GMR - ECOLI - GREMLIN Contacts

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GMR - Cyclic di-GMP phosphodiesterase Gmr

UniProt:	P77334	Sequences: MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVITSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEAHSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSGNAYEVELWIPTCKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTDSITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGIALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALENDQLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVVRQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIENDELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKRA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13415
Length:	661 (549)
Sequences:	10904 (8735)
Seq/√Len:	372.8

ECOLI - GMR YEGE DOSP YFGF YLIE YFEA YHJK CSRD YLAB YJCC RTN YCGG ADRB
BACSU - YKOW

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
439_L	650_F	4.761	1.00
432_W	636_R	4.113	1.00
477_L	519_E	3.972	1.00
235_I	239_T	3.873	1.00
584_Q	588_R	3.821	1.00
642_A	645_M	3.747	1.00
305_E	308_Q	3.719	1.00
472_G	503_Q	3.629	1.00
551_S	578_D	3.429	1.00
405_E	457_D	3.417	1.00
514_K	553_L	3.197	1.00
423_V	446_Q	3.167	1.00
473_R	512_A	3.024	1.00
619_V	636_R	2.962	1.00
426_Y	482_Q	2.847	1.00
122_S	221_T	2.817	1.00
622_A	626_A	2.687	1.00
608_Q	634_N	2.647	1.00
573_A	596_S	2.647	1.00
484_A	488_D	2.641	1.00
369_D	372_A	2.589	1.00
447_S	451_G	2.566	1.00
251_M	319_L	2.532	1.00
270_V	358_V	2.532	1.00
412_N	447_S	2.492	1.00
487_R	526_P	2.422	1.00
627_F	631_N	2.417	1.00
462_A	471_L	2.416	1.00
478_D	481_R	2.408	1.00
516_V	520_L	2.404	1.00
125_V	218_C	2.294	1.00
425_H	646_P	2.222	1.00
443_V	475_V	2.222	1.00
528_D	579_A	2.205	1.00
482_Q	486_W	2.189	1.00
558_H	579_A	2.151	1.00
482_Q	647_A	2.141	1.00
499_I	509_I	2.133	1.00
447_S	450_R	2.051	1.00
270_V	334_A	2.045	1.00
422_L	443_V	2.029	1.00
364_P	367_G	2.027	1.00
146_L	192_C	1.994	1.00
430_I	641_F	1.952	1.00
625_D	636_R	1.951	1.00
483_V	522_F	1.949	1.00
625_D	641_F	1.899	1.00
424_I	474_W	1.880	1.00
547_I	557_V	1.876	1.00
474_W	478_D	1.874	1.00
200_F	221_T	1.867	1.00
123_A	143_Y	1.861	1.00
639_F	644_P	1.850	1.00
295_D	298_L	1.848	1.00
423_V	452_L	1.838	1.00
191_T	195_Q	1.833	1.00
117_V	135_R	1.825	1.00
295_D	345_F	1.822	1.00
268_G	362_L	1.821	1.00
226_E	230_Q	1.818	1.00
123_A	220_G	1.813	1.00
480_V	516_V	1.812	1.00
477_L	520_L	1.796	1.00
128_D	132_N	1.795	1.00
446_Q	452_L	1.793	1.00
478_D	482_Q	1.777	1.00
424_I	475_V	1.772	1.00
276_N	389_R	1.762	1.00
601_R	609_A	1.759	1.00
604_V	631_N	1.753	1.00
150_D	192_C	1.746	1.00
486_W	647_A	1.731	1.00
646_P	649_A	1.719	1.00
429_K	528_D	1.715	1.00
275_D	357_S	1.713	1.00
291_Q	294_R	1.710	1.00
421_Q	447_S	1.690	1.00
246_P	250_A	1.688	1.00
443_V	471_L	1.683	1.00
254_L	309_V	1.673	1.00
420_D	478_D	1.664	1.00
255_I	370_S	1.664	1.00
591_H	623_K	1.663	1.00
429_K	438_S	1.655	1.00
597_Q	627_F	1.653	1.00
125_V	133_I	1.645	1.00
425_H	452_L	1.642	1.00
494_R	556_Q	1.639	1.00
138_R	142_D	1.626	1.00
208_G	212_N	1.625	1.00
523_E	526_P	1.624	1.00
227_R	230_Q	1.621	1.00
613_Q	634_N	1.617	1.00
367_G	376_H	1.616	1.00
591_H	627_F	1.613	1.00
429_K	635_E	1.605	1.00
291_Q	348_G	1.602	1.00
591_H	597_Q	1.598	1.00
186_E	227_R	1.595	1.00
622_A	640_L	1.587	1.00
601_R	631_N	1.573	1.00
304_L	310_L	1.569	1.00
250_A	254_L	1.567	1.00
573_A	589_D	1.555	1.00
322_A	333_M	1.553	1.00
625_D	640_L	1.552	1.00
387_G	393_C	1.533	1.00
448_P	451_G	1.521	1.00
334_A	360_I	1.519	1.00
406_Y	464_E	1.509	1.00
625_D	629_T	1.507	1.00
436_V	653_W	1.500	1.00
424_I	479_V	1.498	1.00
412_N	450_R	1.496	1.00
621_S	624_E	1.493	1.00
559_L	577_I	1.491	1.00
272_L	356_C	1.490	1.00
281_N	289_G	1.488	1.00
384_A	393_C	1.470	1.00
450_R	457_D	1.466	1.00
487_R	523_E	1.465	1.00
613_Q	635_E	1.460	1.00
513_L	550_F	1.459	1.00
200_F	226_E	1.452	1.00
415_K	419_N	1.448	1.00
556_Q	578_D	1.445	1.00
443_V	474_W	1.440	1.00
188_W	198_F	1.438	1.00
501_A	534_S	1.437	1.00
579_A	615_I	1.432	1.00
429_K	579_A	1.425	1.00
225_E	228_R	1.425	1.00
110_L	114_E	1.409	1.00
205_V	213_E	1.406	1.00
645_M	653_W	1.403	1.00
139_L	142_D	1.402	1.00
477_L	516_V	1.396	1.00
298_L	301_L	1.392	1.00
604_V	633_I	1.392	1.00
483_V	495_V	1.389	1.00
120_A	124_I	1.380	1.00
335_S	339_T	1.378	1.00
326_S	329_A	1.367	1.00
499_I	529_V	1.365	1.00
292_L	354_T	1.363	1.00
355_S	390_G	1.362	1.00
517_L	555_A	1.355	1.00
409_L	461_Y	1.353	1.00
346_R	351_E	1.345	1.00
590_I	627_F	1.339	1.00
636_R	641_F	1.335	1.00
341_L	356_C	1.333	1.00
274_L	296_V	1.332	1.00
232_R	236_L	1.329	1.00
486_W	651_E	1.328	1.00
415_K	421_Q	1.319	1.00
489_K	651_E	1.316	1.00
514_K	549_Q	1.302	1.00
235_I	244_G	1.295	1.00
161_M	164_R	1.290	1.00
286_H	378_D	1.289	1.00
239_T	250_A	1.283	1.00
232_R	235_I	1.280	1.00
580_I	607_A	1.280	1.00
577_I	612_L	1.276	1.00
649_A	652_R	1.274	1.00
254_L	257_H	1.265	1.00
528_D	558_H	1.261	1.00
268_G	330_L	1.259	1.00
266_K	365_E	1.258	1.00
366_H	394_V	1.255	1.00
276_N	410_D	1.251	1.00
164_R	188_W	1.247	1.00
191_T	197_L	1.247	1.00
494_R	528_D	1.247	1.00
154_Q	158_K	1.243	1.00
331_E	394_V	1.242	1.00
421_Q	445_W	1.242	1.00
341_L	345_F	1.238	1.00
251_M	321_L	1.236	1.00
447_S	453_I	1.236	1.00
383_T	386_E	1.235	1.00
113_A	117_V	1.230	1.00
437_R	635_E	1.221	1.00
424_I	443_V	1.220	1.00
271_Y	381_M	1.218	1.00
123_A	137_N	1.217	1.00
125_V	140_C	1.216	1.00
384_A	391_Q	1.216	1.00
250_A	309_V	1.211	1.00
296_V	341_L	1.210	1.00
626_A	630_K	1.209	1.00
126_I	215_F	1.198	1.00
261_H	323_S	1.196	1.00
590_I	600_V	1.193	1.00
292_L	345_F	1.192	1.00
421_Q	448_P	1.184	1.00
230_Q	234_R	1.180	1.00
456_L	584_Q	1.179	1.00
184_E	200_F	1.175	1.00
422_L	474_W	1.173	1.00
287_L	371_T	1.172	1.00
601_R	605_A	1.171	1.00
479_V	495_V	1.170	1.00
413_L	422_L	1.168	1.00
114_E	118_S	1.165	1.00
188_W	196_R	1.160	1.00
579_A	613_Q	1.160	1.00
279_K	410_D	1.159	1.00
251_M	311_A	1.157	1.00
515_Q	519_E	1.152	1.00
505_A	538_E	1.140	1.00
431_T	435_E	1.140	1.00
602_A	609_A	1.140	1.00
450_R	453_I	1.139	1.00
432_W	625_D	1.139	1.00
593_Q	596_S	1.136	1.00
383_T	393_C	1.135	1.00
330_L	334_A	1.134	1.00
117_V	124_I	1.131	1.00
342_R	390_G	1.128	1.00
527_I	555_A	1.122	1.00
616_A	633_I	1.119	1.00
288_F	350_I	1.116	1.00
429_K	496_A	1.115	1.00
351_E	415_K	1.115	1.00
274_L	356_C	1.115	1.00
607_A	614_V	1.109	1.00
331_E	335_S	1.107	1.00
338_L	392_F	1.107	1.00
485_K	489_K	1.107	1.00
278_K	382_Y	1.106	1.00
459_I	468_I	1.104	1.00
480_V	527_I	1.103	1.00
584_Q	618_G	1.102	1.00
228_R	232_R	1.101	1.00
346_R	349_L	1.101	1.00
540_D	575_F	1.096	1.00
360_I	394_V	1.096	1.00
189_I	199_L	1.095	1.00
315_G	382_Y	1.093	1.00
626_A	629_T	1.092	1.00
579_A	635_E	1.091	1.00
207_S	213_E	1.088	1.00
512_A	516_V	1.087	1.00
291_Q	295_D	1.077	1.00
147_K	150_D	1.072	1.00
482_Q	485_K	1.070	1.00
379_T	399_M	1.069	1.00
295_D	299_A	1.068	1.00
642_A	653_W	1.067	1.00
164_R	168_A	1.066	1.00
476_I	516_V	1.064	1.00
140_C	144_T	1.063	1.00
113_A	116_V	1.062	1.00
544_L	548_Q	1.057	1.00
465_S	469_V	1.053	1.00
510_F	546_V	1.047	1.00
271_Y	319_L	1.045	1.00
492_N	526_P	1.044	1.00
482_Q	651_E	1.041	1.00
429_K	494_R	1.041	1.00
273_D	385_K	1.037	1.00
497_V	527_I	1.036	1.00
347_I	352_V	1.031	1.00
146_L	150_D	1.030	1.00
317_E	378_D	1.024	1.00
276_N	279_K	1.022	1.00
127_L	218_C	1.019	1.00
455_P	458_F	1.018	1.00
496_A	528_D	1.018	1.00
528_D	556_Q	1.017	1.00
256_D	370_S	1.012	1.00
378_D	382_Y	1.011	1.00
361_A	376_H	1.011	1.00
126_I	217_I	1.005	1.00
363_S	373_I	1.003	1.00
250_A	253_D	1.002	1.00
198_F	223_I	1.001	1.00
132_N	155_S	1.001	1.00
238_N	249_N	0.997	1.00
483_V	487_R	0.996	1.00
510_F	514_K	0.995	1.00
284_Y	350_I	0.994	1.00
231_E	234_R	0.993	1.00
405_E	450_R	0.992	1.00
275_D	389_R	0.990	1.00
412_N	449_E	0.990	1.00
360_I	392_F	0.988	1.00
484_A	487_R	0.987	1.00
376_H	400_N	0.987	1.00
465_S	468_I	0.984	1.00
463_E	468_I	0.980	1.00
258_A	267_V	0.979	1.00
372_A	376_H	0.979	1.00
141_E	148_E	0.978	1.00
509_I	513_L	0.977	1.00
109_G	112_F	0.976	1.00
481_R	485_K	0.975	1.00
423_V	646_P	0.974	1.00
517_L	522_F	0.974	1.00
136_F	141_E	0.973	1.00
303_C	337_I	0.972	1.00
481_R	520_L	0.969	1.00
277_F	293_L	0.967	1.00
300_I	310_L	0.967	1.00
544_L	574_R	0.967	1.00
187_L	201_R	0.966	1.00
477_L	481_R	0.965	1.00
619_V	628_L	0.965	1.00
313_P	319_L	0.965	1.00
420_D	477_L	0.961	1.00
106_L	110_L	0.961	1.00
135_R	148_E	0.960	1.00
430_I	436_V	0.959	1.00
608_Q	614_V	0.959	1.00
198_F	224_T	0.957	1.00
299_A	344_P	0.957	1.00
267_V	363_S	0.956	1.00
338_L	358_V	0.954	1.00
484_A	520_L	0.951	1.00
388_G	391_Q	0.951	1.00
256_D	260_N	0.949	1.00
476_I	513_L	0.948	1.00
479_V	497_V	0.948	1.00
615_I	635_E	0.947	1.00
410_D	414_R	0.947	1.00
645_M	649_A	0.941	1.00
470_P	473_R	0.939	1.00
441_A	495_V	0.937	1.00
254_L	311_A	0.933	1.00
297_S	310_L	0.933	1.00
340_R	343_L	0.933	1.00
136_F	140_C	0.932	1.00
314_G	317_E	0.932	1.00
396_T	399_M	0.932	1.00
262_A	363_S	0.931	1.00
190_P	196_R	0.929	1.00
547_I	576_P	0.929	1.00
467_L	470_P	0.928	1.00
229_A	233_L	0.927	1.00
275_D	388_G	0.925	1.00
513_L	529_V	0.924	1.00
604_V	608_Q	0.920	1.00
453_I	460_S	0.919	1.00
426_Y	441_A	0.919	1.00
561_D	617_E	0.918	1.00
133_I	218_C	0.916	1.00
305_E	336_R	0.915	1.00
299_A	345_F	0.914	1.00
549_Q	552_Q	0.913	1.00
273_D	382_Y	0.911	1.00
127_L	133_I	0.909	1.00
136_F	151_V	0.908	1.00
429_K	615_I	0.908	1.00
124_I	219_S	0.906	1.00
141_E	147_K	0.905	1.00
148_E	152_I	0.903	1.00
273_D	316_D	0.903	1.00
305_E	333_M	0.903	1.00
203_K	216_L	0.903	1.00
252_Q	371_T	0.903	1.00
240_D	312_R	0.902	1.00
622_A	625_D	0.898	1.00
282_D	382_Y	0.898	1.00
540_D	543_A	0.897	1.00
233_L	236_L	0.895	1.00
438_S	494_R	0.891	1.00
280_V	292_L	0.890	1.00
320_V	337_I	0.889	1.00
548_Q	552_Q	0.885	1.00
138_R	141_E	0.882	1.00
484_A	521_N	0.881	1.00
383_T	387_G	0.875	1.00
446_Q	451_G	0.874	1.00
270_V	322_A	0.874	1.00
469_V	506_D	0.873	1.00
431_T	634_N	0.873	1.00
175_V	179_S	0.871	1.00
241_S	249_N	0.870	1.00
189_I	197_L	0.868	1.00
118_S	138_R	0.865	1.00
155_S	158_K	0.863	1.00
517_L	524_Y	0.862	1.00
510_F	549_Q	0.859	1.00
333_M	336_R	0.858	1.00
304_L	320_V	0.857	1.00
413_L	462_A	0.856	1.00
397_P	401_Q	0.856	1.00
335_S	338_L	0.854	1.00
334_A	392_F	0.854	1.00
265_N	324_N	0.853	1.00
431_T	437_R	0.852	1.00
234_R	238_N	0.851	1.00
275_D	355_S	0.847	1.00
199_L	220_G	0.847	1.00
123_A	139_L	0.846	1.00
413_L	416_A	0.844	1.00
203_K	218_C	0.843	1.00
573_A	593_Q	0.840	1.00
532_T	561_D	0.838	1.00
434_G	629_T	0.837	1.00
425_H	446_Q	0.837	1.00
331_E	392_F	0.831	1.00
205_V	215_F	0.831	1.00
416_A	422_L	0.825	1.00
259_I	363_S	0.823	1.00
163_R	188_W	0.822	1.00
255_I	321_L	0.821	1.00
513_L	516_V	0.821	1.00
480_V	522_F	0.821	1.00
408_W	412_N	0.821	1.00
294_R	298_L	0.817	1.00
462_A	466_G	0.813	1.00
511_T	549_Q	0.812	1.00
201_R	220_G	0.812	1.00
276_N	464_E	0.811	1.00
206_H	215_F	0.809	1.00
599_L	606_V	0.809	1.00
278_K	282_D	0.809	1.00
647_A	651_E	0.808	1.00
253_D	257_H	0.808	1.00
542_L	546_V	0.808	1.00
288_F	291_Q	0.807	1.00
322_A	330_L	0.806	1.00
246_P	309_V	0.805	1.00
486_W	650_F	0.805	1.00
258_A	323_S	0.803	1.00
272_L	320_V	0.801	1.00
201_R	218_C	0.801	1.00
357_S	389_R	0.800	1.00
480_V	520_L	0.800	1.00
430_I	653_W	0.799	1.00
223_I	227_R	0.798	1.00
304_L	308_Q	0.798	1.00
423_V	648_V	0.798	1.00
128_D	134_Q	0.797	1.00
270_V	320_V	0.796	1.00
273_D	281_N	0.795	1.00
107_S	110_L	0.794	1.00
296_V	345_F	0.794	1.00
473_R	515_Q	0.793	1.00
494_R	526_P	0.792	1.00
286_H	382_Y	0.788	1.00
186_E	200_F	0.788	1.00
522_F	527_I	0.787	1.00
418_E	470_P	0.786	1.00
539_N	542_L	0.785	1.00
238_N	253_D	0.782	1.00
387_G	391_Q	0.782	1.00
138_R	148_E	0.782	1.00
116_V	217_I	0.781	1.00
504_L	535_C	0.781	1.00
511_T	515_Q	0.781	1.00
161_M	196_R	0.780	1.00
362_L	394_V	0.778	1.00
556_Q	613_Q	0.778	1.00
257_H	323_S	0.778	1.00
339_T	342_R	0.777	1.00
106_L	109_G	0.776	1.00
253_D	309_V	0.776	1.00
292_L	347_I	0.775	1.00
310_L	320_V	0.775	1.00
439_L	495_V	0.774	1.00
281_N	315_G	0.774	1.00
473_R	477_L	0.774	1.00
516_V	519_E	0.773	1.00
372_A	375_R	0.771	1.00
126_I	137_N	0.767	1.00
281_N	290_D	0.766	1.00
319_L	374_I	0.766	1.00
439_L	493_L	0.766	1.00
224_T	228_R	0.765	1.00
514_K	518_Q	0.765	1.00
134_Q	215_F	0.762	1.00
506_D	512_A	0.760	1.00
415_K	418_E	0.760	1.00
251_M	255_I	0.758	1.00
334_A	338_L	0.758	1.00
364_P	376_H	0.757	1.00
140_C	151_V	0.757	1.00
513_L	555_A	0.755	1.00
564_T	586_F	0.754	1.00
395_F	400_N	0.753	1.00
288_F	352_V	0.752	1.00
400_N	404_F	0.749	1.00
267_V	373_I	0.748	1.00
530_E	581_K	0.746	1.00
551_S	557_V	0.746	1.00
587_V	600_V	0.745	1.00
111_S	115_Q	0.744	1.00
430_I	434_G	0.744	1.00
288_F	347_I	0.743	1.00
536_L	571_Q	0.743	1.00
604_V	628_L	0.743	1.00
316_D	385_K	0.743	1.00
573_A	599_L	0.741	1.00
508_T	512_A	0.741	1.00
532_T	617_E	0.740	1.00
259_I	267_V	0.737	1.00
529_V	557_V	0.737	1.00
226_E	229_A	0.736	1.00
409_L	412_N	0.734	1.00
271_Y	313_P	0.734	1.00
416_A	421_Q	0.732	1.00
499_I	503_Q	0.728	1.00
442_L	498_N	0.726	1.00
303_C	336_R	0.725	1.00
338_L	356_C	0.724	1.00
325_T	330_L	0.723	1.00
483_V	520_L	0.722	1.00
587_V	616_A	0.721	1.00
282_D	378_D	0.720	1.00
440_E	498_N	0.719	1.00
129_S	213_E	0.716	1.00
198_F	227_R	0.716	1.00
117_V	120_A	0.714	1.00
123_A	140_C	0.714	1.00
264_N	305_E	0.712	1.00
245_L	297_S	0.712	1.00
262_A	267_V	0.712	1.00
127_L	156_V	0.711	1.00
529_V	555_A	0.710	1.00
591_H	624_E	0.710	1.00
105_D	108_H	0.710	1.00
136_F	148_E	0.709	0.99
122_S	139_L	0.709	0.99
639_F	643_K	0.708	0.99
517_L	520_L	0.705	0.99
504_L	546_V	0.704	0.99
353_Y	414_R	0.701	0.99
420_D	474_W	0.700	0.99
383_T	402_R	0.698	0.99
303_C	340_R	0.698	0.99
510_F	553_L	0.697	0.99
476_I	497_V	0.696	0.99
434_G	622_A	0.696	0.99
302_S	340_R	0.696	0.99
184_E	202_N	0.695	0.99
127_L	203_K	0.695	0.99
589_D	592_K	0.693	0.99
401_Q	405_E	0.689	0.99
160_F	165_E	0.689	0.99
454_P	460_S	0.689	0.99
598_S	609_A	0.688	0.99
605_A	608_Q	0.687	0.99
616_A	628_L	0.687	0.99
160_F	164_R	0.686	0.99
205_V	216_L	0.686	0.99
112_F	126_I	0.686	0.99
591_H	621_S	0.685	0.99
116_V	126_I	0.684	0.99
281_N	385_K	0.683	0.99
183_Y	203_K	0.683	0.99
469_V	503_Q	0.682	0.99
267_V	321_L	0.681	0.99
228_R	231_E	0.681	0.99
645_M	650_F	0.679	0.99
334_A	358_V	0.677	0.99
597_Q	631_N	0.677	0.99
589_D	596_S	0.676	0.99
498_N	581_K	0.676	0.99
280_V	289_G	0.675	0.99
161_M	188_W	0.674	0.99
117_V	137_N	0.674	0.99
110_L	113_A	0.674	0.99
582_L	603_I	0.674	0.99
487_R	490_G	0.673	0.99
329_A	332_A	0.672	0.99
574_R	595_V	0.671	0.99
330_L	360_I	0.670	0.99
614_V	634_N	0.670	0.99
308_Q	336_R	0.670	0.99
548_Q	576_P	0.668	0.99
571_Q	574_R	0.667	0.99
441_A	479_V	0.667	0.99
428_P	642_A	0.667	0.99
127_L	173_N	0.666	0.99
275_D	385_K	0.665	0.99
459_I	532_T	0.664	0.99
173_N	203_K	0.663	0.99
275_D	390_G	0.662	0.99
144_T	189_I	0.661	0.99
124_I	137_N	0.660	0.99
537_I	571_Q	0.657	0.99
588_R	624_E	0.654	0.99
181_N	205_V	0.654	0.99
124_I	135_R	0.654	0.99
284_Y	352_V	0.653	0.99
395_F	399_M	0.652	0.99
479_V	483_V	0.651	0.99
330_L	362_L	0.651	0.99
116_V	119_E	0.651	0.99
459_I	463_E	0.649	0.99
277_F	281_N	0.646	0.99
628_L	633_I	0.645	0.99
254_L	258_A	0.643	0.99
338_L	390_G	0.643	0.99
281_N	316_D	0.642	0.99
446_Q	450_R	0.640	0.99
507_Q	542_L	0.639	0.99
641_F	644_P	0.637	0.99
403_V	407_L	0.637	0.99
125_V	220_G	0.637	0.99
305_E	325_T	0.637	0.99
287_L	375_R	0.636	0.99
137_N	140_C	0.636	0.99
363_S	367_G	0.634	0.99
496_A	579_A	0.633	0.99
590_I	597_Q	0.633	0.99
445_W	451_G	0.633	0.99
366_H	376_H	0.632	0.99
332_A	336_R	0.632	0.99
270_V	360_I	0.630	0.99
229_A	236_L	0.630	0.99
605_A	609_A	0.630	0.99
314_G	382_Y	0.628	0.99
485_K	488_D	0.627	0.99
398_E	402_R	0.626	0.99
186_E	226_E	0.625	0.99
481_R	519_E	0.625	0.99
235_I	238_N	0.624	0.99
119_E	217_I	0.621	0.99
233_L	238_N	0.621	0.99
116_V	120_A	0.620	0.99
546_V	549_Q	0.620	0.99
471_L	475_V	0.620	0.99
108_H	112_F	0.620	0.99
462_A	468_I	0.619	0.99
126_I	135_R	0.619	0.99
127_L	131_G	0.619	0.99
485_K	651_E	0.618	0.99
229_A	232_R	0.618	0.99
597_Q	601_R	0.617	0.99
468_I	502_R	0.616	0.99
414_R	470_P	0.615	0.99
327_Q	331_E	0.615	0.99
241_S	244_G	0.614	0.99
473_R	516_V	0.611	0.99
278_K	378_D	0.611	0.99
483_V	526_P	0.611	0.99
463_E	500_S	0.610	0.98
511_T	514_K	0.609	0.98
116_V	121_H	0.609	0.98
161_M	168_A	0.606	0.98
135_R	138_R	0.605	0.98
476_I	529_V	0.605	0.98
268_G	360_I	0.603	0.98
301_L	310_L	0.603	0.98
650_F	653_W	0.602	0.98
570_S	585_V	0.600	0.98
125_V	203_K	0.599	0.98
286_H	315_G	0.598	0.98
145_G	191_T	0.596	0.98
121_H	217_I	0.593	0.98
410_D	465_S	0.593	0.98
545_S	549_Q	0.593	0.98
564_T	585_V	0.593	0.98
472_G	475_V	0.589	0.98
540_D	544_L	0.589	0.98
141_E	151_V	0.589	0.98
495_V	522_F	0.588	0.98
164_R	187_L	0.588	0.98
604_V	614_V	0.587	0.98
501_A	571_Q	0.586	0.98
363_S	366_H	0.585	0.98
121_H	204_F	0.583	0.98
498_N	560_D	0.583	0.98
443_V	452_L	0.582	0.98
587_V	590_I	0.581	0.98
604_V	634_N	0.581	0.98
328_S	331_E	0.581	0.98
580_I	612_L	0.579	0.98
589_D	593_Q	0.579	0.98
273_D	277_F	0.579	0.98
426_Y	439_L	0.578	0.98
162_S	165_E	0.577	0.98
627_F	630_K	0.577	0.98
204_F	217_I	0.576	0.98
296_V	300_I	0.576	0.98
345_F	354_T	0.576	0.98
476_I	555_A	0.575	0.98
357_S	388_G	0.574	0.98
504_L	547_I	0.574	0.98
508_T	511_T	0.572	0.98
125_V	136_F	0.572	0.98
569_L	603_I	0.571	0.98
456_L	460_S	0.571	0.98
277_F	289_G	0.571	0.98
156_V	218_C	0.571	0.98
483_V	527_I	0.570	0.98
160_F	168_A	0.569	0.98
127_L	216_L	0.568	0.98
619_V	625_D	0.568	0.98
440_E	581_K	0.567	0.98
594_P	597_Q	0.567	0.98
140_C	220_G	0.566	0.98
368_S	372_A	0.565	0.98
136_F	144_T	0.562	0.97
398_E	401_Q	0.562	0.97
512_A	515_Q	0.561	0.97
107_S	111_S	0.561	0.97
598_S	601_R	0.561	0.97
417_L	471_L	0.560	0.97
606_V	610_L	0.560	0.97
501_A	531_L	0.559	0.97
144_T	220_G	0.559	0.97
515_Q	518_Q	0.556	0.97
116_V	124_I	0.555	0.97
545_S	548_Q	0.555	0.97
277_F	385_K	0.554	0.97
537_I	543_A	0.554	0.97
238_N	250_A	0.554	0.97
422_L	462_A	0.553	0.97
424_I	441_A	0.552	0.97
325_T	329_A	0.552	0.97
550_F	553_L	0.551	0.97
599_L	603_I	0.550	0.97
453_I	459_I	0.549	0.97
252_Q	370_S	0.549	0.97
335_S	392_F	0.549	0.97
339_T	343_L	0.548	0.97
146_L	159_L	0.546	0.97
544_L	576_P	0.546	0.97
176_F	216_L	0.545	0.97
423_V	443_V	0.545	0.97
286_H	289_G	0.545	0.97
284_Y	288_F	0.545	0.97
105_D	109_G	0.544	0.97
431_T	635_E	0.542	0.97
559_L	571_Q	0.541	0.97
435_E	492_N	0.541	0.97
266_K	325_T	0.540	0.97
504_L	575_F	0.540	0.97
248_R	317_E	0.540	0.97
109_G	114_E	0.540	0.97
417_L	474_W	0.538	0.97
359_G	377_A	0.537	0.97
299_A	343_L	0.537	0.97
650_F	654_Y	0.536	0.97
113_A	217_I	0.536	0.97
208_G	214_I	0.536	0.97
434_G	625_D	0.536	0.97
248_R	290_D	0.535	0.97
424_I	478_D	0.534	0.97
277_F	316_D	0.534	0.97
530_E	617_E	0.534	0.97
476_I	499_I	0.534	0.97
473_R	506_D	0.534	0.97
461_Y	465_S	0.533	0.97
463_E	532_T	0.533	0.97
504_L	509_I	0.532	0.96
315_G	378_D	0.531	0.96
485_K	647_A	0.529	0.96
651_E	654_Y	0.529	0.96
498_N	639_F	0.529	0.96
126_I	218_C	0.529	0.96
364_P	373_I	0.529	0.96
408_W	449_E	0.528	0.96
541_E	574_R	0.528	0.96
282_D	286_H	0.527	0.96
412_N	445_W	0.526	0.96
438_S	496_A	0.525	0.96
116_V	122_S	0.525	0.96
200_F	223_I	0.525	0.96
253_D	256_D	0.525	0.96
532_T	586_F	0.524	0.96
327_Q	365_E	0.524	0.96
258_A	262_A	0.524	0.96
412_N	448_P	0.523	0.96
440_E	560_D	0.522	0.96
454_P	457_D	0.521	0.96
239_T	246_P	0.521	0.96
443_V	458_F	0.520	0.96
128_D	131_G	0.519	0.96
225_E	229_A	0.518	0.96
133_I	137_N	0.517	0.96
596_S	624_E	0.517	0.96
242_I	294_R	0.517	0.96
119_E	137_N	0.517	0.96
402_R	405_E	0.516	0.96
426_Y	478_D	0.515	0.96
163_R	196_R	0.515	0.96
117_V	126_I	0.515	0.96
428_P	645_M	0.514	0.96
535_C	571_Q	0.514	0.96
536_L	559_L	0.512	0.96
355_S	388_G	0.512	0.96
465_S	470_P	0.512	0.96
629_T	636_R	0.511	0.96
409_L	445_W	0.511	0.96
582_L	633_I	0.511	0.96
413_L	445_W	0.510	0.96
359_G	380_A	0.510	0.96
557_V	577_I	0.510	0.96
287_L	348_G	0.509	0.95
473_R	503_Q	0.509	0.95
258_A	309_V	0.509	0.95
268_G	325_T	0.509	0.95
376_H	395_F	0.508	0.95
206_H	217_I	0.508	0.95
123_A	199_L	0.508	0.95
442_L	639_F	0.507	0.95
119_E	122_S	0.507	0.95
414_R	467_L	0.507	0.95
123_A	217_I	0.507	0.95
258_A	261_H	0.507	0.95
517_L	553_L	0.506	0.95
273_D	278_K	0.506	0.95
171_R	175_V	0.504	0.95
133_I	136_F	0.504	0.95
278_K	281_N	0.503	0.95
536_L	543_A	0.503	0.95
333_M	337_I	0.503	0.95
428_P	436_V	0.503	0.95
379_T	403_V	0.502	0.95
338_L	355_S	0.502	0.95
273_D	289_G	0.502	0.95
289_G	316_D	0.502	0.95
121_H	221_T	0.502	0.95
146_L	191_T	0.501	0.95
426_Y	486_W	0.501	0.95
498_N	530_E	0.501	0.95
274_L	355_S	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rnhA	2	0.6263	100	0.359	Contact Map
4j40A	2	0.3782	100	0.365	Contact Map
3pjxA	1	0.6293	100	0.381	Contact Map
3gfzA	2	0.5688	100	0.469	Contact Map
4hjfA	1	0.3918	100	0.504	Contact Map
4hu4A	1	0.3707	100	0.58	Contact Map
3sy8A	6	0.5946	100	0.584	Contact Map
2r6oA	2	0.3858	100	0.584	Contact Map
4kieA	1	0.3918	100	0.584	Contact Map
4rniA	2	0.3812	100	0.589	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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