GREMLIN Database
TFAS - Putative tail fiber assembly protein homolog from prophage CPS-53
UniProt: P77326 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14134
Length: 114 (105)
Sequences: 486 (362)
Seq/√Len: 35.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_L92_I5.3901.00
52_Q56_L3.7071.00
13_V17_P2.7181.00
72_Q89_L2.6951.00
24_T27_D2.6621.00
30_D33_K2.2130.99
70_K97_A2.1600.99
70_K93_D2.1360.99
36_T41_Q2.0560.99
42_H46_V2.0480.99
69_L89_L1.8170.97
60_A88_V1.8150.97
77_L93_D1.8050.97
99_D102_T1.7400.96
22_P27_D1.7390.96
9_S14_C1.6330.94
24_T36_T1.5980.93
68_Q72_Q1.5950.93
70_K77_L1.5620.93
29_W40_A1.4450.89
77_L97_A1.4120.88
67_I96_T1.4100.88
72_Q92_I1.4030.88
89_L92_I1.3770.87
37_D40_A1.3360.85
77_L81_E1.3300.85
68_Q89_L1.3040.84
89_L97_A1.2830.83
93_D97_A1.2800.83
86_N90_D1.2790.83
40_A44_V1.2710.82
66_L96_T1.2660.82
69_L72_Q1.2390.81
29_W37_D1.1960.78
63_S66_L1.1780.77
50_E53_R1.1730.77
75_R93_D1.1680.76
71_L77_L1.1630.76
70_K96_T1.1570.76
79_Q82_T1.1530.76
89_L93_D1.1350.74
53_R56_L1.1240.74
67_I77_L1.1150.73
26_Y29_W1.1100.73
75_R94_A1.1030.72
61_M69_L1.0990.72
71_L97_A1.0900.71
50_E100_T1.0760.70
57_I65_S1.0350.67
103_A106_V1.0320.67
69_L77_L1.0320.67
90_D94_A1.0150.66
67_I93_D1.0120.65
13_V19_T1.0110.65
32_E38_T1.0040.65
18_A37_D0.9950.64
67_I97_A0.9900.64
10_R13_V0.9850.63
67_I89_L0.9730.62
11_G29_W0.9470.60
69_L97_A0.9410.60
67_I73_A0.9200.58
9_S16_R0.9200.58
70_K89_L0.9170.58
67_I70_K0.9160.58
29_W41_Q0.9120.57
83_S107_I0.9120.57
14_C17_P0.9060.57
15_M39_E0.9030.57
81_E97_A0.8970.56
61_M92_I0.8900.55
67_I71_L0.8670.54
98_T106_V0.8630.53
70_K81_E0.8590.53
18_A27_D0.8450.52
81_E93_D0.8320.51
14_C18_A0.8250.50
93_D96_T0.8240.50
67_I92_I0.8160.49
7_I10_R0.8120.49
72_Q97_A0.8100.49
63_S67_I0.8020.48
81_E96_T0.8020.48
72_Q86_N0.8000.48
11_G37_D0.7950.47
11_G14_C0.7940.47
77_L89_L0.7930.47
75_R90_D0.7920.47
89_L95_V0.7840.46
47_D54_Q0.7830.46
64_I70_K0.7740.46
24_T41_Q0.7730.45
22_P34_W0.7690.45
27_D36_T0.7650.45
26_Y40_A0.7640.45
51_A55_S0.7530.44
45_A52_Q0.7510.44
46_V100_T0.7500.43
70_K92_I0.7400.43
34_W37_D0.7380.42
13_V16_R0.7380.42
69_L93_D0.7270.42
49_A103_A0.7220.41
57_I61_M0.7220.41
71_L93_D0.7080.40
23_L27_D0.7050.40
26_Y44_V0.7040.40
68_Q90_D0.7030.40
28_K37_D0.6780.38
94_A97_A0.6700.37
58_D62_A0.6680.37
68_Q96_T0.6550.36
53_R68_Q0.6530.36
88_V112_P0.6480.35
90_D93_D0.6440.35
57_I95_V0.6410.35
66_L70_K0.6360.34
71_L92_I0.6320.34
49_A106_V0.6280.34
45_A51_A0.6220.33
66_L73_A0.6150.33
26_Y37_D0.6070.32
67_I85_L0.6070.32
9_S13_V0.6030.32
41_Q44_V0.5950.31
71_L94_A0.5900.31
61_M70_K0.5860.30
78_M81_E0.5840.30
22_P31_G0.5810.30
28_K32_E0.5790.30
67_I81_E0.5590.28
95_V99_D0.5530.28
88_V91_Y0.5490.28
28_K40_A0.5450.28
60_A112_P0.5440.27
18_A29_W0.5390.27
54_Q63_S0.5370.27
40_A43_S0.5330.27
53_R75_R0.5330.27
24_T45_A0.5310.27
45_A62_A0.5290.26
49_A104_P0.5270.26
61_M64_I0.5260.26
10_R14_C0.5240.26
95_V98_T0.5230.26
70_K75_R0.5180.26
29_W34_W0.5130.25
47_D98_T0.5130.25
27_D34_W0.5120.25
48_A110_E0.5100.25
16_R21_A0.5070.25
10_R58_D0.5060.25
92_I97_A0.5050.25
20_I41_Q0.5040.25
75_R86_N0.5030.25
61_M89_L0.5030.25
52_Q55_S0.5030.25
25_P36_T0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kz6A 1 0.7982 99.7 0.58 Contact Map
1d0nA 5 0.4211 3.7 0.949 Contact Map
2mnjA 1 0.1754 3.6 0.949 Contact Map
3al0C 1 0.4825 3.1 0.951 Contact Map
3i0yA 2 0.3333 2.8 0.952 Contact Map
4s2rP 2 0.9737 2.6 0.953 Contact Map
4h10B 1 0.193 1.9 0.956 Contact Map
2o6nA 3 0.2895 1.9 0.956 Contact Map
2oa5A 4 0.7193 1.7 0.957 Contact Map
1ux5A 2 0.4737 1.6 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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