GREMLIN Database
PGRR - HTH-type transcriptional regulator PgrR
UniProt: P77333 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13923
Length: 299 (287)
Sequences: 79646 (58181)
Seq/√Len: 3434.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_P77_D3.5891.00
18_E27_R3.3761.00
158_I294_K2.6611.00
99_T141_F2.5821.00
70_V84_S2.4251.00
235_A242_A2.2811.00
14_V27_R2.2651.00
174_Y190_H2.2211.00
159_R162_P2.1901.00
165_P246_Y2.1701.00
162_P271_G2.1681.00
95_T126_Q2.1611.00
23_R26_A2.1211.00
159_R271_G2.1201.00
95_T124_D2.0661.00
48_L63_A2.0481.00
17_E72_G2.0481.00
11_A38_I2.0391.00
183_S186_Q2.0081.00
70_V77_D1.9701.00
13_V68_L1.9641.00
115_T292_R1.9611.00
236_I257_K1.9571.00
13_V72_G1.9541.00
232_I252_A1.9511.00
162_P269_L1.9501.00
97_R126_Q1.9341.00
14_V17_E1.9101.00
13_V17_E1.9091.00
193_I240_G1.9071.00
11_A35_L1.9031.00
14_V18_E1.8851.00
16_A60_P1.8761.00
167_A246_Y1.8711.00
74_M78_I1.8581.00
170_G261_V1.8531.00
236_I252_A1.8431.00
68_L72_G1.8211.00
21_F39_V1.7911.00
52_T59_V1.7251.00
191_Q222_Q1.7101.00
67_L81_A1.7041.00
167_A260_R1.6811.00
66_H84_S1.6771.00
157_A273_H1.6681.00
135_D140_R1.6311.00
16_A68_L1.6091.00
116_F289_F1.5911.00
17_E27_R1.5861.00
18_E23_R1.5761.00
156_I278_H1.5721.00
13_V71_L1.5651.00
12_F68_L1.5621.00
11_A30_M1.5271.00
179_S186_Q1.5251.00
134_T138_S1.5161.00
8_D38_I1.5101.00
91_R122_E1.5061.00
22_T32_Q1.4971.00
8_D45_R1.4731.00
158_I276_Y1.4641.00
62_E65_E1.4551.00
5_E8_D1.4521.00
116_F123_I1.4501.00
70_V73_P1.4481.00
31_A34_A1.4471.00
20_S23_R1.4461.00
205_R209_I1.4401.00
8_D41_R1.4391.00
49_R52_T1.4381.00
14_V28_L1.4221.00
146_R275_Y1.4031.00
13_V75_L1.4031.00
282_A286_F1.4021.00
156_I276_Y1.3861.00
148_G273_H1.3771.00
70_V80_S1.3771.00
290_I294_K1.3641.00
74_M81_A1.3571.00
106_K229_D1.3551.00
276_Y290_I1.3521.00
93_S122_E1.3491.00
172_P257_K1.3391.00
6_I78_I1.3381.00
137_V154_D1.3251.00
136_V144_G1.3211.00
274_L290_I1.3121.00
97_R128_T1.3101.00
288_L291_D1.3071.00
164_I247_D1.3061.00
135_D141_F1.3031.00
143_A286_F1.3011.00
54_T59_V1.2991.00
67_L82_M1.2861.00
115_T119_S1.2841.00
77_D80_S1.2781.00
143_A274_L1.2721.00
45_R82_M1.2691.00
231_I242_A1.2661.00
190_H241_L1.2661.00
170_G241_L1.2611.00
117_L222_Q1.2611.00
252_A257_K1.2421.00
119_S292_R1.2341.00
246_Y250_E1.2321.00
69_S73_P1.2311.00
117_L191_Q1.2201.00
233_D236_I1.2121.00
250_E254_K1.2121.00
70_V81_A1.2101.00
114_R118_K1.1961.00
66_H69_S1.1941.00
172_P259_I1.1921.00
65_E69_S1.1891.00
40_R44_E1.1861.00
159_R273_H1.1861.00
246_Y260_R1.1831.00
12_F51_L1.1821.00
180_V259_I1.1781.00
129_I132_G1.1671.00
212_G217_V1.1601.00
157_A275_Y1.1591.00
30_M34_A1.1551.00
175_F190_H1.1541.00
12_F16_A1.1431.00
193_I231_I1.1351.00
37_Q41_R1.1251.00
37_Q40_R1.1231.00
115_T118_K1.1181.00
12_F50_L1.1171.00
96_I289_F1.1161.00
114_R237_D1.1141.00
181_P264_K1.1071.00
191_Q220_E1.0961.00
73_P80_S1.0961.00
21_F58_V1.0891.00
36_S40_R1.0851.00
116_F292_R1.0831.00
9_L71_L1.0811.00
126_Q224_L1.0761.00
120_H288_L1.0731.00
15_V24_A1.0721.00
232_I236_I1.0681.00
291_D294_K1.0681.00
225_L231_I1.0651.00
14_V24_A1.0641.00
74_M77_D1.0571.00
7_A10_M1.0561.00
10_M79_D1.0551.00
169_V260_R1.0541.00
66_H70_V1.0541.00
111_P237_D1.0461.00
38_I41_R1.0451.00
287_S291_D1.0451.00
260_R263_D1.0431.00
137_V152_D1.0241.00
60_P64_G1.0201.00
158_I290_I1.0191.00
171_S238_G1.0161.00
112_A293_L1.0131.00
182_T186_Q1.0071.00
233_D237_D1.0061.00
168_I241_L1.0001.00
82_M86_S0.9941.00
79_D82_M0.9891.00
165_P269_L0.9871.00
251_R255_E0.9821.00
30_M35_L0.9791.00
16_A51_L0.9791.00
184_V265_F0.9781.00
11_A28_L0.9781.00
79_D83_A0.9701.00
116_F120_H0.9671.00
169_V249_V0.9631.00
76_H80_S0.9611.00
15_V21_F0.9551.00
67_L71_L0.9531.00
194_N221_G0.9521.00
12_F60_P0.9421.00
170_G174_Y0.9421.00
283_G286_F0.9301.00
112_A292_R0.9261.00
135_D138_S0.9251.00
12_F42_I0.9241.00
24_A35_L0.9221.00
225_L234_A0.9211.00
41_R44_E0.9211.00
119_S295_Y0.9141.00
124_D220_E0.9061.00
51_L58_V0.9051.00
128_T135_D0.9011.00
206_W209_I0.8991.00
23_R27_R0.8981.00
174_Y191_Q0.8931.00
48_L85_L0.8921.00
66_H88_L0.8891.00
99_T146_R0.8841.00
16_A64_G0.8841.00
141_F144_G0.8781.00
69_S72_G0.8761.00
99_T144_G0.8711.00
277_P280_R0.8711.00
292_R295_Y0.8711.00
102_E227_T0.8691.00
73_P76_H0.8631.00
148_G271_G0.8561.00
154_D278_H0.8531.00
186_Q189_D0.8511.00
155_M275_Y0.8501.00
208_L212_G0.8491.00
19_R59_V0.8481.00
22_T26_A0.8471.00
249_V252_A0.8441.00
7_A38_I0.8441.00
174_Y177_R0.8421.00
191_Q221_G0.8421.00
170_G175_F0.8421.00
123_I285_A0.8391.00
174_Y178_R0.8391.00
178_R191_Q0.8371.00
169_V242_A0.8371.00
98_I143_A0.8321.00
6_I75_L0.8281.00
63_A88_L0.8271.00
28_L35_L0.8241.00
54_T57_S0.8241.00
175_F180_V0.8221.00
282_A287_S0.8201.00
206_W210_R0.8151.00
176_S190_H0.8151.00
156_I159_R0.8131.00
133_L137_V0.8121.00
16_A19_R0.8091.00
161_G164_I0.8041.00
12_F67_L0.8011.00
19_R65_E0.8001.00
94_G285_A0.7991.00
63_A85_L0.7991.00
132_G144_G0.7961.00
128_T141_F0.7961.00
252_A255_E0.7941.00
40_R49_R0.7941.00
291_D295_Y0.7931.00
114_R239_H0.7921.00
32_Q36_S0.7891.00
78_I81_A0.7871.00
15_V39_V0.7861.00
17_E68_L0.7781.00
15_V51_L0.7771.00
192_A219_M0.7771.00
18_E24_A0.7771.00
63_A66_H0.7741.00
183_S264_K0.7741.00
185_S188_I0.7731.00
80_S84_S0.7721.00
77_D81_A0.7681.00
171_S239_H0.7671.00
253_I256_K0.7661.00
284_S288_L0.7651.00
8_D11_A0.7641.00
211_G215_V0.7631.00
19_R57_S0.7621.00
78_I82_M0.7581.00
165_P267_P0.7571.00
92_P120_H0.7561.00
165_P262_L0.7511.00
143_A289_F0.7501.00
173_D177_R0.7501.00
117_L239_H0.7451.00
185_S215_V0.7441.00
249_V253_I0.7421.00
234_A239_H0.7421.00
119_S288_L0.7381.00
86_S89_Q0.7371.00
169_V244_L0.7311.00
188_I217_V0.7271.00
137_V155_M0.7251.00
100_T105_A0.7251.00
169_V253_I0.7231.00
10_M14_V0.7221.00
81_A85_L0.7211.00
21_F35_L0.7201.00
71_L74_M0.7201.00
52_T61_T0.7151.00
15_V35_L0.7141.00
59_V65_E0.7131.00
245_P248_Q0.7111.00
60_P65_E0.7111.00
72_G76_H0.7111.00
116_F288_L0.7101.00
253_I260_R0.7081.00
177_R259_I0.7081.00
97_R141_F0.7041.00
170_G259_I0.6991.00
205_R224_L0.6941.00
171_S174_Y0.6931.00
227_T230_L0.6921.00
34_A38_I0.6901.00
170_G176_S0.6851.00
63_A67_L0.6831.00
97_R142_D0.6821.00
211_G214_E0.6821.00
195_L231_I0.6821.00
65_E68_L0.6781.00
183_S265_F0.6771.00
142_D286_F0.6761.00
62_E66_H0.6761.00
196_Y224_L0.6751.00
43_E48_L0.6751.00
210_R214_E0.6691.00
181_P262_L0.6661.00
189_D220_E0.6661.00
145_V293_L0.6641.00
52_T57_S0.6641.00
94_G123_I0.6641.00
124_D224_L0.6621.00
288_L292_R0.6621.00
209_I213_R0.6601.00
115_T295_Y0.6591.00
76_H79_D0.6551.00
80_S83_A0.6541.00
207_R211_G0.6521.00
223_L234_A0.6521.00
251_R254_K0.6511.00
100_T109_L0.6491.00
10_M13_V0.6481.00
173_D176_S0.6481.00
39_V43_E0.6461.00
192_A241_L0.6461.00
67_L85_L0.6461.00
173_D238_G0.6451.00
139_E277_P0.6421.00
43_E53_R0.6421.00
70_V74_M0.6401.00
96_I285_A0.6391.00
7_A41_R0.6381.00
71_L75_L0.6341.00
21_F57_S0.6331.00
26_A29_S0.6321.00
210_R213_R0.6281.00
136_V275_Y0.6231.00
24_A28_L0.6201.00
173_D259_I0.6191.00
280_R283_G0.6181.00
161_G272_Y0.6171.00
106_K233_D0.6171.00
206_W211_G0.6141.00
172_P256_K0.6111.00
15_V20_S0.6101.00
212_G219_M0.6091.00
168_I187_L0.6081.00
175_F179_S0.6041.00
109_L112_A0.6021.00
168_I192_A0.6001.00
208_L211_G0.6001.00
66_H85_L0.5981.00
231_I235_A0.5961.00
105_A129_I0.5951.00
164_I270_P0.5951.00
83_A87_D0.5951.00
175_F178_R0.5941.00
284_S287_S0.5931.00
143_A290_I0.5921.00
147_L270_P0.5901.00
196_Y226_N0.5901.00
168_I243_Y0.5861.00
111_P114_R0.5841.00
10_M75_L0.5821.00
176_S182_T0.5821.00
33_S37_Q0.5811.00
46_L67_L0.5811.00
136_V155_M0.5801.00
96_I143_A0.5791.00
31_A37_Q0.5781.00
60_P68_L0.5761.00
289_F293_L0.5761.00
7_A11_A0.5751.00
225_L230_L0.5751.00
276_Y287_S0.5741.00
34_A37_Q0.5731.00
156_I279_R0.5721.00
166_M243_Y0.5691.00
234_A240_G0.5681.00
46_L85_L0.5681.00
93_S124_D0.5651.00
207_R210_R0.5621.00
51_L60_P0.5621.00
205_R208_L0.5611.00
48_L52_T0.5601.00
5_E45_R0.5601.00
174_Y241_L0.5521.00
75_L79_D0.5501.00
134_T140_R0.5501.00
205_R211_G0.5491.00
111_P115_T0.5461.00
204_N208_L0.5461.00
176_S179_S0.5431.00
69_S84_S0.5421.00
209_I212_G0.5401.00
204_N207_R0.5401.00
228_I245_P0.5391.00
11_A39_V0.5381.00
104_A108_I0.5381.00
200_S224_L0.5371.00
12_F64_G0.5351.00
46_L49_R0.5331.00
160_I274_L0.5281.00
181_P186_Q0.5251.00
75_L78_I0.5251.00
99_T128_T0.5251.00
11_A24_A0.5241.00
30_M38_I0.5221.00
70_V85_L0.5221.00
49_R63_A0.5211.00
244_L249_V0.5201.00
145_V274_L0.5191.00
39_V51_L0.5181.00
120_H123_I0.5171.00
71_L78_I0.5101.00
113_M125_I0.5101.00
94_G120_H0.5091.00
94_G122_E0.5091.00
108_I112_A0.5081.00
286_F290_I0.5081.00
83_A86_S0.5081.00
16_A65_E0.5071.00
21_F32_Q0.5071.00
106_K227_T0.5061.00
87_D92_P0.5051.00
195_L228_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2esnA 3 0.9799 100 0.072 Contact Map
1uthA 2 0.7358 100 0.075 Contact Map
3fzvA 4 0.9565 100 0.076 Contact Map
3fxqA 3 0.9699 100 0.091 Contact Map
1ixcA 4 0.9732 100 0.091 Contact Map
3szpA 3 0.9699 100 0.093 Contact Map
1al3A 1 0.689 100 0.097 Contact Map
3hhgA 3 0.9799 100 0.097 Contact Map
2h98A 2 0.6756 100 0.098 Contact Map
4x6gA 4 0.9799 100 0.099 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0136 seconds.