GREMLIN Database
ABGA - p-aminobenzoyl-glutamate hydrolase subunit A
UniProt: P77357 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13352
Length: 436 (361)
Sequences: 27628 (19546)
Seq/√Len: 1028.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_T176_K3.2991.00
234_H293_S3.1211.00
234_H295_L2.8191.00
75_F79_R2.8101.00
56_V73_R2.7961.00
103_D174_V2.6761.00
255_A328_V2.6261.00
144_M410_D2.5181.00
240_A249_G2.5131.00
232_D295_L2.4691.00
357_Q429_N2.4581.00
316_Q320_Q2.4451.00
236_T329_G2.4351.00
357_Q425_R2.4311.00
110_V174_V2.4211.00
353_S429_N2.3981.00
312_F316_Q2.3931.00
235_F259_A2.3691.00
236_T293_S2.3641.00
77_R80_Q2.3041.00
234_H331_E2.2471.00
163_T424_A2.2381.00
232_D297_K2.2281.00
256_A281_M2.1961.00
236_T331_E2.1561.00
110_V176_K2.1491.00
256_A294_A2.1341.00
232_D333_R2.1271.00
73_R77_R2.1241.00
313_D317_Q2.1191.00
282_Q295_L2.1131.00
101_T174_V2.0911.00
112_A201_V2.0741.00
78_A100_A2.0651.00
256_A296_L2.0571.00
47_G417_A2.0191.00
280_V297_K1.9771.00
352_Q356_A1.9611.00
81_Q162_H1.9351.00
354_Q429_N1.8881.00
60_S73_R1.8651.00
358_V425_R1.8601.00
68_E72_Q1.8541.00
163_T167_F1.8461.00
190_R194_D1.8381.00
49_S162_H1.8271.00
258_Q261_L1.8261.00
257_A260_T1.8211.00
129_S408_K1.8061.00
76_E80_Q1.7731.00
351_L426_T1.7701.00
259_A319_I1.7551.00
320_Q324_T1.7421.00
234_H333_R1.6831.00
72_Q76_E1.6651.00
69_F72_Q1.6631.00
50_L420_V1.6291.00
257_A261_L1.6241.00
77_R81_Q1.6191.00
53_G77_R1.6141.00
83_A102_L1.5981.00
309_Q313_D1.5961.00
75_F87_W1.5801.00
425_R428_L1.5721.00
381_M386_Q1.5631.00
356_A362_N1.5621.00
314_R317_Q1.5621.00
56_V69_F1.5611.00
73_R76_E1.5541.00
250_H255_A1.5491.00
252_A294_A1.5431.00
55_E59_E1.5381.00
75_F98_I1.5311.00
254_L264_H1.5251.00
239_A292_A1.5181.00
162_H166_Q1.5131.00
349_A352_Q1.5111.00
258_Q326_Y1.5081.00
68_E96_T1.5001.00
52_L56_V1.4971.00
50_L159_G1.4961.00
56_V60_S1.4951.00
307_I310_Y1.4921.00
112_A178_I1.4921.00
56_V59_E1.4821.00
74_E117_M1.4761.00
245_K248_D1.4761.00
106_R172_H1.4751.00
191_A195_A1.4601.00
156_I419_A1.4581.00
71_L117_M1.4581.00
191_A194_D1.4521.00
350_W429_N1.4511.00
112_A204_F1.4421.00
262_A321_G1.4251.00
84_L103_D1.4221.00
77_R162_H1.4201.00
109_P202_D1.4161.00
425_R429_N1.4031.00
238_T250_H1.3941.00
283_A294_A1.3921.00
310_Y314_R1.3901.00
48_Y52_L1.3841.00
229_T308_N1.3761.00
76_E79_R1.3741.00
262_A318_A1.3711.00
196_G199_D1.3681.00
392_S395_V1.3661.00
418_I421_E1.3621.00
235_F256_A1.3531.00
231_F298_V1.3501.00
59_E140_C1.3361.00
270_S314_R1.3281.00
258_Q325_M1.3271.00
52_L55_E1.3231.00
312_F334_L1.3071.00
323_A330_V1.3071.00
51_A55_E1.3021.00
152_G411_F1.3011.00
313_D316_Q1.2981.00
55_E413_E1.2941.00
355_A422_T1.2931.00
79_R85_A1.2871.00
102_L165_K1.2851.00
354_Q425_R1.2801.00
274_S311_V1.2741.00
358_V421_E1.2721.00
317_Q321_G1.2651.00
113_F427_A1.2631.00
233_A296_L1.2621.00
104_T174_V1.2601.00
417_A421_E1.2591.00
105_G172_H1.2331.00
414_Q418_I1.2111.00
62_R70_T1.2071.00
49_S52_L1.2061.00
319_I330_V1.2031.00
250_H328_V1.2021.00
203_Y430_F1.1961.00
75_F85_A1.1961.00
353_S357_Q1.1931.00
165_K168_E1.1911.00
143_G414_Q1.1901.00
58_N147_A1.1901.00
235_F255_A1.1901.00
125_E408_K1.1871.00
86_Q101_T1.1841.00
253_L281_M1.1741.00
53_G73_R1.1711.00
350_W354_Q1.1661.00
352_Q368_V1.1631.00
113_F157_G1.1401.00
152_G209_I1.1391.00
317_Q320_Q1.1221.00
64_G185_G1.1201.00
310_Y313_D1.1191.00
349_A353_S1.1181.00
72_Q75_F1.1151.00
47_G414_Q1.1131.00
211_T404_H1.1121.00
50_L155_A1.1121.00
53_G159_G1.1101.00
140_C413_E1.1061.00
47_G51_A1.1041.00
316_Q332_T1.0981.00
127_D138_A1.0821.00
207_V423_L1.0791.00
59_E137_F1.0781.00
345_P349_A1.0701.00
353_S356_A1.0691.00
108_G173_G1.0681.00
69_F73_R1.0641.00
260_T296_L1.0611.00
266_I314_R1.0561.00
161_A177_L1.0561.00
354_Q358_V1.0551.00
74_E154_T1.0531.00
110_V202_D1.0481.00
261_L265_A1.0481.00
167_F428_L1.0441.00
412_D415_V1.0441.00
57_V70_T1.0411.00
60_S69_F1.0391.00
263_L315_A1.0371.00
139_S142_A1.0361.00
167_F424_A1.0351.00
56_V77_R1.0331.00
83_A100_A1.0321.00
278_V298_V1.0291.00
304_S307_I1.0281.00
286_G289_V1.0161.00
109_P173_G1.0111.00
58_N150_H1.0101.00
262_A265_A1.0081.00
231_F312_F1.0051.00
124_E127_D1.0011.00
312_F336_G0.9971.00
49_S53_G0.9921.00
318_A322_A0.9901.00
421_E425_R0.9811.00
254_L260_T0.9791.00
232_D335_M0.9781.00
65_L182_A0.9721.00
206_A388_Q0.9701.00
318_A321_G0.9701.00
260_T278_V0.9661.00
253_L283_A0.9661.00
314_R318_A0.9651.00
258_Q262_A0.9561.00
81_Q165_K0.9551.00
190_R379_L0.9541.00
258_Q265_A0.9531.00
140_C143_G0.9501.00
144_M412_D0.9501.00
199_D383_R0.9481.00
71_L98_I0.9471.00
50_L416_L0.9441.00
262_A322_A0.9411.00
57_V73_R0.9411.00
160_L423_L0.9391.00
97_G181_P0.9371.00
203_Y347_W0.9341.00
84_L101_T0.9341.00
232_D287_R0.9341.00
424_A428_L0.9301.00
356_A361_V0.9281.00
420_V424_A0.9271.00
160_L424_A0.9261.00
55_E140_C0.9231.00
321_G324_T0.9221.00
354_Q357_Q0.9221.00
102_L171_L0.9221.00
71_L75_F0.9171.00
176_K201_V0.9171.00
163_T421_E0.9141.00
117_M179_F0.9101.00
287_R297_K0.9061.00
281_M294_A0.9041.00
214_P217_T0.9041.00
338_A341_S0.9041.00
205_T430_F0.9011.00
157_G177_L0.8971.00
321_G325_M0.8901.00
159_G162_H0.8901.00
260_T281_M0.8891.00
320_Q323_A0.8881.00
129_S141_N0.8881.00
350_W353_S0.8881.00
322_A325_M0.8861.00
236_T292_A0.8841.00
348_V387_H0.8811.00
233_A259_A0.8811.00
354_Q426_T0.8791.00
161_A165_K0.8701.00
256_A260_T0.8661.00
55_E138_A0.8591.00
282_Q285_S0.8581.00
49_S77_R0.8541.00
143_G412_D0.8541.00
391_A394_V0.8521.00
204_F384_V0.8491.00
411_F416_L0.8491.00
99_V176_K0.8451.00
348_V352_Q0.8451.00
258_Q264_H0.8431.00
233_A319_I0.8401.00
415_V418_I0.8361.00
254_L265_A0.8351.00
346_Q349_A0.8351.00
115_V154_T0.8341.00
111_M203_Y0.8301.00
53_G162_H0.8231.00
152_G416_L0.8231.00
278_V296_L0.8221.00
254_L257_A0.8211.00
344_S347_W0.8211.00
317_Q324_T0.8181.00
222_S349_A0.8151.00
163_T420_V0.8121.00
167_F170_G0.8101.00
83_A165_K0.8101.00
351_L387_H0.8091.00
56_V76_E0.8061.00
322_A326_Y0.8051.00
350_W426_T0.8051.00
205_T426_T0.8031.00
346_Q350_W0.8001.00
309_Q312_F0.7991.00
63_M66_P0.7991.00
162_H165_K0.7991.00
65_L185_G0.7961.00
402_A408_K0.7931.00
117_M154_T0.7931.00
119_A133_Y0.7931.00
78_A158_L0.7931.00
305_D309_Q0.7891.00
403_G406_N0.7861.00
392_S396_F0.7771.00
85_A100_A0.7761.00
83_A161_A0.7731.00
70_T117_M0.7691.00
63_M121_D0.7691.00
222_S345_P0.7681.00
141_N144_M0.7641.00
416_L420_V0.7621.00
302_G308_N0.7611.00
253_L294_A0.7601.00
156_I160_L0.7571.00
238_T406_N0.7571.00
159_G420_V0.7561.00
102_L161_A0.7521.00
229_T312_F0.7521.00
53_G155_A0.7491.00
81_Q158_L0.7461.00
271_E274_S0.7461.00
113_F160_L0.7441.00
255_A326_Y0.7401.00
74_E179_F0.7391.00
156_I420_V0.7341.00
393_Y411_F0.7341.00
163_T166_Q0.7341.00
72_Q87_W0.7331.00
414_Q417_A0.7331.00
105_G170_G0.7321.00
261_L264_H0.7301.00
379_L383_R0.7291.00
173_G202_D0.7291.00
379_L382_A0.7291.00
252_A291_P0.7281.00
263_L276_V0.7271.00
71_L96_T0.7251.00
80_Q162_H0.7241.00
79_R87_W0.7231.00
51_A140_C0.7221.00
395_V400_L0.7211.00
359_A422_T0.7211.00
351_L422_T0.7201.00
160_L420_V0.7201.00
235_F296_L0.7131.00
221_G370_A0.7121.00
323_A328_V0.7081.00
137_F140_C0.7081.00
206_A377_A0.7071.00
77_R158_L0.7061.00
305_D382_A0.7051.00
276_V300_T0.7051.00
231_F315_A0.7031.00
53_G56_V0.7021.00
176_K200_D0.6991.00
306_V310_Y0.6961.00
336_G341_S0.6951.00
259_A296_L0.6941.00
57_V154_T0.6921.00
300_T311_V0.6911.00
54_R145_M0.6901.00
350_W430_F0.6901.00
282_Q297_K0.6891.00
240_A290_V0.6891.00
250_H327_G0.6861.00
59_E138_A0.6831.00
102_L177_L0.6821.00
124_E128_V0.6821.00
119_A148_C0.6811.00
402_A406_N0.6791.00
395_V401_A0.6771.00
205_T347_W0.6731.00
53_G57_V0.6711.00
309_Q336_G0.6691.00
393_Y396_F0.6681.00
74_E158_L0.6661.00
230_K287_R0.6651.00
157_G207_V0.6651.00
267_A276_V0.6641.00
355_A358_V0.6611.00
189_A193_V0.6581.00
155_A159_G0.6581.00
385_Q388_Q0.6511.00
53_G158_L0.6491.00
63_M144_M0.6481.00
154_T179_F0.6471.00
308_N312_F0.6461.00
78_A83_A0.6461.00
111_M427_A0.6441.00
74_E98_I0.6431.00
79_R84_L0.6431.00
55_E58_N0.6401.00
280_V295_L0.6391.00
141_N146_H0.6381.00
233_A332_T0.6381.00
377_A386_Q0.6371.00
138_A145_M0.6351.00
110_V173_G0.6341.00
67_D71_L0.6321.00
82_G85_A0.6321.00
145_M150_H0.6321.00
258_Q322_A0.6321.00
204_F386_Q0.6301.00
344_S349_A0.6291.00
187_R338_A0.6291.00
51_A417_A0.6281.00
156_I207_V0.6271.00
54_R155_A0.6271.00
182_A185_G0.6261.00
95_F191_A0.6261.00
282_Q293_S0.6221.00
251_N291_P0.6221.00
413_E417_A0.6221.00
156_I423_L0.6201.00
337_A340_A0.6191.00
152_G156_I0.6181.00
334_L337_A0.6171.00
69_F76_E0.6151.00
247_E272_G0.6141.00
358_V361_V0.6141.00
113_F205_T0.6111.00
63_M133_Y0.6111.00
194_D383_R0.6111.00
323_A329_G0.6101.00
152_G155_A0.6081.00
403_G408_K0.6081.00
219_V222_S0.6061.00
164_L169_S0.6061.00
384_V388_Q0.6051.00
98_I179_F0.6041.00
146_H410_D0.6031.00
138_A141_N0.6031.00
51_A413_E0.6031.00
421_E424_A0.6021.00
187_R191_A0.6011.00
302_G311_V0.5991.00
233_A298_V0.5971.00
422_T426_T0.5951.00
64_G186_T0.5951.00
125_E407_E0.5951.00
259_A318_A0.5941.00
184_E405_H0.5921.00
230_K299_E0.5911.00
196_G200_D0.5881.00
403_G410_D0.5871.00
375_E388_Q0.5861.00
178_I192_M0.5801.00
316_Q334_L0.5791.00
231_F332_T0.5791.00
148_C151_D0.5791.00
93_G97_G0.5791.00
235_F252_A0.5791.00
104_T107_P0.5781.00
83_A177_L0.5771.00
104_T108_G0.5771.00
204_F377_A0.5771.00
254_L258_Q0.5751.00
110_V201_V0.5741.00
243_G372_A0.5731.00
147_A150_H0.5721.00
114_R178_I0.5721.00
54_R413_E0.5711.00
259_A263_L0.5701.00
49_S159_G0.5691.00
342_S345_P0.5671.00
347_W350_W0.5661.00
178_I380_M0.5661.00
405_H409_F0.5641.00
358_V422_T0.5631.00
207_V391_A0.5621.00
352_Q367_R0.5601.00
97_G192_M0.5601.00
255_A258_Q0.5601.00
198_V384_V0.5591.00
313_D320_Q0.5581.00
359_A418_I0.5571.00
355_A363_Q0.5551.00
401_A404_H0.5551.00
115_V157_G0.5541.00
255_A322_A0.5541.00
114_R180_Q0.5531.00
402_A410_D0.5521.00
336_G339_T0.5511.00
305_D339_T0.5511.00
204_F380_M0.5501.00
128_V137_F0.5501.00
144_M148_C0.5501.00
215_A415_V0.5471.00
109_P203_Y0.5461.00
254_L261_L0.5461.00
217_T363_Q0.5461.00
306_V309_Q0.5451.00
81_Q166_Q0.5431.00
178_I204_F0.5421.00
208_H212_G0.5421.00
79_R82_G0.5421.00
169_S428_L0.5421.00
281_M296_L0.5411.00
384_V387_H0.5411.00
60_S141_N0.5401.00
235_F319_I0.5401.00
85_A98_I0.5401.00
207_V419_A0.5391.00
94_G195_A0.5381.00
182_A187_R0.5371.00
300_T315_A0.5371.00
57_V155_A0.5371.00
125_E128_V0.5361.00
193_V383_R0.5361.00
106_R174_V0.5351.00
99_V178_I0.5331.00
60_S70_T0.5311.00
108_G172_H0.5311.00
217_T362_N0.5311.00
58_N62_R0.5301.00
298_V315_A0.5281.00
231_F334_L0.5251.00
160_L164_L0.5241.00
210_G404_H0.5231.00
391_A419_A0.5231.00
319_I323_A0.5221.00
110_V200_D0.5221.00
228_T302_G0.5201.00
300_T306_V0.5201.00
140_C145_M0.5181.00
67_D182_A0.5181.00
87_W92_E0.5161.00
252_A290_V0.5131.00
319_I332_T0.5131.00
145_M413_E0.5121.00
271_E307_I0.5111.00
356_A363_Q0.5081.00
324_T329_G0.5071.00
189_A380_M0.5071.00
259_A322_A0.5061.00
61_S66_P0.5061.00
239_A407_E0.5051.00
192_M197_V0.5041.00
277_N299_E0.5041.00
128_V410_D0.5041.00
51_A54_R0.5031.00
101_T110_V0.5021.00
128_V133_Y0.5011.00
197_V200_D0.5011.00
67_D181_P0.5011.00
253_L257_A0.5011.00
354_Q422_T0.5001.00
260_T298_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3io1A 4 0.828 100 0.288 Contact Map
3pfoA 2 0.8784 100 0.321 Contact Map
4ewtA 4 0.8716 100 0.323 Contact Map
1xmbA 1 0.8372 100 0.346 Contact Map
1ysjA 2 0.8211 100 0.348 Contact Map
3iszA 2 0.8188 100 0.365 Contact Map
4pqaA 2 0.828 100 0.369 Contact Map
3ramA 4 0.8417 100 0.37 Contact Map
1cg2A 4 0.8624 100 0.373 Contact Map
2zogA 2 0.8899 100 0.376 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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