1.00
233_A	332_T	0.638	1.00
377_A	386_Q	0.637	1.00
138_A	145_M	0.635	1.00
110_V	173_G	0.634	1.00
67_D	71_L	0.632	1.00
82_G	85_A	0.632	1.00
145_M	150_H	0.632	1.00
258_Q	322_A	0.632	1.00
204_F	386_Q	0.630	1.00
344_S	349_A	0.629	1.00
187_R	338_A	0.629	1.00
51_A	417_A	0.628	1.00
156_I	207_V	0.627	1.00
54_R	155_A	0.627	1.00
182_A	185_G	0.626	1.00
95_F	191_A	0.626	1.00
282_Q	293_S	0.622	1.00
251_N	291_P	0.622	1.00
413_E	417_A	0.622	1.00
156_I	423_L	0.620	1.00
337_A	340_A	0.619	1.00
152_G	156_I	0.618	1.00
334_L	337_A	0.617	1.00
69_F	76_E	0.615	1.00
247_E	272_G	0.614	1.00
358_V	361_V	0.614	1.00
113_F	205_T	0.611	1.00
63_M	133_Y	0.611	1.00
194_D	383_R	0.611	1.00
323_A	329_G	0.610	1.00
152_G	155_A	0.608	1.00
403_G	408_K	0.608	1.00
219_V	222_S	0.606	1.00
164_L	169_S	0.606	1.00
384_V	388_Q	0.605	1.00
98_I	179_F	0.604	1.00
146_H	410_D	0.603	1.00
138_A	141_N	0.603	1.00
51_A	413_E	0.603	1.00
421_E	424_A	0.602	1.00
187_R	191_A	0.601	1.00
302_G	311_V	0.599	1.00
233_A	298_V	0.597	1.00
422_T	426_T	0.595	1.00
64_G	186_T	0.595	1.00
125_E	407_E	0.595	1.00
259_A	318_A	0.594	1.00
184_E	405_H	0.592	1.00
230_K	299_E	0.591	1.00
196_G	200_D	0.588	1.00
403_G	410_D	0.587	1.00
375_E	388_Q	0.586	1.00
178_I	192_M	0.580	1.00
316_Q	334_L	0.579	1.00
231_F	332_T	0.579	1.00
148_C	151_D	0.579	1.00
93_G	97_G	0.579	1.00
235_F	252_A	0.579	1.00
104_T	107_P	0.578	1.00
83_A	177_L	0.577	1.00
104_T	108_G	0.577	1.00
204_F	377_A	0.577	1.00
254_L	258_Q	0.575	1.00
110_V	201_V	0.574	1.00
243_G	372_A	0.573	1.00
147_A	150_H	0.572	1.00
114_R	178_I	0.572	1.00
54_R	413_E	0.571	1.00
259_A	263_L	0.570	1.00
49_S	159_G	0.569	1.00
342_S	345_P	0.567	1.00
347_W	350_W	0.566	1.00
178_I	380_M	0.566	1.00
405_H	409_F	0.564	1.00
358_V	422_T	0.563	1.00
207_V	391_A	0.562	1.00
352_Q	367_R	0.560	1.00
97_G	192_M	0.560	1.00
255_A	258_Q	0.560	1.00
198_V	384_V	0.559	1.00
313_D	320_Q	0.558	1.00
359_A	418_I	0.557	1.00
355_A	363_Q	0.555	1.00
401_A	404_H	0.555	1.00
115_V	157_G	0.554	1.00
255_A	322_A	0.554	1.00
114_R	180_Q	0.553	1.00
402_A	410_D	0.552	1.00
336_G	339_T	0.551	1.00
305_D	339_T	0.551	1.00
204_F	380_M	0.550	1.00
128_V	137_F	0.550	1.00
144_M	148_C	0.550	1.00
215_A	415_V	0.547	1.00
109_P	203_Y	0.546	1.00
254_L	261_L	0.546	1.00
217_T	363_Q	0.546	1.00
306_V	309_Q	0.545	1.00
81_Q	166_Q	0.543	1.00
178_I	204_F	0.542	1.00
208_H	212_G	0.542	1.00
79_R	82_G	0.542	1.00
169_S	428_L	0.542	1.00
281_M	296_L	0.541	1.00
384_V	387_H	0.541	1.00
60_S	141_N	0.540	1.00
235_F	319_I	0.540	1.00
85_A	98_I	0.540	1.00
207_V	419_A	0.539	1.00
94_G	195_A	0.538	1.00
182_A	187_R	0.537	1.00
300_T	315_A	0.537	1.00
57_V	155_A	0.537	1.00
125_E	128_V	0.536	1.00
193_V	383_R	0.536	1.00
106_R	174_V	0.535	1.00
99_V	178_I	0.533	1.00
60_S	70_T	0.531	1.00
108_G	172_H	0.531	1.00
217_T	362_N	0.531	1.00
58_N	62_R	0.530	1.00
298_V	315_A	0.528	1.00
231_F	334_L	0.525	1.00
160_L	164_L	0.524	1.00
210_G	404_H	0.523	1.00
391_A	419_A	0.523	1.00
319_I	323_A	0.522	1.00
110_V	200_D	0.522	1.00
228_T	302_G	0.520	1.00
300_T	306_V	0.520	1.00
140_C	145_M	0.518	1.00
67_D	182_A	0.518	1.00
87_W	92_E	0.516	1.00
252_A	290_V	0.513	1.00
319_I	332_T	0.513	1.00
145_M	413_E	0.512	1.00
271_E	307_I	0.511	1.00
356_A	363_Q	0.508	1.00
324_T	329_G	0.507	1.00
189_A	380_M	0.507	1.00
259_A	322_A	0.506	1.00
61_S	66_P	0.506	1.00
239_A	407_E	0.505	1.00
192_M	197_V	0.504	1.00
277_N	299_E	0.504	1.00
128_V	410_D	0.504	1.00
51_A	54_R	0.503	1.00
101_T	110_V	0.502	1.00
128_V	133_Y	0.501	1.00
197_V	200_D	0.501	1.00
67_D	181_P	0.501	1.00
253_L	257_A	0.501	1.00
354_Q	422_T	0.500	1.00
260_T	298_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3io1A	4	0.828	100	0.288	Contact Map
3pfoA	2	0.8784	100	0.321	Contact Map
4ewtA	4	0.8716	100	0.323	Contact Map
1xmbA	1	0.8372	100	0.346	Contact Map
1ysjA	2	0.8211	100	0.348	Contact Map
3iszA	2	0.8188	100	0.365	Contact Map
4pqaA	2	0.828	100	0.369	Contact Map
3ramA	4	0.8417	100	0.37	Contact Map
1cg2A	4	0.8624	100	0.373	Contact Map
2zogA	2	0.8899	100	0.376	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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