GREMLIN Database
YBBY - Putative purine permease YbbY
UniProt: P77328 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13620
Length: 433 (388)
Sequences: 4285 (2212)
Seq/√Len: 112.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_A209_L5.3631.00
182_L205_T5.2571.00
154_M176_S4.2661.00
141_M416_G4.1061.00
183_V202_G3.8971.00
52_L331_A3.7201.00
226_W335_A3.7021.00
208_L212_F3.4641.00
219_S223_E3.4071.00
386_V419_L3.1921.00
186_M201_V3.1101.00
175_L210_W3.0631.00
113_L246_V3.0191.00
108_A292_V2.8871.00
175_L215_P2.8821.00
218_H221_S2.8071.00
55_A328_L2.7671.00
178_A205_T2.7011.00
375_R428_P2.6311.00
383_P420_A2.6311.00
224_L335_A2.6101.00
180_M354_V2.5761.00
18_F326_I2.4821.00
102_S236_A2.4731.00
260_I280_S2.4091.00
14_G322_Y2.4051.00
57_A287_M2.4031.00
204_I208_L2.2371.00
67_R274_N2.2221.00
53_A294_L2.2011.00
207_W216_S2.1881.00
264_D272_A2.1551.00
175_L213_C2.1521.00
11_L326_I2.1461.00
178_A182_L2.1321.00
59_F324_S2.1201.00
174_A178_A2.0991.00
10_S322_Y2.0801.00
221_S339_L2.0801.00
208_L211_Y2.0741.00
182_L186_M2.0471.00
222_G225_H2.0361.00
129_L425_N2.0321.00
182_L209_L2.0171.00
59_F321_I1.9921.00
314_D319_S1.9871.00
62_A321_I1.9721.00
32_L82_I1.9641.00
101_T236_A1.9301.00
422_L426_L1.9011.00
220_L342_S1.8901.00
108_A289_L1.8791.00
171_P215_P1.8621.00
104_A292_V1.8501.00
207_W342_S1.8421.00
52_L328_L1.8151.00
183_V351_V1.8071.00
170_L174_A1.7891.00
209_L213_C1.7831.00
185_A189_F1.7641.00
144_A360_L1.7611.00
224_L338_R1.7501.00
212_F215_P1.7171.00
325_V329_L1.7061.00
186_M190_L1.7011.00
131_T424_D1.6811.00
273_G276_R1.6661.00
153_G345_L1.6651.00
18_F323_G1.6501.00
102_S106_G1.6211.00
103_L106_G1.6121.00
108_A112_V1.6111.00
115_M289_L1.5971.00
276_R279_R1.5891.00
219_S222_G1.5881.00
221_S224_L1.5751.00
194_F201_V1.5511.00
174_A177_V1.5511.00
54_T71_M1.5391.00
193_R197_Y1.5191.00
190_L194_F1.5191.00
83_L86_T1.5131.00
379_R423_M1.5071.00
180_M382_L1.4971.00
177_V181_C1.4861.00
270_Q273_G1.4701.00
206_G347_V1.4691.00
220_L223_E1.4671.00
383_P419_L1.4511.00
115_M285_G1.4441.00
133_S380_L1.4431.00
238_S241_I1.4281.00
269_Q276_R1.4251.00
112_V116_L1.4241.00
171_P213_C1.4111.00
59_F62_A1.4101.00
17_W305_S1.3961.00
101_T105_V1.3751.00
181_C185_A1.3711.00
99_I102_S1.3681.00
111_G118_G1.3641.00
209_L212_F1.3601.00
79_W83_L1.3601.00
86_T103_L1.3541.00
85_I241_I1.3541.00
4_F318_R1.3451.00
107_I111_G1.3441.00
386_V415_V1.3401.00
309_L315_Y1.3311.00
211_Y218_H1.3261.00
108_A111_G1.3251.00
418_L422_L1.3111.00
370_I376_N1.3111.00
335_A338_R1.3050.99
21_I25_T1.3030.99
166_F169_Q1.3020.99
101_T237_L1.2950.99
205_T209_L1.2860.99
263_T309_L1.2810.99
190_L195_A1.2720.99
58_C71_M1.2670.99
372_F380_L1.2630.99
52_L294_L1.2570.99
111_G289_L1.2550.99
8_R12_L1.2520.99
63_F321_I1.2470.99
197_Y201_V1.2400.99
59_F328_L1.2350.99
105_V237_L1.2260.99
265_V369_Q1.2240.99
62_A320_F1.2140.99
406_R410_S1.2090.99
70_I263_T1.2040.99
56_L328_L1.2010.99
115_M286_F1.1970.99
155_L167_K1.1850.99
118_G278_R1.1790.99
171_P174_A1.1750.99
259_A303_V1.1720.99
89_E238_S1.1710.99
201_V205_T1.1650.99
82_I103_L1.1460.99
237_L242_I1.1410.99
102_S107_I1.1320.99
115_M119_F1.1300.99
151_F389_F1.1280.99
382_L419_L1.1270.98
106_G110_S1.1240.98
85_I245_A1.1230.98
228_W334_P1.1200.98
133_S137_L1.1190.98
141_M387_G1.1140.98
75_G252_N1.1110.98
73_G302_F1.1080.98
110_S249_G1.1050.98
405_L408_L1.1040.98
105_V110_S1.1010.98
256_T260_I1.0990.98
64_C286_F1.0960.98
77_L252_N1.0820.98
115_M282_V1.0820.98
105_V242_I1.0810.98
174_A213_C1.0800.98
5_A316_T1.0770.98
106_G114_T1.0750.98
178_A213_C1.0710.98
255_N300_S1.0700.98
107_I292_V1.0660.98
72_E301_P1.0480.98
333_V337_T1.0450.98
384_L388_I1.0440.98
56_L290_I1.0430.97
329_L333_V1.0410.97
107_I114_T1.0370.97
111_G282_V1.0320.97
260_I284_T1.0260.97
106_G111_G1.0200.97
81_T248_T1.0190.97
114_T118_G1.0150.97
171_P175_L1.0150.97
7_S11_L1.0120.97
231_L234_G1.0090.97
259_A306_I1.0080.97
104_A107_I1.0070.97
210_W214_F1.0020.97
65_G279_R0.9990.97
185_A426_L0.9970.97
5_A10_S0.9920.97
20_F308_L0.9920.97
118_G121_G0.9880.97
109_L242_I0.9870.97
107_I110_S0.9850.96
191_P195_A0.9780.96
291_T299_F0.9770.96
28_V76_G0.9740.96
11_L15_F0.9730.96
165_N168_I0.9660.96
70_I301_P0.9650.96
181_C184_L0.9630.96
147_T385_F0.9620.96
99_I103_L0.9590.96
5_A319_S0.9550.96
211_Y216_S0.9550.96
175_L209_L0.9540.96
378_Y382_L0.9530.96
394_P409_L0.9490.96
140_L384_L0.9470.96
267_Y315_Y0.9430.95
105_V118_G0.9420.95
361_F377_I0.9420.95
405_L409_L0.9410.95
210_W215_P0.9400.95
105_V111_G0.9380.95
200_L204_I0.9350.95
318_R321_I0.9340.95
105_V109_L0.9320.95
56_L60_A0.9290.95
71_M323_G0.9230.95
110_S114_T0.9220.95
15_F326_I0.9210.95
256_T280_S0.9180.95
84_T87_L0.9170.95
97_N236_A0.9120.95
221_S342_S0.9080.94
239_P242_I0.9060.94
59_F325_V0.9030.94
61_Q68_R0.9020.94
182_L202_G0.9010.94
11_L322_Y0.8970.94
290_I294_L0.8910.94
84_T88_G0.8900.94
99_I105_V0.8840.94
17_W21_I0.8750.93
102_S238_S0.8740.93
172_P346_P0.8730.93
145_Q413_L0.8710.93
101_T104_A0.8700.93
152_K167_K0.8680.93
4_F10_S0.8670.93
17_W20_F0.8660.93
124_H278_R0.8590.93
256_T284_T0.8560.93
373_T376_N0.8530.92
169_Q172_P0.8520.92
140_L364_L0.8520.92
24_N356_Y0.8480.92
336_L339_L0.8480.92
240_G244_T0.8480.92
98_D236_A0.8400.92
321_I324_S0.8350.92
62_A317_R0.8350.92
229_F332_L0.8330.91
139_M259_A0.8310.91
207_W343_I0.8290.91
217_S220_L0.8250.91
6_V9_E0.8240.91
207_W218_H0.8200.91
156_G167_K0.8150.91
153_G356_Y0.8140.91
75_G300_S0.8130.90
257_Y277_Y0.8120.90
24_N304_S0.8090.90
186_M194_F0.8050.90
208_L329_L0.8040.90
186_M202_G0.7950.89
321_I325_V0.7940.89
55_A324_S0.7900.89
375_R379_R0.7880.89
79_W250_L0.7880.89
104_A110_S0.7880.89
379_R383_P0.7880.89
48_Q337_T0.7860.89
354_V378_Y0.7860.89
50_A297_I0.7850.89
130_F417_I0.7850.89
71_M320_F0.7810.89
180_M184_L0.7780.88
381_A385_F0.7780.88
168_I388_I0.7780.88
21_I305_S0.7720.88
70_I260_I0.7720.88
330_V336_L0.7700.88
306_I309_L0.7700.88
226_W333_V0.7690.88
229_F331_A0.7690.88
28_V74_P0.7690.88
155_L173_F0.7630.87
252_N300_S0.7620.87
53_A290_I0.7620.87
360_L384_L0.7610.87
53_A291_T0.7590.87
13_S17_W0.7590.87
103_L107_I0.7540.87
275_T279_R0.7530.87
74_P78_W0.7530.87
77_L355_S0.7520.87
30_P348_S0.7520.87
80_G83_L0.7490.86
53_A296_V0.7470.86
386_V390_L0.7470.86
27_V153_G0.7450.86
312_T326_I0.7450.86
25_T54_T0.7440.86
390_L415_V0.7430.86
153_G348_S0.7420.86
49_Y52_L0.7420.86
112_V227_Q0.7390.86
18_F330_V0.7360.86
70_I308_L0.7360.86
250_L254_S0.7350.85
100_A104_A0.7350.85
225_H228_W0.7340.85
357_L361_F0.7330.85
156_G168_I0.7320.85
175_L346_P0.7320.85
288_T299_F0.7310.85
137_L383_P0.7310.85
250_L262_G0.7310.85
11_L222_G0.7260.85
270_Q275_T0.7210.84
50_A74_P0.7200.84
286_F290_I0.7200.84
101_T232_G0.7190.84
194_F198_G0.7180.84
125_R129_L0.7170.84
109_L113_L0.7160.84
111_G285_G0.7150.84
129_L421_V0.7150.84
21_I71_M0.7120.84
25_T50_A0.7100.83
114_T249_G0.7060.83
256_T300_S0.7050.83
382_L423_M0.7050.83
361_F380_L0.7020.83
150_F176_S0.7010.83
69_A320_F0.7000.83
171_P209_L0.6980.82
23_C29_P0.6980.82
109_L237_L0.6970.82
102_S105_V0.6970.82
221_S338_R0.6900.82
372_F376_N0.6900.82
177_V213_C0.6850.81
202_G205_T0.6850.81
187_I311_Q0.6840.81
416_G420_A0.6840.81
116_L120_S0.6820.81
75_G78_W0.6820.81
98_D101_T0.6780.81
263_T301_P0.6740.80
216_S342_S0.6730.80
14_G323_G0.6730.80
139_M142_L0.6720.80
263_T306_I0.6700.80
186_M198_G0.6700.80
49_Y53_A0.6690.80
338_R341_C0.6680.80
210_W213_C0.6630.79
203_T351_V0.6630.79
107_I118_G0.6620.79
218_H342_S0.6610.79
412_G416_G0.6600.79
154_M353_L0.6600.79
150_F179_V0.6600.79
387_G416_G0.6580.79
185_A190_L0.6560.78
152_K155_L0.6560.78
239_P243_L0.6560.78
105_V108_A0.6550.78
182_L201_V0.6540.78
56_L294_L0.6540.78
172_P175_L0.6530.78
112_V115_M0.6530.78
199_L308_L0.6520.78
110_S118_G0.6510.78
326_I330_V0.6500.78
155_L168_I0.6490.78
267_Y270_Q0.6490.78
149_I153_G0.6480.77
89_E99_I0.6480.77
183_V364_L0.6480.77
211_Y426_L0.6470.77
221_S335_A0.6460.77
102_S111_G0.6430.77
187_I378_Y0.6400.77
173_F177_V0.6400.77
190_L193_R0.6380.76
280_S284_T0.6370.76
229_F250_L0.6370.76
72_E256_T0.6370.76
50_A54_T0.6360.76
113_L253_I0.6350.76
255_N284_T0.6340.76
224_L334_P0.6340.76
186_M205_T0.6340.76
385_F388_I0.6310.76
77_L142_L0.6310.76
83_L87_L0.6300.75
133_S376_N0.6290.75
213_C336_L0.6290.75
4_F7_S0.6270.75
118_G282_V0.6250.75
86_T99_I0.6250.75
204_I339_L0.6230.75
268_P315_Y0.6220.75
17_W308_L0.6210.74
188_I359_L0.6200.74
252_N255_N0.6190.74
246_V249_G0.6190.74
338_R342_S0.6170.74
140_L367_S0.6150.74
68_R280_S0.6150.74
174_A209_L0.6140.74
188_I361_F0.6140.74
289_L293_P0.6130.73
37_Q87_L0.6130.73
25_T28_V0.6120.73
266_F310_T0.6110.73
310_T365_V0.6110.73
114_T252_N0.6110.73
27_V30_P0.6110.73
249_G288_T0.6100.73
325_V369_Q0.6070.73
329_L408_L0.6070.73
110_S117_I0.6060.73
203_T348_S0.6060.73
38_L297_I0.6040.72
203_T254_S0.6040.72
219_S224_L0.6030.72
379_R428_P0.6030.72
372_F377_I0.6030.72
259_A301_P0.6000.72
205_T208_L0.6000.72
169_Q174_A0.6000.72
196_R428_P0.5980.72
80_G84_T0.5970.72
357_L377_I0.5970.72
82_I86_T0.5970.72
147_T381_A0.5950.71
167_K170_L0.5950.71
60_A283_A0.5940.71
147_T388_I0.5920.71
167_K393_L0.5920.71
227_Q333_V0.5920.71
104_A111_G0.5900.71
153_G352_M0.5890.71
245_A346_P0.5880.70
66_H276_R0.5880.70
195_A372_F0.5880.70
131_T307_G0.5880.70
82_I245_A0.5870.70
367_S370_I0.5860.70
142_L302_F0.5860.70
99_I111_G0.5850.70
7_S326_I0.5840.70
257_Y261_R0.5830.70
208_L222_G0.5820.70
303_V362_S0.5820.70
226_W230_P0.5780.69
99_I106_G0.5770.69
135_M334_P0.5750.69
288_T291_T0.5750.69
365_V369_Q0.5750.69
77_L300_S0.5750.69
89_E98_D0.5730.68
25_T327_C0.5730.68
156_G173_F0.5720.68
21_I365_V0.5720.68
259_A362_S0.5720.68
348_S351_V0.5700.68
201_V204_I0.5700.68
89_E241_I0.5690.68
137_L372_F0.5680.68
303_V414_L0.5670.68
380_L384_L0.5660.67
15_F155_L0.5660.67
304_S356_Y0.5650.67
258_G387_G0.5640.67
89_E102_S0.5620.67
286_F289_L0.5620.67
124_H128_R0.5620.67
31_T83_L0.5610.67
125_R130_F0.5610.67
183_V354_V0.5610.67
32_L39_P0.5600.67
284_T300_S0.5590.67
55_A59_F0.5590.67
105_V114_T0.5590.67
72_E288_T0.5570.66
57_A283_A0.5560.66
7_S10_S0.5550.66
105_V119_F0.5540.66
32_L203_T0.5540.66
99_I109_L0.5540.66
53_A287_M0.5530.66
114_T253_I0.5520.66
207_W211_Y0.5520.66
136_V363_A0.5520.66
286_F321_I0.5520.66
387_G412_G0.5510.65
74_P300_S0.5510.65
233_S422_L0.5490.65
111_G288_T0.5480.65
230_P354_V0.5480.65
360_L364_L0.5480.65
371_T376_N0.5470.65
5_A428_P0.5470.65
138_F180_M0.5460.65
417_I420_A0.5440.64
421_V429_W0.5440.64
252_N260_I0.5430.64
404_T407_P0.5430.64
305_S308_L0.5420.64
130_F192_Q0.5400.64
52_L332_L0.5400.64
111_G114_T0.5380.64
317_R321_I0.5380.64
204_I426_L0.5370.63
143_G150_F0.5370.63
106_G118_G0.5370.63
102_S241_I0.5360.63
61_Q317_R0.5360.63
262_G362_S0.5360.63
206_G214_F0.5350.63
88_G221_S0.5350.63
133_S379_R0.5340.63
178_A212_F0.5320.63
382_L388_I0.5320.63
108_A234_G0.5320.63
199_L268_P0.5310.63
59_F63_F0.5300.62
244_T408_L0.5300.62
391_M394_P0.5290.62
114_T282_V0.5280.62
54_T70_I0.5280.62
211_Y214_F0.5280.62
61_Q65_G0.5280.62
137_L420_A0.5260.62
314_D348_S0.5260.62
101_T107_I0.5250.62
218_H328_L0.5240.62
69_A267_Y0.5240.62
18_F244_T0.5240.62
147_T353_L0.5230.61
123_G257_Y0.5220.61
318_R322_Y0.5220.61
58_C300_S0.5220.61
208_L227_Q0.5220.61
113_L117_I0.5200.61
250_L404_T0.5200.61
368_Q377_I0.5200.61
13_S130_F0.5200.61
289_L292_V0.5190.61
19_F379_R0.5190.61
78_W288_T0.5180.61
116_L422_L0.5180.61
54_T248_T0.5170.61
264_D269_Q0.5170.61
145_Q412_G0.5170.61
185_A422_L0.5170.61
85_I244_T0.5140.60
81_T412_G0.5140.60
261_R313_G0.5140.60
125_R274_N0.5130.60
187_I198_G0.5130.60
370_I377_I0.5130.60
102_S110_S0.5130.60
365_V373_T0.5130.60
39_P89_E0.5110.60
166_F172_P0.5110.60
89_E236_A0.5110.60
49_Y295_A0.5110.60
72_E260_I0.5100.60
260_I272_A0.5070.59
264_D268_P0.5070.59
331_A337_T0.5070.59
22_F50_A0.5060.59
129_L424_D0.5060.59
27_V31_T0.5040.59
58_C324_S0.5020.58
52_L313_G0.5000.58
212_F229_F0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.9122 100 0.402 Contact Map
3o7qA 1 0.8568 55.2 0.966 Contact Map
2nwlA 3 0.4965 31.6 0.971 Contact Map
4ikvA 1 0.9145 24.7 0.972 Contact Map
2jlnA 1 0.8037 20.9 0.973 Contact Map
3wdoA 1 0.8661 16.3 0.974 Contact Map
3mktA 1 0.9376 16.2 0.974 Contact Map
4xnjA 1 0.8776 14.4 0.975 Contact Map
2gfpA 2 0.4088 13.9 0.975 Contact Map
2cfqA 1 0.8845 12.2 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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