MPPA - ECOLI - GREMLIN Contacts

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MPPA - Periplasmic murein peptide-binding protein

UniProt:	P77348	Sequences: MKHSVSVTCCALLVSSISLSYAAEVPSGTVLAEKQELVRHIKDEPASLDPAKAVGLPEIQVIRDLFEGLVNQNEKGEIVPGVATQWKSNDNRIWTFTLRDNAKWADGTPVTAQDFVYSWQRLVDPKTLSPFAWFAALAGINNAQAIIDGKATPDQLGVTAVDAHTLKIQLDKPLPWFVNLTANFAFFPVQKANVESGKEWTKPGNLIGNGAYVLKERVVNEKLVVVPNTHYWDNAKTVLQKVTFLPINQESAATKRYLAGDIDITESFPKNMYQKLLKDIPGQVYTPPQLGTYYYAFNTQKGPTADQRVRLALSMTIDRRLMTEKVLGTGEKPAWHFTPDVTAGFTPEPSPFEQMSQEELNAQAKTLLSAAGYGPQKPLKLTLLYNTSENHQKIAIAVASMWKKNLGVDVKLQNQEWKTYIDSRNTGNFDVIRASWVGDYNEPSTFLTLLTSTHSGNISRFNNPAYDKVLAQASTENTVKARNADYNAAEKILMEQAPIAPIYQYTNGRLIKPWLKGYPINNPEDVAYSRTMYIVKH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13376
Length:	537 (489)
Sequences:	23112 (17644)
Seq/√Len:	797.9

ECOLI - MPPA OPPA YGIS SAPA DDPA DPPA GSIB NIKA YEJA YBAE SGRR
BACSU - OPPA DPPE APPA YHJP
HALSA - Q9HMW4 Q9HMI3
SULSO - Q97VK5 Q97VF7 Q97UG7 Q97UH5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
215_K	226_V	4.096	1.00
159_T	167_K	3.216	1.00
161_V	167_K	3.201	1.00
308_R	370_A	3.194	1.00
363_Q	366_T	3.093	1.00
100_D	164_H	3.029	1.00
162_D	165_T	2.931	1.00
116_V	120_Q	2.899	1.00
320_R	324_E	2.893	1.00
468_K	472_Q	2.828	1.00
213_V	226_V	2.736	1.00
476_E	481_A	2.719	1.00
380_K	409_D	2.686	1.00
116_V	160_A	2.625	1.00
302_G	305_A	2.577	1.00
380_K	411_K	2.510	1.00
315_M	363_Q	2.492	1.00
318_D	321_L	2.460	1.00
313_L	402_W	2.429	1.00
85_Q	97_T	2.409	1.00
366_T	370_A	2.389	1.00
87_K	97_T	2.382	1.00
36_E	241_K	2.357	1.00
191_K	195_E	2.346	1.00
18_S	21_Y	2.317	1.00
113_Q	160_A	2.313	1.00
110_V	209_N	2.309	1.00
73_N	77_E	2.299	1.00
465_A	468_K	2.273	1.00
382_T	413_Q	2.273	1.00
159_T	169_Q	2.243	1.00
461_F	496_Q	2.242	1.00
93_I	167_K	2.238	1.00
108_T	192_A	2.211	1.00
70_V	86_W	2.174	1.00
307_Q	311_L	2.160	1.00
308_R	311_L	2.154	1.00
105_A	228_N	2.149	1.00
95_T	167_K	2.140	1.00
308_R	367_L	2.132	1.00
403_K	409_D	2.128	1.00
73_N	79_V	2.100	1.00
103_K	109_P	2.087	1.00
88_S	92_R	2.074	1.00
382_T	411_K	2.074	1.00
481_A	484_A	2.074	1.00
224_V	241_K	2.026	1.00
463_N	492_I	2.019	1.00
93_I	169_Q	1.997	1.00
472_Q	485_D	1.995	1.00
103_K	230_H	1.990	1.00
156_L	171_D	1.985	1.00
67_E	81_G	1.985	1.00
102_A	110_V	1.976	1.00
478_T	481_A	1.946	1.00
463_N	496_Q	1.942	1.00
113_Q	191_K	1.934	1.00
36_E	243_T	1.898	1.00
301_K	430_D	1.894	1.00
256_R	261_D	1.883	1.00
97_T	165_T	1.865	1.00
484_A	488_A	1.862	1.00
114_D	191_K	1.844	1.00
453_T	462_N	1.830	1.00
40_H	262_I	1.826	1.00
119_W	168_I	1.824	1.00
49_D	121_R	1.811	1.00
111_T	114_D	1.802	1.00
84_T	100_D	1.786	1.00
399_A	403_K	1.783	1.00
213_V	229_T	1.780	1.00
466_Y	489_A	1.778	1.00
297_F	500_A	1.758	1.00
115_F	166_L	1.752	1.00
465_A	488_A	1.751	1.00
216_E	224_V	1.746	1.00
218_V	221_E	1.738	1.00
473_A	486_Y	1.733	1.00
307_Q	496_Q	1.702	1.00
226_V	241_K	1.696	1.00
316_T	406_L	1.693	1.00
38_V	243_T	1.690	1.00
334_A	504_Q	1.688	1.00
216_E	222_K	1.673	1.00
469_V	488_A	1.667	1.00
465_A	492_I	1.642	1.00
423_S	428_N	1.642	1.00
84_T	97_T	1.637	1.00
491_K	495_E	1.635	1.00
19_L	22_A	1.630	1.00
35_Q	240_Q	1.618	1.00
101_N	109_P	1.617	1.00
106_D	190_Q	1.615	1.00
473_A	485_D	1.606	1.00
222_K	243_T	1.592	1.00
157_G	169_Q	1.591	1.00
215_K	241_K	1.590	1.00
113_Q	163_A	1.587	1.00
311_L	363_Q	1.580	1.00
360_L	363_Q	1.565	1.00
378_P	409_D	1.563	1.00
227_P	240_Q	1.561	1.00
113_Q	116_V	1.544	1.00
297_F	431_V	1.539	1.00
258_L	275_K	1.529	1.00
422_D	426_T	1.527	1.00
453_T	467_D	1.525	1.00
17_I	21_Y	1.520	1.00
16_S	19_L	1.516	1.00
108_T	190_Q	1.515	1.00
488_A	491_K	1.514	1.00
218_V	222_K	1.510	1.00
84_T	99_R	1.510	1.00
111_T	163_A	1.507	1.00
320_R	333_P	1.501	1.00
464_P	468_K	1.496	1.00
469_V	485_D	1.485	1.00
317_I	398_V	1.484	1.00
70_V	96_F	1.482	1.00
416_E	419_T	1.464	1.00
452_S	467_D	1.461	1.00
112_A	160_A	1.460	1.00
392_Q	396_I	1.455	1.00
311_L	497_A	1.455	1.00
212_Y	239_L	1.434	1.00
462_N	467_D	1.433	1.00
88_S	93_I	1.424	1.00
247_I	256_R	1.421	1.00
300_Q	460_R	1.419	1.00
485_D	488_A	1.418	1.00
476_E	485_D	1.412	1.00
314_S	497_A	1.405	1.00
55_G	58_E	1.403	1.00
86_W	96_F	1.384	1.00
95_T	165_T	1.383	1.00
274_Q	277_L	1.381	1.00
483_N	487_N	1.380	1.00
307_Q	495_E	1.377	1.00
224_V	243_T	1.376	1.00
362_A	365_K	1.375	1.00
452_S	462_N	1.374	1.00
67_E	232_W	1.366	1.00
67_E	209_N	1.338	1.00
365_K	369_S	1.333	1.00
413_Q	423_S	1.323	1.00
472_Q	481_A	1.318	1.00
492_I	496_Q	1.317	1.00
103_K	228_N	1.312	1.00
190_Q	193_N	1.309	1.00
281_P	513_P	1.307	1.00
323_T	333_P	1.302	1.00
313_L	408_V	1.300	1.00
484_A	487_N	1.296	1.00
442_E	482_R	1.294	1.00
401_M	405_N	1.290	1.00
161_V	165_T	1.288	1.00
105_A	213_V	1.288	1.00
304_T	381_L	1.283	1.00
309_V	368_L	1.278	1.00
102_A	209_N	1.276	1.00
481_A	485_D	1.276	1.00
38_V	263_D	1.268	1.00
468_K	471_A	1.268	1.00
109_P	164_H	1.262	1.00
110_V	188_P	1.259	1.00
97_T	164_H	1.255	1.00
38_V	245_L	1.254	1.00
304_T	313_L	1.253	1.00
116_V	158_V	1.248	1.00
88_S	95_T	1.248	1.00
106_D	192_A	1.243	1.00
283_Q	513_P	1.234	1.00
14_V	17_I	1.234	1.00
472_Q	476_E	1.230	1.00
168_I	177_F	1.229	1.00
13_L	16_S	1.221	1.00
215_K	224_V	1.221	1.00
469_V	492_I	1.220	1.00
301_K	305_A	1.218	1.00
156_L	169_Q	1.217	1.00
346_T	349_P	1.216	1.00
385_Y	412_L	1.209	1.00
40_H	253_A	1.196	1.00
256_R	262_I	1.192	1.00
257_Y	510_L	1.192	1.00
88_S	91_N	1.188	1.00
172_K	475_T	1.184	1.00
225_V	244_F	1.183	1.00
37_L	264_I	1.183	1.00
160_A	163_A	1.177	1.00
385_Y	414_N	1.177	1.00
118_S	188_P	1.175	1.00
461_F	466_Y	1.168	1.00
94_W	177_F	1.167	1.00
80_P	86_W	1.166	1.00
397_A	401_M	1.162	1.00
99_R	102_A	1.162	1.00
120_Q	124_D	1.161	1.00
115_F	188_P	1.158	1.00
323_T	331_E	1.156	1.00
222_K	245_L	1.155	1.00
296_A	432_I	1.153	1.00
34_K	240_Q	1.152	1.00
99_R	232_W	1.146	1.00
383_L	410_V	1.144	1.00
82_V	209_N	1.143	1.00
367_L	370_A	1.141	1.00
465_A	469_V	1.136	1.00
71_N	79_V	1.134	1.00
427_G	460_R	1.132	1.00
361_N	365_K	1.127	1.00
263_D	514_W	1.127	1.00
366_T	369_S	1.125	1.00
417_W	421_I	1.124	1.00
105_A	230_H	1.123	1.00
480_K	483_N	1.123	1.00
321_L	401_M	1.123	1.00
158_V	166_L	1.122	1.00
258_L	279_D	1.117	1.00
309_V	371_A	1.117	1.00
263_D	512_K	1.112	1.00
399_A	412_L	1.110	1.00
369_S	374_G	1.105	1.00
71_N	81_G	1.093	1.00
361_N	406_L	1.090	1.00
316_T	402_W	1.089	1.00
402_W	410_V	1.088	1.00
213_V	228_N	1.080	1.00
311_L	367_L	1.078	1.00
381_L	410_V	1.076	1.00
286_T	506_T	1.073	1.00
492_I	495_E	1.071	1.00
61_V	225_V	1.070	1.00
283_Q	511_I	1.067	1.00
327_L	503_Y	1.067	1.00
87_K	95_T	1.066	1.00
227_P	237_T	1.064	1.00
307_Q	497_A	1.062	1.00
94_W	178_V	1.054	1.00
480_K	484_A	1.050	1.00
109_P	163_A	1.050	1.00
96_F	168_I	1.048	1.00
285_Y	511_I	1.042	1.00
472_Q	488_A	1.039	1.00
82_V	102_A	1.039	1.00
233_D	236_K	1.038	1.00
105_A	207_I	1.028	1.00
90_D	93_I	1.025	1.00
340_D	504_Q	1.021	1.00
362_A	366_T	1.021	1.00
192_A	196_S	1.020	1.00
139_G	174_L	1.019	1.00
117_Y	191_K	1.017	1.00
381_L	431_V	1.009	1.00
332_K	506_T	1.009	1.00
451_T	471_A	1.007	1.00
252_A	256_R	1.006	1.00
227_P	234_N	1.006	1.00
114_D	117_Y	1.004	1.00
274_Q	278_K	1.003	1.00
112_A	161_V	1.002	1.00
399_A	410_V	1.001	1.00
84_T	164_H	0.997	1.00
14_V	18_S	0.995	1.00
469_V	489_A	0.995	1.00
314_S	319_R	0.990	1.00
469_V	472_Q	0.988	1.00
461_F	498_P	0.986	1.00
308_R	371_A	0.979	1.00
193_N	207_I	0.979	1.00
120_Q	123_V	0.978	1.00
398_V	402_W	0.977	1.00
104_W	114_D	0.977	1.00
473_A	489_A	0.974	1.00
37_L	239_L	0.971	1.00
346_T	487_N	0.968	1.00
97_T	100_D	0.966	1.00
400_S	403_K	0.961	1.00
82_V	115_F	0.960	1.00
361_N	405_N	0.959	1.00
363_Q	367_L	0.955	1.00
395_A	412_L	0.951	1.00
466_Y	493_L	0.951	1.00
94_W	170_L	0.950	1.00
262_I	265_T	0.950	1.00
324_E	329_T	0.949	1.00
226_V	229_T	0.948	1.00
471_A	475_T	0.945	1.00
466_Y	470_L	0.945	1.00
277_L	286_T	0.941	1.00
297_F	313_L	0.940	1.00
112_A	166_L	0.937	1.00
311_L	315_M	0.935	1.00
359_E	405_N	0.933	1.00
400_S	405_N	0.932	1.00
70_V	178_V	0.929	1.00
321_L	325_K	0.928	1.00
113_Q	117_Y	0.925	1.00
322_M	394_I	0.925	1.00
419_T	423_S	0.925	1.00
227_P	236_K	0.923	1.00
327_L	331_E	0.923	1.00
68_G	81_G	0.920	1.00
95_T	161_V	0.918	1.00
44_E	217_R	0.915	1.00
311_L	495_E	0.915	1.00
255_K	258_L	0.913	1.00
276_L	282_G	0.912	1.00
17_I	20_S	0.909	1.00
177_F	181_T	0.909	1.00
100_D	109_P	0.908	1.00
174_L	180_L	0.908	1.00
105_A	208_G	0.907	1.00
67_E	231_Y	0.903	1.00
346_T	491_K	0.903	1.00
170_L	177_F	0.901	1.00
314_S	500_A	0.896	1.00
97_T	162_D	0.896	1.00
393_K	396_I	0.895	1.00
444_S	474_S	0.894	1.00
323_T	503_Y	0.894	1.00
105_A	214_L	0.885	1.00
272_M	275_K	0.884	1.00
254_T	258_L	0.878	1.00
65_L	225_V	0.876	1.00
452_S	471_A	0.876	1.00
479_V	483_N	0.875	1.00
37_L	515_L	0.875	1.00
83_A	96_F	0.875	1.00
318_D	401_M	0.875	1.00
415_Q	423_S	0.873	1.00
282_G	510_L	0.869	1.00
160_A	166_L	0.867	1.00
70_V	78_I	0.862	1.00
70_V	83_A	0.862	1.00
116_V	166_L	0.858	1.00
254_T	276_L	0.856	1.00
466_Y	492_I	0.856	1.00
117_Y	194_V	0.856	1.00
139_G	172_K	0.854	1.00
319_R	333_P	0.853	1.00
337_F	501_P	0.852	1.00
489_A	492_I	0.852	1.00
16_S	21_Y	0.852	1.00
15_S	19_L	0.852	1.00
106_D	207_I	0.847	1.00
247_I	262_I	0.830	1.00
120_Q	158_V	0.829	1.00
217_R	223_L	0.829	1.00
384_L	423_S	0.827	1.00
364_A	406_L	0.825	1.00
68_G	187_F	0.824	1.00
424_R	432_I	0.823	1.00
470_L	489_A	0.821	1.00
257_Y	282_G	0.819	1.00
257_Y	265_T	0.818	1.00
447_L	451_T	0.816	1.00
296_A	459_S	0.815	1.00
379_L	408_V	0.815	1.00
92_R	156_L	0.815	1.00
487_N	491_K	0.814	1.00
274_Q	328_G	0.813	1.00
96_F	178_V	0.812	1.00
176_W	442_E	0.812	1.00
269_P	272_M	0.807	1.00
44_E	246_P	0.806	1.00
102_A	164_H	0.805	1.00
279_D	282_G	0.804	1.00
472_Q	475_T	0.802	1.00
82_V	110_V	0.799	1.00
65_L	214_L	0.798	1.00
89_N	95_T	0.797	1.00
227_P	239_L	0.796	1.00
114_D	118_S	0.793	1.00
382_T	430_D	0.789	1.00
315_M	359_E	0.788	1.00
488_A	492_I	0.786	1.00
295_Y	398_V	0.786	1.00
276_L	510_L	0.785	1.00
385_Y	395_A	0.783	1.00
66_F	208_G	0.783	1.00
332_K	340_D	0.782	1.00
212_Y	237_T	0.779	1.00
253_A	265_T	0.779	1.00
306_D	373_Y	0.778	1.00
35_Q	239_L	0.777	1.00
92_R	169_Q	0.777	1.00
373_Y	376_Q	0.772	1.00
288_P	506_T	0.772	1.00
291_G	437_V	0.771	1.00
444_S	448_T	0.765	1.00
315_M	367_L	0.764	1.00
101_N	164_H	0.763	1.00
384_L	415_Q	0.763	1.00
353_E	360_L	0.762	1.00
91_N	95_T	0.762	1.00
403_K	408_V	0.762	1.00
64_D	225_V	0.761	1.00
316_T	361_N	0.760	1.00
444_S	486_Y	0.759	1.00
457_N	460_R	0.759	1.00
255_K	259_A	0.757	1.00
81_G	232_W	0.757	1.00
300_Q	427_G	0.755	1.00
318_D	359_E	0.754	1.00
214_L	223_L	0.753	1.00
312_A	368_L	0.752	1.00
306_D	371_A	0.750	1.00
139_G	171_D	0.748	1.00
273_Y	277_L	0.747	1.00
137_L	140_I	0.745	1.00
229_T	240_Q	0.744	1.00
368_L	372_G	0.741	1.00
35_Q	238_V	0.740	1.00
299_T	498_P	0.739	1.00
336_H	490_E	0.739	1.00
367_L	371_A	0.738	1.00
396_I	412_L	0.737	1.00
117_Y	195_E	0.736	1.00
92_R	172_K	0.735	1.00
98_L	110_V	0.734	1.00
51_A	121_R	0.734	1.00
102_A	232_W	0.733	1.00
384_L	413_Q	0.732	1.00
464_P	467_D	0.731	1.00
50_P	189_V	0.731	1.00
448_T	474_S	0.728	1.00
461_F	492_I	0.727	1.00
39_R	264_I	0.726	1.00
402_W	431_V	0.725	1.00
96_F	181_T	0.724	1.00
295_Y	431_V	0.721	1.00
317_I	322_M	0.720	1.00
225_V	242_V	0.719	1.00
118_S	189_V	0.716	1.00
368_L	373_Y	0.715	1.00
293_Y	391_H	0.713	1.00
392_Q	414_N	0.712	1.00
265_T	268_F	0.712	1.00
104_W	192_A	0.711	1.00
124_D	127_T	0.710	1.00
482_R	486_Y	0.709	1.00
419_T	422_D	0.708	1.00
226_V	240_Q	0.707	1.00
104_W	188_P	0.706	1.00
69_L	83_A	0.705	1.00
86_W	178_V	0.705	1.00
313_L	431_V	0.704	1.00
322_M	397_A	0.703	1.00
286_T	330_G	0.703	1.00
317_I	402_W	0.702	1.00
309_V	373_Y	0.702	1.00
373_Y	377_K	0.701	1.00
297_F	304_T	0.700	1.00
415_Q	419_T	0.698	1.00
37_L	242_V	0.697	1.00
160_A	167_K	0.696	1.00
64_D	242_V	0.696	1.00
385_Y	392_Q	0.695	1.00
343_A	479_V	0.692	1.00
190_Q	207_I	0.692	1.00
13_L	17_I	0.691	1.00
10_C	13_L	0.690	1.00
451_T	454_H	0.690	1.00
313_L	500_A	0.688	1.00
112_A	116_V	0.686	1.00
368_L	371_A	0.686	1.00
233_D	237_T	0.685	1.00
74_E	519_P	0.685	1.00
350_S	353_E	0.685	1.00
383_L	395_A	0.682	1.00
17_I	22_A	0.682	1.00
192_A	195_E	0.682	1.00
403_K	410_V	0.681	1.00
376_Q	379_L	0.681	1.00
65_L	208_G	0.680	1.00
396_I	399_A	0.680	1.00
73_N	76_G	0.680	1.00
40_H	247_I	0.679	1.00
10_C	16_S	0.679	1.00
264_I	515_L	0.679	1.00
247_I	253_A	0.679	1.00
420_Y	432_I	0.678	1.00
281_P	512_K	0.676	1.00
373_Y	379_L	0.674	1.00
439_D	445_T	0.673	1.00
498_P	501_P	0.673	1.00
34_K	238_V	0.672	1.00
245_L	256_R	0.672	1.00
396_I	400_S	0.672	1.00
110_V	164_H	0.671	1.00
383_L	433_R	0.670	1.00
51_A	122_L	0.670	1.00
11_A	15_S	0.669	1.00
15_S	18_S	0.669	1.00
61_V	223_L	0.668	1.00
140_I	168_I	0.667	1.00
158_V	168_I	0.665	1.00
116_V	159_T	0.662	1.00
402_W	406_L	0.661	1.00
286_T	508_G	0.660	1.00
368_L	406_L	0.660	1.00
123_V	171_D	0.659	1.00
53_A	62_I	0.658	1.00
485_D	489_A	0.657	1.00
104_W	110_V	0.656	1.00
16_S	20_S	0.654	1.00
72_Q	182_A	0.653	1.00
66_F	206_L	0.653	1.00
119_W	181_T	0.652	1.00
402_W	408_V	0.652	1.00
322_M	398_V	0.651	1.00
111_T	191_K	0.650	1.00
374_G	377_K	0.650	1.00
301_K	304_T	0.648	1.00
98_L	164_H	0.648	1.00
313_L	381_L	0.648	1.00
316_T	359_E	0.645	1.00
12_L	16_S	0.642	1.00
214_L	217_R	0.641	1.00
104_W	208_G	0.641	1.00
386_N	391_H	0.641	1.00
44_E	219_V	0.641	1.00
398_V	410_V	0.638	1.00
111_T	164_H	0.637	1.00
257_Y	512_K	0.636	1.00
344_G	483_N	0.636	1.00
306_D	309_V	0.635	1.00
72_Q	78_I	0.633	1.00
280_I	513_P	0.632	1.00
14_V	19_L	0.631	1.00
417_W	434_A	0.630	1.00
471_A	474_S	0.630	1.00
388_S	392_Q	0.629	1.00
10_C	14_V	0.629	1.00
374_G	378_P	0.629	1.00
384_L	429_F	0.629	1.00
120_Q	157_G	0.629	1.00
304_T	309_V	0.628	1.00
108_T	114_D	0.628	1.00
213_V	230_H	0.625	1.00
342_T	345_F	0.620	1.00
117_Y	121_R	0.620	1.00
283_Q	516_K	0.619	1.00
315_M	352_F	0.619	1.00
46_A	55_G	0.619	1.00
467_D	471_A	0.619	1.00
175_P	482_R	0.618	1.00
223_L	246_P	0.617	1.00
48_L	217_R	0.616	1.00
9_C	12_L	0.616	1.00
299_T	459_S	0.616	1.00
30_V	33_E	0.613	1.00
84_T	87_K	0.612	1.00
479_V	482_R	0.611	1.00
306_D	372_G	0.609	1.00
92_R	173_P	0.609	1.00
239_L	515_L	0.608	1.00
512_K	515_L	0.607	1.00
293_Y	394_I	0.606	1.00
96_F	166_L	0.605	1.00
110_V	118_S	0.605	1.00
292_T	334_A	0.604	1.00
294_Y	499_I	0.601	1.00
10_C	17_I	0.600	1.00
368_L	379_L	0.599	1.00
212_Y	241_K	0.599	1.00
112_A	164_H	0.599	1.00
451_T	493_L	0.599	1.00
320_R	323_T	0.598	1.00
511_I	518_Y	0.597	1.00
249_Q	252_A	0.597	1.00
394_I	398_V	0.596	1.00
68_G	209_N	0.595	1.00
9_C	13_L	0.593	1.00
446_F	451_T	0.593	1.00
330_G	508_G	0.593	1.00
386_N	420_Y	0.593	1.00
12_L	15_S	0.592	1.00
447_L	450_L	0.590	1.00
436_W	439_D	0.589	1.00
172_K	471_A	0.588	1.00
300_Q	305_A	0.588	1.00
466_Y	469_V	0.588	1.00
317_I	502_I	0.587	1.00
254_T	272_M	0.587	1.00
66_F	209_N	0.586	1.00
212_Y	227_P	0.583	1.00
346_T	490_E	0.583	1.00
91_N	477_N	0.582	1.00
348_E	491_K	0.582	1.00
309_V	379_L	0.581	1.00
86_W	97_T	0.581	1.00
251_S	255_K	0.578	1.00
67_E	233_D	0.578	1.00
69_L	115_F	0.577	1.00
394_I	503_Y	0.577	1.00
373_Y	408_V	0.577	1.00
221_E	245_L	0.576	1.00
46_A	58_E	0.575	1.00
365_K	406_L	0.574	1.00
497_A	500_A	0.572	1.00
448_T	452_S	0.572	1.00
297_F	314_S	0.572	1.00
98_L	102_A	0.572	1.00
104_W	209_N	0.572	1.00
368_L	408_V	0.571	1.00
53_A	58_E	0.570	1.00
234_N	238_V	0.569	1.00
78_I	178_V	0.569	1.00
317_I	500_A	0.569	1.00
72_Q	76_G	0.569	1.00
11_A	17_I	0.569	1.00
125_P	128_L	0.569	1.00
257_Y	262_I	0.569	1.00
349_P	352_F	0.568	1.00
65_L	206_L	0.568	1.00
371_A	376_Q	0.567	1.00
359_E	401_M	0.567	1.00
234_N	237_T	0.565	1.00
14_V	21_Y	0.565	1.00
401_M	406_L	0.565	1.00
206_L	214_L	0.565	1.00
301_K	428_N	0.564	1.00
348_E	487_N	0.563	1.00
117_Y	192_A	0.562	1.00
299_T	305_A	0.560	1.00
264_I	511_I	0.559	1.00
59_I	184_F	0.558	1.00
476_E	482_R	0.556	1.00
120_Q	160_A	0.556	1.00
323_T	327_L	0.555	1.00
9_C	15_S	0.554	1.00
295_Y	502_I	0.554	1.00
315_M	364_A	0.554	1.00
120_Q	191_K	0.554	1.00
41_I	244_F	0.553	1.00
361_N	368_L	0.552	1.00
273_Y	284_V	0.552	1.00
250_E	253_A	0.551	1.00
360_L	366_T	0.550	1.00
88_S	94_W	0.549	1.00
228_N	231_Y	0.548	1.00
451_T	470_L	0.547	1.00
55_G	417_W	0.547	1.00
12_L	17_I	0.547	1.00
36_E	224_V	0.546	1.00
93_I	159_T	0.545	1.00
121_R	194_V	0.545	1.00
463_N	466_Y	0.542	1.00
495_E	498_P	0.542	1.00
395_A	433_R	0.542	1.00
309_V	313_L	0.541	1.00
442_E	445_T	0.541	1.00
214_L	225_V	0.541	1.00
112_A	162_D	0.541	1.00
108_T	191_K	0.540	1.00
473_A	482_R	0.540	1.00
294_Y	434_A	0.540	1.00
345_F	349_P	0.539	1.00
268_F	510_L	0.539	1.00
340_D	345_F	0.539	1.00
415_Q	420_Y	0.538	1.00
38_V	262_I	0.538	1.00
8_T	11_A	0.537	1.00
105_A	209_N	0.537	1.00
410_V	431_V	0.537	1.00
277_L	330_G	0.537	1.00
137_L	186_F	0.535	1.00
451_T	499_I	0.534	1.00
385_Y	388_S	0.533	1.00
382_T	385_Y	0.533	1.00
260_G	512_K	0.532	1.00
469_V	473_A	0.532	1.00
106_D	193_N	0.530	1.00
48_L	223_L	0.529	1.00
303_P	430_D	0.527	1.00
239_L	242_V	0.527	1.00
18_S	22_A	0.526	1.00
80_P	85_Q	0.526	1.00
9_C	16_S	0.524	1.00
71_N	233_D	0.524	1.00
104_W	190_Q	0.523	1.00
369_S	373_Y	0.523	1.00
345_F	348_E	0.523	1.00
321_L	397_A	0.522	1.00
140_I	158_V	0.521	1.00
84_T	98_L	0.520	1.00
68_G	96_F	0.520	1.00
288_P	332_K	0.520	1.00
104_W	118_S	0.518	1.00
245_L	261_D	0.518	1.00
322_M	502_I	0.518	1.00
422_D	425_N	0.518	1.00
251_S	272_M	0.517	1.00
279_D	513_P	0.517	1.00
326_V	397_A	0.516	1.00
273_Y	508_G	0.516	1.00
489_A	493_L	0.516	1.00
330_G	506_T	0.516	1.00
229_T	236_K	0.516	1.00
330_G	333_P	0.515	1.00
89_N	93_I	0.515	1.00
477_N	481_A	0.514	1.00
343_A	483_N	0.512	1.00
70_V	182_A	0.512	1.00
322_M	326_V	0.511	1.00
112_A	165_T	0.511	1.00
447_L	489_A	0.510	1.00
98_L	112_A	0.510	1.00
11_A	14_V	0.510	1.00
194_V	197_G	0.510	1.00
387_T	414_N	0.510	1.00
417_W	420_Y	0.510	1.00
490_E	494_M	0.509	1.00
160_A	165_T	0.508	1.00
34_K	241_K	0.507	1.00
363_Q	370_A	0.507	1.00
313_L	406_L	0.506	1.00
295_Y	500_A	0.505	1.00
421_I	425_N	0.504	1.00
459_S	499_I	0.504	1.00
64_D	244_F	0.503	1.00
70_V	87_K	0.503	1.00
62_I	65_L	0.503	1.00
389_E	392_Q	0.502	1.00
117_Y	189_V	0.502	1.00
421_I	424_R	0.501	1.00
62_I	66_F	0.501	1.00
109_P	114_D	0.501	1.00
389_E	393_K	0.501	1.00
204_G	219_V	0.500	1.00
398_V	433_R	0.500	1.00
104_W	111_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zs6A	1	0.9348	100	0.148	Contact Map
4tozA	1	0.9572	100	0.148	Contact Map
4fajA	1	0.9162	100	0.149	Contact Map
4qflA	1	0.9032	100	0.152	Contact Map
1jetA	1	0.9516	100	0.155	Contact Map
4gl8A	1	0.9125	100	0.167	Contact Map
1xocA	2	0.8883	100	0.185	Contact Map
4wedA	1	0.8566	100	0.19	Contact Map
3m8uA	1	0.905	100	0.196	Contact Map
3tpaA	1	0.9032	100	0.198	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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