GREMLIN Database
YAGS - Putative xanthine dehydrogenase YagS FAD-binding subunit
UniProt: P77324 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13558
Length: 318 (311)
Sequences: 1425 (871)
Seq/√Len: 49.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_L84_V5.1391.00
73_V78_L4.9901.00
178_T188_I4.0841.00
26_K43_E3.6291.00
158_I293_T3.3311.00
19_A27_F3.1701.00
177_E217_T3.1221.00
91_L165_M2.8601.00
287_F290_A2.7561.00
284_D304_K2.6871.00
11_T14_E2.6781.00
292_P297_T2.6611.00
292_P300_L2.6321.00
258_L303_A2.5651.00
253_S276_S2.4221.00
282_V290_A2.4191.00
294_A297_T2.4171.00
74_R77_D2.3941.00
69_I78_L2.3331.00
258_L261_V2.3261.00
19_A49_I2.3261.00
78_L109_T2.3191.00
68_R215_A2.2771.00
69_I109_T2.1671.00
246_A256_V2.1641.00
258_L307_L2.1391.00
189_T192_D2.1361.00
10_N14_E2.0891.00
161_H166_A2.0871.00
109_T216_V2.0831.00
175_V187_S2.0021.00
145_S294_A1.9981.00
204_E263_H1.9740.99
128_P139_A1.9710.99
177_E215_A1.9310.99
16_A180_T1.9140.99
301_L305_R1.9120.99
153_V263_H1.8950.99
229_R309_S1.8460.99
146_R298_F1.8350.99
194_Y264_K1.8300.99
231_V306_T1.8240.99
268_I286_L1.8200.99
146_R233_D1.8180.99
186_R211_E1.8050.99
120_P147_Q1.7960.99
14_E18_S1.7860.99
68_R177_E1.7770.99
88_Y218_L1.7580.99
74_R95_L1.7560.99
267_R272_D1.7400.99
52_N74_R1.7290.99
145_S293_T1.7240.99
177_E184_K1.7150.98
187_S217_T1.6460.98
179_I184_K1.6330.98
274_Q285_T1.6250.98
61_V83_R1.6220.98
191_A269_E1.5850.97
12_P179_I1.5670.97
27_F212_L1.5490.97
51_V72_L1.5480.97
24_G46_T1.5420.97
278_G281_A1.5320.97
90_V171_L1.5250.97
93_R227_I1.5190.97
33_N238_A1.5140.97
114_L193_F1.5000.96
177_E187_S1.4830.96
200_T203_I1.4740.96
33_N123_Y1.4730.96
195_H204_E1.4660.96
178_T211_E1.4590.96
145_S295_E1.4470.96
170_R190_L1.4400.95
178_T207_L1.4190.95
142_E145_S1.4160.95
254_G282_V1.3900.95
282_V286_L1.3710.94
2_K46_T1.3500.94
33_N36_D1.3460.94
127_Q139_A1.3440.93
56_L72_L1.3410.93
188_I206_A1.3390.93
273_A276_S1.3380.93
68_R217_T1.3370.93
66_G88_Y1.3320.93
12_P56_L1.3290.93
33_N75_N1.3220.93
283_Y307_L1.3220.93
286_L290_A1.3150.93
61_V87_D1.3020.92
74_R108_T1.2960.92
191_A194_Y1.2940.92
75_N98_G1.2850.92
5_T47_H1.2720.91
19_A209_P1.2680.91
249_Q253_S1.2640.91
67_L83_R1.2600.91
58_K73_V1.2560.91
268_I289_S1.2520.91
275_L282_V1.2510.91
286_L289_S1.2440.90
256_V268_I1.2350.90
176_V190_L1.2260.90
90_V172_L1.2200.90
145_S148_H1.2090.89
155_E291_H1.2030.89
19_A210_G1.1910.88
7_E47_H1.1890.88
52_N72_L1.1860.88
16_A179_I1.1820.88
133_L136_S1.1790.88
195_H203_I1.1730.88
73_V109_T1.1680.87
83_R87_D1.1670.87
2_K41_E1.1640.87
193_F206_A1.1540.87
166_A190_L1.1500.87
268_I271_A1.1490.87
282_V287_F1.1480.87
13_A179_I1.1410.86
57_D74_R1.1400.86
282_V289_S1.1400.86
222_L247_I1.1390.86
123_Y238_A1.1360.86
113_L190_L1.1360.86
57_D77_D1.1060.84
41_E44_T1.1050.84
28_I35_L1.1050.84
283_Y287_F1.1030.84
190_L194_Y1.1020.84
233_D298_F1.0920.84
25_A49_I1.0840.83
254_G276_S1.0830.83
12_P212_L1.0820.83
170_R191_A1.0810.83
223_G249_Q1.0710.82
75_N97_A1.0690.82
29_A72_L1.0670.82
261_V307_L1.0660.82
76_T80_A1.0640.82
29_A51_V1.0610.82
221_P224_G1.0460.81
268_I285_T1.0420.81
28_I48_L1.0390.81
114_L213_I1.0390.81
283_Y290_A1.0390.81
261_V303_A1.0370.80
110_A169_M1.0340.80
242_V246_A1.0230.79
178_T208_L1.0220.79
188_I193_F1.0140.79
187_S215_A1.0140.79
310_V314_A1.0120.79
180_T211_E1.0080.78
153_V293_T1.0040.78
175_V189_T1.0010.78
193_F211_E1.0000.78
141_L293_T0.9990.78
19_A22_V0.9980.78
294_A300_L0.9930.77
59_I81_H0.9820.77
244_V306_T0.9790.76
208_L211_E0.9730.76
150_V300_L0.9640.75
182_E210_G0.9620.75
75_N165_M0.9550.75
164_D239_F0.9510.74
153_V160_T0.9510.74
83_R86_R0.9480.74
244_V314_A0.9370.73
287_F303_A0.9340.73
123_Y242_V0.9330.73
29_A52_N0.9320.73
190_L193_F0.9310.73
255_R267_R0.9290.73
103_L237_Y0.9220.72
95_L169_M0.9160.71
65_G218_L0.9140.71
191_A267_R0.9120.71
256_V307_L0.9110.71
200_T206_A0.9100.71
246_A310_V0.9100.71
182_E208_L0.9080.71
258_L268_I0.9060.71
75_N238_A0.9040.70
274_Q278_G0.9000.70
280_Q304_K0.8910.69
75_N123_Y0.8900.69
248_I254_G0.8900.69
148_H160_T0.8850.69
33_N242_V0.8820.69
242_V260_G0.8810.68
36_D98_G0.8720.68
153_V204_E0.8710.68
281_A284_D0.8710.68
37_L42_I0.8650.67
270_A289_S0.8640.67
94_A98_G0.8630.67
7_E18_S0.8600.67
203_I208_L0.8530.66
61_V66_G0.8520.66
181_P211_E0.8490.66
284_D287_F0.8490.66
80_A85_R0.8480.65
142_E293_T0.8480.65
139_A142_E0.8430.65
116_R204_E0.8410.65
92_S96_L0.8400.65
57_D72_L0.8360.64
90_V245_A0.8260.63
243_S259_G0.8250.63
40_L123_Y0.8230.63
129_C140_A0.8220.63
256_V271_A0.8200.63
297_T301_L0.8200.63
16_A212_L0.8190.63
109_T165_M0.8160.62
149_A263_H0.8060.62
156_A199_K0.8050.61
116_R122_F0.8020.61
75_N94_A0.8010.61
51_V110_A0.8000.61
180_T184_K0.7990.61
8_R53_G0.7980.61
164_D230_K0.7970.61
170_R194_Y0.7970.61
77_D101_G0.7970.61
274_Q281_A0.7920.60
145_S296_N0.7910.60
147_Q160_T0.7910.60
268_I288_A0.7830.59
173_D191_A0.7830.59
195_H206_A0.7820.59
151_V292_P0.7770.59
229_R310_V0.7740.58
22_V47_H0.7740.58
8_R50_D0.7730.58
51_V212_L0.7710.58
280_Q297_T0.7710.58
223_G247_I0.7650.57
117_T159_A0.7640.57
283_Y308_A0.7630.57
51_V271_A0.7630.57
90_V226_H0.7610.57
138_C157_C0.7580.57
113_L216_V0.7540.56
76_T101_G0.7540.56
51_V56_L0.7470.56
37_L122_F0.7460.56
229_R313_E0.7450.55
151_V303_A0.7440.55
195_H263_H0.7420.55
196_P264_K0.7420.55
9_V14_E0.7420.55
302_L305_R0.7420.55
27_F210_G0.7410.55
90_V247_I0.7390.55
229_R306_T0.7380.55
28_I314_A0.7360.55
57_D73_V0.7350.54
59_I78_L0.7350.54
80_A166_A0.7340.54
301_L304_K0.7280.54
40_L101_G0.7280.54
82_E86_R0.7250.53
260_G298_F0.7210.53
117_T131_K0.7200.53
250_P277_Q0.7160.53
282_V285_T0.7150.52
17_L110_A0.7140.52
142_E294_A0.7110.52
88_Y220_P0.7110.52
254_G275_L0.7100.52
274_Q279_A0.7060.52
87_D222_L0.7030.51
154_S198_G0.7020.51
148_H263_H0.7010.51
4_F29_A0.7010.51
241_L298_F0.7010.51
75_N218_L0.7010.51
7_E82_E0.6990.51
284_D290_A0.6980.51
240_A243_S0.6960.51
293_T297_T0.6930.50
18_S47_H0.6930.50
224_G310_V0.6930.50
150_V261_V0.6920.50
175_V217_T0.6880.50
49_I136_S0.6850.49
280_Q290_A0.6840.49
42_I125_T0.6840.49
77_D95_L0.6820.49
223_G226_H0.6800.49
250_P279_A0.6790.49
280_Q284_D0.6790.49
194_Y263_H0.6750.48
93_R286_L0.6740.48
115_Q162_P0.6720.48
23_P209_P0.6700.48
9_V85_R0.6690.48
151_V268_I0.6670.48
158_I294_A0.6670.48
269_E286_L0.6610.47
8_R106_Q0.6600.47
65_G220_P0.6580.47
227_I313_E0.6560.46
148_H153_V0.6540.46
136_S139_A0.6540.46
200_T204_E0.6510.46
203_I256_V0.6500.46
1_M4_F0.6500.46
33_N98_G0.6470.46
49_I94_A0.6450.45
270_A288_A0.6440.45
12_P27_F0.6410.45
227_I310_V0.6410.45
75_N95_L0.6410.45
153_V233_D0.6370.45
60_E68_R0.6360.44
247_I255_R0.6360.44
113_L194_Y0.6350.44
15_A65_G0.6350.44
36_D238_A0.6350.44
11_T225_K0.6340.44
230_K239_F0.6320.44
29_A108_T0.6300.44
66_G94_A0.6290.44
269_E273_A0.6290.44
144_F233_D0.6270.44
14_E17_L0.6250.43
221_P249_Q0.6240.43
61_V184_K0.6240.43
256_V282_V0.6230.43
93_R305_R0.6230.43
120_P292_P0.6190.43
109_T247_I0.6190.43
41_E226_H0.6190.43
93_R235_A0.6170.43
160_T262_A0.6170.43
124_D146_R0.6160.42
66_G218_L0.6150.42
192_D291_H0.6110.42
150_V303_A0.6100.42
36_D237_Y0.6100.42
178_T206_A0.6090.42
167_V257_A0.6070.42
303_A307_L0.6070.42
130_N137_G0.6070.42
43_E122_F0.6060.41
12_P279_A0.6040.41
188_I207_L0.6030.41
93_R313_E0.6030.41
93_R226_H0.6020.41
7_E14_E0.6010.41
58_K81_H0.6010.41
178_T210_G0.6010.41
204_E262_A0.5980.41
98_G238_A0.5980.41
158_I292_P0.5930.40
94_A161_H0.5920.40
35_L55_G0.5920.40
190_L263_H0.5920.40
12_P16_A0.5910.40
75_N109_T0.5910.40
116_R237_Y0.5900.40
281_A285_T0.5900.40
163_S166_A0.5860.39
11_T49_I0.5860.39
226_H247_I0.5840.39
285_T288_A0.5820.39
78_L95_L0.5810.39
90_V227_I0.5790.39
98_G165_M0.5770.39
34_L38_M0.5750.38
33_N97_A0.5740.38
16_A181_P0.5720.38
78_L169_M0.5720.38
76_T109_T0.5710.38
241_L306_T0.5690.38
51_V213_I0.5660.38
2_K120_P0.5660.38
14_E215_A0.5660.38
59_I83_R0.5650.37
225_K314_A0.5650.37
91_L97_A0.5640.37
186_R208_L0.5630.37
22_V209_P0.5610.37
196_P263_H0.5610.37
115_Q163_S0.5600.37
29_A170_R0.5590.37
139_A148_H0.5590.37
55_G72_L0.5570.37
106_Q226_H0.5570.37
44_T133_L0.5560.37
156_A202_H0.5540.36
66_G69_I0.5520.36
270_A314_A0.5510.36
298_F306_T0.5500.36
28_I268_I0.5500.36
33_N237_Y0.5490.36
51_V69_I0.5490.36
190_L264_K0.5480.36
167_V243_S0.5470.36
39_K109_T0.5450.36
36_D75_N0.5440.35
123_Y204_E0.5430.35
150_V293_T0.5420.35
69_I217_T0.5410.35
193_F208_L0.5410.35
222_L225_K0.5390.35
164_D243_S0.5390.35
248_I311_L0.5390.35
91_L218_L0.5390.35
176_V193_F0.5380.35
129_C138_C0.5370.35
11_T18_S0.5370.35
37_L43_E0.5360.35
306_T309_S0.5360.35
39_K45_P0.5350.35
44_T193_F0.5330.34
35_L39_K0.5300.34
95_L103_L0.5300.34
27_F49_I0.5290.34
77_D100_S0.5290.34
75_N96_L0.5290.34
35_L106_Q0.5280.34
29_A109_T0.5280.34
33_N263_H0.5270.34
69_I216_V0.5270.34
37_L302_L0.5270.34
97_A235_A0.5260.34
114_L206_A0.5240.34
5_T48_L0.5220.33
252_G278_G0.5220.33
37_L204_E0.5210.33
17_L136_S0.5200.33
80_A231_V0.5200.33
18_S49_I0.5180.33
296_N300_L0.5180.33
147_Q305_R0.5170.33
198_G201_P0.5170.33
49_I269_E0.5170.33
155_E192_D0.5160.33
5_T202_H0.5150.33
35_L254_G0.5140.33
258_L271_A0.5120.33
274_Q282_V0.5110.32
82_E288_A0.5100.32
100_S124_D0.5090.32
122_F131_K0.5090.32
72_L123_Y0.5090.32
92_S109_T0.5090.32
280_Q289_S0.5080.32
6_Y22_V0.5070.32
179_I211_E0.5070.32
152_G266_W0.5060.32
254_G278_G0.5060.32
69_I73_V0.5060.32
39_K294_A0.5030.32
33_N205_T0.5030.32
95_L114_L0.5010.32
39_K127_Q0.5010.32
186_R197_P0.5010.32
29_A309_S0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rm6B 1 0.956 100 0.307 Contact Map
1t3qC 1 0.8365 100 0.482 Contact Map
1n62C 1 0.8396 100 0.485 Contact Map
3hrdC 1 0.8522 100 0.487 Contact Map
2w3sA 1 0.8208 100 0.508 Contact Map
1ffvC 1 0.8396 100 0.509 Contact Map
3nvzB 1 0.8428 100 0.524 Contact Map
3zyvA 3 0.8333 100 0.548 Contact Map
3uncA 2 0.8428 100 0.583 Contact Map
3tx1A 1 0.7264 97.5 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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